Gentadueto bụ otu n’ime ọgwụ ndị a na-eji agwọ ndị ọrịa shuga. Ọ nwere mmetụta hypoglycemic na-adịgide adịgide ma na-enye gị ohere ịnọgide na-enwe ọkwa glucose nkịtị ruo ogologo oge.
International Nonproprietary Aha
INN: Linagliptin + Metformil
Gentadueto bụ otu n’ime ọgwụ ndị a na-eji agwọ ndị ọrịa shuga.
ATX
A10BD11
Ha weputara udi ya na ihe mebere ya
Ọgwụ dị n'ụdị mbadamba ihe mkpuchi-fim. Ihe bụ isi na-arụ ọrụ: linagliptin 2.5 mg na metformin hydrochloride na usoro nke 500, 850 ma ọ bụ 1000 mg. A na-ewebata ihe ndi ozo: arginine, stachi ọka, copovidone, silicon dioxide, magnesium stearate. A na-eme ka mkpụkọ ihe nkiri ahụ site na titanium dioxide, odo na odo na-acha ọbara ọbara nke iron, propylene glycol, hypromellose, talc.
Mbadamba 2.5 + 500 mg: biconvex, oval, nke nwere ihe nkiri na-acha odo odo. N'aka nke aka, enwere ihe osise nke onye rụpụtara ya, n’aka nke ọzọ enwere ihe odide "D2 / 500".
Mbadamba pensụl 2,5 + 850 bụ otu, naanị agba nke uwe ihe nkiri ahụ bụ oroma dị mma, na mbadamba 2.5 + 1000 mg nwere agba nke shei light pink.
Omume ọgwụ
Linagliptin bụ onye na - egbochi enzyme DPP-4. Ọ na - egbochi incretins na polypeptide insulinotropic na-adabere glucose. Ndi incretins na-etinye aka na ịnọgide na-enwe ọkwa glucose ọbara dị nkịtị. Akụkụ nọ n'ọrụ na-ejikọ enzymes ma na-eme ka ịta ụba nke incretins. Ihe nzuzo insulin na-asọpụrụ glucose na-abawanye, ma na - eme ka glucagon na - agbada, nke na-ahụkarị uru glucose bara.
Metformin bụ biguanide. Ọ nwere mmetụta hypoglycemic na-adịgide adịgide. Plasma glucose na-ebelata. N'okwu a, a naghị akpali imepụta insulin, ya mere hypoglycemia na-etolite naanị n'ụdị na-adịghị ahụkebe. A na-ebelata glucose njikọta n'ihi mgbochi nke glycogenesis na gluconeogenesis. N'ihi mmụba insulin na-abawanye nke ndị na-anabata ya, a na-eme ka glucose dị mma site na mkpụrụ ndụ na-apụta.
Metformin na-akpali njikọ nke glycogen n’ime mkpụrụ ndụ.
Metformin na-akpali njikọ nke glycogen n’ime mkpụrụ ndụ. Ọ nwere ezigbo mmetụta na metabolism lipid. Na-ebelata ịta nke cholesterol na triglycerides n'ime ọbara. Ojiji nke linagliptin ya na uzo ihe sulfonylurea na metformin belata HbA1c (site na 0.62% ma e jiri ya tụnyere placebo; mbu HbA1c bu 8.14%).
Mlọ ọgwụ
A na-abanye ngwa ngwa ngwa ngwa diges. A na-ekesasị akụkụ ahụ na - ekwekọghị. Bioavailability na ikike ijikọ ihe ndị nwere protein dị obere. Cchụ ego na-apụta mgbe mmụba nke akụrụngwa na-agbanweghi agbanwe.
Ihe ngosi maka ojiji
Ngosiputa nke uzo iji ogwu a bu:
- ịgwọ ụdị ọrịa shuga abụọ nke ọrịa mellitus na ndị ọrịa enweghị njikwa glycemic zuru oke na oke nke metformin;
- nchikota ya na ogwu ndi ozo na insulin n’ime ndi okenye nwere oria oria shuga, ma oburu n’eji metformin na ogwu ndia eweputaghi nchịkwa glycemic zuru ezu;
- usoro ọgwụgwọ nke ndị mmadụ na - ewere metformin na linagliptin na mbụ.
Ihe ngosiputa maka ojiji nke ogwu a bu ọgwụgwọ nke oria oria nke abuo n’anuche ndi mmadu n’enweghi ikike igha oke na oke metformin.
A na-eji ya dị ka mgbakwunye nri na mmega ahụ iji meziwanye njikwa glycemic n'ime ndị nwere ụdị ọrịa 2.
Ihe ngbanwe
Amachibidoro ị toụ ọgwụ ahụ n'ọnọdụ ndị a:
- ụdị 1 ọrịa shuga mellitus;
- hypersensitivity na otu onye;
- ọrịa mamịrị ketoacidosis;
- lactic acidosis;
- Ọnọdụ nke shuga;
- okpu gbasara akwara;
- ọrịa na-akpalite hypoxia anụ ahụ: mkpochapụ akwara obi, ọdịda dị mkpụmkpụ, nkụchi obi na nso nso;
- afọ imeju;
- ịxụbiga mmanya ókè.
Jiri nlezianya
Ekwesịrị ilebara anya na ndị ọrịa gafere afọ 80.
Etu esi ewere Gentadueto?
Emere ogwu a maka nchịkwa ọnụ. Iji belata ọdịdị nke nsonaazụ na-achọghị, a na-atụ aro mbadamba iji nri.
Ọrịa mamịrị
Ọgwụ kwa ụbọchị bụ 2.5 mg + 500 mg, 2.5 mg + 850 mg ma ọ bụ 2.5 mg + 1000 mg. Na-a tabletsụ mbadamba ugboro abụọ kwa ụbọchị. A hotara dose ahụ na-eburu n'uche ogo mgbaàmà nke ọrịa ahụ na ohere nke onye ahụ na-arụ ọrụ na ahụ. Usoro kachasị elu kwa ụbọchị ekwesịghị ịdị elu karịa 5 mg + 2000 mg.
Akụkụ Mmetụta Gentadueto
Ọtụtụ mgbe, n'iji ojiji mejupụtara metformin yana linagliptin, afọ ọsịsa na-eme. Mgbe ị na-ewere linagliptin na metformin yana njikọ nke usoro sulfonylurea, hypoglycemia na-apụtakarị. Ọ na - etolitekwa mgbe ị na - ewere linagliptin, metformin na insulin.
Ihe mgbaàmà nke mgbaàmà ọjọọ:
- nasopharyngitis;
- ụkwara ụkwara;
- agụụ riri;
- afọ ọsịsa
- ọgbụgbọ
- akpụkpọ anụ akpụkpọ ụkwụ ya tinyere itching;
- ụba lipase ọbara;
- hypoglycemia;
- afọ ntachi
- arụ ọrụ nke imeju;
- lactic acidosis;
- ntaramahụhụ;
- mgbu afọ.
Mmetụta ikike ịchịkwa usoro
Ọ bụghị emetụta.
Ntụziaka pụrụ iche
Dika ihe omumu si di, oburu na ijiko ogwu a na udiri sulfonylurea, uto hypoglycemic na-eme ngwa ngwa karie ihe nzaghachi placebo. Ọgwụ n’onwe ya na-akpata ọrịa hypoglycemia. Ọ bụrụ na -ejighị ya nke ọma, lactic acidosis nwere ike ime, nke na-etinye ndụ mmadụ n'ihe egwu.
Ugboro azụ nke metformin na ị intoụbiga mmanya oke nwere ike iduga mmepe nke lactic acidosis, ọkachasị na agụụ agụụ ogologo oge, erighị nri na-edozi ahụ, ma ọ bụ ọdịda imeju.
Jiri na agadi
A nabatara ọgwụ ahụ maka ịkọtara ndị mmadụ site na afọ 65. Ma n'otu oge ahụ, ịkwesịrị nyochaa ọrụ akụrụ mgbe niile, n'ihi na okenye, ihe egwu dị na imepe nsogbu gbasara akụrụụụ dị elu, nke ejiri ọgwụ metformin na - egbochi ihe ọ bụla.
Inye umuaka
Ejighị ọgwụ ahụ mee ihe gbasara ụmụaka.
Jiri n'oge ime na lactation
Cannweghị ike ị pụ ọgwụ n’oge mmeme ahụ. Iji zere ihe ize ndụ nke intrauterine ebu n'afọ, ị kwesịrị ịgbanwee insulin ngwa ngwa o kwere mee.
Enweghị nnyocha zuru ezu banyere otu ngwa ngwa dị ike si abanye na mmiri ara ara, mana enwere ihe ize ndụ maka nwa amụrụ ọhụrụ. Yabụ, maka oge ọgwụgwọ dị otú a, ọ ka mma ịhapụ inye ara.
Ngwa maka ọrụ ezughi oke ọrụ
Site na njikwa elu creatinine dị elu, a machibidoro ọgwụ ahụ. Nke a metụtakwara nnukwu akwara afọ n’ala na usoro na-adịghị ala ala.
Jiri maka ọrụ imeju na-arụ ọrụ
N'oge ezughi oke, anaghị anabata ọgwụ ahụ, n'ihi mgbe ị na-a theụ ọgwụ ahụ site na sistemụ ịba ọcha n'anya, ịba ọcha n'anya na dysfunctions imeju ga-ekwe omume.
Gentadueto overdose
Enweghị data na oke oke. N'ime ule nke ụlọ ọgwụ, a chọpụtaghị ị linụ ọgwụ mgbochi agbatị. N'iji otu ụdị metformin, a hụghị hypoglycemia, mana enwere ikpe nke lactic acidosis. Lactic acidosis bu ọnọdụ di mgbagwoju anya nke choro igba ulo ogwu. Metformin buputara site na hemodialysis.
Mmekọrịta na ọgwụ ndị ọzọ
Nchịkwa ugboro ugboro nke ọgwụ ma ọ bụ akụrụngwa ya na-arụ ọrụ dị iche iche anaghị agbanwe ọgwụ ọgwụ. You nwere ike iji ọgwụ ahụ wee mee ihe yana Glibenclamide, Warfarin, Digoxin na ụfọdụ ọgwụ mgbochi mgbochi nke mgbochi.
Ngwakọta ndị amachibidoro
Nweghị ike iji ọgwụ a jikọtara ya na ritonavir, rifampicin na ụfọdụ ọgwụ mgbochi.
Can nweghị ike iji ọgwụ ahụ jikọta ya na ritonavir.
Ngwakọta anaghị atụ aro
A naghị atụ aro ka ịjikọta mbadamba mbadamba na thiazolidinediones na ụfọdụ usoro mmanụ mmanụ, n'ihi na ha na-atụnye ụta dị ukwuu na glucose ma na-akpalite glycemia.
Mgwakọta chọrọ ịkpachara anya
Jiri ọgwụ cationic nọ n'ọrụ, dịka ọmụmaatụ, cimetidine. N'ọnọdụ ndị dị otú a, ọ dị mkpa iji nyochaa ọrụ nke sistemụ ebubata ihe gbasara akụrụngwa ma jiri nlezianya nyochaa oke glucose na plasma ọbara.
Mmanya ndakọrịta
Nweghị ike ijikọ ị takingụ ọgwụ na mmanya, maka a na-ebelata ọgwụgwọ ọgwụgwọ, yana nsonaazụ nke ọgwụ na ụjọ na usoro nri na-abawanye.
Nweghị ike ijikọ ị takingụ ọgwụ na mmanya, maka a na-ebelata ọgwụgwọ ọgwụgwọ.
Analogs
Ogwu a nwere otutu analogues nke yiri ya na otu ihe ma obu ihe ndi ozo na aru oru aru oru:
- Avandamet;
- Amaryl;
- Douglimax;
- Velmetia;
- Janumet;
- Vokanamet;
- Galvusmet;
- Glibomet;
- Glybophor;
- Ndị Glucovans;
- Duotrol;
- Dianorm-M;
- Dibizid-M;
- Casano;
- Tụọ;
- Sinjardi;
- Tripride.
Ahịa ọgwụ na-ahapụ okwu
Achọrọ ndenye ọgwụ maka ịzụta.
Enwere m ike ịzụta na ndenye ọgwụ?
Ewezuga.
Ọnụahịa Gentadueto
Ọnụahịa data adịghị, dịka Ugbu a ọgwụ a na-amalite re-asambodo.
Ọnọdụ nchekwa maka ọgwụ
Ọ dị mkpa ịchọta ebe kpọrọ nkụ ma gbaa ọchịchịrị, na-ekpo ọkụ na-adịghị elu karịa + 25 Celsius.
Ọ dị mkpa ịchọta ebe kpọrọ nkụ ma gbaa ọchịchịrị, na-ekpo ọkụ na-adịghị elu karịa + 25 Celsius.
Bọchị mmebi
Ọ bụghị ihe karịrị afọ 3 site na ụbọchị nke edepụtara na nkwakọ ngwaahịa mbụ. Ejila mgbe oge a gasị.
Emeputa
Companylọ ọrụ na-emepụta ihe: Beringer Ingelheim Pharma GmbH & Co. KG, Germany.
Gentadueto Nyocha
Irina, 37 afọ, Ivanovo
Ezigbo ọgwụ nke na-enyere aka mee ka ọkwa shuga dị ka ọ dị ruo awa iri na abụọ. Ọ bụ ihe nwute na ugbu a ọ gaghị ekwe omume ịchọta ya n'ụlọ ahịa ọgwụ, ọ dị mkpa iji họrọ ọgwụ ndị ọzọ nwere otu mmetụta ahụ.
Vladimir, onye gbara afọ 64, Murmansk
Ejiri m ọgwụ a ruo ọtụtụ afọ ruo mgbe ọ na-ere ire. Ihe shuga dị na ya, enweghị mmetụta ọ bụla, ọ dabara adaba iwebata. Ugbu a, m ga-achọ onye nọchiri ya.
Yaroslav, 57 afọ, Chelyabinsk
Ejiri ọgwụ a jikọtara ya na insulin. Ọrịa shuga siri ike. Aghaghị m iji ọgwụ ọzọ dochie ya.
