Isofan insulin (nke mmadụ mepụtara site na mkpụrụ ndụ ihe nketa)

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Site na ọrịa shuga, n'oge na-adịghị anya, insulin nke pancreas mepụtara na-amalite erughi nke insulin, nke a na-agbanye n'ahụ ya bụ erughi nke insulin.

Isofan insulin bụ otu n’ime ihe ndị mejupụtara ọgwụ iji mechie ọgwụ. N'ime ahụ, insulin a na-arụ ọrụ dị ka nke eke: na-ebuga glucose ngafe n'ahụ anụ ahụ, ebe ọ na-agbajikwa, na-enye ahụ ike. Site n'ọrịa shuga 1, Isofan na-ejikọ ya na homonụ dị mkpụmkpụ, nke ezubere iji chịkwaa glycemia postprandial (mgbe ị risịrị nri). Na ụdị ọrịa 2, naanị insulin Isofan nwere ike zuru ezu maka ndị ọrịa mamịrị.

Ngwakọta ọgwụ ahụ

E kpụrụ insulin eji na-arịa ọrịa shuga kewara n'ọtụtụ buru ibu dịka oge nke ime ihe si dị. Iji mezie usoro insulin nke gị kpamkpam, ịchọrọ homonụ nke ụdị abụọ: ogologo (ma ọ bụ ọkara) na mkpụmkpụ (ma ọ bụ ultrashort) - isiokwu banyere ụdị insulin. A na-ekenye Isofan dị ka insulin na-ajụ ajụ. Site n'iji okpukpu abụọ mee ihe kwa ụbọchị, ọ na-enwe ike ịnye ọ̀tụ̀tụ̀ homonụ nke mmiri dị n'ọbara, nke na-ebelata glucose, nke na-abanye n’ọbara n’ogweji n’akụkụ elekere.

Isofan insulin nwere ihe ndi na aru oru aru oru abuo:

  1. Insulin. Na mbụ, a na-eji homonụ na bovine mee ihe, ugbu a ọ bụ naanị eji arụ ọrụ mkpụrụ ndụ ihe eji arụ ọrụ, nke ya na homonụ nke mmadụ na-emepụta. A na-eme ya site na iji ọgwụ nje gbanwere, ọgwụ ahụ nwere oke nsacha, nke anụ ahụ na-ahụkarị ya, o nwekwara ike ibute ihe ndị na-emetụta ya karịa ndị bu ya ụzọ.
  2. Protamine - protein nke a na - eji dị ka ndọtị nke insulin. Site na ya, oge nnabata homonụ sitere na anụ ahụ dị n'okpuru ala n'ime arịa ahụ na-abawanye site awa isii ruo awa iri na abụọ. Na insulin, a na-agwakọta homonụ Isofan na protamine na ichero iche, ya bụ, ọ nweghị ihe ndị ọzọ dị n'ime ihe ngwọta ahụ. Site na aha onye okike, onye sayensị sayensị Hagedorn, a na-akpọkarị insulin Isofan n'akwụkwọ akwụkwọ ahụike dị ka protamine protamine Hagedorn, ma ọ bụ NPH-insulin.

Yabụ na protamine nwere insulin nwere ike ipu kristal, a na-agbakwunye zinc ka ọ dị mma. Phenol na m-cresol dị na nkwadebe ahụ dịka ihe eji echekwa ya; iji nweta azịza na-anọpụ iche, a na-eji acid ma ọ bụ isi na-adịghị ike. Maka analogues nke ụdị dị iche iche, ihe mejupụtara ihe inyeaka dị iche, enyere ndepụta zuru ezu na ntuziaka maka ojiji.

Ọrịa shuga na oke nrụgide ga-abụ ihe mgbe ochie

  • Normalization shuga -95%
  • Mwepu nke akwara mbufụt - 70%
  • Mwepu nke obi ike -90%
  • Bibie ọbara mgbali elu - 92%
  • Mmụba na ume n'ụbọchị, na-eme ka ụra na-ehi ụra n'abalị -97%

Ihe ngosi maka oge atọrọ

Ihe kpatara nhọpụta ọgwụ insulin basal nwa nwere ike ịbụ:

  1. 1dị ọrịa shuga 1. A na-eji usoro insulin eme ihe siri ike, ya bụ, ma a na-eji Isofan na obere insulin eme ihe.
  2. Typesfọdụ ụdị ọria mamịrị.
  3. 2dị nke abụọ, ọ bụrụ na contraindicated hypoglycemic mbadamba ma ọ bụ enyeghị njikwa ọrịa shuga zuru oke. Dịka iwu, a na-eji Isofan agwọ ọrịa insulin. Mkpa nke obere hormone ga-apụta ma emesịa.
  4. 2dị nke 2 n’oge afọ ime.
  5. Dịka onye nnọchi mbadamba, ma ọ bụrụ na ụdị shuga 2 nọ n'ọnọdụ nrụrụ. Mgbe mbelata shuga, a ga-ebugharị onye ọrịa ọzọ ka ọ bụrụ ihe eji eme ya.
  6. Ọrịa afọ ime, ma ọ bụrụ na nri pụrụ iche anaghị belata shuga na nkịtị.

Akara ahia ahia

Isofan insulin bu nnuku insulin mara nma n’uwa. Ogwu ndi ozo ugbua di onu ahia karie ugbua amalitekwa imeri n’agha. Aha ahia Isofan ndị a ka e debara aha ha na Russian Federation:

AhaỌnụahịa, tee.Nkwakọ ngwaahịa, ụzọ nchịkwaEmeputa
Karama, sirinji insulinCartridges, Syringe pen
Biosulin Nsite na 506++Onye na-ere ọgwụ
Rinsulin NPHsite na narị anọ++Heropharm
Rosinsulin Csite na 1080++Osisi Medsintez
Mgbapụta insulin mberedesite na 492+-VIKA
Gensulin N-++MFPDK BIOTEK
Insuran NPH-+-IBCh RAS
Humulin NPHsite na narị isii++Eli Lilly
Insuman Bazal GTsite na 1100++Sanofi
Protafan NMsite na 370++Novo Nordisk
Vozulim-N-++Wokhard Limited

Ọgwụ ndị a dị n'elu bụ analogues. Ha nwere otu uche ma dị nso n'ike, yabụ, na-arịa ọrịa shuga, ọ ga-ekwe omume ịgbanwe site na otu ọgwụ gaa na nke ọzọ na-enweghị nhazi ọ bụla.

Glargin (Lantus, Tujeo) na Detemir (Levemir) bụ insul analogues, molecule ha di iche na Isofan. A na-ahọpụta ọgwụ ndị a dị ka insulins ogologo. Ha nwere mmetụta dị ogologo ma kwụsie ike karị, yabụ ọtụtụ ndị ọrịa mamịrị na-agbanye ha.

Ciplekpụrụ nke ịrụ ọrụ

Isofan insulin nwere mmetụta hypoglycemic. Jiri nwayọ banye n'ime ọbara site na anụ ahụ dị n'okpuru ala, homonụ na-agbasa ahụ niile wee banye na ndị na - anabata insulin nke dị n'ahụ sel. N'ihi nke a, membranes na-aghọ nke nwere mmetụta glucose, ọ nwere ike ịbanye na sel, ebe ọ gwụrụ ma wepụta ike. Ọbara ọbara, karị, mbelata.

Insulin na-enyekwa aka na mmepụta nke glycogen na akwara na umeji, nke a na -emepụta ya na glucose ma bụrụkwa ụdị nchekwa ume nke ahụ. A na-eji ihe ndoputa a mgbe shuga dị ala.

Omume ọzọ dị mkpa nke insulin bụ igbochi ndakpọ na mkpali nke protein na carbohydrate njikọ.

Ogologo oge nke otu ntụtụ dị iche na ndị mmadụ dị iche iche. Ọ dabere na ọnọdụ na ntụtụ nke ọnya, ọkwa ọbara dị n'akụkụ a, ọnụọgụ, ụdị shuga mellitus, ọnọdụ ahụ na ihe ndị ọzọ.

Isofan insulin arụmọrụ ọrụ profaịlụ, data agbatịwo site na ntuziaka maka ojiji:

Profaịlụ eme iheOge awa
Oge site na ntụtụ insulin n'ime ọbara1,5
Oke hormone nke dị na arịa4-8 awa, ekwuputaghi na elu
Ogologo ogebanyere 12, na oke doses - ruru 16 ma ọ bụ karịa

Ọ na - eji ọgwụ enzymes pụrụ iche mebie insulin, ebe a na - eme ọgwụ metabolites, enweghi mmetụta ọ bụla na - akpata ikelata shuga. Oge iwepu ọkara ndụ dịgasị na awa 5-10.

Mmetụta Usofan insulin na-arụpụta

Ihe mmetụta insulin na-emetụta ihe ndị metụtara gburugburu ebe obibi. Ọ bụrụ n’inweta insulin karịa ka ahụ siri chọọ, ndị ọrịa mamịrị na-ebute hypoglycemia. Ha nwere ike ibute ya:

  1. Ibu ọnụ, iri nri - lee edemede banyere ibu ọnụ maka ọrịa shuga.
  2. Ọgba nri na-egbochi nri glucose: ọgbụgbọ, ọgbụgbọ.
  3. Imega ahụ.
  4. Mmeju na ọgwụ antidiabetic.
  5. Ọrịa endocrine.
  6. Ọrịa siri ike nke akụkụ ahụ metụtara metabolism nke insulin: imeju na akụrụ.
  7. Gbanwe saịtị ntinye ahụ, ahụ (nhicha ahụ, ịhịa aka n'ahụ) ma ọ bụ ọnọdụ okpomọkụ (sauna, paịd kpo oku) na-emetụta ya.
  8. Usoro ntụtụ na-ezighi ezi.
  9. Ọgwụ na-eme ka mmetụta insulin dịkwuo elu. Ọgwụ hormonal na diuretic na-enwe mmetụta kasịnụ.
  10. Mmanya na-egbu egbu na nicotine.

Site na algọridim shuga dị ala, a na-ewebata ndị ọrịa shuga niile na-eji insulin eme ihe. Ọ gụnyere oriri nke carbohydrates ngwa ngwa, n'ọnọdụ ndị siri ike - ntụtụ nke 1 mg nke glucagon, onye na-arịa glucose - karịa ihe ị ga-eme ma ọ bụrụ na shuga dị n'ọbara dara nke ọma.

Obere oge, ndị ọrịa nwere ọrịa mellitus na-enwe lipodystrophy (mgbanwe dystrophic na abụba subcutaneous na ntanetị ogologo oge) yana mmeghachi omume hypersensitivity n'ụdị edema, ihe ọkụ, na ọbara ọbara.

Iwu mmeghe

Ọbụrụta nke Isofan ka ahoputara nke mbu, na insulin. Ọ bụ ihe ọbụla maka ndị ọrịa mamịrị ọbụla. Ihe dị ka ngụkọta homonụ na enweghị onwe ya bụ nkeji 0.3-1 kwa kilogram nke ịdị arọ, Isofan na-aza 1/3 ruo 1/2 nke mkpa. Enweghị insulin dị mkpa maka ụdị shuga nke 2, karịa - maka ndị ọrịa nwere oke ibu na nguzogide insulin. Njirimara nke ihe oriri nwere obere mmetụta na Isofan, ebe insulin na-arụ ọrụ dị ukwuu iji kwụọ ụgwọ ọrịa prandial glycemia.

Etu esi edozi Isofan:

  1. Ntụziaka ahụ na-atụ aro ka ị na-eji ọgwụ eme ihe naanị. Iji gbochie ihe ngwọta ịbanye na akwara, ịkwesịrị ịhọrọ ogologo agịga kwesịrị ekwesị. Amachibidoro nchịkwa ọgbụgba.
  2. Maka nlekọta, enwere ike iji sirinji insulin na obere sirinji ọgbara ọhụrụ. Enweghi ike iji insulin nke di n’ime nfuli.
  3. Isofan insulin bụ ihe nkwusioru, ya mere etine na-etolite ka oge na-aga na ala nke vial ahụ. Tupu ịmalite ọgwụ, a gha agwakọta ọgwụ nke ọma. Ọ bụrụ na ọ gaghị ekwe omume imepụta otu agba nke nkwusioru ahụ, insulin na-emebi emebi, enweghị ike iji ya.
  4. Ebe kachasị mma ịnọ gbaa gburugburu bụ apata ụkwụ. A na - ahapụkwa ya inje in የሆድ, buttocks, ubu - otu esi abanye insulin n'ụzọ ziri ezi.
  5. Mee ntụtụ ọhụrụ ọ dịkarịa ala 2 cm site na nke gara aga. Nwere ike ịnọgidesie ike n'otu ebe naanị mgbe ụbọchị atọ gachara.

Iji Oge ime

Enwere ike iji Isofan n'oge ime na HB, ebe ọ bụ na ọ banyeghị n'ọbara nwa site na Plasenta na mmiri ara ehi. N'ime ụmụ nwanyị nwere ọrịa shuga mụrụ nwa, ịgwọ ọrịa insulin bụ naanị ụzọ iji belata glycemia nke enyere ohere na Russia.

Mkpa ọgwụ ahụ maka ọnwa 9 na-agbanwe ugboro ugboro n'otu oge na mgbanwe na usoro homonụ nke nwanyị ahụ, yabụ ịkwesịrị ịhazigharị insulin kwa ụbọchị. Ofchịkwa shuga n’oge a dị ime bụ ihe a ga-eme iji gbochie fetopathy, malformations, ọnwụ nwa ebu n’afọ.

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