N'ihi ọnụ ahịa Amaril dị elu, a na-eji analogues eme ihe ugboro ugboro iji mee ka glucose ọbara dị n'ọrịa ndị ọrịa mamịrị nwere ụdị ọrịa na-enweghị insulin. Ọgwụ a dị mma maka ijikwa glycemia na nri pụrụ iche na egwuregwu.
Agbanyeghị, ọ bụghị onye ọ bụla nwere ike ị nweta ego nke hypoglycemic a. Ya mere, n'isiokwu a, a ga-ekpughe ọgwụ ọgwụ nke Amaril na aha analogues nke bụ isi na Russia.
Emere ọgwụ ọgwụ
Amaryl bụ ọgwụ hypoglycemic nke na-enyere obere shuga ọbara aka site na-akpali ntọhapụ na mmegharị nke insulin njikọta site na mkpụrụ ndụ beta akọwapụtara dị na anụ ahụ.
Mainzọ kachasị eji eme ka usoro njikọ ahụ dịkwuo elu bụ na Amaril na-eme ka nzaghachi nke mkpụrụ ndụ beta na-abawanye na ịba ụba nke glucose n'ọbara mmadụ.
Na obere doses, ọgwụ a na-eme ka ntakịrị mmụba na ntọhapụ nke insulin. Amaryl nwere ihe bara ụba nke ịmụbawanye ihe gbasara ihe dị n’ime sel anụ ahụ na-agbanye insulin.
N'ịbụ onye sitere na usoro sulfonylurea, Amaril nwere ike imetụta usoro nke mmepụta insulin. A na - eme ka nke a sie ike site na eziokwu na oke ọgwụ a na - arụ ọrụ na - eso ụzọ ATP nke sel beta na - emekọrịta ihe. Amaryl na - ekekọta ihe ndi na - edozi aru n’elu akwa akpụkpọ ahụ. Ngwongwo ọgwụ a na-enye ohere ịbawanye uru nke akwara anụ ahụ na insulin.
Ọkpụkpụ glucose na-abanye n’ime mkpụrụ ndụ akwara akwara nke ahụ.
Na mgbakwunye, iji ọgwụ ahụ egbochi mkpụrụ ndụ nke akwara nke imeju na-egbochi ntọhapụ nke glucose. Usoro a na - apụta n'ihi mmụba nke ọdịnaya nke fructose-2,6-biophosphate, nke na - enyere aka na mgbochi nke gluconeogenesis.
Ationme ka insulin njikọta rụọ ọrụ n'ihi eziokwu ahụ bụ na ọgwụ ike nọ n'ọrụ na-akwalite nsụkọta nke ion potassium n'ime sel beta, yana ịba ụba nke potassium n'ime sel na-eduga n'ịba ụba nke homonụ.
Mgbe ị na-eji usoro ọgwụgwọ agwakọta yana ngwakọta na metformin, ndị ọrịa nwere mmelite na metabolic na-achịkwa ọkwa shuga n'ime ahụ.
Na-eduzi usoro ọgwụgwọ ọgwụgwọ yana injections insulin. A na-eji usoro nchịkwa a mee ihe n'ọnọdụ ebe ogo adịghị ike nke metabolic na-adịghị enweta mgbe ị na-ewere otu ọgwụ. Mgbe ị na-eme ụdị ọgwụ a maka ọrịa shuga mellitus, a chọrọ ọgwụ mmachi insulin nke insulin.
A na-eme ka ego nke insulin ji na ụdị ọgwụgwọ a belata.
Pharmacokinetics nke ọgwụ
Site na otu ọgwụ ọgwụ kwa ụbọchị kwa 4 mg, a na-ahụkarị nsonaazụ ya karịa elekere 2.5 wee bụrụ 309 ng / ml. Bi ndu nke ogwu ahu bu 100%. Nri adighi enwe otu uzo esi abanye na mmiri, ma ewepu obere osiso na osiso nke usoro a.
Ihe eji aru oru ahu ike gosiputara n’iji ikike banye n’ime ihe mejuputara mmiri ara ara na site n’igiri uzo. Kedu nke na - egbochi ohere ị theụ ọgwụ n’oge afọ ime na inye nwa ara.
A na-eme metabolism nke ihe na-arụ ọrụ na akwara nke imeju. Isi isoenzyme tinyere aka na metabolism bụ CYP2C9. Na usoro nke metabolism nke kọmpụta nke bụ isi na-arụ ọrụ, etolite metabolites abụọ, nke na-esochi na feces na mmamịrị na-esote.
Ewepụta ọgwụ ahụ site akụrụ na oke 58% na ihe dịka 35% site na enyemaka nke eriri afọ. Achọpụtaghị ihe dị n'ọrụ ọgwụ ahụ na mmamịrị agbanwebeghị.
Dabere na nsonaazụ nke ọmụmụ a, achọtara ya na ọgwụ ọgwụ anaghị adabere na nwoke ma ọ bụ nwanyị na ọgbọ ya.
Ọ bụrụ na onye ọrịa enweela nsogbu akụrụ na usoro ịtụrụ ụjọ, onye ọrịa nwere mmụba nke glimepiride yana mbelata mgbanye ya n'ọbara, nke a na-ebute ngwa ngwa iwepụ ọgwụ ahụ n'ihi ntakịrị njikọta nke ihe arụ ọrụ yana protein.
Isi izugbe nke ọgwụ
A na-ahụta Amaryl dị ka usoro nke atọ nke usoro sulfonylurea. Mba ndị mepụtara ọgwụ ahụ bụ Germany na Italytali. A na-eme ọgwụ ahụ n'ụdị mbadamba na 1, 2, 3 ma ọ bụ 4 mg. Otu mbadamba 1 nke Amaril nwere ihe mejuputara - glimepiride na ndi ozo.
Nsonaazụ nke glimepiride bụ ebumnuche ịbelata glucose ọbara site na mkpali imepụta insulin site na mkpụrụ ndụ beta. Na mgbakwunye, ihe na-arụ ọrụ nwere mmetụta insulinomimetic ma na-abawanye ọgụgụ nke ndị na-anabata mkpụrụ ndụ na homonụ na-ebelata shuga.
Mgbe onye ọrịa ahụ na-ekwu okwu Amaryl, a na-enweta ntinye akwụkwọ kachasị elu nke glimepiride mgbe awa 2.5 gachara. Enwere ike ị medicineụ ọgwụ n’agbanyeghi oge iri nri. Agbanyeghị, iri ntakịrị ihe na-emetụta ọrụ glimepiride. N'ụzọ bụ isi, a na-ewepụta ihe n’akuku n’akwara afọ na akụrụ.
Ọkachamara na-ahụ maka ọgwụgwọ na-enye onye ọrịa nwere ụdị shuga nke 2 ọgwụ Amaril mbadamba dị ka monotherapy ma ọ bụ mgbe ejikọtara ya na ndị ọrụ hypoglycemic.
Agbanyeghị, ị theụ ọgwụ ahụ anaghị egbochi ịga n'ihu na nri kwesịrị ekwesị nke na-ewepụ abụba na carbohydrates dị mfe, na ndụ dị gara gara.
Ntuziaka maka iji ọgwụ ahụ
Nweghị ike ịzụta ọgwụ n’enweghị ọgwụ dọkịta. Tupu iji ọgwụ ahụ, ị ga-agarịrị dọkịta ma jụọ ya ajụjụ gị niile. Ọ bụ ya bụ onye nwere ike ikpebi etu ogwu a si wee nye gị ọgwụ usoro ọgwụgwọ dabere na glucose onye ọrịa.
Miri mbadamba Amaryl ka a na-ewere ya n’onu n’ejighi ire, ma jiri mmiri zuru oke sachaa ya. Ọ bụrụ na onye ọrịa chefuru ị drinkụ ọgwụ ahụ, a machibidoro ya ugboro abụọ. N'oge ọgwụgwọ, ị kwesịrị ị na-enyocha ọkwa shuga mgbe niile, yana ntinye nke gemocolobin glycosylated.
Na mbido, onye ọrịa na-a takesụ otu ọgwụ nke 1 mg kwa ụbọchị. Nke nta nke nta, na oge nke otu ruo izu abụọ, usoro ị ofụ ọgwụ ahụ nwere ike ịbawanye 1 mg. Dịka ọmụmaatụ, 1 mg, mgbe ahụ 2 mg, 3 mg, na ndị ọzọ na- 8 mg kwa ụbọchị.
Ndị ọrịa mamịrị nwere ezigbo glycemic na-a takeụ ọgwụ kwa ụbọchị nke ruru 4 mg.
Ọtụtụ mgbe, a na-a theụ ọgwụ ahụ otu ugboro tupu nri ụtụtụ ma ọ bụ, ọ bụrụ na ịhapụ ịkụ mbadamba, tupu isi nri. N'okwu a, ọkachamara ahụ kwesịrị iburu n'uche ụdị ndụ nke ndị ọrịa mamịrị, oge nri ya na mmega ahụ ya. Imezi ọgwụ ahụ nwere ike ịdị mkpa mgbe:
- mbelata ibu;
- mgbanwe na ndu ndu (nri, nri, oge nri);
- ihe ndi ozo.
Gbalia ichota dọkịta ma bido na nke kacha nta (1 mg) nke Amaril ma oburu na onye oria choro:
- dochie ọgwụ ọzọ eji eme ka shuga dị na Amaril;
- nchikota glimepiride na metformin;
- Nchikota bu glimepiride na insulin.
Ọ baghị uru ị medicineụ ọgwụ maka ndị ọrịa nwere ọrịa gbasara akụrụ, yana ọrịa akụrụ na / ma ọ bụ ọrịa imeju.
Njere uto na mmeghachi omume ojoo
Amaril glimepiride dị na ọgwụ ahụ, yana akụkụ ndị ọzọ, anaghị enwe mmetụta dị mma mgbe niile n'ahụ ahụ ndị ọrịa mamịrị.
Aszọ ndị ọzọ, ọgwụ nwere contraindications.
Amachibidoro ị toara ndị ọrịa ọgwụ n'ọnọdụ ndị a:
- diabetesdị shuga na-akpata insulin;
- oge imu na inye umu ara;
- ọrịa shuga (ketoacidosis) nke na-arịa ọrịa shuga (shuga na-arịa ọrịa metabolism), ọnọdụ nke precca na-arịa ọrịa shuga na coma;
- ndị ọrịa na-erubeghị afọ 18;
- ụyọkọ galactose, ụkọ lactase;
- mmepe nke glucose-galactose malabsorption;
- imebi imeju na akụrụ, ọkachasị ndị ọrịa na-ele ịba ọcha n'anya;
- mmadu anagideghi ihe di n’ime ogwu ahu, nkari sulfonylurea, ndi na acho sulfonamide.
Ntụziaka ejikọtara na-ekwu na n'ime izu mbụ nke ọgwụgwọ, a ga-eji nlezianya mee Amaryl iji zere mmepe nke ọnọdụ hypoglycemic. Na mgbakwunye, na mmebi nke nnabata nri na ọgwụ sitere na nri diges, erughi glucose-6-phosphate dehydrogenase, ọrịa ndị nọ n’onwe ya na ọnụnọ nke ibute ọrịa hypoglycemic, a na-eji Amaril akpachapụ anya.
Site n'iji mbadamba eme ihe na-ekwesịghị ekwesị (dịka ọmụmaatụ, nnabata), mmeghachi omume siri ike nwere ike ịmalite:
- Ọnọdụ hypoglycemic, ihe ịrịba ama nke isi ọwụwa na anya isi, ntị na-adịghị mma, oke iwe, ọgba aghara, iro ụra, ịma jijiji, ịma jijiji na ọhụhụ.
- Usoro nchịkwa mgbochi nke Adrenergic dị ka nzaghachi maka mgbali glucose ngwa ngwa, gosipụtara nchekasị, palpitations, tachycardia, ọnụ ọgụgụ obi na-adịghị mma na ọdịdị nke ọsụsọ oyi.
- Ọgba aghara digestive - mkpọchi ọgbụgbọ, ọgbụgbọ, flatulence, abdominal pain, afọ ọsịsa, mmepe nke ịba ọcha n'anya, ụba ọrụ enzymes imeju, jaundice or cholestasis.
- Mmebi nke usoro hematopoietic - leukopenia, thrombocytopenia, granulocytopenia na ụfọdụ ọrịa ndị ọzọ.
- Allergy, gosipụtara site na rashes akpụkpọ, itching, hives, mgbe ụfọdụ anaphylactic ujo na vasculitis nfụkasị.
Mmeghachi omume ndị ọzọ ga - ekwe omume - nnabata na hyponatremia.
Efu, nyocha na analogues
Ọnụahịa ọgwụ Amaryl na-adabere kpọmkwem n'ụdị ntọhapụ ya. Ebe ọ bụ na ebubata ọgwụ ahụ, yabụ, ọnụ ahịa ya dị oke elu. Ọnụ ego ọnụahịa nke mbadamba Amaryl bụ ndị a.
- 1 mg 30 mbadamba - 370 rubles;
- 2 mg 30 mbadamba - 775 rubles;
- 3 mg 30 mbadamba - 1098 rubles;
- 4 mg 30 mbadamba - 1540 rubles;
Banyere echiche nke ndị ọrịa mamịrị banyere ịdị irè nke ọgwụ, ha dị mma. Site na iji ọgwụ ogologo oge, ọkwa glucose na-alaghachi na nkịtị. Ọ bụ ezie na ndepụta ahụ nwere ọtụtụ nsonaazụ ndị ọ ga-ekwe omume, pasent nke mmalite ha dị obere. Agbanyeghị, enwere nyocha ndị na-adịghị mma nke ndị ọrịa metụtara oke ọnụ ahịa ọgwụ ahụ. Ọtụtụ n'ime ha ga-achọ nnọchi ndị Amaril.
N'ezie, ọgwụ a nwere ọtụtụ okwu na analogues mepụtara na Russian Federation, dịka ọmụmaatụ:
- Glimepiride bụ ọgwụ nwere otu arụ ọrụ, contraindications na mmetụta dị n'akụkụ. Ihe dị iche bụ naanị na ọgwụ ndị ọzọ. Ọnụ ego ọgwụ ahụ (2 mg Nke 30) bụ 189 rubles.
- Diagninide bụ ọgwụ na-ebelata shuga, n'ụdị ya yiri ọgwụ a na-ebubata NovoNorm. Ihe na-arụ ọrụ bụ reaglinide. Novonorm (Diagninide) nwere otu ụdị contraindications na mmeghachi omume na-adịghị mma. Iji ghọta nke ọma ihe dị iche na analogues abụọ a, ọ dị mkpa iji tụọ ụgwọ ọnụahịa: ọnụahịa nke Diaglinide (1 mg Nke 30) bụ 209 rubles, na NovoNorm (1 mg No. 30) bụ 158 rubles.
- Glidiab bụ ọgwụ Russia, nke bụkwa ihe analog nke ọma ọrịa mellitus Diabeton. Ọnụ ego nke mbadamba nkume Glidiab (80 mg Nke 60) bụ 130 rubles, na ọnụ ahịa ọgwụ Diabeton (30 mg No. 60) bụ 290 rubles.
Amaryl bụ ezigbo shuga na-ebelata shuga, mana dị oke ọnụ. Ya mere, enwere ike dochie ya na ọnụ ala, ma ụlọ (Diclinid, Glidiab), yana ọgwụ dị mbubata (NovoNorm, Diabeton). Ihe mejupụtara ya nwere ma glimepiride, ma ọ bụ ihe ndị ọzọ na-eme ka mbelata glucose. Knowingmara banyere analogues, dọkịta na onye ọrịa ahụ ga-ekpebi ọgwụ dị mma ị toụ. Vidio dị n'isiokwu a na-aga n'ihu na isiokwu nke Amaril maka ọrịa shuga.
