Insulin Protafan: analogues (ọnụahịa), ntuziaka, nyocha

Protafan insulin na-ezo aka na insulin na-arụ ọrụ mmadụ.

Mkpa iji ọgwụ insulin Protafan NM penfill nwere ike ime na ọtụtụ ọrịa na ọnọdụ. Nke mbu, tinyere udiri 1 na udiri oria abuo. Na mgbakwunye, ọgwụ ahụ gosipụtara na ọkwa nke iguzogide ọgwụ hypoglycemic mbụ.

A na-ejikwa ọgwụ a yana ọgwụ ejikọtara ọnụ (nke a na-eleghara ọgwụ mgbochi hypoglycemic nke ọgwụ) ma ọ bụrụ na a na-achọpụta ọrịa shuga n'ime ụmụ nwanyị dị ime ọ bụrụ na ọgwụgwọ nri anaghị enyere aka;

Ọrịa ọgbụgba na mgbochi ịwa ahụ (jikọtara ma ọ bụ monotherapy) nwekwara ike ịbụ ihe kpatara agba a.

Kedụ ka m ga-esi dochie ọgwụ, analogues

1. Insulin Bazal (ihe dika 1435 rubles);
2. Humulin NPH (ọnụ ahịa ihe dịka 245 rubles);
3. Protafan NM (ọnụahịa ihe dị ka 408 rubles);
4. Aktrafan NM (ọnụahịa gbasara)
5. Protafan NM Penfill (ọnụ ahịa ruru 865 rubles).

Njirimara nke ogwu

Ọgwụ bụ nkwusioru ewepụtara n’okpuru anụahụ.

Otu, ihe na-arụ ọrụ:

Isulin insulin-mmadu semisynthetis (semisynthetic mmadu). O nwere nkezi oge ihe. Protafan NM bụ contraindicated na: insulinoma, hypoglycemia na hypersensitivity na-arụ ọrụ.

Etu esi ewere na n’ime usoro onunu ogwu?

A na-etinye insulin otu ugboro ma ọ bụ ugboro abụọ n'ụbọchị, ọkara otu awa tupu nri ụtụtụ. N'ebe a, ebe a ga-eme inje, ọ ga-agbanwe ya mgbe niile.

Ekwesịrị ịhọrọ dose ahụ maka onye ọrịa ọ bụla n'otu n'otu. Olu ya na-adabere n’otú glucose dị n’ime mmamịrị na ọbara ọbara, yana n’omume nke otu ọrịa. N'ụzọ bụ isi, a na-enye ọgwụ ahụ otu oge kwa ụbọchị ma ọ bụ 8-24 IU.

N’aka umuaka na ndi okenye ndi nwere insulin, a na-ebelata oke onodu ahu ka o bu 8 IU kwa ubochi. Na maka ndị ọrịa nwere oke mmụọ, onye dibia bekee nwere ike inye gị ọgwụ gafere 24 IU kwa ụbọchị. Ọ bụrụ na ọgwụ kwa ụbọchị karịrị 0.6 IU kwa kilogram, mgbe ahụ ọgwụ ọgwụ abụọ na-ahụ maka ọgwụ abụọ, nke a na-eme n'ebe dị iche iche.

Ndị ọrịa na-anata 100 IU ma ọ bụ karịa kwa ụbọchị, mgbe ha na-agbanwe insulin, ha ga-anọrịrị na-elekọta ndị dọkịta mgbe niile. Should ga-eji dochie ọgwụ ọzọ site na ịchekwa ọkwa glucose ọbara.

Ngwongwo ogwu

Njirimara insulin Protafan:

• lowers glucose ọbara;
• na - eme ka mmịkọta glucose na anụ ahụ;
• na-eme ka njikọ protein dị mma;
• na-ebelata ọnụego ihe na -emepụta glucose site na umeji;
• na - eme ka glycogenogenesis dịkwuo mma;
• na-eme ka lipogenesis dịkwuo mma.

Microinterakti na ndị na-anabata ya na akpụkpọ ahụ dị na mpụga na-akwalite nguzobe nnabata nke nnabata nke insulin. Site na mkpali na sel imeju na abụba, njikọta nke CAMP ma ọ bụ banye n’ime akwara ma ọ bụ sel, nnabata insulin na-arụ ọrụ n’usoro nke dị n’ime sel.

Ọ na-amalite njikọ nke ụfọdụ enzymes isi (glycogen synthetase, hexokinase, pyruvate kinase, wdg).

Nbelata nke glucose ọbara sitere na:

• Mmụba glucose na-aba ụba n’ime sel;
• mkpali nke glycogenogenesis na lipogenesis;
• ịba ụba na nnabata glucose site na anụ ahụ;
• njikọta protin;
• mbelata na ọnụego shuga nke imeju na-amịpụta, i.e. mbelata nke mmebi nke glycogen na ndi ozo.

Kedu mgbe ọgwụ a na-abata, ole olekwa ka ọ ga-adị?

Ozugbo emere iwebata nkwusio akwụkwọ ahụ, nsonaazụ ahụ anaghị eme. Ọ na-amalite ime ihe na 60 - 90 nkeji.

Mmetụta kasịnụ na-apụta n'etiti awa anọ na awa 12. Oge ime ihe sitere na awa iri na otu ruo awa iri na anọ na anọ - ọ dabere na ntụtụ na usoro nke insulin.

Nsonaazụ

Hypoglycemia (ọhụhụ na anya na okwu, pallor nke anụ ahụ, mmegharị ahụ gbagwojuru anya, ọsụsọ mụbara, agwa ọhụụ, ahụkarị mmụọ, mgbakasị ahụ, ịma jijiji, ịba ụba, agụụ, ụjọ, iwe, ehighị ụra, nchekasị, ụra ụra, paresthesia n'ọnụ, isi ọwụwa. ;

Mmeghachi omume nfụkasị ahụ (mbelata ọbara mgbali, urticaria, mkpụmkpụ ume, fever, angioedema);

Mmụba na ụzọ titter nke ọgwụ mgbochi insulin na mmụba na glycemia;

Acidosis na-arịa ọrịa shuga na hyperglycemia (megide nzụlite nke ọrịa na ahụ ọkụ, ụkọ nri, ọgwụ na-efu, obere usoro): nsị ihu, ụra, agụụ, agụụ, agụụ mgbe niile.

Hypoglycemic coma;

Na nmalite ọgwụgwọ mbụ - njehie na edema (ihe na-adị nwa oge nke na-ebute ọgwụgwọ ndị ọzọ);

Mmetụta nke nsụhọ (mgbe ụfọdụ ọ na-etolite coma na precoatose steeti);

N'ebe ntinye ahụ, itching, hyperemia, lipodystrophy (hypertrophy ma ọ bụ atrophy nke subcutaneous fat);

Na nmalite ọgwụgwọ bụ nsogbu ịre ahụ nwa;

Mmeghachi omume mgbochi nke mmadụ na insulin.

Mgbaàmà nke ịdoụbiga mmanya ókè:

• ogwe
• igba;
• hypoglycemic coma;
• palpitations
• ehighi ura
• ọhụhụ ụzọ na okwu;
• ịma jijiji
• mmeghari ebugharị;
• iro ụra
• afọ nri;
• omume iju;
• Nchekasị
• mgbakasị ahụ
• paresthesia na onu ogugu;
• Obi erughị ala
• pallor
• tua egwu
• isi ọwụwa.

Etu esi eleghara ịdoụbiga mmanya ókè?

Ọ bụrụ na onye ọrịa ahụ nọ n'ọnọdụ ahụ, mgbe ahụ dọkịta deputara dextrose, nke a na-enye site na dropper, intramuscularly ma ọ bụ intravenously. A na-ejikwa Glucagon ma ọ bụ usoro dextrose hypertonic deprorose.

N'ihe banyere klaasị hypoglycemic, 20 ruo 40 ml, i.e. Ngwọta 40% dextrose ruo mgbe onye ọrịa na-apụta site na Coma.

Ndụmọdụ dị mkpa:

1. Tupu i were insulin site na ngwugwu, ịkwesịrị ịlele na ihe ngwọta dị n'ime karama ahụ nwere agba na-acha ọcha. Ọ bụrụ n'igwe ojii, mmiri ma ọ bụ akụkụ ala ọzọ ka ahụrụ, amachibidoro ya.
2. Okpomoku nke ogwu tupu ochichi kwesiri ibu ulo.
3. Na ọnụnọ nke ọrịa na-efe efe, ịrụ ọrụ nke gland thyroid, ọrịa Addiosn, ọdịda akụrụ na-adịghị ala ala, hypopituitarism, yana ndị ọrịa mamịrị agadi, usoro insulin kwesịrị ka edozi ya n'otu n'otu.

Ihe na - akpata hypoglycemia nwere ike ịbụ:

• nnyefere
• vomiting
• mgbanwe ọgwụ;
• ọrịa na-ebelata mkpa insulin (ọrịa imeju na akụrụ, hypofunction nke thyroid gland, pituitary, adrenal cortex);
• enweghị nrube isi na nri nri;
• nmekorita ya na ogwu ndi ozo;
• afọ ọsịsa
• nsụ anụ ahụ;
• mgbanwe nbanye saịtị.

Mgbe ị na-ebufe onye ọrịa si insulin anụmanụ n’ime insulin nke mmadụ, mbelata ogo glucose ọbara nwere ike pụta. Ntughari ya na insulin nke mmadu kwesiri ikwesiri idi nlele ahuike ya, ekwesiri iburu ya site na nlezianya nke dọkịta.

N'oge ịmụ nwa na mgbe a mụsịrị nwa, enwere ike belata mkpa nke insulin. N’oge ị na-agba ara, ịkwesịrị ilebara nne gị anya ọtụtụ ọnwa, ruo mgbe ọ ga-egbo mkpa insulin.

Ihe nwere ike ime ka ọrịa hypoglycemia na-arịa ọrịa nwere ike ime ka mmadụ nwekwuo ike ịnya ụgbọ ma nwee usoro na igwe.

Site na iji shuga ma ọ bụ ihe oriri dị elu na carbohydrates, ndị ọrịa mamịrị nwere ike ịkwụsị ụdị hypoglycemia dị nwayọọ. Ọ bụ ihe amamihe dị na ya na onye ọrịa a nwere shuga dịkarịa ala 20 mgbe niile.

Ọ bụrụ na eyigharị hypoglycemia, ọ dị mkpa ịgwa dọkịta onye ga-eme mgbanwe ọgwụgwọ ahụ.

N’ime afọ ime, a ga-elele mbelata (1 ọkara) ma ọ bụ ịrị elu (2-3 ọkara) nke ahụ ịchọrọ insulin.

Mmekọrịta na ọgwụ ndị ọzọ

Hypoglycemia na-emeziwanye site na:

• MA inhibitors (selegiline, furazolidone, procarbazine);
• sulfonamides (sulfonamides, ọgwụ nje hypoglycemic).
• NSAIDs, ACE inhibitors na salicylates;
• steroid anabolic na methandrostenolone, stanozolol, oxandrolone;
• carbonic anhydrase inhibitors;
• ethanol;
• androgens;
• chloroquine;
• bromocriptine;
• quinine;
• tetracyclines;
• quinidine;
• clofribate;
• pyridoxine;
• ketoconazole;
• Nkwadebe Li +;
• mebendazole;
• theophylline;
• fenfluramine;
• cyclophosphamide.

A na-eme ka hypoglycemia site na:

1. Ihe mgbochi H1 - vitamin na-anabata ya;
2. glucagon;
3. epinephrine;
4. somatropin;
5. phenytoin;
6. GCS;
7. nikotin;
8. mẹ ụnwunna iya;
9. wii wii;
10. estrogens;
11. morphine;
12. loop na thiazide diuretics;
13. diazoxide;
14. BMKK;
15. ndị na-emegide calcium;
16. homonụ thyroid;
17. clonidine;
18. heparin;
19. ọgwụ mgbochi tricyclic;
20. sulfinpyrazone;
21. danazole;
22. nnabata ọmiko.

E nwekwara ọgwụ ọgwụ ndị nwere ike ime ka ike gwụ insulin na mmụba nke insulin. Ndị a gụnyere:

• pentamidine;
• ndị na - egbochi beta;
• octreotide;
• reserpine.