Metformin: ihe edepụtara, ntuziaka, nsonaazụ ya

Ọgwụ ịrịa ọrịa shuga kachasị n'ụwa bụ Metformin, nde mmadụ 120 na-eji ya kwa ụbọchị. Akụkọ ihe mere eme nke ọgwụ ahụ nwere ihe karịrị afọ iri isii, n'oge a rụrụ ọtụtụ ọmụmụ, na-egosi ịdị irè ya na nchekwa maka ndị ọrịa. Ọtụtụ mgbe, a na-eji Metformin maka ọrịa shuga 2 iji belata nguzogide insulin, mana n'ọnọdụ ụfọdụ, enwere ike iji ya gbochie mmepe nke nsogbu carbohydrate yana mgbakwunye na usoro insulin maka ọrịa 1.

Ọgwụ nwere obere contraindications mana enweghị mmetụta kachasị n'akụkụ ndị nnọchianya hypoglycemic ọzọ: ọ naghị eme ka ihe ọ bụla ghara ịdị hypoglycemia.

Ọ bụ ihe nwute, Metformin ka nwere ntụpọ. Dabere na nyocha, na otu ụzọ n'ụzọ ise nke ndị ọrịa nwere oke oriri, eriri afọ na-ahụ nsogbu. O kwere omume iwelata ọgwụ ị ga-a toụ ọgwụ site na nri digestive site na iji nwayọọ nwayọọ na-abawanye usoro onunu ogwu ma jiri usoro ịhapụ oge ọhụụ.

Ọrịa shuga na oke nrụgide ga-abụ ihe mgbe ochie

• Normalization shuga -95%
• Mwepu nke akwara mbufụt - 70%
• Mwepu nke obi ike -90%
• Bibie ọbara mgbali elu - 92%
• Mmụba na ume n'ụbọchị, na-eme ka ụra na-ehi ụra n'abalị -97%

Metformin egosi

Metformin sitere na ọgwụ ewu ahụ, ahịhịa a na-ahụkarị nwere mgbada shuga. Iji belata ihe ọxicụxicụ ma mee ka uto hypoglycemic nke ewu pụta, amalitere ọrụ na nkesa nke bekee na-arụ ọrụ. Ha ghọrọ biguanides. Ugbu a, Metformin bụ naanị ọgwụ dị na otu a nke gaferela nchịkwa nchekwa, ndị nke ọzọ tụmadịrị imebi imeju ma mụbaa ihe egwu nke lactic acidosis.

N'ihi ịdị irè ya na nsonaazụ ya na-adịghị ala ala, ọ bụ ọgwụ nke mbụ na ọgwụgwọ nke ọrịa shuga ụdị 2, ya bụ, a na-enye ya iwu na mbu. Metformin anaghị abawanye njikọ insulin. Kama nke ahụ, n'ihi mbelata ọbara shuga, a na-akwụsị homonụ na oke olu, nke na-abụkarị mgbe ọrịa shuga 2dị nke abụọ malitere.

Nnabata ya na-enye gị ohere:

1. Mee ka nzaghachi nke sel dị na insulin, ya bụ, belata nguzogide insulin - ihe kachasị na-akpata ọgba aghara nke carbohydrate na ndị oke oke. Metformin yana nri na nrụgide nwere ike ịkwụ ụgwọ maka ọrịa shuga nke 2, o yikarịrị ka ọ ga-agwọ ọrịa shuga ma nyere aka wepụ metabolic syndrome.
2. Belata mkpo carbohydrates site na eriri afọ, nke na -ebelata sugar sugar.
3. Iji kwụsịlata ịmịpụta glucose na umeji, maka ọkwa nke ọbara ya na-ebelata na afọ efu.
4. Mmetụta profaịlụ akwara ọbara: bulie ọdịnaya nke lipoproteins dị ukwuu na ya, belata cholesterol na triglycerides na-emebi arịa ọbara. Mmetụta a na-ebelata ihe ọghọm nsogbu vaskụla nke ọrịa shuga.
5. Meziwanye ọnya ọbara ndị dị na arịa ndị ahụ, belata nrachi nke leukocytes, ya bụ, belata ihe ize ndụ nke atherosclerosis.
6. Belata ibu n’arụ, kachasị n’ihi ihe kachasị dị ize ndụ maka metabolism nke abụba visceral. Mgbe afọ 2 nke iji, ịdị arọ nke ndị ọrịa dara 5%. Site na mbelata nke iri caloric, nsonaazụ nke ibu belata nke ukwuu.
7. Nagide obara na - emebi aru, ya bu, mee ka nri ha ka nma.
8. Iji bute osome na akwa nke polycystic, yabụ, enwere ike iwere ya mgbe ị na-eme atụmatụ ịtụrụ ime.
9. Chedo cancer. Ihe omume a ghe oghe n’oge na-adịbeghị anya. Nchoputa emere ekpughere akuko nke antitumor na ogwu a. A na-amalite ọrụ ndị ọzọ iji mụọ ma gosipụta mmetụta a.
10. Jiri nwayọ nwayọ nwayọ. Nke a bụ mmetụta kachasị emetụ n'ahụ Metformin, a rụrụ nnwale naanị na anụmanụ, ha gosipụtara mmụba na ndụ ndụ nke akwara nnwale. Enweghị nsonaazụ nke nnwale ụlọ ọgwụ zuru oke na ntinye nke ndị mmadụ, yabụ ọ dị mbido ikwu na Metformin dị ogologo ndụ. Ruo ugbu a, nkwupụta a bụ eziokwu naanị maka ndị ọrịa nwere ọrịa shuga.

N'ihi ọtụtụ ihe mmadụ na-eme n'ahụ, ihe ngosipụta maka iji Metformin ejedebeghị na ọgwụgwọ nke ọrịa shuga 2. Enwere ike iwere ya nke ọma iji gbochie nsogbu nke carbohydrate, iji mee ka ịdị arọ ya dị mfe. Nnyocha e mere egosiwo na n'ime ndị nwere ọrịa shuga (ndidi glucose na-adịghị ala ala), oke ibu, ọbara mgbali elu, insulin karịrị akarị) ya na Metformin naanị, ọrịa shuga bụ pasent 31% anaghị enwe ike ime. Dinggbakwunye nri na agụmakwụkwọ ahụ na atụmatụ ahụ mere ka nsonaazụ ahụ dịkwuo mma: 58% nke ndị ọrịa nwere ike izere ọrịa shuga.

Metformin belatara ihe egwu niile ọrịa shuga jiri 32%. Ọgwụ a gosipụtara ọmarịcha nsonaazụ na mgbochi macroangiopathies: enwere ike belata 40% nke nkụchi obi na ọrịa strok. Ihe omume a yiri ka ọ rụpụtara nke ndị na - ekwe ụtarị amata - ọgwụ maka nrụgide na akpụ.

Releasedị ọgwụ ntọhapụ na usoro onunu ogwu

A na-akpọ ọgwụ mbụ nwere Metformin Glucofage, akara nke ụlọ ọrụ French bụ Merck nweburu. N'ihi eziokwu ahụ bụ na ihe karịrị afọ iri agaala kemgbe mmepe nke ọgwụ na inweta patent maka ya, ịmịpụta ọgwụ ndị nwere otu ihe mejupụtara - mkpụrụ ndụ ihe nketa, bụ nke iwu kwadoro.

Dabere na nyocha nke ndị dọkịta, ndị a ma ama na-elu ha:

• German Siofor na Metfogamma,
• Israel Metformin-Teva,
• Russian Glyfomin, Novoformin, Formmetin, Metformin-Richter.

Generics nwere uru a na-agaghị agbagha agbagha: ha dị ọnụ ala karịa ọgwụ mbụ. Ha enweghị enweghị ndọghachi azụ: n'ihi njirimara nke mmepụta, mmetụta ha nwere ike ịbụ nke na-esighi ike, yana ihichacha nke ọma. Maka imepụta mbadamba mbadamba, ndị na-emepụta ihe nwere ike iji ọgwụ ndị ọzọ, nke nwere ike ibute nsonaazụ ndị ọzọ.

A tọhapụrụ ọgwụ ahụ n'ụdị mbadamba maka nchịkwa ọnụ, onunu ogwu nke 500, 850, 1000 mg. A na - ahụta mmetụta belata shuga na nsogbu nke carbohydrate metabolism na - amalite site na 500 mg. Maka ọrịa shuga, ọgwụ kachasị mma bụ 2000 mg.. Site na mmụba na ya na 3000 mg, mmetụta hypoglycemic na-eto nwayọ karịa ihe ọghọm nke nsonaazụ ndị ọzọ. Increaseba ụba na usoro onunu ogwu abụghị naanị ihe ezi uche dị na ya, mana ọ dịkwa ize ndụ. Ọ bụrụ na mbadamba 2 nke 1000 mg ezughi inye aka glycemia, a na-enye ndị ọrịa ọgwụ mgbakwunye shuga na-ebelata ọgwụ ndị ọzọ.

Na mgbakwunye na Metformin dị ọcha, a na-emepụta ọgwụ jikọtara ọnụ maka ọrịa shuga, dịka ọmụmaatụ, Glibomet (yana glibenclamide), Amaryl (ya na glimepiride), Yanumet (ya na sitagliptin). Ebumnuche ha ziri ezi na ọrịa shuga ogologo oge, mgbe ọrụ pancreatic malitere imebi.

Enwekwara ọgwụ ike na ogologo oge - Glucofage Long (usoro 500, 750, 1000 mg) analogues Metformin Long, Gliformin Prolong, Formine Long. N'ihi ntọala pụrụ iche nke mbadamba, nnabata ọgwụ a na-eji nwayọ nwayọ, nke a na-eduga n’ibelata okpukpu abụọ ugboro ole nsonaazụ si eriri afọ. A na-echekwa mmetụta hypoglycemic ahụ n'ụzọ zuru ezu. Mgbe agbatịchara Metformin, akụkụ a na-adịghị arụ ọrụ nke mbadamba ihe ahụ ga-abụ abụrị na feces. Naanị ndọghachi n'ụdị a bụ ntakịrị mmụba na ọkwa triglycerides. Ma ọ bụghị ya, ọ nwere mmetụta dị mma na profaịlụ nke ọbara.

Etu ị ga-esi metformin

Bido were 1% nke 500 mg. Ọ bụrụ na anabata ọgwụ ahụ nke ọma, a na-abawanye usoro onunu ogwu ka 1000 mg. Mmetụta dị ala na -eme ka a na-enwelata shuga, a na-ahụkarị ọdịda glycemia mgbe izu abụọ nke nchịkwa gasịrị. Ya mere, a na-abawanye ọgwụ ahụ site na mg mg 500 n'otu izu ma ọ bụ abụọ, ruo mgbe a ga-akwụghachi ọrịa shuga ume. Iji belata mmetụta na-adịghị mma na mgbaze, a na-ekewa ọgwụ kwa ụbọchị ụzọ 3.

Metformin na-eji nwayọ nwayọ amalite ị drinkụ mmiri na mbadamba 1, oge mbụ ịhazigharị ọgwụ mgbe ụbọchị 10-15 gachara. Ego kachasị nyere bụ mbadamba 3 nke 750 mg, 4 mbadamba 500 mg. Ọgwụ ahụ dum na-egbu mmanya otu oge, n'oge nri abalị. Mbadamba enweghị ike ịzọpịa ma kesaa ya na akụkụ, ebe ọ bụ na imebi ihe owuwu ha ga-eduga na mmebi nke ọrụ ogologo oge.

You nwere ike iwere Metformin ogologo oge, nkwụsịtụ ọgwụgwọ adịghị mkpa. N'oge a na-eri nri, carb nri na mmega ahụ anaghị kagbuo. Na ọnụnọ nke oke ibu, ha na - ebelata calorie.

Ogologo oge nwere ike ibute enweghi vitamin B12, ya mere ndi oria n’eji obia na-ewere Metformin kwesiri iri nri umu anumanu kwa ubochi, karia imeju, akụrụ na ehi, wee lee ule kwa afọ maka oke anapụ B12.

Nchikota nke metformin yana ogwu ndi ozo:

Nsonaazụ na contraindications

Mmetụta ọghọm dị na ị Metụ Metformin na ugboro ole ha nwere:

Lactic acidosis bụ ọnọdụ dị ụkọ mana enwere ọnwụ. N'ime ntuziaka maka iji ya, a na-ekenye ya akụkụ niile. Ihe gbasara acidosis di elu na:

• ịdoụ ọgwụ metformin;
• alisụrụma;
• ọdịda odida;
• enweghị oxygen n'ihi ọrịa angiopathy, anaemia, ọrịa ngụgụ;
• ụkọ vitamin B1 siri ike;
• na nká.

Ekwesịrị ịkwụ ụgwọ nlebara anya mgbe ị na-ewere Metformin na ndakọrịta ya na mmanya. Contraụ ọgwụ iji gbochie ya ị isụ ọgwụ bụ ị alcoụ mmanya na-egbu egbu, yana nsogbu imeju. Ọbụna ma ọ bụrụ na ị na-eme atụmatụ ị drinkụ otu iko mmanya zuru oke, a ga-akagbu Metformin mbụ na awa 18, agbatịwo - otu ụbọchị. Ogologo oge dị otú a ga-aka njọ ụgwọ ọrụ nke ọrịa shuga, yabụ ọ bụ ihe ezi uche dị na ya ịhapụ mmanya kpamkpam.

Dabere na ndị ọrịa, nsogbu nri nri na nri na-abụkarị nwa oge ma na-apụ n’anya ozugbo ahụ anụ ahụ metụtara ọgwụ. Ọtụtụ mgbe ha na-agafe n’enweghị ọgwụgwọ mgbe izu abụọ gachara. Iji belata ahụ erughị ala, a na-abawanye usoro onunu ogwu nwayọ. N'ọnọdụ ụfọdụ, ọ bara uru ịgbanwee gaa na Glucophage Long anabataghị.

Ndepụta nke contraindications:

1. Ọnọdụ chọrọ insulin insulin nwa oge gụnyere nnukwu ọrịa shuga (ketoacidosis, precoma na coma), ịwa ahụ, nkụchi obi, nkụchi obi.
2. Ọrịa mamịrị na-arịa ọrịa shuga, na-amalite na ọkwa 3.
3. Ọrịa akụrụ, na-enwe mgbagwoju anya nwa oge site na akpịrị ịkpọ nkụ, ujo, ọrịa siri ike.
4. Na mbufe lactic acidosis.
5. Iri calorie ezughi oke (1000 kcal ma ọ bụ ihe na-erughị).
6. Ime Ọrịa shuga 2dị nke abụọ, a ga-akwụsịkwa Metformin yana ọgwụ insulin na-atụ aro ya na nhazi.

Ọ bụghị contraindication maka iwere Metformin, kama ọ chọrọ nlekọta nlekọta ahụike karịa afọ 60, ma ọ bụrụ na onye ọrịa ahụ nwere ọrịa akụrụ ma ọ bụ nwee nnukwu nsogbu. Ọgwụ nwere ike ịbanye na mmiri ara ara, mana ahụghị mmetụta ọjọọ na nwa ahụ. Mgbe ị na-enye ya nri, a na-enye ya akara na ntuziaka maka iji “jiri nlezianya”. Nke a pụtara na dọkịta ga-eme mkpebi ikpeazụ, na-atụle uru na ọghọm dị na Metformin.

Ihe analogs Metformin - otu esi edochi?

Ọ bụrụ na anabataghị Metformin, enwere ike dochie ya na ọgwụ ogologo oge ma ọ bụ analogue nke onye nrụpụta ọzọ.

Na ọnụnọ nke contraindications, a na-ahọpụta ọgwụ nwere usoro ọrụ yiri ya, mana ihe mejupụtara dị iche:

Mgbanwe nke ọgwụ a ga-eme naanị dị ka onye dọkịta gwara ya ma n'okpuru nlekọta ya.

Ngwa Mgbakwunye Metformin

Metformin nwere ike ọ gaghị enyere mmadụ niile aka ifelata. Egosiputara na odi nma ya bu n’onu aru. Ọ bụ ihe karikarị na ụmụ nwoke, oke oke ibu na-agbakọ na afọ n'ụdị visceral abụba. Ekwuputala na Metformin na - enyere aka belata ma ọ bụ jigide ịdị arọ anụ ahụ, belata pasent nke abụba visceral, na ogologo oge - itinyeghachi ahụ ike karịa na anụ ahụ. A na-atụ aro na ọgwụ nwere ike imetụta sistemụ ụjọ, na-ebelata agụụ. Ọ dị nwute, ọ bụghị ihe niile na-achọpụta mmetụta a.

A na-atụ aro ka ọ jiri Metformin maka oke ibu naanị maka ndị ọrịa nwere oke ibu (BMI≥30) ma ọ bụ mgbe ijikọta oke ibu (BMI≥25) na ọrịa shuga, ọrịa obi obi, atherosclerosis. N'okwu a, ọgwụ a na-arụ ọrụ karịa, ebe ọ bụ na ihe ka ọtụtụ n'ime ndị ọrịa dị otú ahụ nwere nguzo insulin.

Sourcesfọdụ isi kwuru ọgwụ dị ka onye na-egbochi carbohydrate na eriri afọ. N'ezie ọ adịghị egbochi ịmịkọta glucose, kama ọ na-eme ka ọ kwụsịlata, ọdịnaya calorie nke nri ga-adịgide otu ihe ahụ. Ya mere, ịkwesighi ịnwe ifefu ego ole na ole na Metformin iji nweta ọnụ ọgụgụ zuru oke. Na nke a abụghị onye inyeaka.

Limkpa Ọkụ Ngwa

Enweghị ike ịkpọ Metfomin ụzọ dị mma dị ukwuu maka ịdị felata. Site na nyocha, iji ọgwụ ahụ ogologo oge ka ị na-ejigide usoro iri nri ndị gara aga na-enye kilogram 0.5-4.5 dị arọ. Achọpụtara nsonaazụ kachasị mma na otu ndị ọrịa nwere ọrịa metabolic: mgbe ị na-ewere 1750 mg nke Glucofage Ogologo ụbọchị, ọkara belata ọnwa mbụ bụ 2.9 n'arọ. N'otu oge ahụ, akpịrị na akpịrị ọbara ha na-alaghachikwa etu o si dị, mgbali ọbara ha belatara ntakịrị.

Nchịkwa insulin na-eduga n'ịbawanye ụba nke insulin, nke na-egbochi mmebi nke abụba, usoro nke ifelata na-ebelata. Site na nyocha insulin enyocha site na nyocha, iwere Metformin na-enye gị ohere "ịkwanye" metabolism ma bido usoro ifelata. Dị ka ọ na-adịkarị, mmadụ enweghị ike ime ya ma ọ bụrụ na-enweghị obere kalori, na mma, obere nri carb. Ha ga - enyere aka ịgbalite metabolism na egwuregwu ọ bụla.

Malysheva banyere Metformin

Onye na-ekwu okwu televishọn a ma ama bụ Elena Malysheva na-ekwu maka Metformin naanị dị ka ụzọ isi mee ka ndụ dị ogologo, n’ebughị ụzọ kwuo na ndị ọkà mmụta sayensị ewebeghị ezigbo ihe akaebe na nke a. Iji belata ibu, ọ na-enye nri kalori dị ala. Site n’inwe ezigbo ahụ ike, nke a bụ ezigbo ohere iji wepụ oke abụba. Ndị na-arịa ọrịa shuga enweghị ike iso ụdị nri a, ebe ọ bụ na carbohydrates jupụtara.

Nhọrọ ọgwụ

Irè Glucofage na analogues ya dị nso, ọnụahịa ahụ dịkwa iche iche, yabụ na ọ nweghị mkpa onye ị ga-ahọrọ. Ọ bụrụ na a na-anagide ọgwụ ogologo oge, ọ nwere obere nsogbu ịwụda ọgwụ, ebe ọ na-a drunkụ mmanya otu ugboro n'ụbọchị.

Metformin maka ọrịa thyroid

Ọ bụrụ na usoro ndị a dị n'elu anaghị enye nsonaazụ, ma ịdị arọ ahụ akwụrụ, ịkwesịrị ị paya ntị na ọnọdụ nke pancreas. Ọ dị mma ịre ule maka hypothyroidism (thyrotropin, thyroxine, triiodothyronine) ma gaa na endocrinologist. Anabatara ọgwụgwọ homonụ ka ijikota na iji Metformin.

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