Tricyclic antidepressant nwere antihistamine, mmeghachi omume anticholinergic. A na-eji ya agwọ ọrịa ọ bụghị naanị ọnọdụ nkụda mmụọ, kamakwa somatoform neurosis na mmebi nke eriri afọ, usoro bronchopulmonary na akụkụ ndị ọzọ.
Aha
Aha mba ofesi: Amitriptyline.
ATX
Antidepressants, N06A A09.
Ha weputara udi ya na ihe mebere ya
Ere ọgwụ
25 mg nke ihe na-arụ ọrụ n'ime otu mbadamba dị na ngwugwu 20, 50, 100 PC.
A na-eji Amitriptyline agwọ ọrịa ọ bụghị naanị ọnọdụ nkụda mmụọ, kamakwa somatoform neuroses.
Releasedị wepụtara adịghị adị
Ngwọta nke 10 mg / ml 10 ampoules nke 2 ml maka injections intramuscular. Akara maka umu nke 10 na 25 mg, ngwugwu nke 50 pcs.
Usoro nke ime ihe
Ngwakọta tricyclic. A rụpụtara nsonaazụ ya n'ihi igbochi reuptake nke neurotransmitters - adrenaline, norepinephrine, serotonin, dopamine. N'ihi ya, ihe ndị edepụtara edepụtara nọ na mpekere synaptik ogologo ma na-agbakọta. Ọnọdụ ahụ na-adịwanye mma, ọrụ ụbụrụ na-esikwu ike.
O nwere anticholinergic, mmetụta antihistamine, n'ihi nke a na - eji ya eme ihe dị ka ihe na - akụda mmụọ, nchekasị na ọgwụ ịrahụ ụra. Ọ bụ ọrịa timoanaleptik, Corrects depression depression na buuru ụzọ ma ngụgụ na mgbochi. Akpali ume na inhibitory mmetụta na sistem ụjọ bụ ọgwụ dabere.
Mlọ ọgwụ
Ahapụrụ ya na ngwe nri. A na-enweta ntinye uche kachasị ruo awa 2-12 mgbe nchịkwa gasịrị. Nri anaghị emetụta mmịpụta nke ọgwụ. Ọtụtụ n'ime ya - 92-95% jikọtara na protein plasma.
Penetrates site na ụbụrụ ọbara na mgbochi mgbochi hematoplacental, yana n'ime mmiri ara.
Metabolism na-aputa n'ime imeju, akụrụ kewapụrụ ya. Oge kpochapu ọkara ndụ bụ 40-75 awa.
Ihe achoro maka
Na-ezo aka psychoanaleptics. A na-eji ya na ọgwụgwọ nke nkụda mmụọ nke etiology ọ bụla, bụ nke na-agwụ agwụ, na-eme ka nguzozi nke neurotransmitters ghara ịdị mma. A na-eji ya maka ọrịa asthenovegetative syndrome, schizophrenic psychosis, nsogbu nke ụbụrụ, yana nchegbu, ehighị ụra nke ọma.
A na-eji Amitriptyline mee ihe maka nsogbu uche na mgbakasị.
Dika ihe eji eme ihe anticholinergic, na - eme ka ihe mgbu ghara iburu mmadu nsogbu n'obi, obara n’ahoria. Ọ nwere mmetụta mgbochi mkpali n'ihi mmetụta antihistamine.
Na-ebelata acidity nke afọ, na-egosipụta mmetụta M-anticholinergic na H1-histamine-igbochi, nke na-enye ya ohere iji ọnya afọ na ọnya duodenal (dị ka ngosipụta nke somatoform neurosis).
A na-eji ya maka ụkwara ume ọkụ bronchial - ọ nwere ihe antiallergic ma gbasaa bronchi, na-ebelata ihe nzuzo ha.
A na - egosikwa mmetụta ya analgesic maka fibromyalgia, isi ọwụwa (migraines). Ọ na - ewepụ mkpachapụ uche uche, ụjọ, ehighị ụra. Ngwongwo nke antidepressant iji belata mmeputa homonụ nke nrụgide - cortisol - na-edozi mkpụrụ ndụ ụbụrụ pụọ na ọnwụ.
A na-eji ya eme ihe dịka ọgwụ mgbochi maka nsogbu iri nri - anorexia, bulimia, yana maka dystonia neurocirculatory.
N'ihi nguzozi n'etiti ihe ogwugwo na mkpali, Amitriptyline anaghị akpata mgbaàmà na - arụpụta - ihe ijuanya, ihe ijuanya, ọrịa ara, n'adịghị ka Imipramine.
Amitriptyline na-enyere aka iwepụ ehighị ụra.
Ihe ngbanwe
A na - egbochi ọgwụ ahụ maka ọgwụ hyperensitivity, ya na atherosclerosis siri ike, ọrịa obi na - arịa obi, nkụchi obi, oke ịba ọcha n'anya (gụnyere porphyria), psychosis manic, ọgwụgwọ na monoamine oxidase inhibitors (n'ime izu abụọ mgbe ịkwụsị iji).
Can nweghị ike ị takeụ ọgwụ ahụ nye ụmụ nwanyị dị ime na ụmụaka na-erubeghị afọ 16.
Etu ị ga-esi
A na-ekpebi usoro ahụ dabere na ọrịa na afọ nke ndị ọrịa.
Usoro usoro onunu ogwu
Iji gwọọ nkụda mmụọ, a na-eji ọgwụ 25 mg mee ihe, n'ime ụbọchị 5-6 na-esote ọ na-abawanye ruo mgbe a ga-enweta nsonaazụ ọgwụgwọ.
Site na ọgwụgwọ ụlọ, oke kachasị bụ 200 mg.
Mgbe emeziwanye, a na-eji nwayọ belata ọgwụ ahụ ka ọ bụrụ nke kachasị dị irè, na-abụkarị 50-100 mg kwa ụbọchị. Ogologo oge nchịkwa bụ ugboro 2-3 n'ụbọchị ma ọ bụ otu oge n'abalị, n'ihi na ọgwụ ị na-ehi ụra nwere.
Ọtụtụ ọgwụ ị na-a isụ ọgwụ bụ 2-3 ugboro n'ụbọchị ma ọ bụ otu ugboro n'abalị.
Ọ bụrụ n ’ụbọchị echere nnabata, a ga-eme nnabata na-esote n’enweghị mgbanwe. Ọgwụgwọ ya bụ ọnwa 3-6. N'ime ndị okenye, ọgwụgwọ na-amalite site na iji 25 mg, na-abawanye nwayọ, ebe ibu dị na sistem obi nwere ike.
Reg na-amalite usoro ụmụaka
6mụaka 6-12 gbara afọ 10-30 mg kwa ụbọchị ma ọ bụ na-eburu ibu nke 1-5 mg / kg kwa ụbọchị.
Na-a drugụ ọgwụ maka ọrịa shuga
N'ihi mmụba nke adrenaline, antidepressant na-eme ka glucose dị n'ọbara, yabụ, na-arịa ọrịa shuga, a na-amụbawanye ọgwụ ahụ, na-achịkwa ihe ngosi a.
Ego ole ka ọ dị irè
A na-echekwa ya na anụ ahụ ruo awa 80-150. Mgbe oge a gasịrị, egosiri ya.
Otu esi kagbuo amitriptyline
A na-egosipụta ọrịa kagbuo mgbakasị ahụ site na mgbakasị ahụ, ehighị ụra nke ọma, isi ọwụwa, asthenia. Ya mere, mwepụ nke ọgwụ ahụ kwesịrị ime nwayọọ - a na-ebelata ọgwụ nke nta nke nta.
Ọrịa isi ọwụwa na-egosipụta ọrịa isi ọwụwa.
Nsonaazụ
N'ime akụkụ ahụ dị iche iche, mmetụta ndị otu na-egosipụta onwe ha n’ụzọ dị iche iche.
Ọkpụkpụ afọ
Mmetụta anticholinergic na-esobelata mmụba nke salivation, ọnụ akọrọ, mbelata afọ acid, ọgbụgbọ, ọgbụgbọ, ọrụ nke ọrụ moto, na obi mgbawa. Ikekwe mmepe nke ụlọ ahụ mkpọnwụ, afọ ntachi, afọ ọsịsa.
Ahụhụ Hematopoietic
Mbelata na ọnụ ọgụgụ leukocytes na platelet, eosinophilia.
Site n'akụkụ nke metabolism
Uru dị arọ, ọzịza ụkwụ, gynecomastia na ndị ọzọ na - akpaghasị ọbara, mụbara ọbara shuga.
Sistemụ akwara Central
Dizziness, adịghị ike, orthostatic ida, tinnitus, nightmares. Maka nsogbu na gland thyroid (hypothyroidism), ị theụ ọgwụ ahụ na-akpata ọnọdụ manic ma ọ bụ hypomania. Ikekwe ịba ụba nke ịda mba na ebumnuche igbu onwe ya. Na Akwụkwụ na-adọ, ọ nwere ike kpalite mmụba nke ọdịdọ akwụkwụ.
Maka nsogbu na gland thyroid (hypothyroidism), ị theụ ọgwụ ahụ na-akpata ọnọdụ manic.
Ahụhụ
Site n’ịbawanye ụba, ọ na - akpata ọnya ọnya, itching, mgbe ụfọdụ ụbụrụ Quincke, mmeghachi omume anaphylactoid, mkpụmkpụ ume.
Ntụziaka pụrụ iche
Iwere ọgwụ ahụ n'ọnọdụ dịgasị iche iche chọrọ ịkpachara anya.
Jiri n'oge ime na lactation
Enweghi ike iji ya n’oge di ime na n’azu ube. Mmetụta puru iche nke nsị mmetụta dị na ụbụrụ nwa ebu n’afọ na-etolite, ụmụ amụrụ ọhụrụ.
Jiri na agadi
Ejiri ha jiri nlezianya mee ihe, n'ihi na ịka nká nwere ihe ize ndụ nke ịmalite ọbara mgbali elu na ọgụ nke infarction myocardial.
Site na ịrụ ọrụ ọrụ imeju
A na-eme ọgwụgwọ n'okpuru nchịkwa nke ACT, ALT, bilirubin kpọmkwem, alkaline phosphatase, ọkwa transglutaminase. Ọ bụrụ na ọ dị mkpa, a na-eji hepatoprotector.
N'ọnọdụ arụ ọrụ na-emebi emebi, a na-eme Amitriptyline ọgwụgwọ n'okpuru ọkwa nke AcT, Alt.
Na arụ ọrụ ezumike ọrụ
A na-enyocha creatinine na urea n'ime ọbara.
Mmetụta ikike ịchịkwa usoro
Mmetụta hypnotic na-ebelata ịta.
Mmanya ndakọrịta
Na-eme ka mmanya nke ethanol kwụsị. Na mmanya.
Dodoụbiga ya ókè
Ọ na-egosipụta onwe ya dị ka hallucinations, ọnwụ nke nsụhọ, mmepe nke ụlọ ahụ mkpọnwụ, nkwarụ, belata ahụ ọkụ, palpitations.
N'ihe banyere nsi, ịnwere onwe ịnya isi.
Ọ dị mkpa lavage gastric, mmanye diuresis, ịba ọcha n'anya.
Mmekọrịta na ọgwụ ndị ọzọ
Amachibidoro iji antidepressant na MAO inhibitors (Furazolidone, St John's wort, wdg), tricyclic antidepressants (Clomipramine, Imipramine), ọmịiko - Reserpine, SSRIs (Clozapine, wdg) - ọrịa serotonin ga-ekwe omume.
Amachibidoro iji ọgwụ mgbochi a na MAO inhibitors, antidecressan tricyclic, ọmịiko.
Na-eme ka mmetụta mgbochi inhibitory dị na sistem na-egbu egbu nke mmanya, antipsychotics (Atarax, Triftazin), barbiturates, ọgwụ maka ọrịa Parkinson. Na-ebelata ogo mmetụta antihypertensive nke beta-egbochi ya na ọgwụ ndị ọzọ maka ọbara mgbali elu. Na-ebelata ọrụ nke anticonvulsants.
Barbiturates na carbamazepine na -ebelata ị ofụ ọgwụ ahụ, na-eme ka ntụgharị ahụ dị ngwa ngwa, cimetidine, na ntụle, na-enye aka na njigide ọbara. Iji ya na Sucralfate na-ejikọ ọnụ na-ebelata ịmịkọrọ.
Mgbe ejikọtara ya na homonụ thyroid, mmụba nke arrhythmia na psychomotor na-akpata nsogbu, a na-ahụta mmerụ nke obi, na tachycardia.
Ejiri ndakọrịta na Grandaxin ka eji agwọ ụra ehighị ụra, ura ụra. Na mgbochi anticholinergic - mmepe nke mgbochi ụbụrụ na-eme mkpagide.
Analogs nke amitriptyline
A na-emepụta ihe ndị na-arụ ọrụ site na ọtụtụ ụlọ ọrụ (Nycomed, Grindeks, Ozone, Zentiva) dịka akụkụ nke nkwadebe analogran Anafranil, Saroten, Doxepin, Clofranil, wdg.
Ahịa ọgwụ na-ahapụ okwu
Relelị site na ndenye ọgwụ.
Enwere m ike ịzụta na ndenye ọgwụ
N’ebe ụfọdụ n’ụlọ ahịa ọgwụ, a na-ere ọgwụ ahụ n’elu ahịa.
Ọnụahịa
Ọnụ ego nke mbukota mbadamba 50 bụ 21-30 rubles. Ampoules iri nke 2 ml, 10 mg / ml riri 52 rubles.
Usoro na nchekwa nke ọgwụ Amitriptyline
Chekwaa n’ebe di okpomoku na okpomoku adighi akari 25 Celsius. Ekwela ka ụmụaka ghara iru ya. Ndụ shelf bụ afọ 3.
Nyocha banyere amitriptyline
Nyocha nke ndị ọkachamara na ndị ọrịa ha banyere ọgwụ bụ nke kachasị mma.
Ndị isi mgbaka
Vlasov V.A.
Ọgwụ enweghị ego ma dịkwa irè. Enweghị ike izere ọtụtụ mmetụta ndị ọ na-akpata ọbụna n'ihi nyocha ruo ọtụtụ iri afọ. Gosipụta site n'oge na omume. Agbanyeghị, ekwesighi maka ndị ọrịa niile, ụfọdụ nwere ike ibute agụụ igbu onwe ya, yabụ ọ bụ ihe na-achọsi ike ịme ọgwụgwọ n'ụlọ ọgwụ.
Andreev A.L.
Ọ gosipụtara arụmọrụ ya ọ bụghị naanị na nkụda mmụọ, kamakwa na usoro psychosomatic - ndị ọrịa nwere ọnya afọ, ụkwara ume ọkụ, ụbụrụ na-agbakasị ahụ na-agbake mgbe ewere ya. Agbanyeghị, ọgwụ riri ahụ ga-ekwe omume.
Ndị ọrịa
Michael K.
Ihe ogwu a nyere aka ngbu. Enwere m ọrịa mgbu afọ ọfụma. Ọgwụ a na-emekwa ka ọnọdụ gbanwee.
Dmitry Sh.
Enwere ọnya afọ, nrụgide na-arụ ọrụ kpalitere ọdịdị ya. Onye dibia bekee gwara gi ogwu a. Site na nsonaazụ, m na-achọpụta ụra ụra na obere mbelata libido na ikike.
