Baeta - njirimara nke iji ndị ọgwụ antidiedi

Onye na-ahụ maka ọgwụ antidiabetic maka nchịkwa paịteral nke Baeta bụ nke klaasị nke ndị agonist ma na-enyere aka mee ka nchịkwa glucose dị n'etiti ndị ọrịa nwere ụdị mellitus II nke ọrịa.

Incretin bụ homonụ nke mucosa eriri afọ na-emeghachi omume oriri, ihe na-akpali insulin na-adabere na insulin.

Usoro nke Byet na-enye gị ohere ịlụ ọgụ na ọrịa mellitus na-enweghị insulin na-enweghị insulin n'ọtụtụ ebe n'otu oge.

• Ọ na - egbochi ihe glucose nke hormone a na - eme, nke na - eme ka nchịkọta glucose dị n'ahụ.
• Na-agba mkpụrụ ndụ panc-na-agba ume ume imepụta insulin.
• Ọ na - egbochi nzipu nke nri na afọ, na - egbochi nnabata nke glucose dị ukwuu n'ọbara.
• Na-achịkwa ogige nke satiety na agụụ, na-egbochi agụụ.

Usoro ndị a na - enyere aka belata oke nri a na - a consumedụ, na - ekwe ka onye ọrịa shuga felata ma gbochie ya ịbawanye n'ọbara shuga.

Ugbu a, ndị ọkachamara na-amụ banyere nsonaazụ mmiri ọgwụ dị na sistem na akwara ozi. Nnyocha ụmụ anụmanụ egosila na iji ọgwụ dị na klaasị eme ihe na-eduga n'ịghachite akụkụ ahụ nke mkpụrụ ndụ pancreatic mebiri emebi.

Ndị na-emepụta ihe

Onye na-emepụta ọgwụ Beat bụ ụlọ ọrụ Eli Lilly na ụlọ ọrụ ọgwụ ụlọ ọrụ, nke hiwere na 1876 na Indianapolis (USA, Indiana).

Nke a bụ ụlọ ọrụ ọgwụ mbụ bidoro mepụta insulin n'ụlọ mmepụta ihe na 1923.

Companylọ ọrụ ahụ mepụtara ma mepụta ọgwụ maka ndị mmadụ rere ere nke ọma na ihe karịrị otu narị mba, na steeti iri na atọ enwere ụlọ ọrụ maka mmepụta ha.

Ntuziaka nke abụọ nke ụlọ ọrụ ahụ bụ imepụta ọgwụ maka mkpa ọgwụgwọ ọgwụ.

Ngwakọta

Onye na - arụ ọrụ nke ọgwụ ahụ bụ 250 microgram nke exenatide.

Ihe ndị ọzọ bụ sodium acetate trihydrate, glacial acetic acid, mannitol, metacresol na mmiri maka ịgba ntụtụ.

Baeta dị n'ụdị mkpịsị mkpụrụ ọgwụ disposable nwere ọgwụ na-enweghị atụ maka ntụtụ n'okpuru anụ ahụ nkeji 60 tupu iri nri n'ụtụtụ na mgbede.

Ihe ngosi

A na-atụ aro ka Baeta na ọgwụgwọ nke ọrịa mellitus na-abụghị insulin na-akpata (ụdị II) iji mee ka njikwa glycemic dị mfe:

• n'ụdị monotherapy - megide nzụlite nke nri nri dị ala na-arụ ọrụ na-arụ ọrụ na-arụ ọrụ;
• na ngwakọta ọgwụgwọ:
  • dị ka mgbakwunye na ọgwụ ndị na-eme ka okpukpu dị ala (metformin, thiazolidinedione, sulfonylureaeri);
  • maka iji ya na metformin na basal insulin.

N'okwu a, usoro mmanụ sulfonylurea nwere ike ịchọ mbelata usoro onunu ogwu. Mgbe ị na-eji Byeta, ị nwere ike belata ọgwụ ị na-eme ozugbo site na 20% wee gbanwee ya n'okpuru njikwa glycemia.

Maka ọgwụ ndị ọzọ, enweghị ike ịgbanwe usoro nchịkwa mbụ.

Na nkenke, a na-atụ aro ka ndị ọgwụ ọgwụ ndị nwere ọgwụ ndị ọzọ ka jikọta ya na ndị ọrụ hypoglycemic ndị ọzọ iji bulie ọrụ ha na oge igbu oge insulin.

Ekwesighi iji exenatide eme ihe maka:

• mmadụ nwere ike iji ihe ndị ọgwụ a mejupụtara ya mee ihe;
• mellitus na-arịa insulin na-akpata ọrịa shuga (ụdị nke m);
• mebiri emebi akụrụ ma ọ bụ imeju akwara;
• ọrịa nke usoro nri, na paresis (mbelata nke contraility) nke afọ;
• afọ ime na lactation;
• ọrịa akwara ma ọ bụ ọrịa gara aga.

Edebela ụmụaka akwụkwọ ruo mgbe ha toro.

Ugboro nke ihe dị njọ mgbe ị na-eji Byet sitere na 10 ruo 40%, a na-egosipụta ya tumadi na ọgbụgba dị mkpụmkpụ na ọgbụgbọ na mmalite ọgwụgwọ. Oge ụfọdụ mmeghachi omume mpaghara nwere ike ime na ntụtụ.

Analogues nke ọgwụ

Ajuju nke iji dochie anya Bayet na ozo, dika iwu, nwere ike ibilite n'okpuru onodu ndi a:

• ọgwụ ahụ adịghị ala ala glucose;
• a na-egosipụta mmetụta nke ọma;
• Ọnụahịa ahụ dị oke.

Ọgwụ Baeta generics - ọgwụ nke ejiri ọgwụgwọ ọgwụgwọ na okike ebikọtara ya.

Ihe analogues ya zuru oke n'okpuru ikike nke Lilly na Companylọ ọrụ bụ nke Bristol-Myers Squibb Co (BMS) na AstraZeneca mepụtara.

Countriesfọdụ mba na-ere ahịa Byetu n'okpuru ika ọgwụ Bydureon.

Baeta Long bụ onye nnọchianya hypoglycemic nwere otu ọrụ na-arụ ọrụ (exenatide), naanị ogologo ọrụ. Zuru oke mmekorita nke Baeta. Ọnọdụ eji eme ihe - otu ụzọ dị okirikiri ụbọchị asaa ọ bụla.

Otu ọgwụ ọgwụ yiri nke a gụnyere Victoza (Denmark) - ọgwụ na-ebelata shuga, ihe na-arụ ọrụ bụ liraglutide. Site na akụrụngwa ọgwụgwọ, ihe na-egosi na contraindications, ọ bụ yiri nke Baete.

Incretin agonists nwere naanị otu usoro onunu ogwu - ịgba ntụtụ.

Otu nke abụọ nke klaasị ọgwụ ọjọọ nọchiri anya ọgwụ ndị na - egbochi mmepụta enzyme dipeptidyl peptidase (DPP-4). Ha nwere ihe ndi di egwu na ihe ogwu ha.

Ndị na-egbochi DPP-4 gụnyere Januvia (Netherlands), Galvus (Switzerland), Transgenta (Germany), Ongliza (USA).

Dị ka Baeta na Victoza, ha na-abawanye ọkwa insulin site na ịbawanye oge nke incretins, na-egbochi mmepụta glucagon ma na-akpali ịtụgharị mkpụrụ ndụ.

Naanị anaghị emetụta ọnụego ntọhapụ nke afọ ma adịghị eme ka oke belata.

Ngosiputa maka iji otu ndi ogwu a bu kwa mellitus oria-non-insulin-non-insulin (ụdị II) na usoro monotherapy ma obu ya na ogwu ndi ozo.

Otu uru dị na ya bụ iji usoro ọnụọgụ ọgwụ ha n'ụdị mbadamba maka nchịkwa ọnụ, nke ga-enye gị ohere ịbanye ọgwụ ahụ n'ime ahụ na-ejighị ọgwụ ịgba.

Baeta ma ọ bụ Victoza: nke ka mma?

Ọgwụ abụọ ahụ nwere otu ahụ - analogues anarol nke incretin, nwere ụdị ọgwụgwọ ahụ.

Ma Victoza nwere mmetụta dị omimi karịa nke na-enyere aka belata ibu nke ndị ọrịa buru ibu nke nwere ọrịa shuga II.

Victoza nwere mmetụta dị ogologo karị, a na-atụ aro ka a na-enye ya ọgwụ ọgwụ subcutaneous otu ugboro kwa ụbọchị na agbanyeghị iri nri, ebe a ga-enye Bayetu ugboro abụọ n'ụbọchị otu awa tupu nri.

Ọnụahịa ire ere nke Viktoza n'ụlọ ahịa ọgwụ dị elu.

Dọkịta na-aga ya na-eme mkpebi banyere nhọrọ nke ọgwụ, na-eburu n'uche njirimara onye ọrịa, ogo nke mmetụta yana ịtụle ogo ọrịa ahụ.

Vidiyo ndị metụtara