Ọrịa shuga phosphate bụ otu n’ime ọrịa ndị a na-adịghị ahụkebe na usoro ụmụaka.
Nke a bụ ọrịa sitere na mkpụrụ ndụ ihe butere, na-adakarị ọrịa yiri rickets, nke na-ebuso ndabere nke ike phosphate reabsorption na mkpo tubules.
Mgbanwe ndị dị otú a na-eduga na mmepe nke hypophosphatemia, mmịpụta nke calcium na site na eriri afọ ma, n'ihi ya, ọkpụkpụ na-adịghị mma.
Dị ka ị maara, ihe kachasị dị mkpa anụ ahụ bụ Calcium, nke mmadụ na-enweta site na gburugburu ebe obibi ya na nri nri. A na - eme ka mmiri ọgwụ kemikal dịrị n'ime ihe ndị a.
A na - ejikọta pathogenesis nke ọrịa shuga phosphate na mkpụrụ ndụ ihe nketa nke na - eduga n'ịgba aghara na usoro nke phosphate site na akụrụ gbasara akwara n'ime ọbara, nke na - esochi na - ebute usoro ọnya nke metụtara ọgbụgba akwara ọkpụkpụ, nrụrụ ala, na ụba isi.
Gịnị kpatara oria ji ebilite?
Ọrịa shuga phosphate n'ime ụmụaka bụ n'ihi mmụba n'otu mkpụrụ ndụ ihe nketa dị na Xromosome.
Ihe-eketa bu oria dika udiri akari, ya bu, site na nna nria aru rue umu-nwanyi nile, site kwa na nne nne rue 50% umu nwoke amuru na 25% nke umu aka (ma oburu na nwunye nwere oria).
N'ime omume ụmụaka, a na-achọpụta ọrịa nke hypophosphatemic rickets, nke na-apụta na ọrịa kansa nke akụrụ.
Na ọgwụ, a na-ahụkwa ọrịa shuga paraneoplastic phosphate, nke na-apụta n'ihi mmụba dị ukwuu nke ihe homonụ parathyroid site na mkpụrụ ndụ akpụ. Na mgbakwunye, ọrịa mkpụrụ ndụ ihe nketa a nwere ike ịbụ akụkụ nke nsogbu sistemu, ọkachasị ọrịa Fanconi.
Kedu ka esi gosiputa oria a?
Na ọgwụ ọgbara ọhụrụ, ọ bụ ọdịnala ịmata ọdịiche dị n'okirikiri hypophosphatemic rickets, nke egosipụtara site na afọ mbụ nke ndụ obere onye ọrịa ma nwee njiri mara nke ha.
Ọrịa shuga phosphate ma ọ bụ hypophosphatemia nke metụtara chromosome bụ ọrịa a ketara eketa, ihe kacha akpata ya bụ nrụpụta nke phosphorus na mkpụrụ ndụ akwara, na-eduga n'ịbelata mkpokọta phosphates na ọbara, mmepe nke phosphaturia na ọdịdị nke rickets dị ka mgbanwe na -akpata anụ ahụ na-eguzogide usoro onunu vitamin zuru oke.
Ọrịa ahụ gosipụtara n'ime afọ abụọ mbụ nke ndụ nwata ahụ ma gosipụta ya site na njiri mara ihe mgbaàmà ndị a:
- ntụgharị azụ na azụmazụ ike nke ike akwara;
- mmebi ma ọ bụ ezughi oke enamel na ezé;
- ntutu isi
- nkwuputa nrụrụ nke ala akahụ, na-apụta yana usoro nke nwata ahụ;
- ihe omimi ihe ogugu nke rickets, nke na-aga n’ihu na otutu usoro vitamin D;
- mbelata nke ọkwa phosphates n’ime ọbara na mmụba ha na mmamịrị;
- Ọkpụkpụ na - egbu oge usoro akwara ahụ dị ka afọ ndụ ha si dị.
Ọrịa shuga IIdị II nke Phosphate bụ ụdị hypophosphatemia nke mkpụrụ ndụ ihe kpebiri, nke bụ akara autosomal na enweghị njikọ X na chromosome mmekọahụ.
A na-ahụ ụdị ọrịa shuga phosphate II nke ọrịa dịka:
- ntiwapụ nke ọrịa mbụ site na afọ nke ọnwa iri na abụọ;
- akụkụ dị mkpa nke ala akụkụ ahụ na nrụpụta ọkpụkpụ ahụ;
- ụkọ azụmazụ na nnukwu ahụ ike;
- ihe mgbaàmà redio nke rickets dị nro na osteomalacia nke anụ ahụ;
- N ’ụlọ nyocha, a na-ebelata phosphates n’ọbara na ụba mmamịrị n’ime mmamịrị na-egbochi ọ̀tụ̀tụ̀ calcium nkịtị.
Ọrịa shuga phosphate nke atọ ma ọ bụ agarị agbụrụ bụ ọrịa mkpụrụ ndụ ihe nketa nke eketare onwe ya n'ụdị nnabata ma bụrụkwa ihe doro anya sitere na vitamin D. Ihe mgbaàmà mbụ nke ọrịa ahụ na-apụta ọbụna n’oge a bụ nwa ọhụrụ.
Mgbe ị na-enyocha obere onye ọrịa, ọ ga-ekwe omume ikpebi ọnụnọ nke ọtụtụ ọnụọgụ ọrịa, n'etiti ndị:
- mgbakasị ahụ, anya mmiri, ụjọ;
- mbelata ụda olu;
- Ọrịa nkwarụ;
- obere ume, mmepe ngwa ngwa nrụrụ;
- enamel ezighi ezi;
- mbubreyo nke ije;
- hypophosphatemia kpebisiri ike na ọbara, yana hyperphosphaturia na mmamịrị;
- Mgbanwe ndị dị mgbagwoju anya dị ka rickets na mpaghara okirikiri, yana ihe ịrịba ama nke osteoporosis nke anụ ahụ axial ka edekọtara.
Phosphate ọrịa shuga ụdị IV ma ọ bụ vitamin D3 ụkọ bụ ọrịa sitere n'aka nke a na-ebunye ụmụaka site n'aka ndị nne na nna na usoro mgbanwe akpaaka ma na-esite na nwata.Ihe omuma ndi a bu njiri nke oria Type phosphate:
- nrụrụ valgus nke akụkụ ala, ịkpụ akụkụ nke ọkpụkpụ dị iche iche;
- ogwe
- isi nkwọcha na ọrịa mgbagwoju anya nke enamel ezé;
- X-ụzarị na-achọpụta ihe mgbaàmà nke ụdị rickets.
Kedu otu esi ekpebi ọrịa ahụ?
Ndụmọdụ ndị a na-atụ aro maka ọrịa shuga phosphate n'ihe metụtara nchọpụta nke usoro ahụpịatị gụnyere omume nnabata nke ọtụtụ ọmụmụ iji chọpụta nsogbu nke phosphate reabsorption na mkpụrụ ndụ akụrụ.
Otu n'ime usoro nchọpụta bụ:
- nchikota nke ndi nne na nna nke umu aka umu ha, ndi huru ya na ihe nlere ahu, ukwu nkpuru ya, ito uto na ihe ndi ozo;
- nyocha ebumnuche nke obere onye ọrịa na nhọrọ nke syndromes na-eduga;
- nyocha mkpụrụ ndụ ihe nketa maka anomalies nke X chromosome na ihe nketa eketa na mmepe nke hypophosphatemia;
- urinalysis, n’ime nke nnukwu phosphate na-edebe nzuzo;
- Nyocha x-ray nke ọkpụkpụ ọkpụkpụ ụmụaka nwere nkọwa nke osteomalacia, osteoporosis, nsogbu a kapịrị ọnụ na mpaghara uto;
- nyocha ọbara ọbara n'ụlọ nyocha maka mbelata phosphate na mkpo calcium nkịtị.
Njirimara ọgwụgwọ
N'afọ ole na ole gara aga, ọrịa shuga phosphate siri ike ịgwọ, ya mere ọ fọrọ nke nta ka ọ ghara ikpuchi nrụrụ ọkpụkpụ ọkpụkpụ siri ike. Taa, ekele maka nchọpụta ọgbara ọhụrụ, enwere ike imeziwanye ọnụ ọgụgụ ahụ, dị ka nke hypophosphatemia si nwee ihe ịga nke ọma na mgbazi ọgwụ ọ bụrụhaala na achọpụtara ọrịa ahụ n'oge yana achọta usoro ọgwụgwọ zuru oke.
Ọgwụ maka ọrịa shuga phosphate gụnyere:
- nhọpụta vitamin nke D dị elu (site na 25 puku ruo 250 puku nkeji / ụbọchị);
- ihe eji eme kalselia, uzu agha;
- oriri nke vitamin A na E, ngwakọta citrate.
Ọkpụkpụ anụ arụ nke azụ azụ kwesịrị ịgụnye ọtụtụ ọmụmụ nke ịhịa aka na aka ọkachamara, yana yikwasị akwa corset na-akwado, nke ga-enyere ọkpụkpụ aka itolite n'ọnọdụ dị mma.
Ọ ga - egbochi ọrịa?
Ebe obula oria a bu nke akuru aru ike, a gha apuru igbochi ya site na ilele ndi ezin’ulo na-acho inweta omumu banyere omumu n’ime oge imu nwa.
Ndụ mkpụrụ ndụ ihe nketa
Elebara nsogbu a anya kwesiri ịkwụ ndị di na nwunye ebe otu n'ime ndị mmekọ na-arịa ọrịa a. Ọkachamara ọkachamara ga-akọwa ike ịmụ nwa dị mma ma dọọkwa aka na ntị n'ihe ize ndụ dị n'ịtụrụ nwa nke ga-eketa ọrịa nke nne na nna ya.
Ihe mgbochi nke abụọ nke oria a gụnyere na njirimara oge a nke ndị ọrịa nwere ike na ọgwụgwọ zuru oke nke ụmụaka nwere ndị nwere akara mbụ nke hypophosphatemia.Site na nzaghachi na-enweghị nsogbu na nsogbu ahụ, nwatakịrị ahụ nwere ọtụtụ nsogbu na nsonaazụ ya, gụnyere:
- na-adabaghị n'etiti ndị ọgbọ na mmepe anụ ahụ na nke uche;
- ọdịdị nnukwu nrụrụ nke ọkpụkpụ azụ na nke ala ala;
- nnukwute ogwu nke ezé enamel;
- mgbaghoju nke okpukpu pelvic, nke warawara nke diamita ya;
- imebi mmepe nke ossicles auditory na ntị nke ntị na ntị ịnụ;
- urolithiasis na ọdịda akụrụ sitere na ya.
Vidiyo ndị metụtara
Dr. Komarovsky na rickets na vitamin D nke ụmụaka nwere:
Na mkpokọta, prognosis maka ọrịa shuga phosphate dị mma, mana ụmụaka dị otú ahụ nwere ike ịchọ nrụzigharị ogologo oge yana mmegharị mmekọrịta n'etiti ndụ nwere nkwarụ ọkpụkpụ. Ndi obere oria ndi a kwesiri ka edebanye aha ha na mgbe nile ka oge na ele ha anya site na ndi okacha amara ha (endocrinologist, nephrologist).
