Glimecomb na-ezo aka ọgwụ eji maka ụdị ọrịa shuga 2.
Ngwá ọrụ nwere ihe hypoglycemic jikọtara ọnụ.
Mgbe ị theụsịrị ọgwụ ahụ, a na-amawanye usoro nke glucose dị n'ọbara onye ọrịa.
Ozi izugbe, ihe mejupụtara na ụdị ntọhapụ
Ọgwụ ahụ akọwapụtara na-ezo aka n'ụgwọ ndị ọrịa hypoglycemic ejiri ọnụ. Ngwá ọrụ ahụ nwere mmetụta jikọtara ọnụ. Na mgbakwunye na mmetụta belata shuga, Glimecomb nwere mmetụta nke pancreatic. N'ọnọdụ ụfọdụ, ọgwụ ahụ nwere mmetụta extrapancreatic.
Ihe mejupụtara ọgwụ ahụ nwere Metformin hydrochloride na 500 mg na Gliclazide - 40 mg, yana sorbitol na ssum silium nke na-ebu mmiri. Na obere ego, magnesium stearate na povidone dị na ọgwụ.
Ọgwụ dị n'ụdị mbadamba cylindrical na ọcha, ude ma ọ bụ ndo odo. Maka mbadamba ihe, a na-anabata marbling. Erere nwere ihe egwu na bevel.
A na-ere Glimecomb na mbadamba 10 n'ime paịlị. Otu mkpọ nwere ngwugwu 6.
Pharmacology na pharmacokinetics
Glimecomb bụ ọgwụ ngwakọta na-agwakọta ndị ọrụ hypoglycemic nke ìgwè biguanide na usoro sulfonylurea.
Ejiri mara onye na-anọchite anya onye na-ahụ anya.
Gliclazide bụ otu n'ime isi ihe dị na ọgwụ ahụ. Ọ bụ usoro nke sulfonylurea.
Ihe a na - enye aka:
- mmepụta insulin na-arụ ọrụ;
- mbelata n'ọbara glucose ọbara;
- belata adhesion platelet, nke na-egbochi ịmalite obara nke ọbara n’ime arịa;
- normalization nke vaskụla permeability.
Gliclazide na - egbochi ihe microthrombosis. Mgbe ị prolongụ ọgwụ ogologo oge na ndị ọrịa nwere ọrịa nephropathy, a na-achọpụta mbelata proteinuria (ọnụnọ protein na mmamịrị).
Gliclazide na-emetụta oke ibu nke onye ọrịa na-a theụ ọgwụ. Site na nri kwesiri ekwesi na ndi ọrịa oria na - ewere Glimecomb, a na - ahụtalata oke ibu.
Metformin, nke bụ akụkụ nke ọgwụ ahụ, na-ezo aka n'òtù biguanide. Ihe ahụ na-ebelata ọ̀tọ glucose n’ọbara, na-enyere aka mee ka ike gwụ usoro dị n’itinye glucose si n’afọ na eriri afọ. Metformin na-enyere aka ịgbalite ngwa ngwa iji glucose site na anụ ahụ.
Ihe na-ebelata cholesterol, obere lipoproteins dị ala. N'okwu a, Metformin anaghị emetụta ọkwa nke lipoproteins nke njupụta dị iche. Dị ka Glyclazide, belata ịdị arọ nke onye ọrịa. Ọ nweghị mmetụta ọ bụla na enweghi insulin n'ime ọbara. Emeghị ka ntinye hypoglycemic mmeghachi omume. Gliclazide na metformin na-anabata ma wepu ya na onye ọrịa. Ihe eji amata Gliclazide bu ihe kariri nke Metformin.
Mkpuchi Gliclazide kacha n'ọbara erute mgbe awa atọ gachara ọgwụ a malitere. A na - eme ihe a site na akụrụ (70%) na eriri afọ (12%). Iwepu ọkara ndụ na-eru awa iri abụọ.
Bioavailability nke Metformin bụ 60%. Ihe ahụ na-agbakọta n’ịgha mkpụrụ ndụ ọbara uhie. Nkeji ọkara bụ 6 awa. Drawepu iwe ahụ na-aputa ihe site na akụrụ, yana eriri afọ (30%).
Ihe ngosi na contraindications
A na-atụ aro ọgwụ ahụ maka ndị ọrịa mamịrị nwere ọrịa shuga 2 ọ bụrụ:
- ọgwụgwọ mbụ na nri na mmega ahụ arụghị arụ ọrụ ọfụma;
- enwere mkpa iji dochie ọgwụ nkwonkwo ejikọtara na mbụ site na iji Gliclazide na Metformin na ndị ọrịa nwere ọkwa glucose ọbara dị ala.
Ejiri ọgwụ ahụ gosipụtara ọtụtụ ọgwụ contraindications, n'etiti ndị:
- ọnụnọ nke ọrịa shuga 1;
- nnabata nke ọgwụ ahụ;
- arụ ọrụ akụrụ;
- ime
- afọ imeju;
- lactic acidosis;
- nkụchi obi;
- ọrịa shuga;
- lactation
- ọrịa dị iche iche;
- infarction myocardial;
- Ọrịa porphyrin;
- precca ọrịa shuga;
- ihe mbu ịwa ahụ;
- oge onye ọrịa na-ele nyocha X-ray na nyocha ya site na iji redioisotopes na ntinye nke ndị na-emegide iodine (a machibidoro ya iwere ụbọchị abụọ tupu ọmụmụ ndị a);
- nnukwu mmerụ ahụ;
- Ọnọdụ ujo na - akpata ọrịa obi na akụrụ;
- okpu iku ume;
- ịxụbiga mmanya ókè;
- shuga dị ala (hypoglycemia);
- nnukwu ọrịa akụrụ;
- mmanya na-egbu egbu;
- na -eme nnukwu ọkụ n’arụ ahụ;
- dabere na ndị ọrịa nwere nri hypocaloric;
- na-ewere miconazole;
- ọrịa mamịrị ketoacidosis.
Ntuziaka maka iji ya na ndụmọdụ pụrụ iche
Usoro onunu ogwu a diri onye obula. A na-atụ aro ka ị were mbadamba 1-3 kwa ụbọchị. N'ime ụbọchị ọgwụgwọ na-esochi, mmụba nke dose ahụ ga-ekwe omume, dabere na ndị na-egosi shuga n'ọbara onye ọrịa na ogo ngosipụta nke ọrịa ya. Maka Glimecomb, usoro ọgwụgwọ kachasị bụ mbadamba ise kwa ụbọchị.
A na-atụ aro ị drugụ ọgwụ ahụ n'ụtụtụ na mgbede. A na-a medicineụ ọgwụ ahụ n'oge nri ma ọ bụ mgbe nri gasịrị.
Agaghị atụ aro ka ngwaọrụ ahụ ruo afọ 60, na-arụ ọrụ na ọnọdụ anụ ahụ siri ike. Site n'ịrụsi ọrụ ike na ịbanye Glimecomb na ndị agadi, lactic acidosis nwere ike ịmalite.
Ime ime bụ otu n’ime ihe ndị a na - egbochi ị thisụ ọgwụ a. Mgbe ime dị, yana tupu atụmatụ ya, ọ dị mkpa iji ọgwụ insulin dochie ọgwụ ahụ.
Breastfeụ ara bụ kwa mgbochi n'ihi nnabata dị ukwuu nke mmiri ọgwụ a intoụ ara. Ọ dị mkpa ịkagbu nri maka nne nke Glimecomb nke nne ma ọ bụ ịkwụsị ị takingụ ọgwụ n'onwe ya n'oge a na-enye ya ara.
Iji kpachara anya, ọ dị mkpa iji ndị ọrịa nwere ọgwụ a:
- ahụ ọkụ;
- nsogbu thyroid;
- adrenal ezughi oke.
Amachibidoro ọgwụ a maka ndị ọrịa nwere ọrịa imeju, yana ọrụ akwara nwere nsogbu, yana ujo, akpịrị ịkpọ nkụ na ihe ịtụnanya ndị ọzọ.
A na-a onlyụ ọgwụ ahụ naanị n'okpuru obere kalori nri nwere obere carbohydrate. N'ụbọchị mmalite ọgwụgwọ, achọrọ nchịkwa shuga ọbara. A na-eme ọgwụgwọ nke ọgwụ ahụ naanị na ndị ọrịa ahụ na-enweta nri na-edozi ahụ mgbe niile.
Sulfonylureas, nke bụ akụkụ nke ọgwụ ahụ, nwere ike ịkpasu hypoglycemia. Ọ na - eme ya site na nri nwere obere kalori na mmega ahụ. Ọ dị mkpa ka ịhazigharị ọgwụ mgbe niile, ọkachasị ndị ọrịa nwere agadi.
Hypoglycemia nwere ike ịdakwasị ndị ọrịa mgbe ị na-ewere:
- mmanya ethyl;
- ọgwụ mgbochi-anaghị egbochi steroidal.
Ibu onu na - ebulitekwa nsogbu nke hypoglycemia n’ebe ndị ọrịa nọ, yana ọgwụ dịka reserpine na clonidine na-ekpuchi ya.
N'ihe banyere ọrụ ịwa ahụ na ndị ọrịa, ọ bụrụ na ha nwere apa ọkụ, mmerụ ahụ, ọrịa na-efe efe, yana myalgia, lactic acidosis, ịkwụsị ọgwụ ahụ ozugbo.
Ọgwụ nwere ike imetụta ịnya ụgbọ ala. Ekwesịrị ịkpachara anya.
Ekwesiri ịkwụsị iwere Glimecomb ụbọchị 2 tupu yana ịbanye na ahụ onye ọrịa ahụ onye na-enweta rediopaque na ayodiin.
Mmetụta akụkụ na ị andụbiga mmanya ókè
Otu n'ime mmetụta ndị na-eme n'ihi ị theụ ọgwụ ahụ ga-ekwe omume:
- hypoglycemia nwere nnukwu ọsụsọ, adịghị ike, dizzness, agụụ, na ike gwụ;
- lactic acidosis nwere ura, ọbara mgbali ala, adịghị ike, mgbu afọ, myalgia;
- ọgbụgbọ
- anaemia
- nsogbu ọhụụ;
- urticaria;
- nfụkasị vasculitis;
- afọ ọsịsa
- itching
- hemolytic anaemia;
- itching
- erythropenia;
- n’ọnọdụ ndị a na-adịghị ahụkebe, ịba ọcha n’anya;
- imeju imeju.
Mgbaàmà kachasị a ofụ nke ịdoụbiga mmanya ókè bụ hypoglycemia na lactic acidosis. Mgbaàmà abụọ a chọrọ ọgwụgwọ ozugbo n'ụlọ ọgwụ. N'okwu abụọ ahụ, a kwụsịrị ọgwụ ahụ. N'okwu nke mbụ, onye ọrịa ahụ na-enweta nlekọta ahụike, a na-eme hemodialysis.
Site na hypoglycemia dị nro na nke kwesịrị ekwesị, ọ zuru ezu maka ndị ọrịa ị toụ ọgwụ shuga n'ime. N'ụdị siri ike, a na-enye onye ọrịa glucose ọbara (40%). Nhọrọ ọzọ nwere ike ịbụ glucagon, nke ejiri intramuscularly na subcutaneously. Ọgwụgwọ na-ewere ọnọdụ mgbe onye ọrịa na-a takingụ nri nwere carbohydrate.
Njikọ Ọgwụ na Analogs
Ọgwụ ahụ na ọgwụ ndị ọzọ na-emekọ ihe:
- a na - eme ka mmetụta hypoglycemic dịkwuo elu mgbe ejikọtara ya na enalapril, cimetidine, miconazole, clofibrate, ethionamide, steroid anabolic, cyclophosphamide, tetracycline, reserpine na ndị ọzọ na - enwe mmetụta hypoglycemic;
- belata hypoglycemic mmetụta mgbe ejikọtara ya na Clonidine, Phenytoin, Acetazolamide, Furosemide, Danazole, Morphine, Glucagon, Rifampicin, nicotinic acid na ọgwụ buru ibu, estrogen, nnu nke lithium, ọgwụ mgbochi;
- ojiji a na-ejikọ ọnụ na nifedipine na-eme ka iwepụ metformin kwụsịlata;
- nhazi na ọgwụ cationic na-abawanye oke nke metformin n'ọbara site na 60%;
- na - eme ka ịbawanye uru nke metformin na - achịkwa ọgwụ na furosemide.
Glimecomb nwere analogues na okwu ndi ozo:
- Glidiab;
- Glyformin;
- Glidiab MB;
- Gliformin Prolong;
- Metglib;
- Mpempe;
- Glyclazide MB;
- Diabetalong;
- Gliclazide-Akos.
Erere vidiyo na-egosi mgbaàmà na ọgwụgwọ nke ọrịa shuga:
Echiche nke ndị ọkachamara na ndị ọrịa
Site na nyocha ndị ọrịa, enwere ike ikwubi na Glimecomb na-ebelata shuga ọbara nke ọma ma na-anabatakwa nke ọma, Otú ọ dị, ndị dọkịta na-ekwusi ike na ịkpachara anya ya n'ihi ọtụtụ nsonaazụ ya.
Glimecomb bụ ọgwụgwọ dị mma maka ọrịa shuga 2dị nke Abụọ. Ma nyere ya ọtụtụ contraindications dị na ya, a na-atụ aro ka o jiri nlezianya dezie ya ọtụtụ ndị ọrịa. Karịsịa ndị agadi.
Anna Zheleznova, 45 afọ, endocrinologist
Ezigbo ọgwụ maka ijikwa shuga ọbara. Anụrụ m ya ruo otu ọnwa, enweghị mmetụta ọ bụla, ọ bụ ezie na enwere ọtụtụ n'ime ha na ntuziaka. Obere ọnụahịa ahụ.
Lovehụnanya, 57 afọ
Anọ m na-arịa ụdị ọrịa shuga 2 ruo oge ụfọdụ. Ana m anabata Glimecomb. Ogwu di nma ma obughi oke onu. Ọ na-ebelata shuga nke ọma. Isi ihe bụ iri nri nke ọma ma rie nri.
Alexandra, onye dị afọ 51
A na-enye ọgwụ ndị akọwapụtara site na ndenye ọgwụ. Ọnụ ahịa ya dị site na 440-580 rubles. Ọnụahịa nke ndị mmekọ ụlọ ọzọ sitere na 82 ruo 423 rubles.
