Capsules na mbadamba Amikacin bụ ụdị ọgwụ ọgwụ adịghị adị maka ịgwọ ọrịa na-efe efe.
Releasedị ntọhapụ ndị dị na ha
Ọgwụ dị n'ụdị abụọ:
- Ngwọta ezubere maka intramuscular ma ọ bụ nchịkwa intravenous. Ọ na-acha ọbara ọbara, na-acha odo odo ma ọ bụ na-enweghị odo. A na-ere ya na ampoules iko, na ngwongwo dị warara na ngwugwu kaadiboodu. Otu ampoule nwere 500 mg ma ọ bụ 1 g nke akụrụngwa nọ n'ọrụ.
- Uzuzu bu mmanu eji agbanye n’ime mmiri. Ọ na-ese na-acha ọcha ma ọ bụ nso na-acha ọcha, ọ nwere ike ịmịkọrọ mmiri. Erere na 10 ml vials enyere n'ime katọn.
A na-emepụta ọgwụ ahụ n'ụdị abụọ: azịza maka nchịkwa intramuscular ma ọ bụ nchịkwa intravenous na ntụ maka nhichapụ na mmiri.
Ngwakọta ọrụ nọ n'ọrụ bụ amikacin (n'ụdị sulfate). Ọgwụ ahụ enweghị ihe ndị ọzọ na-arụ ọrụ.
Ihe ndi ozo nke uzo a bu ihe ndi ozo dika sodium citrate maka injection, sodium disulfite, dilite na igirigi ibu sulphuric acid, mmiri maka injection.
International Nonproprietary Aha
Aha mba ọzọ akwadoghị ọgwụ ahụ bụ Amikacin.
ATX
Koodu ATX - J01GB06
Omume ọgwụ
Ọ bụ onye na-ahụ maka ọgwụ nje, onye nnọchite nke aminoglycoside otu. Ọ nwere mmetụta nje na-enye ụfọdụ gram-nke ọma, yana microorganisms nke aerobic gram. Ọ na-egosi mmezi arụmọrụ megide streptococci. Na-eme ka ọrụ ọgwụ nje nke benzylpenicillin na-emegide fete enterococci.
Ọrịa Anaerobic na-eguzogide ọgwụ na amikacin.
Mlọ ọgwụ
A na-ahụta ọnya nke nwere ihe na-egbochi nje ihe n'ọbara maka awa 10-12 ruo mgbe m nwesịrị m. Na protein protein, ọgwụ ahụ jikọtara aka 4-11%.
Amikacin banye na akwara niile, mmiri a na - eme ka mmiri banye n’ime sel. A na - achọta oke mmamịrị na akụkụ ahụ nke nwere ezigbo ọbara - imeju, akụrụ, splin, ngụgụ, myocardium. Obere ihe nke ihe ahu mejuputara na bile, mmiri ara, ara ahu, mmiri ara, akwara, okpukpu ya na ngwongwo nke abuba. Amikacin gafere n’etiti Plasenta, achọpụtara n’ime ọbara nwa amụrụ n’afọ na mmiri amniotic.
Amikacin
Denye ọgwụ maka ọgwụgwọ nke ọrịa na-efe efe na mkpali. A na-eji ọgwụ ahụ eme ihe n'ọnọdụ ebe ndị na-akpata ọrịa ahụ bụ microorganisms gram-na-adịghị mma (na-eguzogide ọgwụ sitamicin, kanamycin, sisomycin) ma ọ bụ symbioses nke micromgan-gram-positive na gram-positive microorganisms.
A na-atụ aro ka ọ jiri Amikacin maka ọrịa na-efe efe nke anụ ahụ, usoro ụjọ ahụ, akụkụ pelvic, sistem akụkụ okuku ume, nkwonkwo na ọkpụkpụ:
- akwara, mbufụt ma ọ bụ ọnya afọ, ọrịa ndị ọzọ na-efe efe;
- peritonitis na ọrịa ndị ọzọ nke oghere afọ;
- urethritis, cystitis, pyelonephritis;
- ọrịa endocarditis;
- meningitis;
- sepsis
- ọrịa biliary tract;
- ọnya ọnya, ọnya, ọkụ na ọrịa akpụkpọ ndị ọzọ;
- ọnya na-efe efe mgbe ochie na ọnya;
- ọrịa nke imi na akpịrị;
- osteomyelitis.
Ihe ngbanwe
Amachibidoro iji Amikacin tinye ya na:
- mmadụ inabata ya ọgwụ niile;
- nke a chọpụtara na mbụ amachibidoro aminoglycosides;
- neuritis nke akwara ozi;
- ime
- oke nsogbu akụrụ, ya na uremia gbagwojuru anya (site na ngwa nke protein metabolism) na azotemia (nsị site na ihe nwere nitrogen).
Ndị nwere botulism, myasthenia gravis, akpịrị ịkpọ nkụ, nsogbu ọgwụ, na ọrụ na-arụ ọrụ kwesịrị ịkpachara anya mgbe ị na-eji amikacin. Nke a metụtakwara ụmụ aka, ụmụ amụrụ ime, ụmụ nwanyị na-elekọta nwa, ụmụ amaala agadi.
Etu esi ewere amikacin?
Denye ọgwụ ahụ intramuscularly na intravenously (ntapu ma ọ bụ iyi). A na-adụ ndị okenye ọdụ ka ha na-etinye ọgwụ mgbochi 10 ruo 15 kwa kilogram nke oke ahụ. Usoro ego egosipụtara bụ kwa ụbọchị, emere ya maka onunu 2 ma ọ bụ atọ. N'ọnọdụ nsogbu akụrụngwa ezumike ezumike, a ga-enwe mkpa ịgbanwe ọgwụ.
Usoro izizi maka ịmụ nwa na ụmụ amụrụ ọhụrụ bụ 10 mg / kg. Na-esote, a na-ebelata ya ka 7.5 mg / n'arọ, etinyere kwa awa iri na abụọ ọ bụla.
Enwere ike ịgwọ ọgwụ mgbochi nke ukwuu n'ọbara.
Oge ọgwụgwọ ọ dabere na usoro nchịkwa nke ọgwụ (site na ụbọchị atọ ruo ụbọchị asaa maka i / v, site na ụbọchị 7 ruo 10 maka m / m).
Kedu otu esi esi azụ nwa?
Ofzọ nke ntụ ntụ ntụ ntụ na-adabere na usoro nchịkwa:
- maka v / m - ihe dị n'ime vial a na-agwakọta na 4-5 ml mmiri maka ịgba ọgwụ;
- maka drip iv - a na-agbaze ọdịnaya nke vial na 200 ml nke 0.9% sodium chloride solution ma ọ bụ 5% dextrose solution;
- maka inpa jet iv - 0.9% sodium chloride solution, 5% ihe dextrose ma ọ bụ mmiri ntụtụ (site na 4 ruo 5 ml) agbakwunyere ọdịnaya nke vial ahụ.
Ọ dị mkpa ijide n'aka na ọdịnaya nke amikacin na ihe ngwọta maka nchịkwa intraven karịrị 5 mg / ml.
Ọ ga - ekwe omume ị forụ ọgwụ maka ọrịa shuga?
Ọ bụrụ na ụdị shuga na-akpata insulin, Amikacin ka ejiri nlezianya dezie ya. Mgbe ị na-ahọrọ usoro ọgwụgwọ, ọ bara uru ịtụle ọnọdụ onye ọrịa ahụ.
Nsonaazụ nke Amikacin
Dị ka ọgwụ ndị ọzọ, Amikacin nwere ike ibute mmepe nke mmeghachi omume ọjọọ.
Sistemụ akwara Central
Site n'akụkụ akụkụ akwara dị n'etiti nwere ike ime:
- iro ụra
- isi ọwụwa
- nsogbu ahu
N'ọnọdụ ụfọdụ, ọgwụ ahụ nwere mmetụta neurotoxic, gosipụtara na nkwonkwo akwara, nsogbu ọdịdọ, ọnya aka.
Site na usoro urinary
N'oge ọgwụgwọ na amikacin, ngosipụta nke nephrotoxicity nwere ike ime, dị ka oliguria, microredituria, proteinuria.
Ahụhụ
Site na mmetọ nke ọgwụ ndị dị na ọgwụ ahụ, mmeghachi omume nfụkasị ndị a nwere ike ime:
- hyperemia nke anụ ahụ;
- Ire Quincke;
- akpukpo anụ;
- ahụ ọkụ
- itching
Mmetụta ikike ịchịkwa usoro
Site na mmepe nke mmeghachi omume na-adịghị mma site na sistemụ akwara nke etiti, ọ ka mma ịjụ ịchịkwa usoro.
Ntụziaka pụrụ iche
Tupu ị theụ ọgwụ ahụ, ọ dị mkpa iji chọpụta nsi nke ọrịa nje. Iji mee nke a, jiri diski dị 30 μg nke amikacin jiri diski.
Ọ dị mkpa iji hụ na plasma ọdịnaya nke amikacin anaghị agafe 25 μg / ml.
N'oge usoro ọgwụgwọ, ọ dị mkpa iji nyochaa arụmọrụ akwara auditory, akụrụngwa na ngwa vestibular. Ọ dị mma ime nke a otu ugboro n’izu.
N'ọnọdụ maka ule ụda olu na-adịghị eju afọ, belata dose ma ọ bụ kwụsị ọgwụ ahụ.
Ọ bụrụ na arụ ọrụ ezumike mkpirikpi, ogologo oge iji ya ma ọ bụ iji ọgwụ were ọgwụ buru ibu, nephrotoxicity nwere ike ịmalite.
Site na ọrịa na-efe efe na mkpali nke akwara, a chọrọ ọtụtụ mmiri.
Enweghị ezigbo nsonaazụ nwere ike igosi ntopute nke microorganisms na-eguzogide ọgwụ. N'okwu a, a kagburu Amikacin, a na-eme ọgwụgwọ kwesịrị ekwesị.
Jiri na agadi
Maka ndị okenye, ejiri ọgwụ jiri Amikacin dezie ya.
Inye umuaka
Ọgwụgwọ nke ụmụ aka bu ụzọ amalite site na 10 mg / kg. Mgbe ahụ, a na-enye ọgwụ ahụ na 7.5 mg / kg maka awa 18-24 ọ bụla.
Ọgwụ nke mbụ maka ndị ọrịa sitere na afọ 0 ruo 6 bụ 10 mg / kg. Mgbe ahụ, a na-ahụ ọgwụ ahụ kwa awa 12 na 7.5 mg / kg. Usoro ọgwụgwọ ahụ na-ewe ụbọchị asaa ruo ụbọchị iri.
Jiri n'oge ime na lactation
Edeghị Amikacin maka ndị ọrịa dị ime.
Jiri ọgwụ mgbe ị na-enye nwa ara, ma ọ bụrụ na enwere njiri mara.
Dodoụbiga ya ókè
N'ọnọdụ ịdoụbiga mmanya ókè, mmeghachi omume nsị nwere ike ịmalite: ataxia, akpịrị ịkpọ nkụ, anya mmiri, ntị anụrị, nsogbu nke urination, ọgbụgbọ, ọgbụgbọ, agụụ nri, ịnụ ntị na nsogbu iku ume.
Iji wepu nsonaazụ nke ịdoụbiga mmanya ókè, enwere ike iji ọgwụ diitisation na akụrụngwa ọwụwa akụrụngwa. O nwekwara ike iji ọgwụ anticholinesterase, ikuku nke ikuku, sọlfọ nnu.
Mmekọrịta na ọgwụ ndị ọzọ
Amikacin na-eso ihe ndị a:
- ya na cephalosporins, benzylpenicillin, carbenicillin - enwere mmụba nke amikacin na ọgwụ ndị edepụtara;
- ya na ọgwụ diuretic (karịsịa furosemide), penisiliniins, NSAIDs, cephalosporins, sulfonamides - mụbara neuro- na nephrotoxicity;
- ya na uzo purare dika otutu ihe nwere ike imeghari akwara;
- ya na indomethacin (ya na nchịkwa parenteral) - mmepe nke mmetụta nsí nke ọgwụ aminoglycosides;
- ya na polymyxin B, vancomycin, nalidixic acid, cisplatin - ịba ụba nke nephro- na ototoxicity;
- na ọgwụ mgbochi astiastenic - mbelata ịdị irè nke ọgwụ ndị a kpọtụrụ aha;
- ya na methoxyflurane, capreomycin, parenteral polymyxins na ọgwụ ndị ọzọ nwere mmetụta yiri ya - ịbawanye ohere nke njide iku ume.
Ekwesịrị icheta na Amikacin enweghị ọgwụ n'ụzọ kwekọrọ n'ihe ndị a: heparin, capreomycin, hydrochlorothiazide, potassium chloride, erythromycin, amphotericin B, nitrofurantoin, penicillins, cephalosporins, vitamin C na B.
Mmanya ndakọrịta
A notụla mmanya mgbe ị na-eji Amikacin. Nchikota a na ebulite ibu na imeju, na-ebute mmepe nke mmeghachi omume ojoo.
Analogs
Ọdịmma analogues maka akụkụ akụrụngwa:
- Amikabol;
- Amikacin Ferein;
- Amikacin Vial;
- Sọlfọ Amikacin;
- Amicositis;
- Amikin;
- Seleomycin;
- Lycacin;
- Hemacin;
- Fercycline.
Ahịa ọgwụ na-ahapụ okwu
Purchasezụta Amikacin, ị ga-achọ ọgwụ.
Ọnụahịa
Ọnụ ego ọgwụ a na-akwụ na-adabere na ọnụọgụ ampoules (karama) dị na mkpọ, oke ahịa ọgwụ na ihe ndị ọzọ. Ọnụ ego kachasị elu nke Amikacin na Russia bụ 2500-2600 rubles. kwa otu iko 50 nke ntụ ntụ.
Ọnọdụ nchekwa maka ọgwụ
A na-echekwa ntụ ntụ na ebe a ga-edobe ya n'ebe kpọrọ nkụ na ebe gbara ọchịchịrị, ebe ụmụaka na-enweghị ike iru. Okpomoku a na-anabata ọgwụ ịchekwa ọgwụ dịgasị n'etiti + 5 ... + 25 Celsius.
Bọchị mmebi
Amikacin na-ejigide akụrụngwa ya ọnwa iri isii na isii.
Emeputa
Onye mepụtara ọgwụ ahụ bụ Kraspharm OJSC, nke dị na mpaghara Krasnoyarsk.
Nyocha
Yana, 31 afọ, Perm: "Mgbe nwa m nwanyị chọpụtara ọrịa eriri afọ, anyị zụtara Amikacin n'ụdị ntụ ntụ. Dọkịta ahụ na-ekwu maka ịkwadebe ọgwụ ahụ dị ka ntuziaka ya si gbasa ya na ọgwụ. Ọgwụ ahụ gara nke ọma, enweghị mmetụta ọ bụla."
Olga, onye gbara afọ 27, Ufa: “Amalitere m iji Amikacin mgbe m jidere oyi baa m, ana m ajeụ kwa ụbọchị ruo ụbọchị 5. Enweghị nsogbu ọ bụla, belụsọ ntakịrị ọgbụgba nke kwụsịrị mgbe mwepụ ọgwụ ọjọọ. M na-ahụ na ọgwụ ahụ na-adị mgbe niile ụlọ ọgwụ ụlọ ọgwụ. "
