Otu ìgwè nke statins (cholesterol na-ebelata ọgwụ) gụnyere Lovastatin dị irè. A na-eji ọgwụ ahụ eme ihe ọ bụghị naanị na ọgwụgwọ nke hypercholesterolemia, hyperlipoproteinemia, kamakwa na mgbochi nke ọrịa obi.
Ekwesịrị iji ọgwụ a jikọta ya na nri pụrụ iche, mmega ahụ na idozi ibu. N'isiokwu a, ị nwere ike ịmụtakwu banyere Lovastatin, ntuziaka maka ojiji, ọnụahịa, nyocha, analogues.
Ofzọ usoro nke ọgwụ ahụ
Lovastatin bụ otu ọgwụ ọgwụ na-agbadata ume nke na-emebi njikọta cholesterol na imeju na mbido oge. A na-ahụ ọgwụ a dị ka ihe kacha mkpa n'etiti ndị ọzọ. A na - enweta ya site na biocultures Aspergillusterreus na Monascusruber.
N'otu oge, n'ime ọgwụ ndị na-agbari nri, ọgwụ ahụ na-enyefe onwe ya nsonaazụ nke enzymes diges ma jiri nwayọọ nwayọọ banye. Ọzọkwa, ka ọ na-abawanye nzere nke ọgwụ ahụ, ọ na-abanye ngwa ngwa ka ọ na-abanye na ngwu. Ihe na-arụ ọrụ na-abanye n’ime anụ ahụ, wee banye n’ime ọbara. Ihe ruru Plasma kachasị ruru ka awa 2-4 gachara. Ime ka ahụ mmadụ banye na anụ ahụ ndị ọzọ dị n'ụdị beta-hydroxy acid.
Ebumnuche nke Lovastatin bụ maka usoro abụọ. Nke izizi, ọ na - akụghasị njikọ nke cholesterol n'ime imeju, na - egbochi mgbanwe nke mbelata ya na abụ. Nke abuo, o na eduga na mmezi nke catabolism (usoro mmebi nke metabolic) nke LDL. N'akụkụ usoro a, enwere mmụba na HDL, ma ọ bụ cholesterol dị mma.
Ọkara ndụ nke ihe nọ n'ọrụ bụ awa 3. A na-ekepụta Metabolites na ihe dị ike site na akụrụ na eriri afọ.
Ntuziaka maka iji ọgwụ ahụ
Lovastatin 20 mg ma ọ bụ 40 mg dị na ụdị mbadamba, akụkụ a na-arụ ọrụ nke nwere otu aha. Ihe ndi ozo nke ogwu a bu lactose monohydrate, sitashi, cellulose, magnesium stearate, butylhydroxyanisole, citric na ascorbic acid.
A na-ere ọgwụ naanị mgbe mmadụ nwere ọgwụ dọkịta nyere ya. Mgbe ị na-azụ ngwaahịa a, onye ọrịa ahụ kwesịrị ị attentiona ntị na ntinye ahụ etinyere. Ntụziaka ahụ nwere ọtụtụ ihe ngosi maka iji ọgwụ a:
- ọgwụgwọ nke hypercholisterinemia bụ isi jikọtara, ụdị IIa na IIb;
- ọgwụgwọ hyperlipoproteinemia (nke nwere mgbagwoju anya na ọrịa shuga na nephrotic syndrome);
- ọgwụgwọ nke atherosclerosis akwara (ya na ọgwụ nje vitamin na abụba na-adịghị eju afọ);
- mgbochi nke ọrịa obi;
- ọrịa hypertriglyceridemia.
Ekwesịrị iji mbadamba ihe mee ihe 1 oge kwa ụbọchị n'oge nri abalị. Usoro onunu ogwu a dabere na oria. Yabụ, na hyperlipidemia, otu ọgwụ 10-80 mg ka enyere n’aka. Usoro ọgwụgwọ nke pathology na-amalite site na obere doses, na ikike nke dọkịta, enwere ike ịba ụba nke nta nke nta. Ọ na-atụ aro ka ịhọrọ usoro onunu ogwu kwa izu anọ. Enwere ike kee oke kachasị (80 mg) na usoro onunu abuo - n'ụtụtụ na mgbede.
N'ime ọgwụgwọ nke atherosclerosis, ezigbo usoro ọgwụgwọ bụ 20-40 mg. Ọ bụrụ na ọgwụgwọ adịghị arụ ọrụ, mmụba gaa 60-80 mg ga-ekwe omume. Ọ bụrụ na onye ọrịa ahụ na-a fiụ fibrates ma ọ bụ nicotinic acid n’otu oge, ekwesighi iji Lovastatin ihe na-erughị 20 mg kwa ụbọchị. Ọzọkwa, usoro onunu ogwu aghaghi ibelata n'ọnọdụ ndị a:
- Eji mkpuchi immunosuppressants mee ihe.
- Ojiji nke ọgwụ nje.
- Ọgwụ na ọgwụ antifungal.
- Ọgwụgwọ ọrịa nke imeju nke etiology ma ọ bụ nke izugbe.
- Ọgwụ nke nwere anticoagulants.
Ọ dị mkpa iji chekwaa ọgwụ n'oge okpomọkụ agaghị erughị ogo 25 Celsius.
Mgbe mmebi ahụ gwụsịrị, nke bụ afọ 2, amachibidoro iji ngwaahịa a.
Ngwurugwu mgbochi na nsonaazụ ya
Lovastatin nwere ndepụta contraindications dị obere. Amachibidoro iji ọgwụ a eme ihe maka myopathy (ọrịa neuromuscular na-adịghị ala ala), ịtụrụ ime, cholestasis, nsị imeju, na-erubeghị afọ 18 na hypersensitivity nke akụkụ ahụ.
Ekwesịrị iji ọgwụ ahụ mee ihe na-akpachara anya na ndị ọrịa nwere ọrịa akwara ọbara banyere ọrịa grafting. N’ọnọdụ ọbụla ị gaghị a medicationụ ọgwụ n ’mmanya.
N'ọnọdụ ụfọdụ, ọgwụ nwere ike ibute nsonaazụ. N'ime ha, ọ dị mkpa igosipụta:
- Mmeghachi omume metụtara ọrụ eriri afọ: ọgụ nke ọgbụgbọ, obi mgbawa, ịba ụba gas, mgbanwe uto, afọ ọsịsa, dochie afọ ntachi.
- Ọgba aghara nke usoro akwara dị n’etiti: isi ọwụwa, ụra na-adịghị mma, nchekasị, ọgbụgbọ, paresthesia, myositis, ihe mgbu akwara na myalgia. Mgbe ị na-eji cyclosporine, gemfibrozil ma ọ bụ nicotinic acid, enwere ohere nke rhabdomyolysis.
- Mmeghachi omume nke sistemụ biliary: ụba ọrụ nke bilirubin, alkaline phosphatase, transminases imeju na creatine phosphokinase. Mgbe ụfọdụ, ịba ọcha n'anya, cholestatic jaundice na biliary cholestasis ga-ekwe omume.
- Mmeghachi omume nfụkasị ahụ: itching, ọnya anụ ahụ, urticaria, angioedema, arthralgia.
- Ndakpọ nke nku anya: atrophy nke akwara optic na mmepe nke cataracts.
- Mmetụta ndị ọzọ: mbelata ikike, ọrịa ịba, alopecia.
Doụbiga ihe ọ symptomsụ symptomsụ mgbe ị na-eji ọtụtụ ọgwụ ọgwụ ahụ anaghị ahụ ya. Ndabere nke usoro ọgwụgwọ bụ nhichapụ nke Lovastatin, lavage gastric, ojiji nke anwansi (unyi na-arụ ọrụ, Smecta, Polysorb, Atoxil) na-achịkwa ọrụ dị mkpa, ọrụ imeju na ọrụ phosphokinase creatine.
Mmekọrịta na ụzọ ndị ọzọ
Ekwesighi iji Lovastatin mee ihe na ogwu niile, n'ihi mmekorita ha na aru nwere ike ime ka anyi mee ihe ojoo. Ọzọkwa, ụfọdụ ọgwụ nwere ike ime ka ịta ụta nke ihe arụ ọrụ dị, ma ụfọdụ nwere ike belata.
Nnukwu ihe egwu nke mbibi akwara na myopathy, yana mmụba nke ọdịnaya ahụ na - arụ ọrụ, na - akpasu ojiji nke Lovastatin n'otu oge yana nicotinic acid, Cyclosporine, Ritonavir, Erythromycin, Nefazodone na Clarithromycin.
Ojiji siri ike nke otu ogwu nwere nkpuru osisi grape, fenofibrate, gemfibrozil na-abawanye ohere nke myopathy.
Ewu ọbara na-abawanye site na iji warfarin na-eme ihe. A na - ebelata bioavailability nke lovastatin mgbe ị na - eji colestyramine. Iji mee ka bioavailability nke ọgwụ ahụ ka ọ bụrụ ihe a na-ahụkarị, ọ dị mkpa iji ọgwụ dị n’agbata awa 2-4.
Site na ọrịa concomitant, onye ọrịa ahụ ga-agakwuru dọkịta banyere ị medicationsụ ọgwụ.
Offọdụ n'ime ha ekwekọghị na Lovastatin, yabụ, machibidoro ị useụ ọgwụ ọ bụla.
Efu, analogues na nyocha onye ọrịa
O di nwute, ugbu a enweghi ike izuta Lovastatin n'ihi E mepụtaghị ya na Russia.
Lọ ọrụ ọgwụ dị ka Lekpharm (Belarus), Replekpharm AD (Macedonia) na Kievmedpreparat (Ukraine) bụ ndị na-emepụta ọgwụ.
N'akụkụ a, dọkịta ahụ nwere ike ịkọpụta analog nke Lovastatin, nke nwere otu usoro ọgwụgwọ ahụ.
Ọgwụ kachasị ewu ewu bụ:
- Holetar. O nwere ihe eji eme ihe - lovastatin, yabụ na ọ bụ okwu maka Lovastatin. Ogwu ahu nwere otu ihe egosi, contraindications na mmeghachi omume ojoo dika Lovastatin.
- Cardiostatin. Ọgwụ ọzọ a ma ama bụ okwu maka Lovastatin, n'ihi na nwere otu akuku ahu aru oru. Mgbe ị na-ewere Cardiostatin, a na-achọpụta mmetụta ọgwụgwọ akpọrọ maka izu abụọ, yana kachasị ka izu isii nke ị weeksụ ọgwụ ahụ gasịrị. Ọnụ ego dị 290 rubles (na ngwugwu nke mbadamba 30 nke 20 mg).
- Pravastatin. Ọ nwere ụdị ọrụ dị iche iche. Ihe eji eme ihe bu pravastatinum. A na-eji ọgwụ ahụ eme ihe maka hypercholesterolemia bụ isi na dyslipidemia gwara ọgwa, yana maka mgbochi nke ọrịa obi nke ischemic. Ojiji Pravastatin ga - ekwe omume dị ka ihe mgbochi nke abụọ maka infarction myocardial, angina pectoris na hyperlipidemia post-transplant.
- Zokor. Ihe na-arụ ọrụ nke ọgwụ ahụ bụ simvastatin. Isi ihe na-egosi ọgwụ ahụ bụ ọgwụgwọ nke hypercholesterolemia. Ejikwa Zokor ka prophylactic iji gbochie mmepe nke ọrịa obi. Nkezi ọnụ bụ 380 rubles (mbadamba 28 nke 10 mg) na 690 rubles (mbadamba 28 nke 20 mg).
Dabere na Index Vyshkovsky, ndị isi n'ahịa ọgwụ Russia bụ Cardiostatin, Mevacor, Holetar na Rovacor.
Nzaghachi na Lovastatin, ma ndị ọrịa ma ndị dọkịta, dị mma. Ọgwụ ahụ dị mma ma nabata ndị ọrịa, ọbụlagodi iji ogologo oge.
Mmeghachi omume metụtara ọrịa dyspeptik na-egosi mgbe ụfọdụ na mmalite ọgwụgwọ. Mgbe izu abụọ gasị, mgbe anụ ahụ mechara nwee mmetụta na-arụ ọrụ, ihe mgbaàmà akwụsị. N'oge ụfọdụ, ọkwa nke ALT na AST na-abawanye, yabụ na ọ dị mkpa ijikwa ọdịnaya ha.
Mgbe ọnwa 1.5 site na mmalite nke ọgwụgwọ, a na-eme nnyocha njikwa. Dịka iwu, enwere ọnọdụ dị mma na nyocha ahụ, i.e. itinye egbugbere ọnụ.
Akọwara etu esi wedata cholesterol na vidiyo n’okwu a.
