Enwere ọtụtụ ọgwụ metabolic metụtara abụba na metabolism metabolism. Otu n’ime ha bụ Tiogamma.
Ọgwụ a na - etinye aka na usoro metabolic na - eme na imeju, na - enyere aka belata cholesterol, mụbaa ọkwa glycogen na imeju, na - emetụta nkwụsị nke mkpụrụ ndụ na insulin ma si otú a na - enyere aka belata ọkwa shuga dị n'ọbara, nke dị ezigbo mkpa maka ọrịa shuga (karịsịa ụdị nke abụọ), na ekwupụtakwala ihe ndị na-egbochi antioxidant.
O siri ike nye mmadụ nkịtị ịghọta ihe Tiogamma sitere na mmetụta ọ na-akpata. N'ihi mmetụta pụrụ iche nke anụ ahụ nwere n'ahụ ahụ, a na-enye ọgwụ ahụ ka ọ bụrụ ọgwụ hepatoprotective, hypoglycemic, hypoliplera na hypocholesterolemic ọgwụ, yana ọgwụ na-eme ka akwara neurotrophic.
Omume ọgwụ
Thiogamma bụ nke metabolic otu ọgwụ, ihe na-arụ ọrụ n'ime ya bụ thioctic acid, nke anụ ahụ na - arụkarị site n'oge anụ ahụ decarboxylation nke alpha-ketone acid, bụ antioxidant endogenous, na - arụ ọrụ dị ka coenzyme nke mitochondrial multienzyme ma na - etinye aka ozugbo na ike nke intracellular cell.
Acid Thioctic na-emetụta ọkwa glucose, na-enye aka na-ekenye glycogen n'ime imeju, yana wedata insulin na-eguzogide n'ọkwa sel. Ọ bụrụ na nchịkọta nke alfa-lipoic acid dị n’ahụ na-emebi n'ihi mmerụ ahụ ma ọ bụ nnakọta nke ngwaahịa na-emebi emebi (dịka ọmụmaatụ, ozu ketone na ketosis mamịrị), yana oke mkpokọ nke radicals na-enweghị nsogbu, ihe na-ezighi ezi na sistemụ aerobic glycolysis na-apụta.
Thioctic acid na - aputa ihe n’anu ahu n’uzo abuo nke aru oru, ya mere, n’eme ihe n’eme ka aru di ya nma, bu kwa ihe ndi n’echebe aru.
Thiogamma na ngwọta na mbadamba
Ọ na-etinye aka na nhazi nke abụba na metabolism metabolism. N'ihi hepatoprotective, antioxidant na mmetụta antitoxic, ọ na-eme ka ọ dị mma ma na-eweghachi ọrụ imeju.
Thioctic acid na mmetụta ọgwụ ya na ahụ dị ka ọrụ nke vitamin B Ọ na-eme ka akwara neurotrophic dịkwuo elu ma na-akpali ịmaliteghachi anụ ahụ.
Pharmacokinetics nke Thiogamma dị ka ndị a:
- mgbe a na -ekwu ya site na ọnụnụ, thioctic acid fọrọ nke nta ka ọ bụrụ n'ụzọ zuru oke na n'ụzọ ziri ezi ngwa ngwa site n'akụkụ akụkụ eriri afọ. A na - ekewa ya n'ụdị metabolites site na akụrụ nke 80-90% nke ihe ahụ, metabolites na - akpụzi site na ọzịza nke akụkụ yinye na conjugation, a na - eme ka metabolism bụrụ nke a na - akpọ "first way effect" site na imeju. Oke ruru ịta ahụ ruru na nkeji 30-40. Bioavailability ruru 30%. Ọkara ọkara bụ minit 20-50, ikpochapụ plasma bụ 10-15 ml / min;
- mgbe ị na-eji ọgwụ thioctic acid mee ihe, a na-achọpụta ebe kachasị na - eme ihe mgbe nkeji 10-15 ma ọ bụ 25-38 μg / ml, mpaghara nke oge ịta ahụ bụ ihe dịka 5 hg h / ml.
Ihe eji arụ ọrụ
Ihe na - arụ ọrụ nke ọgwụ Tiogamma bụ thioctic acid, nke otu nke metabolites endogenous.
N'ime usoro ndị na-egbu egbu, ihe na-arụ ọrụ bụ alfa lipoic acid n'ụdị nnu meglumine.
Ndị pụrụ iche n'ụdị mbadamba bụ microcellulose, lactose, talc, colloidal silicon dioxide, hypromellose, sodium carboxyl methyl cellulose, magnesium stearate, macrogol 600, semethicone, sodium lauryl sulfate.
N’ime ihe ngbochu ogwu, meglumine, macrogol 600 na mmiri maka igba ogwu dika ihe ndi ozo.
Mpempe mwepụta
E nwere ọtụtụ ụdị usoro onunu ogwu dabere na acid thioctic: mbadamba mkpuchi, ihe ndọta maka infusion, usoro edozi nke edozibere maka infusion.
Nchikota ọgwụ ndi ndi n’enwe ha nyere:
- ụdị mbadamba dị ka ihe na-arụ ọrụ nwere 600 mg nke thioctic (α-lipoic) acid. Mbadamba nkume ndị ahụ dị ka nke ọma, kpuchie ya na obere odo na-acha ọcha. Mbadamba mbadamba n'akụkụ ọ bụla dị n'ihe ize ndụ;
- 1 ampoule nke 20 milliliters nke ihe ngwọta siri ike maka infusion dị ka ihe na-arụ ọrụ nwere 1167.7 mg nke alpha-lipoic n'ụdị nnu meglumine, nke kwekọrọ na 600 milligrams nke thioctic acid. Ọ nwere ọdịdị nke ihe ndozi doro anya nke hue na-acha akwụkwọ ndụ akwụkwọ ndụ;
- edozi edozi edozi nke edozila nke edoziworo nke ọma maka ọgwụ mbulata nke karama-50 mililiters ma nwee 1167.7 mg nke thioctic acid n'ụdị nnu meglumine dị ka ihe na-arụ ọrụ, nke dabara na 600 mg nke alfa lipoic. Ngwọta doro anya nwere agba sitere na odo odo ruo odo odo.
Tiogamma: kedu ihe edepụtara?
Thiogamma bụ otu nke nhazi metabolic endogenous, na-ekere òkè na carbohydrate na abụba metabolism na ọkwa cellular, na-enyere aka belata glucose ọbara, na-akwalite mkpokọta nke glycogen na imeju, na-ebelata insulin iguzogide, nwere antioxidant na mmetụta antitoxic, nwere hepatoprotective, hypolip virus na hypocholesteric mmetụta .
N'ihi njirimara ya, nsonaazụ ahụ yana usoro metabolic na-aga n'ihu, edepụtara Thiogamma dị ka ọgwụ mgbochi ọgwụgwọ yana:
- polyneuropathy na-arịa ọrịa shuga;
- ị neuroụ neuropathy;
- ịba ọcha n'anya nke etiologies dị iche iche, cirrhosis, ọrịa imeju na-egbu egbu;
- n'ihe banyere nsị na-egbu egbu, yana nnu nke ọla dị iche iche dị arọ;
- na mmanya n. egbu.
Thiogamma nwere ọtụtụ ọgwụ mgbochi dị njọ, dị ka ịgwọ mmadụ n'otu n'otu na alfa lipoic acid, enweghị lactase, enweghị anagide galactose.
Enweghị ike ị were ya n'ọnọdụ malabsorption, ya bụ, ike gwụrụ iji nwetakwa ụtarị na glucose site na eriri afọ, n'ọrịa obi na akụkụ okuku ume, infarction myocardial, nnukwu ọrịa obi, ọrịa akụkụ akwara, ụkwara akụrụ, akpịrị ịkpọ nkụ, ahoụrụma na-adịghị ala ala, yana ọrịa ndị ọzọ. na ọnọdụ ndị na-eduga na lactic acidosis.
Mgbe ị na-eji Thiogamma, ọgbụgbọ, dizzness, vomiting, afọ ọsịsa, mgbu afọ, ọsụsọ nke ukwuu, mmeghachi omume nfụkasị ahụ n'ụdị ọnya anụ ahụ, hypoglycemia kwere omume, ebe a na-eme ka glucose na-eme ngwa ngwa.
Ugha iku ume na okpo iku ume mgbe ana akari.
Mgbe ị na-eji Tiogamma, ndị nwere ọrịa shuga kwesịrị ijide n’aka na-achịkwa ọ̀tụ̀tụ̀ shuga dị ala, ebe ọ bụ na thioctic acid na-eme ka oge glucose gharazie ike, nke, mgbe ọkwa ya dara nke ukwuu, nwere ike ibute nkụja hypoglycemic.
Site na mbelata shuga na mberede, ọkachasị na mbido ị takingụ Thiogamma, oge ụfọdụ ịbelata insulin ma ọ bụ ọgwụ hypoglycemic. Amachibidoro ị ofụ mmanya na ọgwụ nwere mmanya egbu egbu n'oge iji Tiogamma, ebe ọ bụ na a na-ebelata mmetụta ọgwụgwọ, yana ụdị siri ike nke neuropathy na-aba n'anya nwere ike ime.
Alpha-lipoic acid ekwekọghị na nkwadebe nke nwere dextrose, Ringer-Locke, cisplatin mgbe ejikọtara ọnụ. Ọ na-ebelata ịdị irè nke nkwadebe nwere iron na ọla ndị ọzọ.
Efu
A na-emepụta Thiogamma na Germany, ọnụahịa nkezi bụ:
- maka ịkwakọ mbadamba nke 600 mg (mbadamba 60 kwa mkpọ) - 1535 rubles;
- maka ịkwakọ mbadamba nke 600 mg (iberibe 30 kwa mkpọ) - 750 rubles;
- maka uzo maka infusion nke 12 ml / ml na 50 ml vials (iberibe 10) - 1656 rubles;
- kwa ihe omuma maka inye okpukpu iri na karama mm / mmiri nke 50 ml - 200 rubles.
Vidiyo ndị metụtara
N'iji alfa lipoic maka oria shuga na vidiyo:
Nkọwa nke ọgwụ Thiogamma bụ ihe mmeghe ma enweghị ike iji ya dịka nkuzi. Yabụ, tupu ịzụta ma jiri ya na aka gị, ịkwesịrị ịgakwuru dọkịta nke ga-ahọrọ ụzọ dị mkpa ọgwụgwọ na usoro ị ofụ ọgwụ a dị.
