Glimecomb bụ ihe nnọchianya hypoglycemic na-achọ na ụdị ọrịa shuga 2 nke ọrịa mellitus. Ogwu ahu n’otu n’otu meziwanye steeti metabolism, belata ihe egwu nke atherosclerotic plaques n’elu akwara vaskụla, na-ebelata oke ahụ n’ịba oke ibu. Edere ọgwụ ahụ naanị na enweghị mmetụta nke iri nri na mmega ahụ.
International Nonproprietary Aha
Glyclazide + Metformin.
Glimecomb bụ ihe nnọchianya hypoglycemic na-achọ na ụdị ọrịa shuga 2 nke ọrịa mellitus.
ATX
A10BD02.
Ha weputara udi ya na ihe mebere ya
A na-eme ọgwụ ahụ n'ụdị mbadamba ọcha maka iji ọnụ mee ya, nke e ji agba odo na-acha odo odo ma ọ bụ nke nwere ude mara mma. Mediclọ ọgwụ na - agwakọta ngwakọta ọrụ abụọ: 40 mg nke gliclazide na 500 mg nke metformin hydrochloride. Povidone, magnesium stearate, sorbitol na sodium sodium na-arụ ọrụ dị ka ihe inyeaka. Mbadamba ụrọ dị na nkeji iri na ngwugwu ọnya. N’otu kaadiboodu dị 6 blisters.
Omume ọgwụ
Ọgwụ a na-ezo aka na njikọta hypoglycemic ejikọtara ọnụ maka nchịkwa ọnụ. Ogwu ahu nwere ogwu nke puru iche.
Glyclazide bụ usoro sitere na sulfonylurea. Usoro ihe eji eme ihe sitere na kemịkalụ kemịkalụ sitere na mkpali nke ọrụ nzuzo nke mkpụrụ ndụ beta pancreatic. N'ihi mmetụta hypoglycemic, ike nke mkpụrụ ndụ ahụ na insulin na-abawanye, mmepụta nke homonụ na-abawanye. Ihe dị n’ọrụ na-eweghachi ọrụ mmalite nke agwaetiti nke Langerhans ma na-ebelata oge site n’oge iri nri ruo n’ime izochi insulin.
Glimecomb na - akwalite ịbelata oke mgbe ị na - agbaso nri dị na okirikiri oke ibu.
Na mgbakwunye na isonye na metabolism nke carbohydrate, ọgwụ ahụ na-eme ka microcirculation capillary mara mma, belata nchịkọta platelet, si otú a na-egbochi mmepe nke thrombosis vaskụla. Na nloghachi iwere Glimecomb, a na - ahụkarị oke nke vaskụla olu, a na - akwụsị microthrombosis na atherosclerosis, a na - eweghachite parietal fibrinolysis eke. Ọgwụ bụ ihe mbuso agha nke ịba ụba vaskụla na adrenaline na microangiopathies. Ọ na - akwalite ibu ibu ka ọ na --ebi nri n’agba ya oke.
Metformin hydrochloride bụ ìgwè biguanide. Akụrụngwa na-arụ ọrụ na-ebelata ịba ụba plasma nke shuga site na ibelata gluconeogenesis na hepatocytes ma belata ogo glucose na obere eriri afọ. Na kemịkal na-ekere òkè na metabolism nke lipid, belata ogo ogo lipoproteins dị ala, triglycerides na cholesterol n'ime ọbara. Ọ na - enyere aka ibelata ibu n’arụ, mana n’enweghi insulin n’ime ọbara, a naghị enweta ọgwụgwọ ọria ahụ. N'oge ọmụmụ ihe banyere ụlọ ọgwụ, ọ nweghị ihe ndekọ hypoglycemic edekọtara.
Mlọ ọgwụ
| Gliclazide | Metformin |
| Site na nlekọta nchịkwa ọnụ, a na-achọpụta ọnụego mmiri dị elu. Mgbe ị na-eji 40 mg, a na-ekpebi ịba ụba nke ihe dị na plasma mgbe awa 2-3 gachara. Isoro nkwuputa plasma di elu - 85-97%. N'ihi ịmepụta protein protein, a na-ekesa ọgwụ ngwa ngwa n’akwara niile. Ọ na-agbanwe mgbanwe na hepatocytes. Iwepu ọkara ndụ na-eme awa 8-20. Ndị ọrụ na-arụ ọrụ na-etisapụta na mmamịrị site na 70%, yana feces dị 12%. | Ngwa ngwa ngwa site na microvilli n'ime obere eriri afọ site na 48-52%. A ga - eme bioavailability mgbe ewere ya na afọ efu bụ 50-60%. A na-enweta ntinye uche kachasị 1-2 awa mgbe nchịkwa. Njikọ protein na Plasma dị ala. A na-achọpụta cumu ọbara ọbara. Nkeji ọkara bụ 6.2 awa. A na-ewepụ ọgwụ ahụ site na akụrụ n'ụdị mbụ ha na 30% site na eriri afọ. |
A na-eji ọgwụ ahụ agwọ ụdị ọrịa shuga 2.
Ihe ngosi maka ojiji
A na-eji ọgwụ ahụ agwọ ọrịa shuga 2dị nke 2, mgbe arụmọrụ dị ala nke usoro ọgwụgwọ nri, mmega ahụ na usoro ọgwụgwọ ọgwụ na Metformin na Gliclazide.
A na-eji onye na-ahụ maka hypoglycemic eme ihe maka ọgwụgwọ ọgwụ na ọgwụ 2 na ndị ọrịa nwere ọrịa shuga na-enweghị insulin na-achịkwa, ma ọ bụrụ na a na-achịkwa glucose ọbara nke ọma.
Ihe ngbanwe
Achọghị ọgwụ a maka iji ya mee ihe ndị a:
- ụdị 1 ọrịa shuga mellitus;
- lactic acidosis;
- ọkwa plasma dị ala;
- akpịrị na-arịa ọrịa shuga, precoma;
- ọrịa mamịrị ketoacidosis;
- usoro egwu nke akụrụ na akụrụ na ọrịa na - akpaghasị ọrụ nke akụkụ ahụ (akpịrị ịkpọ nkụ, usoro na - efe efe na usoro mkpali, ujo);
- porphyria;
- na-ewere miconazole;
- arụ ọrụ imeju na-ezighi ezi;
- ụkpa obi, ụnwụ oxygen, ọdịda iku ume, infarction myocardial;
- ịxụbiga mmanya na-egbu egbu, iwepụ ihe mgbaàmà;
- ọnọdụ nke usoro ọgwụgwọ insulin dị mkpa (mmerụ ahụ mgbe ọ gasịrị, oge ịhazigharị mgbe ịwa ahụ gachara, ọkụ);
- ihe na-erughị awa 48 na n'ime ụbọchị 2 mgbe a na-ese foto iji ihe dị iche iche nwere ayodiin;
- nri nwere obere kalori na mgbe ewere ya erughị 1000 kcal kwa ụbọchị;
- hypersensitivity nke ahụ onye ọrịa na akụkụ ọgwụ ahụ.
Na mgbakwunye, a naghị atụ aro ọgwụ ahụ maka ndị agadi na-arụ ọrụ na ọnọdụ nke mgbatị anụ ahụ siri ike, n'ihi mmepe mmepe nke lactic acidosis.
A ga-akpachara anya wee nwee ahụ ọkụ, nsị adrenal gland, arụ ọrụ na-ekwesịghị ekwesị nke ọgbụgba ahụ, gland thyroid.
Otu esi ewere glimecomb
Emere ọgwụ a maka nchịkwa ọnụ n'oge nri ma ọ bụ ozugbo nri. Ọ bụ dibia a na-anabatabegoro usoro usoro ọgwụgwọ yana oge ọgwụgwọ ọ ga-adị, na-esetịpụ usoro ọgwụgwọ nke otu onye dabere n'ọbara nke ọbara.
Na-arịa ọrịa shuga
Otu usoro onodu ogwu nke izizi bu 540 mg nke mbadamba ime ihe nlere anya kwa ubochi rue oge 1-3. N'ọnọdụ ka ukwuu, a na-a theụ ọgwụ ahụ ugboro abụọ n'ụbọchị - n'ụtụtụ na tupu ụra. A na - ahọrọ ubochi ubochi rue nwa oge rue mgbe ikwado ugwo nke usoro a
Nsonaazụ nke glimecomb
Mmeghachi omume na-egbu ahụ n'ahụ onye ọrịa na-etolite na nchịkwa na-adịghị mma nke ọgwụ ma ọ bụ megide nzụlite nke ọrịa nke abụọ.
Emere ọgwụ a maka nchịkwa ọnụ n'oge nri ma ọ bụ ozugbo nri.
Ọkpụkpụ afọ
Nsonaazụ sistem nke digestive
- dyspepsia, nsogbu nke mgbaze;
- mmetụta nke ịdị arọ nke afọ;
- ọgbụgba, vomiting;
- ihe mgbu epigastric;
- na uto nke ire nchara n’elu mgbọrọgwụ nke ire;
- nri riri.
N'ọnọdụ ndị a na-adịghị ahụkebe, ọrụ nke hepatocytic aminotransferases, alkaline phosphatase na-eme ka ọ dịkwuo mma. Ikekwe mmepe nke hyperbilirubinemia ruo ihe mere nke cholestatic jaundice, na-achọ ịkwụsị ọgwụ.
Ahụhụ Hematopoietic
Ọgwụ nwere ike ibute ọrụ nke ụmị ọbara ọbara, n'ihi nke ọnụ ọgụgụ ọbara nwere akpụ na-agbada, agranulocytosis, ọbara ọgbụgba na-amalite.
Sistemụ akwara Central
Eleghi anya mbelata ihe achoro ihu, isi ọwụwa.
Site na usoro akwara obi
Arrhythmia, uche nke ọbara na-agbapụta.
Usoro endocrine
Ọ bụrụ na emebiela usoro dosing ma ọ bụrụ na esoghị nri ahụ, ihe ize ndụ nke hypoglycemia na-abawanye, nke a na-esonyere na adịghị ike dị ukwuu, nsogbu mgbanwe akwara nke nwa oge, ịsụsọ dị elu, ọnwụ nke mmetụta uche, ọgba aghara na nhazi.
Site n'akụkụ nke metabolism
Na-emegide nzụlite nke ọrịa metabolic, lactic acidosis nwere ike ịpụta. Ejiri usoro ihe ọmụmụ oge adịghị ike, nnukwu ihe mgbu na akwara, ọdịda iku ume, mgbu n'ime afọ, mbelata okpomọkụ na mbelata ọbara mgbali, na bradycardia.
Ahụhụ
A na-egosipụta mmeghachi omume anaphylactoid n'ụdị usoro ọgwụ sulfonylurea n'ụdị vasculitis nfụkasị, urticaria, macula, ihe ọkụ na pruritus, edema Quincke, ụjọ anaphylactic.
Mmetụta ikike ịchịkwa usoro
N'oge ọgwụgwọ na Glimecomb, a ghaghị ilezi anya mgbe ị na-anya ụgbọala, na-arụ ọrụ site na usoro mgbagwoju anya na ọrụ ndị ọzọ chọrọ ịta ahụhụ site na onye ọrịa.
Ntụziaka pụrụ iche
Mgbe ị na-a sulfụ ọgwụ sulfonylurea, enwere ihe ize ndụ nke ịmalite hypoglycemia siri ike ma na-adị ogologo oge, nke chọrọ ọgwụgwọ pụrụ iche n'ọnọdụ ọnọdụ yana nchịkwa ọgbụgba nke 5% glucose ngwọta maka ụbọchị 4-5.
Ihe ọghọm nke ibute ọrịa na-abawanye site na nri ezughi ezu, imega ahụ ogologo oge ma ọ bụ ijikwa oge nke ọtụtụ ọgwụ hypoglycemic. Iji belata ohere nke usoro ọgwụgwọ, mmadụ kwesiri ịgbasochi ndụmọdụ nke ntuziaka ahụ anya na ọgwụ ma nweta nkọwa zuru oke mgbe ị na-ahụ maka dibịa bekee.
Imeghari dose chọrọ ka anụ ahụ na mmetụta uche gabiga ókè ma ọ bụ mgbanwe nri.
Jiri na agadi
Ndị dị ihe karịrị afọ 60 ekwesịghị ị theụ ọgwụ ahụ ebe ha na-emega ahụ ike n'ihi oke ụba nke lactic acidosis.
Inye umuaka
A naghị atụ aro ị toụ ọgwụ ahụ ruo afọ 18.
A naghị atụ aro ị toụ ọgwụ ahụ ruo afọ 18.
Jiri n'oge ime na lactation
Mgbe ime dị, a gha edochi nchịkwa Glimecomb site na ọgwụ insulin, n'ihi na usoro ọmụmụ ihe nke ihe ndị na-arụ ọrụ site na mgbochi plasta. Enweghị data na teratogenic mmetụta nke ogige ọrụ abụọ ahụ na-arụ ọrụ.
Enwere ike ịpụpụ Glyclazide na metformin na mmiri ara nne, ya mere, n'oge ọgwụgwọ nke onye na-ahụ maka hypoglycemic, a ga-akagbu ume ọmụmụ.
Ngwa maka ọrụ ezughi oke ọrụ
A na-egbochi ọgwụ a maka arụ ọrụ akụrụ na-arịa ọrịa kansa na-arịa ọrịa mamịrị.
Jiri maka ọrụ imeju na-arụ ọrụ
Amachibidoro ọgwụ a iji arụ ọrụ imeju na-adịghị mma.
Glimecomb overdose
Site n'iji ọgwụ ọjọọ eme ihe, lactic acidosis na ọnọdụ hypoglycemia nwere ike ịmalite. Ọ bụrụ na enwere akara nke lactic acid oxidation nke anụ ahụ, ị ga-akpọrịrị ụgbọ ihe mberede maka onye ahụ metụtara. N'ọnọdụ ọnọdụ, usoro ịba ọcha n'anya dị irè.
Ọ bụrụ na mmụọ amaghị, nnabata ọbara nke 40% dị mkpa iji intramuscularly ma ọ bụ subcutaneously.
N'ọnọdụ nke nsụhọ, ọ dị mkpa ibute ọgbụgba ọbara 40%, glucagon, intramuscularly ma ọ bụ subcutaneously, dị mkpa. Mgbe obi dịchara ya mma, onye ọrịa ahụ chọrọ nri nwere carbohydrate.
Mmekọrịta na ọgwụ ndị ọzọ
Mgbe ị na-a drugsụ ọgwụ ndị ọzọ na Glimecomb, a na-ahụta mmeghachi omume ndị a:
- Ngkwalite mmetụta ọgwụgwọ na njikọ ya na captopril, coumarin anticoagulants, beta-blockers, bromocriptine, antifungal, salicylates, fibrates, MAO inhibitors, ọgwụ tetracycline, ọgwụ mgbochi na-abụghị steroidal na mgbochi ụkwara nta.
- Glucocorticosteroids, barbiturates, ọgwụ antiepileptik, calcium tubule inhibitors, thiazide, diuretics, Terbutaline, Glucagon, Morphine na-eme ka mbelata ihe omume hypoglycemic.
- Cardiac glycosides na-abawanye ohere nke ventricular extrasystole, ebe na-ebelata ụmị ọkpụkpụ, na-amụba ohere nke myelosuppression.
Ọgwụ na-ebelata plasma foro nke Furosemide site na 31% na ọkara ndụ ya na 42%. Nifedipine na-eme ka mmịpụta nke metformin dịkwuo elu.
Ọgwụ na-ebelata plasma foro nke Furosemide site na 31% na ọkara ndụ ya na 42%.
Mmanya ndakọrịta
Amachibidoro ị toụ mmanya n'oge ọgwụgwọ. Ethanol kpalitere ihe ize ndụ nke mmanya oke na mmepe nke lactic acidosis. Ethanol na - eme ka enwere ike ịbawanye hypoglycemia.
Ihe ị ga-eji dochie
Analogues nke ogwu a, yiri ya na ihe mejupụtara kemịkalụ na akụrụngwa ọgwụ, gụnyere:
- Diabefarm;
- Glyformin;
- Gliclazide MV.
Switbugharị na ọgwụ ọzọ ga-ekwe omume na enweghị ọgwụgwọ ọgwụgwọ site na ị Gụ Glimecomb yana n'okpuru nlezianya nke dọkịta na-eleta.
Ahịa ọgwụ na-ahapụ okwu
N'aka ọgwụ ka erere ọgwụ ahụ.
Enwere m ike ịzụta na ndenye ọgwụ
Amachibidoro ire ọgwụ a n'efu n'ihi ihe egwu nke hypoglycemia mgbe ị na-a theụ ọgwụ na-ezighi ezi.
Ọnụ ahịa glimecomb
Ọnụ ego nke mbadamba ihe dị 567 rubles.
Ọnọdụ nchekwa maka ọgwụ
Ekwesịrị ịchekwa ọgwụ a site na ụmụaka, n'ebe akọrọ, gbara ọchịchịrị na oke okpomọkụ agaghị akarị + 25 Celsius.
Bọchị mmebi
Afọ 2
Emeputa
Ugbo mmiri na ebe ogwu “AKRIKHIN”, Russia.
Amachibidoro ire ọgwụ a n'efu n'ihi ihe egwu nke hypoglycemia mgbe ị na-a theụ ọgwụ na-ezighi ezi.
Nyocha banyere Ọrịa mamịrị maka Glimecomb
Arthur Kovalev, 40 afọ, Moscow
Maka ọrịa shuga 2dị nke Abụọ, ana m ewere mbadamba Glimecomb ihe fọrọ nke nta ka ọ bụrụ otu afọ. Iri anụ ahụbebeghị, n'ihi na mgbe ị theụsịrị ọgwụ ịchọrọ iri. Ma mgbe m takeụrụ ọgwụ mgbede tupu m lakpuo ụra, ọnọdụ ahụ ga-adị mma. N'ụtụtụ, shuga dịgasị site na 6 ruo 7.2 mgbe ị takingụ ọgwụ ahụ na nri ụtụtụ.
Kirill Gordeev, onye gbara afọ 29, Kazan
Ọgwụ a na-ebelata shuga dị n’ọbara. Ana m anabata ọnwa asatọ. Etinyekwa m ọgwụ insulin. Mgbe nkwụsịtụ butere homonụ ahụ, ana m a Iụ ọgwụ nwa oge, mana ha gosipụtara oke arụmọrụ. Sugar nọgidere n'otu ọkwa ahụ, n'agbanyeghị ọrụ imeju na-arụ ọrụ n'ọnọdụ m.
Ndi dibia nyocha
Marina Shevchuk, endocrinologist, 56 afọ, Astrakhan
Ọgwụ megide nzụlite nke ụdị ọrịa shuga 2 na-akwụ ụgwọ ọrịa glycemia nke ọma. Ntọhapụ a gbanwere nwere ike belata ihe egwu nke ọrịa hypoglycemic syndrome, ya mere ndị ọrịa agadi na ndị mmadụ na-arịa ọrịa nke usoro obi nwere ike were ọgwụ a. M na-eji ọgwụ ahụ eme ihe mgbe niile na usoro m na-adakarị na nhọrọ nke otu. Ọnụahịa dị ala na arụmọrụ dị elu.
Evgenia Shishkina, endocrinologist, 45 afọ, St. Petersburg
Ọgwụ nwere mmetụta dị nfe ma dịkwa irè. Ọ na - enyere aka belata shuga ọbara. N'oge ọgwụgwọ, ọ dị mkpa ịgbaso nri, mana rie nri mgbe niile, yana ịmega ahụ. Achọpụtaghị nsonaazụ yana ịgbasochi usoro usoro usoro onunu ogwu anya. Ihe omume nke ogwu na-amalite n'ime obere oge. Ogwu ahu eguzobewo onwe ya n’ahịa maka oria shuga.
