Ejiri Noliprel 0.625 mee ka mbelata ọbara mgbali elu. Ọgwụ a bụ otu nke ngwaahịa a jikọtara ọnụ ma nwee ọtụtụ ihe eji arụ ọrụ. N'ihi usoro dị iche iche nke ihe ndị a si arụpụta ihe dị mma na –enweta ngwa ngwa.
International Nonproprietary Aha
Perindopril + ebepamide.
ATX
C09BA04.
Ha weputara udi ya na ihe mebere ya
A na-emepụta ọgwụ ahụ na mbadamba mbadamba. Nchikota ihe eji aru oru abuo n’egosiputa ihe oma:
- perindopril erbumin 2 mg;
- ebepamide 0.625 mg.
Ọgwụ dị na ngwugwu nwere mbadamba 14 ma ọ bụ iri atọ.
Ejiri Noliprel 0.625 mee ka mbelata ọbara mgbali elu.
Omume ọgwụ
Ọgwụ a bụ ndị otu nke ndị na - egbochi ACE, mana ha nwekwara ọnya mmụọ, nke na - enye aka iwepụ ihe mgbaàmà nke ọbara mgbali elu. N'ihi njikọta, ngwa ndị nọ n'ọrụ na-eme ka ibe ha na-eme. Mkpụrụ ahụ perindopril na-egbochi ọrụ nke enzyme so na usoro mgbanwe nke angiotensin I n'ime angiotensin II. N'ihi ya, ihe a bụ ihe na - egbochi mgbochi enzyme ma ọ bụ ACE.
Ejiri Angiotensin II mara ikike belata lumen nke arịa ọbara. N'ihi nke a, nrụgide ahụ na-abawanye. Ọ bụrụ na ntụgharị nke usoro angiotensins ji nwayọ nwayọ, na-eji nwayọ na-ekesa ọbara, a na-eweghachi usoro vaskụla. Na mgbakwunye, enzyme angiotensin na-agbanwekwa bụ maka mbibi nke bradykinin, onye ọrụ ya bụ iwelie lumen nke akwara na akwara.
Nke a pụtara na nsonaazụ na ọrụ ACE na-enye aka na mweghachi nke usoro obi. Na mgbakwunye, enwere ike ịchọta ụzọ ndị ọzọ nke perindopril:
- na-emetụta cortex adrenal, ebe ike nke mmepụta nke isi hormone mineralocorticosteroid, aldosterone, na-ebelata;
- o nwere mmetụta na-apụtaghị ìhè na enzyme nke usoro renin-angiotensin, nke na-enye aka n'ịhazi ọbara mgbali elu, yana ọgwụgwọ Noliprel, ọrụ renin na plasma ọbara na-abawanye;
- na-ebelata nguzogide vaskụla, nke a rụpụtara n’arụ ahụ n’ime akwara dị nwayọ na akụrụ.
N'ihi ihe ndị na-arụ ọrụ, Noliprel na-ebelata nrụgide n'ụzọ dị mma ma na-eme ka ọrụ CVS rụọ ọrụ.
N'oge nchịkwa nke Noliprel, anaghị ahụ mmepe nke ngosipụta na-adịghị mma, ọkachasị, nnu anaghị adị n’ime ahụ, nke pụtara na a ga-ewepu mmiri mmiri ngwa ngwa. Na mgbakwunye, mmetụta nke perindopril adịghị akpalite mmepe nke tachycardia. Site na ngwa a, a na-eweghachi ọrụ myocardial. Nke a bụ n'ihi na ebubata ọbara nke akwara n'usorowanye ịbawanye ụba nke mgbidi arịa arịa ọbara. Agbanyeghị, enwere mmụba na mmepụta nke obi.
Akụkụ ọzọ na-arụ ọrụ (ebepamide) bụ otu ihe na ngwongwo na thiazide diuretics. N'okpuru mmetụta ya, ọnụego excretion nke ion kalịnda na-ebelata. N'otu oge, usoro nke iwepụ potassium na magnesium ion si n'ahụ gị na-abawanye. Agbanyeghị, uric acid na-apụ. N'okpuru mmetụta nke ebepamide, a na - akpaghasị usoro nke reabsorption nke sodium ion. N’ihi nke a, itinye uche ha na-ebelata. Agbakwunyere na ewepu chlorine agbatị.
Usoro ndị a na-eso akpata mmụba nke mmamịrị. N'otu oge ahụ, a na-ewepụ mmiri mmiri nke ukwuu, ọbara ọgbụgba na-ebelata. Enwere ike iwepụta indapamide na obere ọnụọgụ, mana ọbụlagodi na nke a enwere mbelata ọbara mgbali, Otú ọ dị, ụdị ọgwụ dị otú a adịghị enye aka na ngosipụta nke mmegharị diuretic.
Site na ọgwụgwọ Noliprel, mmetụta dị mma na-adịgide ruo awa 24 na-esote. Agbanyeghị, enwere ọganihu na ọnọdụ ahụike nke onye ọrịa niile nwere ọrịa mgbali elu ka izu ole na ole gachara. Uru nke Noliprel bụ enweghị ihe ịrịba ama nke iwepụ na njedebe ọgwụgwọ.
Achọpụtala na njikọta ebepamide na perindopril na-enye nsonaazụ ka mma (mbelata ọbara mgbali elu ngwa ngwa karịa nke ọma) karịa mgbe ị na-eji ihe ọ bụla iche. Noliprel anaghị emetụta ọdịnaya nwere ume. Na mgbakwunye, ọgwụ a na-ekwu okwu dị irè maka ọbara mgbali elu ọ bụla. Emere nke a ka ukwuu site na ọnụnọ nke perindopril na ihe mejupụtara.
Mlọ ọgwụ
Site na ngwakọta nke ihe 2 na-arụ ọrụ, ọgwụ ọgwụ ha anaghị agbanwe agbanwe. Ya mere, a na-etinye perindopril ngwa ngwa. Mgbe oge 60 gasịchara, ọnụ ọgụgụ ọrụ nke ihe a na-eru, ebe ọ bụ na ọkwa ịta ahụ na-eru na njedebe dị elu. Perindopril bụ metabolized. Agbanyeghị, naanị otu kọmpụta na - arụ ọrụ yana akụkụ mejupụtara ọgwụ ahụ.
N'oge nri, nnabata nke perindopril na-akwụsịlata. Akụrụ na-ahụ maka ọpụpụ ya. N'ihe banyere ọghọm nke akụkụ a, a na-ejide akụkụ ahụ na-arụ ọrụ n'ime ahụ, nke na-eduga n'ịba ụba na ntinye ya.
Indapamide bụ otu na Njirimara pharmacookinetic na perindopril. Ọ na-etinye obi gị dum ngwa ngwa. Mgbe nkeji 60 gachara, ịta kacha nke ihe a ruru. Ọkara ndụ nke indapamide dịgasị site na 14 ruo awa 24. Maka ntụle, a na-ewepu perindopril n'ahụ mmadụ n'ime awa iri na asaa, mana erutela ọnọdụ ahụ erughi tupu ụbọchị anọ gachara.
Ọ bụrụ na arụ ọrụ ezumike ezumike, ihe na-arụ ọrụ na-agbakọ ahụ.
Ihe ngosi maka ojiji
Ọbara mgbali ike.
Ihe ngbanwe
Mmachibido na nhọpụta nke Noliprel:
- Anabataghị ụdị okike nke ihe ọ bụla na ihe mejupụtara ahụ, mana ọtụtụ mgbe, a na-egosipụta mmeghachi omume na-adịghị mma maka ihe ndị na-arụ ọrụ, na mgbakwunye, a dịghị eji ọgwụ ahụ eme ihe maka hypersensitivity na ọgwụ ndị ọzọ nke otu sulfonamide (diuretics), ACE inhibitors;
- ọrịa obi na-adịghị ala ala n'oge mgbụsị akwụkwọ;
- udiri ịria ure;
- hypokalemia;
- ụkọ lactase, ọrịa glucose-galactose malabsorption syndrome, galactosemia.
Etu esi ewere Noliprel 0.625?
Iji zere nsogbu ma gbochie nsonaazụ, yana iji rụpụta nsonaazụ kacha mma na obere oge dị mkpirikpi, a na-enye ọgwụ ahụ n'ụtụtụ. A na-atụ aro ị takeụ ọgwụ ahụ na afọ efu. Usoro akwadoro bụ 1 mbadamba kwa ụbọchị. Usoro ọgwụgwọ ya na mbido mbụ ya dị ọnwa 1.
Ọ bụrụ na na njedebe nke oge a nsonaazụ dị mma (mbelata nrụgide), a na-enyocha usoro nke ngwaahịa ahụ. N'okwu a, enwere ike inye ọgwụ Noliprel Forte nwere ọtụtụ ihe eji arụ ọrụ nke bụ okpukpu abụọ nke ọgwụ Noliprel.
Kedụ ka esi agwọ ụdị shuga dị afọ 2?
Ọnọdụ bụ isi maka ọgwụgwọ nke ndị ọrịa n’otu a bụ iwelata obere opekempe n’izu mbụ. Yabụ, ị nwere ike ibido mbadamba ọgwụ nke 1 Noliprel. Nke nta nke nta, ọ bụrụ na ọ dị mkpa, ị doseụ ọgwụ ahụ na-abawanye. Agbanyeghị, na nke a, a na-enyocha ihe ndị bụ isi na-egosi ọbara, imeju na akụrụ mgbe niile iji zere nsogbu.
Nsonaazụ Noliprel 0.625
Mmepe na akwara nke ọhụụ, ntị, enweghi ike, hyperhidrosis. N'akụkụ nke usoro akwara obi, a na-egosipụta angina pectoris, nke a na-ahụkarị: infarction myocardial, mbelata ọbara mgbali elu.
Ọkpụkpụ afọ
Vomiting, ọgbụgbọ, ọnya afọ, mgbanwe uto, nsogbu na iwepụ nri, agụụ na-apụ n'anya, nri anaghị agbari, afọ ọsịsa. Mgbe ụfọdụ ọzịza na-amalite (ọnya na eriri afọ). Ọ na-abụkarịkarị onye na-ahụkarị ọrịa ogbu egbu bụ Noliprel.
Ahụhụ Hematopoietic
Ngwakọta ahụ, ma n'otu oge ahụ, akụrụngwa nke ọbara na-agbanwe. Dịka ọmụmaatụ, anaemia, thrombocytopenia, wdg nwere ike ịmalite.
Sistemụ akwara Central
Onye ọrịa ahụ na-agbanwe ọnọdụ obi. Enwere nsogbu na ụra, ọgbụgbọ, isi ọwụwa, uche na-ama jijiji. Naa ihe a na-ahụkarị bụ mgbanwe dị na mmụọ.
Site na usoro urinary
Nnukwu akwara gbasara akwara.
Site na sistem iku ume
Nkpirisi ume, bronchospasm, ụkwara (ọkachasị akpọnwụọ), rhinitis, eosinophilic pneumonia.
Ahụhụ
Vasculitis, tinyere ọbara ọgbụgba, urticaria, ede ede Quincke.
Mmetụta ikike ịchịkwa usoro
Ekwesịrị ịkpachara anya mgbe ị na-anya ụgbọ ala n'oge Noliprel. Mkpa a bụ n'ihi n'eziokwu na na n'okpuru ike nke ihe ndị na-arụ ọrụ, nsogbu ndị a na-ahụ anya nwere ike ịmalite. N'iburu na mmeghachi omume adịghị mma nke ọgwụ a na-atụle, o nwere ike ime ụdị ọrụ ọ bụla chọrọ nlebara anya.
Ekwesịrị ịkpachara anya mgbe ị na-anya ụgbọ ala n'oge Noliprel.
Ntụziaka pụrụ iche
Ọnọdụ ọrịa a dịka idiosyncrasy adịkarịghị etolite.
N'ọnọdụ ụfọdụ, edeghị ọgwụ ahụ ma ọ bụrụ na ọdịda akụrụ bụ n'ihi mmepe nke akwara gbasara akwara stenosis. Ọrịa nke akụkụ a na - abụkarị megide ọrịa obi. Emere nke a site n'ihe gbasara akụrụngwa dị adị.
Site na hypotension akwara, ọ dịghị mkpa ịkwụsị ị takingụ ọgwụ. N'okwu a, nrụgide na-ahazi site na iwebata usoro nke sodium chloride.
Achọrọ ka ịlele ọkwa potassium na plasma mgbe niile.
Ohere inweta etolite neutropenia na-abawanye na ndị ọrịa nwere ọrịa ndị ọzọ, dịka ọmụmaatụ, na arụ ọrụ ezumike ezughi ezu, cirrhosis.
Iwere Noliprel iji ọgwụ akpachapụ anya (ọgwụ nje) na -eme ka ihe oke ụjọ ghara ịba uru.
Na-emegide usoro mgbatị azụ izugbe, mbelata dị ukwuu nwere ike ime ma ọ bụrụ na onye ọrịa ahụ jụrụ ọgwụ ahụ.
Jiri n'oge ime na lactation
Edeghị ọgwụ a. Nke a bụ n'ihi n'eziokwu na mgbe ị na-a breastụ ara, tinyere mmiri ara nne, ihe ndị dị ime na-abanye ahụ mmadụ. Na mgbakwunye, n’oge ime, o yikarịrị ka nwa ebu n’afọ ga-etolite ọrịa.
Jiri na agadi
Usoro mkpochapu ihe ndi eji aru oru eji nwayọ. Enwere ike ịchọ mkpoghachi usoro onunu ogwu.
Nhọpụta nke ụmụ Noliprel 0.625
Ejighị ya n'okpuru afọ 18.
Ngwa maka ọrụ ezughi oke ọrụ
N ’ndabere maka nnukwu mbibi a na - emerụ Noliprel. Ọnọdụ anwụrụ weaker abụghị ihe mere eji ewepu ọgwụ. N'okwu a, ọ dịghị mkpa ịmepụtaghachi ọgwụ ahụ.
Jiri maka ọrụ imeju na-arụ ọrụ
Na ọnọdụ ọgbụgba dị ala na-agafeghị oke, enwere ike iji ọgwụ ahụ. A naghị emepụtagharị ego ole a gụrụ iji gwọọ ya. Na-emegide ezughi oke ọrụ ọrụ imeju, a naghị eji ọgwụ a na-ekwu okwu eme ihe.
Site n ’ịdoụbiga mmanya ókè, mgbanwe nke hypotension na-egosi: iro ụra, ure, wdg.
Nchọgharị nke Noliprel 0.625
Isi ihe kpatara ya bụ hypotension. Na-emegide usoro nrụgide dị ala, ihe mgbaàmà ndị a na-apụta: nkwarụ, ọgbụgbọ, ọgbụgbọ, iro ụra, ọgbụgbọ. Ikekwe, imebi nsụhọ, mgbanwe nke sodium na potassium n’ime ahụ: belata, mụbaa.
Iji kpochapụ ihe ngosi ndị na-adịghị mma, ị kwesịrị ịsacha afọ ahụ, n'ihi nke a, a na-ewepụ oke ọgwụ ahụ n'ahụ. Agbanyeghị, nha a ga-enye nsonaazụ achọrọ naanị ma ọ bụrụ na anabatara Noliprel n'oge na-adịbeghị anya. Na mgbakwunye, a na-ede ọgwụ sorbent, a na-eme ọgwụgwọ mmezi iji weghachite nguzo mmiri-electrolyte.
Mmekọrịta na ọgwụ ndị ọzọ
Jiri nlezianya
Achọrọ nlebara anya kachasị mkpa maka ọnọdụ ahụ mgbe ị na-a Nụ Noliprel na ọgwụ ndị dị otú a:
- Baclofen;
- NSAIDs;
- antidepressants na ọgwụ mgbochi;
- GCS;
- ọgwụ ndị ọzọ nke ihe ha mere bụ iweda ọbara mgbali elu;
- ọgwụ hypoglycemic;
- Allopurinol;
- ihe ndi ozo;
- Metformin;
- nnu nnu;
- Cyclosporin;
- iodine nwere ihe ndi eji eme ya bu ihe eji eme ihe di iche.
A naghị aolụ Noliprel n’otu oge n’arụ mmanya nwere mmanya.
Agaghị atụ aro maka ịgwakọta ọnụ
A naghị eji Noliprel eme ihe n'otu oge na nkwadebe nwere lithium. Edekwala ogwu nke na-akpalite mmepe nke arrhythmias, hypokalemia, cardiac glycosides.
Mmanya ndakọrịta
A dịghị aolụ Noliprel n'otu oge na mmanya nwere mmanya, ebe ọ bụ na n'ọnọdụ nke a, ihe ize ndụ nke hypotension na-ebilite, ibu na imeju na-abawanye.
Analogs
Ndị nọ n'ọnọdụ Noliprel:
- Perindopril gbakwunyere ebepamide;
- Noliprel A;
- Indapamide / Perindopril-Teva;
- Ko-perineva.
Ahịa ọgwụ na-ahapụ okwu
Ọgwụ ndenye ọgwụ.
Enwere m ike ịzụta na ndenye ọgwụ?
Ee e.
Noliprel 0.625
Nkezi ọnụ bụ 600-700 rubles.
Ọnọdụ nchekwa maka ọgwụ
Enweghị ntuziaka akọwapụtara maka ịchekwa Noliprel. Agbanyeghị, a ga-eji mbadamba nkume mee ihe n'ime ọnwa 2 ka ikwesiri ikwesi ntụkwasị obi nke akpa.
Bọchị mmebi
Ọgwụ ahụ na-ejigide Njirimara maka afọ 3.
Emeputa
Servier, onye France.
Nyocha na Noliprel 0.625
Ndi Okacha Cardio
Zhikhareva O. A., Samara
Ọgwụ dị irè. Ọzọkwa, a na-ahụ mgbanwe dị mma na ndị ọrịa n'oge mbụ ọbara mgbali elu, yana n'ụdị ndị siri ike karị. M na-atụle ọghọm ogologo oge nke ịme ihe, mana ọ bụrụ na ọ dị mkpa, ị nwere ike ịbawanye ọgwụ a, mana nke a bụ nsogbu na nsogbu.
Zafiraki V.K., Tula
Ọgwụ na-enyere aka ịbawanye ọnọdụ onye ọrịa na oke ọbara ọgbụgba, na mgbakwunye na-egbochi mmepe nke ọrịa obi. Ọnụahịa ahụ bụ nkezi, ngwugwu nwere ọnụ ọgụgụ mbadamba kwekọrọ na usoro ọgwụgwọ kwa ọnwa, nke dabara adaba ma nye gị ohere ịchekwa ego.
Ndị ọrịa
Veronica, gbara afọ 49, Penza
Ejiri m Noliprel ogologo oge (na-akwụsị oge), n'ihi na mgbali m na-ewelikarị, na mgbe akara nke iwe na-apụ n'anya, ọbara mgbali m ka nọ n'ogo nke oke nke kwesịrị. Dịka m natara, achọpụtara m na ụkwara pụtara megidere nzụlite nke enweghị mgbaàmà ndị ọzọ nke oyi. Mgbe nyocha ahụ gasịrị, ọ tụgharịrị na nke a bụ otu ọgwụ ahụ si arụ ọrụ, aghaghị m ịkwụsị ị itụ ya ma chọta onye nnọchi maka ya.
Eugenia, afọ 29, Vladimir
Noliprel bụ nne ya. Ọ nwara ọgwụ dị iche iche, mana oge niile enwere nsogbu, ọkachasị, mmeghachi omume na-adịghị mma nke anụ ahụ. Mgbe iwere Noliprel, ọnọdụ ahụ jiri nwayọ nwayọ, nrụgide anaghị abawanye. Ọzọkwa, ọgwụ a anaghị asacha calcium, nke dị mkpa na ịka nká.
