Ọrịa shuga mellitus bụ ọrịa nkịtị nke chọrọ ọgwụgwọ oge niile. Ya mere, n'ụdị ọrịa mbụ na ụdị ọrịa nke abụọ nke ọrịa, ndị ọrịa chọrọ insulin insulin, nke na-enyere aka ịme glucose, na-agbanwe ya ngwa ngwa.
Ọtụtụ mgbe, na-arịa ọrịa shuga, a na-eji insulin Aspart eme ihe. Nke a bụ ọgwụ ultrashort.
Ngwá ọrụ bụ ntụnyere nke insulin mmadụ, nke a na-enweta site na teknụzụ DNA eleghachi anya azụ site na iji ụdị Saccharomyces cerevisiae, ebe eji dochie ntụpọ B28 (amino acid) na aspartic acid. Igwe ihe motu di bu 5825.8.
Ngwakọta, ụdị ntọhapụ na mmetụta ọgwụ
Biphasic insulin na - agwakọta protinine soluble na prostine na crystalline na pasent 30 ruo 70%.
Nke a bụ nkwusioru maka sc አስተዳደር, inwe agba ọcha. 1 milliliter nwere 100 nkeji, na otu ED kwekọrọ na 35 μg nke insulin insulin anhydrous.
Ihe anaulin insulin na-eme ka ihe di n’ime ya mejuputara ihe nwere ihe mejuputara insulila cell di n’iru ya. Nke ikpeazụ a na - arụ ọrụ njikọ nke glycogen synthetase, pyruvate kinase na enzymes hexokinase.
Mbelata shuga na-ebilite mgbe ọ na-abawanye n'ụgbọ njem intracellular yana mmelite anụ ahụ dị elu nke glucose. A na - enweta hypoglycemia site na ibelata oge maka ịhapụ glucose site na imeju, glycogenogenesis na mmegharị nke lipogenesis.
A na - enweta ọgwụ insulin Biphsic site na ntule biotechnological mgbe ejiri aspartic acid dochie moleculolo nke promonụ. Insdị insulins ndị dị na biphasic nwere mmetụta yiri nke ahụ na haemoglobin glycosylated, dịkwa insulin nke mmadụ.
Mkpụrụ ọgwụ abụọ ahụ na-arụkwa ọrụ na molar. Agbanyeghị, ọgwụ insulin na-eme ngwa ngwa karịa homonụ mmadụ na-arịa. Ihe protineine nke na -esi mkpu ike na-enwekwa mmetụta dị ogologo oge.
A na - eme ihe mgbe sc sc of the ọgwụ a mechara nkeji iri na ise. Ntinye uche kachasị maka ọgwụ ahụ na-apụta awa 1-4 ka agba ntụtụ ahụ gasịrị. Ogologo oge nke mmetụta ahụ ruru awa 24.
N'ime ọbara, Cmax nke insulin bụ 50% karịa mgbe ị na-eji insulin nke mmadụ na-ahụ ihe. Ọzọkwa, nkezi oge iji rute Cmax erughị ọkara.
T1 / 2 - ruru awa 9, ọ na - egosiputa mmịpụta nke irighiri akwara protamine. A na - ahụta ọkwa insulin kwa ụbọchị 15 ruo 18 ka ọ gbasasịrị.
Mana na oria abuo nke 2, iheoma Cmax di na nkeji iri iteghete. Ọ na - eme ka ọkwa ya erughị 14 na karịa 0 mgbe nchịkwa sc gasịrị. Agaghị agụpụta mpaghara nchịkwa metụtara saịtị ịmịkọrọ.
Usoro onunu ogwu na nhazi
Ọtụtụ mgbe, insulin Degludek, Aspart-insulin na-elekọta subcutaneously. A na-eme ọgwụ mgbochi n'akụkụ ụfọdụ nke ahụ:
- bute;
- Ikwe nkwa
- apata apata
- ubu.
Ikwesiri ime ogwu insulin tupu nri (usoro prandial) ma obu mgbe erichachara (usoro postprandial).
Ọ bụ dibia bekee na-ahụ maka usoro algorithm na usoro onunu ogwu. Mana oge ọgwụ ọ bụla kwa ụbọchị bụ 0-1-1 UNITS kwa kilogram 1 nke ịdị arọ.
N'ọnọdụ ndị siri ike, a na-edozi insulin Aspart biphasic iv. A na-eme usoro ahụ site na iji usoro infusion na outpatient ma ọ bụ inpatient ntọala.
Mmeghachi omume na-emebi emebi, contraindications na ịdoụbiga mmanya ókè
Ojiji nke inspa Asparta nwere ike imetụta ọrụ nke Mgbakọ Mba, ebe ọ bụ na usoro iwu shuga na-ahazi ngwa ngwa na-akpata neuropathy mgbu mgbe ụfọdụ. Ma, ọnọdụ a gafere oge.
Ọzọkwa, insulin biphasic na-eduga n'ọdịdị nke lipodystrophy na mpaghara injection. N’akụkụ akụkụ anụ ahụ nke anụ ahụ, a na-ahụ erughị anya na arụ ọrụ na ntụgharị.
Contraindications bụ ekweghị ibe nọrọ nke ọgwụ na hypoglycemia.
Na mgbakwunye, iji insulin Aspart achọghị ihe ruo afọ 18. Ebe ọ bụ na enweghị data ụlọ ọgwụ na-akwado ịdị irè na nchekwa nke ọgwụ maka akụkụ ahụ na-apụta.
N'ọnọdụ ịdoụbiga mmanya ókè, mgbaàmà ndị a na-apụta:
- ogwe
- mbelata nke ọma na glucose;
- hypoglycemic coma na ọrịa shuga.
Anwe obere oke nke ịba ụba iji mee ka ịkwanye glucose dị ọcha, o zuru ezu iji carbohydrates ngwa ngwa ma ọ bụ drinkụọ mmanya dị ụtọ. You nwere ike tinye uzo glucagon ma obu intramuscularly ma obu uzo ihe dextrose (iv).
N'ihe banyere klaasị hypoglycemic coma, site na 20 ruo 100 ml nke dextrose (40%) na-agbanye n'ụzọ nke jet-intravenous ruo mgbe ọnọdụ onye ọrịa na-ahazi. Iji gbochie mmepe nke ụdị ndị a, a na-atụ aro iri nri na-egbu carbohydrate.
Mmekọrịta na ọgwụ ndị ọzọ na ntuziaka pụrụ iche
Enwere ike ịbawanye hypoglycemic ma ọ bụrụ na ejikọtara insulin nke biphasic yana nchịkwa ọnụ nke ọgwụ ndị a:
- mmanya na-egbu egbu na ọgwụ hypoglycemic;
- MAO / carbonic anhydrase / ACE inhibitors;
- Fenfluramine;
- Bromocriptine;
- Cyclophosphamide;
- somatostatin analogues;
- Theophylline;
- Sulfonamides;
- Pyridoxine;
- Anabolic steroid.
Ojiji nke tetracyclines, Mebendazole, Dizopyramide, Ketonazole, Fluoxetine na Fibrates na-eduga na mbelata dị ukwuu na shuga. Na tricyclic antidepressants, ọgwụ mgbochi, nke nicotine, sympathomimetics, glucocorticosteroids, thiazide diuretics, homonụ thyroid na ọgwụ ndị ọzọ na-eso eme ka ike gwụ hypoglycemic mmetụta.
Drugsfọdụ ọgwụ nwere ike ịba ma belata ọkwa shuga. Ihe ndị a gụnyere nkwadebe lithium, beta-mgbochi, salicylates, clonidine na reserpine.
Ọ dị mma ịmara na ekwesịrị ịchekwa Flekspen na ime ụlọ okpomọkụ, yana mkpịsị ọrịre ọhụrụ na friji. Tupu nhazi, ihe dị na vial ahụ dị mkpa ka agwakọta.
Site na ịba ụba nke mmega ahụ, mkpali ma ọ bụ ọrịa na-efe efe, ọ dị mkpa ịbawanye elu nke usoro insulin. Na mmalite ọgwụ, a naghị atụ aro ya ijikwa usoro na ụgbọ ala dị mgbagwoju anya. Vidiyo dị n'isiokwu a ga - ekwu banyere hormone ahụ ọzọ.
