Na mgbakwunye na usoro ọgwụgwọ nri, a na-eji ọtụtụ ọgwụ iji gwọọ ọrịa a na-ahụkarị dịka atherosclerosis.
Otu n'ime ha bụ fluvastatin, nke bụ ihe hypocholesterolemic iji lụba ụba cholesterol n'ime ọbara mmadụ.
Fluvastatin bụ ihe na-acha ọcha nke nwere agba ọcha ma ọ bụ nke na-acha odo odo. Sọlu nke ọma na mmiri, ụfọdụ ahoụrụma, nwere arịa hygroscopic.
Otu n'ime ọgwụ analogues ọgwụ (mkpụrụ ndụ ihe nketa), nke gụnyere fluvastatin umi ọrụ, bụ Leskol Forte. Ọ bụ mbadamba nkume na-arụ ọrụ ogologo oge. Ha nwere okirikiri, biconvex udi nwere beveled n'ọnụ. Nwere fluvastatin 80 mg na mbadamba 1.
Ọ bụ ọgwụ hypocholesterolemic jikọtara ọnụ artificially. Ọ na-egbochi ọrụ nke HMG-CoA reductase, otu n'ime ọrụ nke bụ ntụgharị nke HMG-CoA gaa na ntụgharị nke sterols, ya bụ cholesterol, mevalonate. Ihe ọ na - eme na imeju, ebe enwere cholesterol, mmụba nke ihe ndị na - anabata LDL, mmụba nke mbido LDL na - akpụ akpụ. N’ihi nke a, n’ihi ihe ndị a rụpụtara, a na-ebelata plasma cholesterol.
Ndị ọkà mmụta sayensị gosipụtara na site na ịba ụba nke LDL cholesterol na triglycerides na plasma ọbara, atherosclerosis na-etolite ma ihe egwu nke ịmalite ọrịa obi na ọrịa vaskụla na-abawanye, nke na-edugakarị ọnwụ. Agbanyeghị, mmụba dị elu nke npoprotein dị elu nwere mmetụta nke na-emegide ya.
Nwere ike lelee mmetụta ụlọ ọgwụ mgbe ị theụ ọgwụ ahụ ka izu abụọ gachara, ana-ahụkarị oke ya n'ime otu ọnwa site na mmalite ọgwụgwọ ma a na-elekọta ya oge niile eji fluvastatin.
Ntinye uche kachasị, ogologo oge nke ime ihe na ọkara ndụ dabere na:
- Formdị usoro eji eji ọgwụ eme ihe;
- Anddi nma na oge iri nri, nke bu abuba n’ime ya;
- Oge nke oge eji;
- Ihe e ji mara mmadụ nke na-arụ ọrụ metabolic.
Mgbe ejiri sodium fluvastatin na ndị ọrịa nwere hypercholesterolemia ma ọ bụ dyslipidemia agwakọta, enwere nnukwu mbelata na LDL na ọkwa triglyceride na mmụba nke cholesterol HDL.
Na oge atọrọ ọ dị mkpa ịgbaso ndụmọdụ ndị pụrụ iche.
Ọ bụrụ na mmadụ nwere ọrịa imeju, a na-ebute ụzọ maka rhabdomyolysis, iji ọgwụ ndị ọzọ nke statin otu ma ọ bụ ị abuseụbiga mmanya na-egbu egbu, a na-eji akọ kpachara anya. Nke a bụ n'ihi nsogbu ọrịa imeju nwere ike ịnweta, yabụ, tupu iwere ya, ka ọnwa anọ gachara ma ọ bụ oge ịbawanye ụba, ndị ọrịa niile kwesịrị iji nlezianya nyocha ọnọdụ nke imeju. Enwere ihe akaebe na n’ọnọdụ ndị a na-adịghị ahụkebe, ojiji nke ihe ahụ mere ka mmalite nke ịba ọcha n'anya, nke chọpụtara naanị oge ọgwụgwọ, na njedebe nke ya
Ojiji nke fluvastatin n'ọnọdụ ụfọdụ nwere ike ibute myopathy, myositis na rhabdomyolysis. Ndị ọrịa ga-agharịrị ime ka dibịa bekee mara banyere ọdịdị mgbu mgbu, ọnya ma ọ bụ adịghị ike, karịsịa na ọnụnọ nke okpomoku;
Iji gbochie mmepe nke rhabdomyolysis tupu eji ya, a na-atụ aro ka ịmụ akwụkwọ mkpokọ nke creatine phosphokinase na ọnụnọ nke ọrịa akụrụ na ndị ọrịa; ọrịa thyroid; ụdị ọrịa ọrịa nile siri ike nke usoro akwara; mmanya riri ahụ.
N'ime ndị ọrịa toro afọ 70, ekwesịrị ịchọpụta mkpa nke ọkwa CPK na ọnụnọ nke ihe ndị ọzọ na-ebute mmepe nke rhabdomyolysis.
N'okwu ndị a niile, dibịa na-aga na-enyocha uru omume ọgwụgwọ ahụ na ihe ọghọm ndị metụtara ya. A na-elekọta ndị ọrịa mgbe niile. N'ihe banyere mmụba dị ukwuu na mkpokọta CPK, a na-ekpebi ikpe mgbe otu izu gasịrị. Ọ bụrụ na ekwenyepụtara nsonaazụ ya, a naghị atụ aro ọgwụgwọ.
Site na mkpocha nke ihe mgbaàmà na nhazi nke itinye uche nke phosphokinase, a na-atụ aro ka ịmaliteghachi ọgwụgwọ na fluvastatin ma ọ bụ ihe oyiyi ndị ọzọ ịmalite site na iji ọgwụ kacha ala ma nọrọ n'okpuru nlekọta mgbe niile.
Isi ihe dị mkpa bụ mmezi nke hypocholesterol nri tupu mmalite nke ọgwụgwọ yana n'oge ọgwụgwọ.
A na-eji ọnụ ede ya n'agbanyeghị nri. Ọ dị mkpa ilo mmiri mbadamba ihe niile, were mmiri dị larịị sachaa ya, otu oge kwa ụbọchị.
Ebe ọ bụ na hypelipPs kachasị ama achọpụta na izu nke anọ, nyocha nke dose ahụ ekwesịghị ibido tupu oge a. Ọgwụgwọ ọgwụgwọ nke Lescol Forte na-adịgide naanị site na iji ogologo oge.
Iji malite usoro ọgwụgwọ, ọgwụ a tụrụ aro bụ mg mg 80 otu ugboro kwa ụbọchị, nke ya na mbadamba 1 nke Leskol Forte 80 mg. Na ọnụnọ nke ọrịa dị nro, enwere ike inye 20 mg nke fluvastatin, ma ọ bụ 1 capsule Leskol 20 mg. Iji họrọ usoro ọgwụgwọ mbụ, dọkịta na-enyocha ọkwa mbụ nke cholesterol n'ime ọbara onye ọrịa, kọwapụta ebumnuche nke ọgwụgwọ ma na-eburu n'uche njirimara onye ọrịa ahụ.
N'ọnọdụ nke onye ọrịa ahụ na-arịa ọrịa obi na akwara ịwa ahụ wee nwee mmerụ ahụ angioneoplastic, usoro ọgwụgwọ akwadoro bụ iji 80 mg kwa ụbọchị.
A naghị eme mgbanwe dose na ndị ọrịa nwere ọrụ mgbazinye nsogbu. Nke a bụ n'ihi eziokwu ahụ bụ na imeju kpochapụrụ Fluvastatin, ma ọ bụ naanị obere akụkụ nke ihe ndị ahụ nwetara n’arụ ahụ na-apụ na mmamịrị.
Mgbe ị na-eme nyocha, egosiri na ịdịmma yana nnabata dị mma ọ bụghị naanị maka ndị ọrịa na-eto eto, kamakwa maka ndị gbara afọ 65.
N'ime ọgbọ karịrị afọ iri isii na ise, ekwuputara azịza nke ọgwụgwọ ahụ, ebe enweghị data na-egosi nnabata ka njọ.
Ọgwụ nwere ọtụtụ nsonaazụ:
- N’oge na-adịghị anya, enwere ike ịhụ ọnọdụ nke thrombocytopenia;
- Ikekwe ihe ndapụta n'ụra, isi ọwụwa, paresthesia, ọnyụnyụ, hypesthesia;
- Ọdịdị nke vasculitis adịkarịghị ekwe omume;
- Ọdịdị nke nsị nke eriri afọ - dyspepsia, mgbu afọ, ọgbụgbọ;
- Ọdịdị nke mmeghachi ahụ anụ ahụ na-adịghị mma, eczema, dermatitis;
- Mgbu mgbu, myopathy, myositis, rhabdomyolysis, na mmeghachi omume yiri nke lupus adịghị ahụkebe.
A na-atụ aro ọgwụ ahụ ka ndị okenye jiri ya mee ihe:
- Mgbe ị na-achọpụta ọkwa dị elu nke cholesterol zuru oke, triglycerides, obere protein lipoprotein cholesterol, apolipoprotein B, yana isi hypercholesterolemia na hyperlipidemia;
- Ọnụnọ nke akwara obi iji mee ka mmepe nke atherosclerosis belata;
- Dị ka ọgwụ mgbochi mgbe angioplasty.
A na - eme ọgwụ ahụ ka ọ bụrụ ihe eji eme ihe ma ọ bụ nfụkasị ahụ mejupụtara ya; ndị ọrịa nwere ọrịa imeju, na-abawanye na ọkwa nke enzymes imeju; n'oge ime na lactation na ụmụ nwanyị; ụmụaka na-erubeghị afọ 10.
N'iji nlezianya mee ya, ọ dị mkpa ịkọ ọgwụ maka ndị ọrịa nwere ọrịa akwụkwụ, na-a alcoụrụma, ọdịda akụrụ na-agbasa myalgia.
Achọpụtaghị mmeghachi omume nkwụghachi azụ na otu nha 80 mg.
N'ihe banyere idegara ọgwụ ndị ọrịa n'ụdị mbadamba ihe na-egbu oge na usoro onyonyo nke 640 mg maka ụbọchị 14, ọdịdị nke nsonaazụ si eriri afọ, mmụba na ọkwa plasma nke transaminases, ALT, AST.
Cytochrome isoenzymes na-ekere òkè na metabolism nke ọgwụ. N'ọnọdụ nke enweghị ike nke otu n'ime ụzọ metabolic na-ebilite, a na-akwụghachi ya ụgwọ maka ndị ọzọ.
Agaghị atụkọta ojiji ọgwụ jikọtara Fluvastatin na HMG-CoA reductase inhibitors.
Mkpụrụ ọgwụ mgbochi na ndị na-egbochi usoro CYP3A4, erythromycin, cyclosporin, intraconazole nwere ntakịrị mmetụta ọhụụ na ọgwụ ọgwụ.
Iji mee ka mmụba ahụ dịkwuo ụtọ, a na-atụ aro ka iji colestyramine mee ihe tupu oge elekere 4 mgbe fluvastatin gasịrị.
Enweghị ọgwụ mgbochi na ngwakọta ọgwụ a na digoxin, erythromycin, itraconazole, gemfibrozil.
Njikwa nkwonkwo nke ọgwụ na phenytoin nwere ike ime ka mmụba na plasma ịta ahụ nke ikpeazụ, yabụ ekwesịrị ịkpachara anya mgbe ị na-ede ọgwụ ndị a. N'ọnọdụ ụfọdụ, enwere ike ịchọ mgbanwe iji usoro onunu ogwu.
Enwere mmụba na mkpokọta na plasma ọbara nke diclofenac mgbe ejikọtara ya na fluvastatin.
Enwere ike iji Tolbutamide na losartan otu oge.
N'ọnọdụ nke mmadụ na-arịa ụdị ọrịa shuga mellitus nke 2 ma were fluvastatin, ekwesịrị ịkpachara anya ma nọrọ n'okpuru nlekọta ahụike mgbe ọ bụla, ọkachasị mgbe ị na-eme ka ọgwụ fluvastatin kwa ụbọchị ruo 80 mg kwa ụbọchị.
Mgbe ejikọtara ọgwụ ahụ na ranitidine, cimetidine na omeprazole, mmụba dị ukwuu na mkpokọta plasma kachasị na AUC nke ihe ahụ ka a na-ahụ, ebe plasma nke Fluvastatin na-ebelata.
Site kpachara anya, jikọta ihe a na anticoagulants nke usoro warfarin. Ọ na-atụ aro ka inyocha prothrombin oge, ọ bụrụ na ọ dị mkpa, dozie usoro ahụ.
Ugbu a, a na-ahụ ọgwụ ahụ n'ọtụtụ nyocha dị mma site n'aka ndị ọrịa were ya dịka ọgwụgwọ. Ekwesịrị iburu n'uche na iji nweta nsonaazụ kachasị, ọ dị mkpa ịgbaso ụzọ ndụ dị mma, nri kwesịrị ekwesị na ịgbalịsi ike. Na mgbakwunye, a na-atụ aro iji ogologo oge eji eme ihe, ebe ọgwụ ahụ nwere mmetụta ọ na-adịte aka, nke ọ na-enwe mmetụta dị mma na ụba cholesterol dị n'ọbara.
A ga-azụtara ọgwụ nwere fluvastatin n'ụlọ ahịa ọgwụ na ọgwụ edenyere ya.
Ndi okacha mara ga ekwu banyere ihe akuko a n’ime vidiyo n’isiokwu a.
