Insulin bụ isi homonụ nke na-eme ka ikelata shuga ma ọ bụ ọrụ maka ibunye glucose na sel niile dị na ahụ. Ọzọkwa, ọrụ nke homonụ ahụ bụ ịkwalite njikọ nke protein, abụba na ime ka ọ bụrụ na amino acid, potassium, magnesium, phosphorus na ihe ndị ọzọ dị n'ọbara.
Ọ bụrụ na pancreas, nke ga - eme ka ọ mepụta insulin, emebiela, mgbe ahụ ahụ ga - akwụsị inweta nri. N'ihi ya, ọkwa insulin na-ebelata, ọkwa glucose n’ọbara, n’ụzọ megidere, na-abawanye. Agbanyeghị, ụdị shuga dị ukwuu a anaghị eji ya maka ebumnuche ya, n'ihi nke ahụ na-ahụ agụụ maka agụụ mkpụrụ ndụ ya na-amalite ịnwụ.
Nke a bụ otú ọrịa shuga si amalite. Na mbu, ndi mmadu nwere oria di otu ebe adi ebe a, ma ugbua, site na mmepe nke ndi sayensi na ndi dibia, ha nwere ohere iji dozie ebe obibi ha site na enyemaka nke insulin.
Nkwadebe insulin bụ bolus na basal. Ejiri ndị nke mbụ kwụọ ụgwọ maka ọnọdụ ahụ mgbe ha risịrị nri, nke ikpeazụ ezubere maka nkwado nke anụ ahụ. Otu n'ime ọgwụ kachasị mma na otu a bụ insulin Bazal.
Insulin Bazal: njirimara bu isi
Nke a bụ ọgwụ hypoglycemic ejiri maka ụdị ọrịa shuga na-adabere insulin. Akụkụ ike nke ọgwụ ahụ bụ insulin mmadụ.
Ọgwụ bụ nkwusioru ọcha maka nchịkwa subcutaneous. Ọ bụ nke otu nke insulins na analogues ha, nke nwere mmetụta zuru oke.
Insulin Insuman Bazal GT na-eme nwayọ, mana nsonaazụ mgbe nchịkwa gachara were ogologo oge. A na-enweta ntughari kachasị elu kachasị elu awa 3-4 mgbe a gbasịrị ya ma na-eru awa 20.
Thekpụrụ nke ọgwụ dị ka ndị a:
- na - agbada glycogenolysis na glyconeogenesis;
- na-ebelata mkpụkọ glucose n'ọbara, na-ebelata mmetụta catabolic, na-enye aka na mmeghachi nke anabolic;
- na-egbochi lipolysis;
- na-akpali guzobe glycogen na akwara, imeju ma na-ebufe glucose n'etiti mkpụrụ ndụ;
- na-akwalite nsị nke potassium na mkpụrụ ndụ;
- na-eme ka njikọ protein na usoro nke ibuga amino acid na sel;
- na-eme ka lipogenesis na akwara na anụ ahụ adipose;
- na-akwalite itinye n'ọrụ nke pyruvate.
N’ime ndị ahụ gbasiri ike, ọkara ndụ ọgwụ a n’ọbara na-ewe nkeji anọ ruo isii. Ma na ọrịa ọrịa akụrụ, oge na-abawanye, mana nke a anaghị emetụta mmetụta metabolic nke ọgwụ.
Ntuziaka maka iji ọgwụ ahụ
Naanị dibịa na-aga ahụ kwesịrị ịhọrọ usoro ọgwụgwọ insulin na-adabere n'ụkpụrụ ndụ, ọrụ na nri onye ọrịa. Ọzọkwa, a na-agbakọ ọnụego ahụ na-adabere n'ihe ngosipụta nke glycemia egosi na steeti metabolism metabolism.
Ogologo ubochi ubochi sitere na 0,5 ruo 1.0 IU / kwa 1 n'arọ nke ịdị arọ. N'okwu a, a na-enye 40-60% nke dose maka insulin ogologo oge.
Ọ dị mma rịba ama na mgbe ị na-agbanwe site na insulin anụmanụ na nke mmadụ, enwere ike ịbelata usoro onunu ogwu. Ma ọ bụrụ na agbanwee ụdị ọgwụ ndị ọzọ, mgbe ahụ nlekọta ahụike dị mkpa. Ekwesịrị ilebara anya na-achọpụta metabolism metabolism na mkpụrụ ụbọchị iri na anọ mbụ tupu mgbanwe a.
A na - edozi insulin Bazal n'okpuru anụahụ na nkeji 45-60. tupu nri, ma mgbe ụfọdụ a na-enye onye ọrịa ahụ ọgwụ mgbochi intramuscular. Ọ dị mma ịmara na oge ọ bụla a ga-ewebata ntụtụ mgbopụ ga-agbanwe.
Onye ọ bụla na-arịa ọrịa shuga kwesịrị ịma na anaghị eji insulin eme ihe maka nfuli insulin, gụnyere ndị nke etinyere. N'okwu a, a na-egbochi nchịkwa ọchịchị nke ọgwụ.
Na mgbakwunye, ọgwụ ahụ agaghị agwakọta ya na insulins nwere ntinye dị iche (dịka ọmụmaatụ, 100 IU / ml na 40 IU / ml), ọgwụ ndị ọzọ na insulins anụmanụ. Nweta Basal Insulin na vial ahụ bụ 40 IU / ml, yabụ ịkwesịrị iji sirinji plastik nke emebere maka ịba ụba nke hormone a. Ọzọkwa, sirinji ekwesịghị ịnwe okpukpu nke insulin nke gara aga ma ọ bụ ọgwụ ọzọ.
Tupu nmalite nke mbu si na vial ahụ, ọ dị mkpa imepe nkwakọ ngwaahịa ahụ site na iwepu okpu plastik na ya. Mana nke mbu, nkwusioru kwesiri ka eweghari ntakịrị ka o we buru mmiri ọcha site n’iru otu.
Ọ bụrụ na mgbe ị shaụchara ọgwụ ahụ emeela ka ọ dị ọcha ma ọ bụ ogwe ma ọ bụ ogwugwo pụtara na mmiri mmiri, a gaghị atụ aro ọgwụ ahụ. N'okwu a, ọ dị mkpa iji mepee karama ọzọ ga-emezu ihe niile a dị n’elu.
Tupu ịnakọta insulin na ngwugwu ahụ, a na-ewebata obere ikuku n'ime sirinji, wee tinye ya na vial ahụ. Mgbe ahụ, a na-eji sirinji gbanye ngwugwu ahụ yana obere olu nke ihe ngwọta na-anakọta.
Tupu ịgba ọgwụ mgbochi, a gha ahapụ ikuku wepụrụ ya. Atherchịkọta mpempe site n’akpụkpọ ahụ, agbanye agịga na ya, mgbe ahụ, a ga-eji nwayọ dozie ihe ngwọta. Mgbe nke ahụ gasịrị, a na-ewepụ mkpịsị ahụ anya na akpụkpọ ahụ wee na-agbanye owu na-abanye na mudị ruo ọtụtụ sekọnd.
Nyocha nke ọtụtụ ndị na-arịa ọrịa shuga na-eme ka eziokwu ahụ bụ na sirinji insulin bụ nhọrọ dị ọnụ ala, mana ọ ka njọ iji ha. Taa, iji mee ka usoro a dị mfe, a na-eji pen sirinji pụrụ iche. Nke a bụ ngwaọrụ nnyefe insulin nke nwere ike ịdịru afọ 3.
A na-eji pen sirinji gluu mee ihe dị ka ndị a:
- Ikwesiri imeghe ngwaọrụ a, jigide akụkụ ya na arụ ọrụ ma dọpụta okpu n'akụkụ.
- Ejidere ihe nkwakọ ngwaahịa ahụ site na ngwa ọrụ.
- A na-etinye katọn ahụ n'ime ihe njide, nke na-acha uhie uhie (n'ụzọ niile) n'akụkụ akụkụ ahụ.
- Tupu iwebata ihe nra n’okpuru anụ ahụ, mkpịsị sirinji kwesịrị ka ọ dị ọkụ karịa n'ọbụ aka.
- A na-ewepụ akpịrịkpa dị na mpụta n'ime agịga.
- Maka kadi ohuru, otu uzo nha bu 4 ano; iji wunye ya, ikwesiri idetu mbido mbido ma bugharia ya.
- A na-etinye agịga (4-8 ml) nke mkpụrụ sirinji n’akpụkpọ ahụ n’akpụkpọ ahụ, ọ bụrụ n’ogologo ya dị 10-12 mm, mgbe ahụ, agbanye agịga n’akụkụ ogo 45.
- Na-esote, jiri nwayọ pịa bọtịnụ mbido nke ngwaọrụ ma tinye nkwusioru ahụ ruo mgbe pịa pụtara, na-egosi na akara ngosi ahụ agbadala na efu.
- Mgbe nke ahụ gasị, chere 10 sekọnd wee dọpụta agịga n’akpụkpọ ahụ.
A ga-ederịrị ụbọchị nke mbido izizi ihe ọ bụla na aha ngwungwu. Ọ dị mma ịmara na mgbe ịmepe nkwusioru ahụ enwere ike ịchekwa ya n ’ọnọdụ okpomọkụ karịa ogo 25 maka ụbọchị 21 n’ebe gbara ọchịchịrị ma dị jụụ.
Nsonaazụ, contraindications, ịdoụbiga mmanya ókè
Insuman Bazal GT enweghi otutu contraindications na mmeghachi omume ojoo. Mgbe ụfọdụ, ọ na-agbadata enweghị ndidi. N'okwu a, mkpịsị mkpịsị nke Quincke, mkpụmkpụ ume nwere ike ịmalite, etuto ahụ na-apụta na anụ ahụ yana oge ụfọdụ iwe na-egbu mgbu.
Nsonaazụ ndị ọzọ na-abụkarị site na ọgwụgwọ na-ezighi ezi, na-agbasoghị ndụmọdụ ọgwụ ma ọ bụ insulin na-amaghị. N'ọnọdụ ndị a, onye ọrịa na-enwekarị hypoglycemia, nke nwere ike ịbịara ya na malfunctions nke NS, migraines, dizzness na ọrịa shuga na isi ọhụụ, ọhụụ, amaghị ihe na ọbụna coma.
Ọzọkwa, nyocha nke ndị na-arịa ọrịa shuga na-ekwu na iji obere ala, nri na-adịghị mma ma na-awụpụ ntụtụ, hyperglycemia na ọrịa shuga acidosis nwere ike ime. Ọnọdụ ndị a bụ mmiri, ụra, agụụ, nkụ, agụụ.
Na mgbakwunye, akpụkpọ ahụ na ntụtụ ahụ nwere ike ịkpụ ọfụma, mgbe ụfọdụ ọ na-eme ọnya na ya. Na mgbakwunye, mmụba na titing nke ọgwụ mgbochi insulin ga-ekwe omume, n'ihi na nke hyperglycemia nwere ike ịmalite. Patientsfọdụ ndị ọrịa na-enweta mmeghachi omume immunological na mmiri nwere homonụ na-arụ ọrụ.
Ọ bụrụ na ịulinụ insulin karịrị akarị, hypoglycemia nke nsogbu dịgasị iche iche nwere ike ịmalite. Site n'ụdị dị nro, mgbe onye ọrịa maara, ọ kwesịrị ị drinkụ mmanya dị ụtọ ngwa ngwa ma ọ bụ rie ngwaahịa nwere carbohydrate. N'ihe banyere mmụọ ịmara, a na-etinye 1 mg nke glucagon intramuscularly, ya na arụmọrụ ya na-eji mmiri glucose (30-50%).
Site na hypoglycemia dị ogologo ma ọ bụ nke siri ike, mgbe nchịkwa glucagon ma ọ bụ glucose, na-atụ aro infusion na usoro glucose na-adịghị ike, nke ga-egbochi nlọghachi.
A na-aga ụlọ ọgwụ na-arịa ọrịa siri ike na ngalaba nlekọta ahụ ike iji jiri nlezianya nyochaa ọnọdụ ha.
Ntụziaka pụrụ iche
Ekwesighi iji otutu ogwu eme ihe insulin Bazal. Ndị a gụnyere ọgwụ nwere mmetụta hypoglycemic, IAFs, obeypyramids, pentoxifylline, mimonoamine oxidase inhibitors, fluoxetine, fibrates, propoxyphene, homonụ mmekọahụ, anabolics na salicylates. Ọzọkwa, ekwesighi ijikọ insulin basal na Phentolamine, Cybenzoline, Ifosfamide, Guanethidine, Somatostatin, Fenfluramine, Phenoxybenzamine, Cyclophosphamide, Trophosphamide, Fenfluramine, sulfonamides, Tritokvalin, tetracyclines,
Ọ bụrụ na iji insulin emekọ ọnụ yana Isoniazid, ihe ndị Phenothiazine, Somatotropin, Corticotropin, Danazole, progestogens, glucocorticosteroids, Diazoxide, Glucagon, diuretics, estrogen, Isoniazid na ọgwụ ndị ọzọ nwere ike belata ike nke insulin. A na-arụ ọrụ yiri nke ahụ site na nnu lithium, clonidine na beta-blockers.
Njikọ ya na ethanol na-eme ka ike gwụ hypoglycemic mmetụta. Mgbe ejikọtara ya na Pentamidine, hypoglycemia nwere ike ịmalite, nke na-aghọ hyperglycemia mgbe ụfọdụ. Ọ bụrụ na ijikọtara ojiji nke insulin na ọgwụ ọmịiko, mgbe ahụ ịda mba ma ọ bụ enweghị nkwụsi ike nke NS nwere ọmịiko.
A na-ahọrọ usoro ọgwụgwọ usoro maka ụfọdụ ndị ọrịa n'otu n'otu. Yabụ, na ndị ọrịa shuga na ndị agadi nwere ọrịa ịba ọcha n'anya, akụrụ, ọdịda oge, mkpa insulin na-ebelata. Ma ọ bụrụ na ahọrọghị ọgwụ ahụ n'ụzọ ziri ezi, mgbe ahụ ndị ọrịa dị otú ahụ nwere ike ịmalite hypoglycemia.
Ọ dị mma ịmara na na stenosis nke akụkụ ụbụrụ ma ọ bụ akwara ụbụrụ na retinopathy na-aba ụba (n'ihe gbasara ikpughe laser), ọ dị mkpa iji nlezianya nyochaa ọkwa nke glycemia. Ebe ọ bụ na, n'ọnọdụ ndị a, mbelata nke ọma nke glucose na-akpata pụrụ iduga n’inwe ọhụhụ kpamkpam.
N'oge afọ ime, a ga-aga n'ihu ịgwọ ọrịa Insuman Bazaol GT. Ọ dị mma icheta na mgbe ọnwa mbụ gachara, mkpa insulin ga-abawanye. Ma mgbe amuchara umu, mkpa ya, karie, ga - agbada, nke mere na hypoglycemia na oria mamellitus nwere ike puta ma a gha acho imezi insulin.
N'ime oge ịra ahụ, ekwesịrị ịga n'ihu na ọgwụgwọ insulin. Mana n'ọnọdụ ụfọdụ, nri na ịhazigharị ọgwụ nwere ike ịdị mkpa.
Ọnụ ahịa insulin Bazal sitere na 1228 ruo 1600 rubles. Ọnụ ego nke mkpụrụ sirinji dị iche site na 1000 ruo 38 000 rubles.
Vidio dị n’isiokwu a na-egosi otu esi abanye insulin n'ụzọ kwesịrị ekwesị.
