Ọrịa pancreatic exocrine insufficiency syndrome: gịnị ka ọ bụ?

Kwa ụbọchị, anụ ahụ na-enweta nri nri nke a ga-agbarịrị ma wepụrụ ha ihe ndị na-edozi ahụ.

Enweghi nkpu nke oria Exocrine bu oria di nkpa nke n’eduba imebi mmeputa nke enzymes nke oma maka igwu nri n’onu.

N'ihi ya, ahụ mmadụ enweghị vitamin na ihe ndị ọzọ na-arụ ọrụ. N'isiokwu a, ị nwere ike ịmatakwu ọrịa pathophysiology nke enweghị nkụpu nke exocrine (ihe kpatara ya, usoro ya na nsonazụ ya), yana usoro nchọpụta, ọgwụgwọ na mgbochi mgbochi.

Gịnị bụ ọrịa?

Otu n'ime usoro kachasị dị n'ahụ ahụ bụ mgbaze nri. Ọ na-amalite mgbe ngwaahịa a banyechara gbasara ọnya ma na-ete ya mmiri. Nri esi efe efe na-abanye n'afọ, na-ezobe pepsin na acid hydrochloric.

Mgbe ọkara otu elekere, ụmụ irighiri nri dị na mmalite nke obere eriri afọ - duodenum 12. Ọ bụ ebe a ka enzymes pụrụ iche na-ahụ maka nnabata nri, ndakpọ abụba na protein, na oriri nke vitamin. Akụkụ ahụ nke usoro nri diges na - emepụta ha - pancreas, nke na - akụri nnukwu ụmụ irighiri irighiri ihe.

Ahụ a na-arụ ọrụ dị mkpa na ahụ mmadụ. Edebere ha dika ndi a:

1. Ọrụ exocrine (mpụga nke mpụga) nwere akụkụ nke ihe ndị ọzọ na - arụ ọrụ nke ihe ọmụmụ - lipase, amylase, na protease - n'ime duodenum site na iji usoro akpọpụtara nke usoro ahụ.
2. Ọrụ endocrine (nzuzo nke ime) na-arụ ọrụ na agwaetiti pancreatic na-emepụta homonụ dịka insulin, glucagon, polypeptide pancreatic, somatostatin na ghrelin ("hormone agụụ").

N'ime ahụike, pancreas na-emepụta enzymes na homonụ zuru ezu, yabụ ọ na-enwe ike ịnye nri nri zuru oke ma kwado usoro metabolic.

Mgbe anụ ahụ enweghị ike iwepụta enzymes kwesịrị ekwesị, oke ikuku nke nkụpu akwara na - amalite. N'ihi usoro nje, a na-enwe ụkọ vitamin na ụkọ nri.

Mwepu zuru oke ma ọ bụ ọgwụgwọ na-adịghị mma na-eduga n'ịzụlite nwata n'oge ọrịa, ọrịa nke akwara ahụ na mbelata nnukwu mgbochi, nke na-eyi ọrịa ibute ọrịa dị iche iche egwu.

Ihe na - akpata enzyme

Dabere na ọnụ ọgụgụ, 10% nke ndị United States na-achọpụta ọrịa exocrine pancreatic insufficiency syndrome.

Ọmụmụ ọgwụ gbasara ọgwụ na-egosi mmekọrịta dị n’etiti ị abuseụbiga mmanya na mmepe nke ọrịa ọgụ. Ndị ọrịa na-arịa ị alcoholụbiga mmanya ókè na-adaba na ndị otu ihe ize ndụ pụrụ iche, ebe ọrịa ahụ gosipụtara onwe ya na 80% nke ikpe.

Usoro etiology nke pathology gụnyere mmetụta nke ọtụtụ ihe. Ọgba aghara na mmepụta enzymes na-apụta maka ebumnuche na enwetara ihe kpatara ya.

Ọrịa pancreatic na-etolite n'ihi agamnihu nke ọrịa ndị ae nwere site n'ọmụmụ:

• cystic fibrosis - mkpụrụ ndụ ihe nketa nke akwara nke akụkụ okuku ume na nri nri, a na-egosipụta ya site na imepụta ihe omimi viscous nke na-egbochi akwara, pancreas, bronchi na bronchioles;
• Ọrịa Schwahman - nkedo nke mkpụrụ ndụ nke ụmị ọkpụkpụ na pancreas, nke na-eme ka mmiri ghara inwe ike zuru ezu;
• lipomatosis - mmụba n’arụ ahụ n'ihi oke inye akwara adipose.

Ihe kpatara ya gụnyere mwepụ ịwa ahụ na ọrịa akwara na palọ. Ọrịa pancreatitis bụ ọrịa e ji dochie anya anụ ahụ anụ ahụ nkịtị. N'ihi ya, a na-ebelata mmepụta nke enzymes, usoro nri diges enweghị ike ịgbari nri kpamkpam.

Ọ dị mma ịmara na a na-achọpụta ọrịa pancreatitis na-adịghị ala ala na ndị ọrịa okenye. Na nwata, mmepe nke oria a bu ihe puru iche. Ọzọkwa, ihe ize ndụ nke pancreatitis na-abawanye na ọrịa shuga.

Na mgbakwunye, ihe na-emetụta ọghọm ngwa mgbukpọ ahụ nwere ike ịgụnye:

1. Ihe ojoo anakpo Pancreatic.
2. Ọria Crohn bụ ọrịa nke otu akụkụ nke sistem nri nri.
3. Enteropathy Gluten - anabataghị ahụ́ nke gluten (protin gilut protein).
4. Ọrịa ọgbụgba - mmụba dị ukwuu nke ọbara na-erugharị na eriri afọ n'ihi mmịpụta nri na-agbadaghị agbari n’ime afọ.
5. Ọrịa Zollinger-Ellison bụ ọnọdụ nke na-ejikọta usoro ọgwụgwọ dịka ọnụnọ etuto n'ime duodenum ma ọ bụ pancreas, yana mmepụta oke mmiri nke hydrochloric acid na afọ.

Ọzọkwa, ihe omume nke ụkọ nwere ike ibute site na ịnyefe ntanetị maka ịwa ahụ na ngwu ahụ.

Ihe nrịba ama nke ezughi oke ume nke oria

Ọmụmụ ihe nyocha egosila na na enweghị ntakịrị nsogbu ọgwụ ikuku, nri ka ga-agbari. N'akụkụ a, na mmalite nke mmepe nke ọrịa ahụ, mmadụ nwere ike ọ gaghị enwe mgbaàmà ọ bụla.

Site na nyocha nnwale nke ịmị mkpụrụ nzuzo, ọ ga - ekwe omume ịchọpụta na eriri afọ nwere ike ịmịpụta pacenti iri isii na isii nke abụba na 84%. N'ụzọ doro anya, a na-eji ọgwụ ndị enzymatic dochie anya ihe dị n'ime na eriri afọ mucosa.

Ihe onyonyo onyonyo a bu oria a bu otutu mgbe ya na ndi ozo banyere ihe digestive system: akpukpo ahu, oria na egbu mgbu, onodu nke okwute n’onu, wdg.

Ihe mgbaàmà kachasị na nke ọdịda nke exocrine bụ afọ ọsịsa. Enwere ike ịhụ irighiri nri na imi ihe n'ime oghere. Ihe a mere bụ n'ihi na anụ ahụ enweghị ike iwepu protein na abụba niile. Na mgbakwunye, feces nwere ịkpọ isi na-adịghị mma.

Ihe ozo ndi ozo banyere oria bu:

• oke ibu na - enweghi isi;
• flatulence (oke flatulence);
• hypovitaminosis (ntutu na-emebi emebi na mbọ aka);
• ike ọgwụgwụ na ike ọgwụgwụ;
• aguija;
• akpịrị ịkpọ nkụ na polyuria (adịkarịghị);
• ihe mgbu siri ike na-agbatị ruo n'azụ.

Oge ufodu na-adi ike nke na emee ka onye obia bia ulo ogwu ma tinye ogwu n’ute.

A na-ahụkarị ihe dị iche iche mgbe ị na-eri nri ọdụdụ na mmanya. N'ụdị ndị ahụ, ọgbụgbọ na afọ ọsịsa ga-ekwe omume.

Zọ nchọpụta usoro isi

Nke mbu, ndi okacha mara ihe kwesiri ige nti na mkpesa nke onye ori. Agbanyeghị, ihe anamnesis enweghị ike ikwu okwu na-ezughi oke nke oke nsogbu mọbụ. Na mgbakwunye, afọ ọsịsa enweghị ike itolite ogologo oge, n'ihi na anụ ahụ na-ejide ikike ọrụ ya, ọ bụ ezie na o zubeghị.

Site na atrophy nke akụkụ ahụ, a na-eme laparoscopy ma ọ bụ laparotomy. Ọ bụrụ na onye ọrịa ahụ na-arịa ọrịa oji, ọ gaghị ekwe omume ịwa ahụ maka ebumnuche nyocha. Nke a bụ n'ihi mmado na fibrosis.

Nnyocha ụlọ nyocha kachasị nke dọkịta nwere ike ịkọwa bụ nyocha fecal na ọbara. Dịka iwu, mmụba na ọrụ ALT, mbelata mmepụta nke abụba, polyunsaturated acid, cholesterol, amylase, lipase, isoamylase na phospholipase A2 nwere ike igosi enweghị arụ nke akụkụ ahụ.

Iji gosipụta ihe kpatara mmerụ ọrụ exocrine pancreatic, ọ dị mkpa ịgụta tomography agbakọrọ (CT).

Naanị dabere na ule niile dị n'elu, dọkịta nwere ike ime nchọpụta, yana dabere na ya, zụlite usoro ọgwụgwọ nke otu onye ma dị irè.

Usoro ọgwụgwọ na mgbochi mgbochi

Treatmentgwọ ọrịa ahụ gụnyere ihe abụọ dị mkpa - nri pụrụ iche na ọgwụgwọ nnọchi. Nri ahụ wepụrụ iri ihe oriri siri ike na-egbu egbu na mmanya na-egbu egbu. Kama nke ahụ, a na-atụ aro iri nri nke mkpụrụ sitere - akwụkwọ nri na mkpụrụ osisi.

Mkpụrụ ọka dị iche iche (millet, oatmeal, buckwheat) nwere mmetụta bara uru na eriri afọ. Ha nwere akwara bara ụba, nke n’adighi n’ime nri n’ime afọ, kama ọ bụ isi iyi nke nri. Iji mezie microflora eriri afọ, ọ dị mma ịgbakwunye ngwaahịa mmiri ara ehi skim na menu. Ma na-abawanye acidity nke afọ, amachibidoro oriri ha.

Ọgwụ eji edochi anya mkpụrụ ego bụ usoro ọla edo n’agha megide ọrịa a. Ọ gụnyere ị drugsụ ọgwụ ọjọọ nwere enzyme pancreatic. Ọgwụ ndị dị otú ahụ na-enwe ike ịkụda protein, abụba na stachi, na-eme ka ọrụ ahụ dịkwuo mma.

Tebụl dị n'okpuru ebe a na-egosi ọgwụ ndị bụ isi e ji agwọ ọrịa.

Iji gbochie mmepe nke usoro pathological, a na-atụ aro ịgbaso iwu ndị a:

1. Jụ àgwà ọjọọ - ị smokingụ sịga na mmanya.
2. Tụgharịa na nri dị mma, na -echibe oriri nke abụba.
3. Were ogige vitamin na mineral.
4. Iri obere nri, mana oge (5-6 ugboro kwa ụbọchị).

Na mgbakwunye, a na-atụ aro izere ọnọdụ ndị na-akpata nrụgide.

Gịnị bụ nsonaazụ nke ọgwụgwọ na-adịghị ike?

Ileghara ọrịa ahụ anya ma ọ bụ ọgwụgwọ na-adịghị arụ ọrụ na-ebute ọtụtụ nsonaazụ na-adịghị mma na ọbụna ọnwụ. Uzo siri ike nke oria nke anakpo exocrine pancreatic na-eduga na mmepe nke ogba aghara, cystic formations na gastritis.

Jaundice ma ọ bụ etuto ahụ adịghị mma. Ọzọkwa, ọkwa siri ike nke ọrịa ahụ nwere ike ibute ọrịa pancreatitis, nke dị oke egwu na ndụ onye ọrịa.

N'oge ọgwụgwọ nke oke nke exocrine, ọ dị mkpa ịlele ọkwa glucose n'ọbara. Ebe ọ bụ na enwere nsogbu ikuku mmiri, ọ dị ka ọ ga - emepụta insulin nke mmadụ belata, homonụ na - ahụ maka iwetulata nnabata shuga. Ma ọ bụghị ya, enwere ihe ize ndụ nke ibute ọrịa shuga.

Ihe ọzọ na-adịghị mma nke ọgwụgwọ ogologo oge bụ ihe riri ahụ mmadụ ahụ na ọgwụ mgbu, ihe ndị na-arụ ọrụ bụ nke ọgwụ ọjọọ. Oge obula mmadu choro otutu ogwu iji wepu ihe mgbu. Dịka ị maara, ihe ndị na-egbu egbu na-enwe mmetụta ọjọọ ọ bụghị naanị na pancreas, kamakwa akụkụ ahụ ndị ọzọ dị n'ime.

Okwesiri iburu n’uche na ogwu nke onwe gi na iji uzo ozo aghaghi inye aka gwọ oria. Naanị usoro ọgwụgwọ siri ike n'oge ga - eme ka ị nwee ezigbo nnabata - mgbake ọfụma na mgbochi nke nsogbu (na - agbasa mgbanwe na akụkụ ahụ na ọrịa shuga).

A kọwapụtara ezughi oke nke exocrine pancreatic na vidiyo n'isiokwu a.