Tresiba nwere insulite dị ogologo - atụmatụ nke ngwa na ịgbakọ usoro

Tresiba bụ insulin Basal kachasị ogologo debara aha ruo taa. Na mbu, emeputara ya maka ndi oria ndi nwere insulin nke ha, ya bu, maka oria di 2. Ugbu a, a nwapụtara ịdị irè nke ọgwụ ahụ maka ndị ọrịa mamịrị nwere ọrịa 1.

A na-emepụta Tresibu site n'aka ndị Danish a ma ama NovoNordisk. Ọzọkwa, ngwaahịa ya bụ Actrapid ọdịnala na Protafan, analogues ọhụrụ nke insulin Levemir na NovoRapid. Ndị ọrịa mamịrị nwere ahụmịhe na-ekwu na Treshiba erughị ala na ndị bu ya ụzọ - Protafan nke oge ọrụ na ogologo Levemir, yana n'ihe banyere nkwụsi ike na ịdị n'otu ọrụ karịrị nke ha.

Reskpụrụ Treshiba

Maka ndị ọrịa mamịrị 1, ịmegharị insulin na-efu site na ntụtụ nke homonụ wuru ewu. Site n'ọrịa shuga dị ogologo 2 dị ogologo, ọgwụ insulin bụ nke kasị dị irè, ọ na-anagide ihe dị mfe ma na-akwụ ụgwọ ọgwụgwọ. Naanị ndọghachi azụ insulin dị ukwuu bụ nnukwu ihe egwu hypoglycemia.

Sugarda shuga dị egwu karịchaa n’abali, n’ihi na enwere ike ịchọpụta ya n’oge, n’ihi ya, ihe nchekwa maka nchekwa insulins dị ogologo na-eto. Na ọrịa shuga mellitus, ogologo ma kwụsie ike, na-ebelata mmetụta nke ọgwụ ahụ, belata obere nsogbu nke hypoglycemia mgbe ọ jisịrị nchịkwa.

Insulin Tresiba mezuru ebumnuche ndị a:

Ọrịa shuga na oke nrụgide ga-abụ ihe mgbe ochie

• Normalization shuga -95%
• Mwepu nke akwara mbufụt - 70%
• Mwepu nke obi ike -90%
• Bibie ọbara mgbali elu - 92%
• Mmụba na ume n'ụbọchị, na-eme ka ụra na-ehi ụra n'abalị -97%

1. Ọgwụ a so n’onye ọhụrụ na - eme ogologo oge, ebe ọ na - arụ ọrụ ogologo oge karịa nke ọzọ, awa iri anọ na anọ ma ọ bụ karịa. Nke a bụ n'ihi eziokwu ahụ bụ na ụmụ irighiri homonụ nke gbanwetụrụ “na-arapara n'ahụ” n’ahụ ma na-ahapụ ha n’ime ọbara nwayọ nwayọ.
2. Oge awa iri abụọ na anọ mbụ, ọgwụ na-abanye n'ọbara n ’ọ bụla, mgbe ahụ mmetụta a na-ebelata nke ọma. Ọnụ ọgụgụ kasị elu nke ihe adịghị kpamkpam, profaịlụ fọrọ nke nta ka ọ dị larịị.
3. Oge inje niile na-emekwa otu ihe. Can nwere ike ijide n’aka na ọgwụ ahụ ga-arụkwa ọrụ dịka ụnyaahụ. Mmetụta nke doses hà yiri ụdị ndị ọrịa nọ n'afọ ndụ dị iche. Mgbanwe nke ihe na Tresiba jiri okpukpu anọ karịa nke Lantus.
4. Tresiba na - akpalite hypoglycemia 36% karịa insulin analogues ogologo oge site na elekere 0:00 ruo 6:00 nke nwere ọrịa shuga 2. Site na oria 1, uru ya apụtachaghị ìhè, ọgwụ ahụ na-ebelata ihe ize ndụ nke hypoglycemia n'ehihie site na 17%, mana ọ na-abawanye ohere nke hypoglycemia ehihie site na 10%.

Ngwakọta nke Tresiba na-arụ ọrụ bụ degludec (n'ụfọdụ ebe - degludec, Bekee degludec). Nke a bụ insulin nke recombinant mmadụ na-agbanwe, nke eji agbanwe mkpụrụ ndụ ya. Dị ka homonụ sitere n'okike, ọ na-enwe ike kegide ndị na-anabata ya, na-akwalite ụzọ nke shuga site n'ọbara banye na anụ ahụ, na-ebelata mmepụta nke glucose na umeji.

N'ihi nhazi ya dịtụ ntakịrị, insulin a nwere ike ibụpụta hexamers dị mgbagwoju anya na katriiki. Mgbe iwebata n’okpuru anụ ahụ, ọ na-etolite ụdị ebe nchekwa, nke a na-agbadata nwayọ nwayọ ma na-agba ọsọ mgbe niile, nke na-ahụ na iwere homonụ nke edobere n'ọbara.

Mkpebi ọkachamara

Arkady Alexandrovich

Endocrinologist na ahụmịhe

Jụọ ọkachamara na ajụjụ

Site na echiche nke physiology, yana ọrịa shuga, Tresiba ka mma karịa insulin insulin ọzọ na-emeghachi ntọhapụ eke nke homonụ.

Mpempe mwepụta

Ọgwụ dị n'ụdị atọ:

1. Tyariba Penfill - katriji nwere usoro, nsụkọta nke homonụ dị n’ime ha bụ ọkọlọtọ - a nwere ike iji sirinji pịnye ma ọ bụ tinye ya n’ime pensụl NovoPen na ihe ndị yiri ya.
2. Tresiba FlexTouch nwere mkpo U100 - mkpịsị mkpụrụ silium dị n’ime ya nke etinye n’elu milimita 3 ml. Enwere ike iji pen dee ya ruo mgbe insulin dị n'ime ya ga-agwụ. Anaghị enye onye ndochi ihe ọ bụla. Usoro usoro onunu ogwu - 1 otu, ihe kasịnụ maka iwebata 1 - nkeji iri asatọ.
3. Tresiba FlexTouch U200 - nke emepụtara iji gboo oke mkpa nke homonụ, nke a na-abụkarị ndị ọrịa nwere ọrịa mellitus nwere nnukwu insulin. A na - eme nyocha insulin ugboro abụọ, yabụ, olu nke ihe ewepụtara n’okpuru akpụkpọ ahụ dị obere. Iji mkpịsị mkpụrụ sirinji, ị nwere ike ịbanye otu ugboro ruo 160. homonụ na nkeji iri abụọ na abụọ. Cartridges nwere nnukwu ịta deg degec N’ọnọdụ ọ bụla ị ga - esi na pensụl mbụ mịnye wee banye n’ime ndị ọzọ, dịka nke a ga - eduga ịba ụba oke ma ọ bụ oke hypoglycemia.

Na Russia, edere ụdị ọgwụ atọ niile aha, mana n'ụlọ ahịa ọgwụ, ha na-enye tumadi Tresib FlexTouch nke itinye uche oge mbụ. Ọnụahịa maka Treshiba dị elu karịa maka ogologo insulins ndị ọzọ. Otu ngwugwu nwere pensụl dị mkpị 5 (15 ml, nkeji 4500) na-akwụ ụgwọ site na 7300 ruo 8400 rubles.

Na mgbakwunye degludec, Tresiba nwere glycerol, metacresol, phenol, zinc acetate. Ihe acidity nke ihe ngwọta dị nso na-anọpụ iche n'ihi mgbakwunye nke hydrochloric acid ma ọ bụ sodium hydroxide.

Na-egosi Treshiba

A na-eji ọgwụ ahụ yana insulins ngwa ngwa maka ọgwụgwọ nnọchi homonụ maka ụdị ọrịa shuga abụọ ahụ. Site n'ọrịa ụdị 2, naanị insulin nwere ike ịkọwa ya na ọkwa nke mbụ. Na mbu, ntuziaka Russia maka ojiji nyere ohere iji Treshiba naanị maka ndị ọrịa okenye. Emechara nyocha nke gosipụtara nchekwa ya maka akụkụ na-eto eto, a gbanwere ntuziaka ahụ, ugbu a ọ na-enye ohere iji ọgwụ ahụ mee ihe na ụmụaka site na 1 afọ.

Ntụziaka maka ojiji

Enweghị ihe ọmụma banyere iwu nchịkwa nke insulin, ụgwọ dị mma maka ọrịa shuga agaghị ekwe omume. Ọ bụrụ na ịgbaso ntuziaka ndị ahụ nwere ike ibute nnukwu nsogbu: ketoacidosis na nnukwu hypoglycemia.

Otu esi eme ka ọgwụgwọ dị mma:

• ya na oria nke mbu, i kwesiri ịhọrọ ya n’ulo ogwu. Ọ bụrụ na onye ọrịa ahụ anatalarị insulin ogologo oge, mgbe ebugharị ya na Tresiba, a na-ebu ụzọ dozie ọgwụ ahụ ka ọ gbanwee agbanwe, wee dozie ya maka data glycemic. Ọgwụ ahụ na-ekpughe ihe niile ọ rụpụtara n'ime ụbọchị 3, yabụ, a na-anabata mgbazi nke mbụ naanị mgbe oge a gafere;
• ya na udiri oria abuo, nmalite amalite bu nkeji iri, na enwe nnukwu ibu - rue 0.2. kwa n'arọ Mgbe ahụ, a na-agbanwe ya nwayọ ruo mgbe glycemia na-agbanwe. Dịka iwu, ndị ọrịa na-ebu oke ibu, na-ebelata ọrụ, nnwale insulin siri ike, na ọrịa mellitus nke na-aba ụba ogologo oge chọrọ ọgwụ Treshiba nke ukwuu. Ka usoro ọgwụgwọ na-aga n'ihu, ha na-eji nwayọ nwayọ;
• n'agbanyeghị eziokwu ahụ bụ na insulin Tresiba na-arụ ọrụ ihe karịrị awa 24, ha na-agbari ya otu ugboro n'ụbọchị n'oge a kara aka. Ihe omume a ga-esote ya ga-adabacha na nke ị meburu;
• enwere ike ịnye ọgwụ ahụ naanị subcutaneously. Ọkpụkpụ intramuscular abụghị ihe a na-achọghị, ebe ọ nwere ike ibute shuga, nsị ọbara na-egbu ndụ;
• saịtị ịgba ọgwụ adịghị mkpa, mana a na-ejikarị apata ụkwụ maka insulins ogologo oge, ebe ọ bụ na a na-etinye homonụ dị mkpirikpi n'ime afọ - esi na ebe ị ga-abanye insulin;
• mkpịsị sirinji bụ ngwaọrụ dị mfe, mana ọ ka mma ma ọ bụrụ na dibịa na-aga na-eme ka ị mata iwu maka ijikwa ya. Na agbanyeghị, a na-agbakọ iwu ndị a na ntuziaka nke agbakwunye na mkpọ ọ bụla;
• Tupu n ’mmalite mmeghe ọ bụla, ị ga-agba mbọ hụ na ọdịdị nke agbanwe agbanwebeghị, katriiki na-emebi emebi, na agịga agịga. Iji lelee ahụike nke sistemụ ahụ anya, a na-etinye nkeji 2 n'ime mkpụrụ sirinji. bya emee mkpọla-ododo. Mgbanye transperent kwesịrị ịpụta na oghere agịga. Maka Treshiba FlexTouch agịga mbụ NovoTvist, NovoFayn na analogues ha sitere na ndị nrụpụta ndị ọzọ dabara adaba;
• mgbe iwebata usoro ahụ, a naghị ewepụ agịga ahụ n’akpụkpọ ahụ ọtụtụ sekọnd, ka insulin ahụ ghara ịwụ. Ohere ekwesịghị ịgbanye ebe a na-agba ya ọgwụ ma ọ bụ kpoo ya.

Enwere ike iji Treshiba jiri ọgwụ niile na-belata shuga, gụnyere insulin mmadụ na analog, yana mbadamba ụrọ edepụtara maka ụdị shuga 2.

Mmetụta dị n'akụkụ

Nsonaazụ ọjọọ nke ọgwụgwọ ọrịa shuga site n’aka Treciba na ntulee ihe ọghọm ha:

Hypoglycemia

Hypoglycemia bụ nsonaazụ nke insulin insres. Enwere ike ibute ya site na iji ọgwụ echefuru echefu, njehie n'oge nchịkwa, enweghị glucose n'ihi njehie nke nri ma ọ bụ na-anaghị ahụ maka mmega ahụ.

Ọtụtụ mgbe, mgbaàmà amalitelarị na ọkwa nke hypoglycemia dị nwayọ. N'oge a, enwere ike ibulite shuga na tii ma ọ bụ ihe ọ juiceụ sweetụ dị ụtọ, mbadamba glucose. Ọ bụrụ na enwere okwu mellitus ọrịa shuga ma ọ bụ nsogbu nke oghere na oghere, mwepu oge dị mkpirikpi amalite, nke a na-egosi ntụgharị nke hypoglycemia na ọkwa siri ike. N'oge a, onye ọrịa ahụ enweghị ike ịnagide mmachi shuga na aka ya, ọ chọrọ enyemaka nke ndị ọzọ.

Iwu nchekwa

All insulins bụ nkwadebe siri ike; n'okpuru ọnọdụ nchekwa na-adịghị mma, ha na-efunahụ arụmọrụ ha. Ihe nrịba ama nke mkpọmkpọ ebe bụ flakes, lumps, sediment, kristal in katriket, cure urukulu. Ha anaghị adị mgbe niile, mgbe mgbe insulin mebiri emebi enweghị ike iji ọdịiche ndị dị na mpụta mara ya.

Ntụziaka maka ojiji akwadoro ịchekwa katiriji emechiri emechi n'oge okpomọkụ dị n'okpuru 8 Celsius. Ndụ shelf bụ naanị izu iri atọ, ma ọ bụrụhaala na a na-agbaso iwu nchekwa. Ekwesighi ịhapụ ọgwụ n'efu, n'ihi na insulin bụ protein n'okike ma mebie ya na ọnọdụ okpomọkụ dị n'okpuru efu.

Tupu ojiji nke mbụ, ewepụrụ Tirmanbu na friji ma ọ dịkarịa ala elekere abụọ. Enwere ike idobe mkpụrụ edemede sirinji ya na kọọdụ bidoro na temprechọ nke ime ụlọ maka izu asatọ. Dabere na ndị ọrịa mamịrị, ọgwụ a na-arụ ọrụ nke ọma ozugbo oge a, na mgbe ụfọdụ ntakịrị oge. Ekwesịrị ka echedo insulin Tresiba site na ultraviolet na radieshọn, okpomọkụ dị elu (> 30 Celsius C). Mgbe ịgba ntụtụ ahụ, wepụ irighiri na pen sirinji ma jiri okpu mechie katrij.

Nyocha Treshiba