Maka ọgwụgwọ ọbara mgbali elu, a na-eji ngwakọta ọgwụ nke otu dị iche iche. Lozarel gbakwunyere bụ ọgwụ na-agwakọta ihe abụọ na-ebelata ọbara mgbali elu ma jikọtara ibe ha.
International Nonproprietary Aha
Hydrochlorothiazide + losartan.
ATX
C09DA01.
Lozarel gbakwunyere bụ ọgwụ na-agwakọta ihe abụọ na-ebelata ọbara mgbali elu ma jikọtara ibe ha.
Ha weputara udi ya na ihe mebere ya
Nhazi mbadamba ihe nkiri eji eme ihe na-agbaze ma ọ bụrụ na ekpughere ya na enzymes eriri afọ. Ihe ndị dị n’ime ha nwere mmetụta:
- Hydrochlorothiazide - 12.5 mg. Thiazide diuretic.
- Losartan - 50 mg. Angiotensin Receptor Antagonist 2.
Ihe ndi ozo n'ime ihe mejuputara enweghi mmetụta di ndu, bu ndi edobere mbadamba.
Omume ọgwụ
Njirimara nke akụkụ ọ bụla na-ekpebi usoro eji arụ ọrụ. Hydrochlorothiazide na-akụghasị nnabata nke sodium, potassium, ion chlorine n'akụkụ akụkụ nke nephrons n'ime akụrụ. A na-etinye ihe ndị a na - arụ ọrụ na - arụ ọrụ ma na - ewepụ oke mmiri. Ntughari uto na-abawanye.
Nsonaazụ nke a bụ mbelata olu olu plasma n’ọbara. Ọrụ nke homonụ renin na-abawanye ngwa ngwa. A na-etinyere ya na ngwa juxtaglomerular nke akụrụ. Mgbe ahapụchara ya n'ime ọbara, renin na-akpali eriri afọ nke adrenal ma na-eme ka mkpụrụ ndụ nke aldosterone dịkwuo elu. Ọ nwere ike ịdọrọ sodium akụkụ ụfọdụ, mana ịbawanye excretion potassium. Homonụ ahụ na-akwalite ịnyefe sodium n'ime ohere ahụ, na-eme ka anụ ahụ hydrophilicity dịkwuo elu, na-agbanwe steeti acid-base n'akụkụ akụkụ alkaline.
Mbelata ọbara mgbali n'okpuru ọrụ hydrochlorothiazide na-apụta n'ihi mbelata olu olu.
Mbelata ọbara mgbali n'okpuru ọrụ hydrochlorothiazide na-apụta n'ihi mbelata olu olu, usoro mmeghachi omume nke mgbidi arịa yana mbelata nke adrenaline na norepinephrine na ya, nke na-enye aka na spasm na warara nke lumen nke arịa. Site n'ọbara ọbara nkịtị, nsonaazụ nke ọgwụ ahụ anaghị etolite.
Ọ na - eme ka mmiri dị n’erụ ahụ dịkwuo elu ruo 1-2 awa mgbe a theụsịrị ọgwụ ahụ, nsonaazụ kachasị na - amalite mgbe awa anọ gachara. Mmetụta ahụ na-adị n’ọrịa ahụ ruo awa iri na abụọ.
Ihe losartan potassium mejuputara diuretic ahu. Ọ na-ahọrọ n'ụzọ dị mma n'ebe ndị na-anabata angiotensin, nke dị na arịa, gland adrenal, akụrụ, na obi. Ọgwụ ahụ na-egbochi mmetụta nke angiotensin 2, mana anaghị akwalite bradykinin. Ọ bụ protein nke na - atọpụ arịa ọbara. Ya mere, losartan enweghi mmeghachi omume ojoo jikọtara ya na peptide a.
Mmụba na mmetụta antihypertensive na-apụta na mmụba na dose nke ọgwụ. Ihe omume a bu:
- nguzogide akpụ akpụ akpụ akpụ belata;
- ọbara mgbali nkịtị;
- aldosterone n'ime ọbara anaghị eto karịa nke nkịtị;
- na akụkụ akwara na-ebelata nrụgide;
- mbelata nke itu obi n’iru;
- mmụba mmamịrị.
N'ime ọrịa obi na-adịghị ala ala, nke na-eduga na enweghị ọrụ, na-eme ka iguzogide mmega ahụ.
N'ime ọrịa obi na-adịghị ala ala, nke na-eduga na enweghị ọrụ, na-eme ka iguzogide mmega ahụ. Ọ na - egbochi akwara obi site na eriri ọbara.
A na-emetụta elektriiki akwara onwe. Ntinye nke norepinephrine n'okpuru ọgwụ ahụ agbanweghị.
Mgbe ị drinkingụsịrị ọgwụ ahụ, nrụgide ahụ na-ada mgbe awa 6 gachara, ma mgbe ahụ, mmetụta hypotensive ji nwayọọ nwayọọ belata. A na-enweta mbelata na-aga n’ihu mgbe izu 3-6 nke ọgwụ oge niile.
Na nyocha nke ulo ogwu, emere gosiputara na ịkwụsị ya losartan adighi eme ka ihe mgbaàmà nke ọghighachi ya na ndi ozo. Ọ na-enyere ndị ọrịa aka n’otu afọ na nwoke na nwanyị.
Mlọ ọgwụ
Mwepu onwe ya na usoro nke losartan na - eme ngwa ngwa na zuru oke. Mgbe ọ gafesịrị umeji, a na-enweta metabolite nọ n'ọrụ n'okpuru enzyme nke sistemụ cytochrome. Nri anaghị emetụta bioavailability, nke bụ 33%. Mgbe otu elekere gasịrị, ntinye uche nke ihe bidoro na-akacha, mgbe awa 3-4 gachara, ọnụego metabolite nọ n'ọrụ na-erute karịa.
Orhapụ hydrochlorothiazide site na eriri afọ bụ naanị na 80%.
Ihe mgbochi ụbụrụ-ọbara anaghị ebufe losartan gaa na sel ụbụrụ. 100 mg ọgwụ a na-a onceụ otu ugboro n’ụbọchị anaghị agbakọ na plasma. Otutu ya na ahihia kpochapu.
Orhapụ hydrochlorothiazide site na eriri afọ bụ naanị na 80%. Mkpụrụ ndụ ịba ọcha ọkụ anaghị emeju ihe a, ya mere akụrụ na-egosipụta ya na ọnọdụ anaghị agbanwe agbanwe. Ọkara ọkara bụ awa 6-8. N'ihe banyere imebi ọrụ nke usoro ịtụ ụjọ, oge a nwere ike iru ihe ruru awa iri abụọ.
Ihe ngosi maka ojiji
Edere ya maka ọgwụgwọ nke ọbara mgbali elu ma ọ bụrụ na enwere ihe ngosi maka ojiji nke ndị na-ejikọ ọnụ.
Ihe ngbanwe
Akpachapụ anya na ihe ndị mejupụtara ya na ihe ndị dị na sulfonamide na-eme ka ọgwụgwọ ghara ikwe omume. Ejila ihe banyere arụ ọrụ na-arụ ọrụ imebi, nke ekenyechara 9 isi ma ọ bụ karịa na Child-Pugh scale. Mgbe mwepu nke creatinine erughị 30 ml / min, soro ọrịa gbasara akwara, ejikwala ya.
Somatic ọrịa nke ojiji nke ọgwụ na contraindicated:
- nnukwu ọgbụgba ọbara ike;
- ọrịa mellitus na-achịkwa nchịkwa;
- Ọrịa Addison;
- gout
- ọrịa malabsorption;
- ụkọ lactase.
Na mmebi nke mmiri-electrolyte nguzozi na Mbelata nke potassium, sodium, mmụba nke calcium, yana hyperuricemia, ojiji nke ọgwụ a contraindicated. Ọ ga - eme ka enweghị mmezi nke ion dị ugbu a dịkwuo elu. Ọ bụrụ na ejiri ọgwụ ndị ọzọ mere ka akpịrị ịkpọ nkụ, mgbe ahụ, a ga-eweghachite mmiri mmiri, amachibidoro ịgwọ ya na nchikota a.
Na anuria, a gaghị enwe ike iji ọgwụ na-eme ihe ruo mgbe a ga-ewepụ ihe kpatara njide.
Jiri nlezianya
Nmebi nke nguzozi nke electrolytes nwere afọ ọsịsa ma ọ bụ vomiting chọrọ iji nlezianya na-eme ihe n’onwe ya dịka njiri egosi. N'okpuru nlekọta ahụike siri ike, a na-eji ya na ọnọdụ ndị a:
- stenosis nke akụrụ
- ụkwara ume ọkụ;
- mmeghachi omume nfụkasị ahụ ugboro ugboro;
- pathology nke anụ ahụ na - ejikọta;
- arrhythmias nke na-egbu egbu;
- akwara obi;
- aortic stenosis;
- hypertrophic cardiomyopathy;
- imebi ọbara nye ụbụrụ;
- mgbe akachasị akụrụ.
Mmechi emechi-emechi na myopia na-emebiwanye ụzọ ha n'okpuru ọrụ hydrochlorothiazide.
Etu esi ewere losarel gbakwunye?
Na mbido, mgbe ahụ, iji nọgide na-enwe ọgwụgwọ ọgwụgwọ, a na-edenye mbadamba 1 kwa ụbọchị, n'agbanyeghị nri. Ma ọ bụrụ na ịnọgidesi ike na hypotensive adịghị etolite n'ime izu 3-4, a na-abawanye usoro ibulite ya abụọ PC. (25 na 100 mg nke ihe eji arụ ọrụ).
Na mbido, mgbe ahụ, iji nọgide na-enwe ọgwụgwọ ọgwụgwọ, a na-edenye mbadamba 1 kwa ụbọchị, n'agbanyeghị nri.
Na-arịa ọrịa shuga
Onye endocrinologist kwesịrị inyocha ma hazie ọgwụ insulin maka ọrịa shuga 1. Ọgwụ nwere ike ibute hyperglycemia, ọdịdị nke glucose na mmamịrị. Aliskiren ma ọ bụ ọgwụ ndị sitere na ya na-emetụta ụzọ nke ọrịa shuga mgbe ejiri ya na onye na-ejikọta ya.
Nsonaazụ Lozarel gbakwunyere
N'ime nyocha nke ụlọ ọgwụ nke njikọta nke hydrochlorothiazide na losartan, ọ nweghị ihe ọjọọ a hụrụ ka ejiri ihe 2 mee ihe. Ha na-egosi naanị n’ụdị nke njiri ọgwụ ọ bụla n’otu n’otu.
Ọkpụkpụ afọ
Ọrịa dyspeptik, ọgbụgbọ, ọgbụgbọ, mgbu afọ, enwere ike ịhụ. Oge ụfọdụ nkụ na-aputa ihe dika nsonaazụ nke mmiri. Ọrịa ọnya, pancreatitis anaghị ahụkarị.
Ahụhụ Hematopoietic
Hemoglobin, platelet count, hematocrit nwere ike belata obere. Mgbe ụfọdụ enwere mmụba nke eosinophils ọbara. Ọkpụkpụ ọbara na mkpụkọ dị ụkọ.
Mgbe ụfọdụ ị takingụ ọgwụ ahụ nwere ike ibute ọgbụgbọ.
Sistemụ akwara Central
Dizziness, ehighị ụra nke ọma, isi ọwụwa kwere omume. Mgbe ụfọdụ paresthesia, neuropathy akụkụ, tinnitus, ụtọ na ọhụhụ, ọgba aghara.
Site na usoro akwara
Ọ na-enwekarị mgbu na azụ, aka na ụkwụ, ahụ erughị ala na nkwonkwo, belata ume ike.
Site na sistem iku ume
Ughkwara ụta, mkpọchi imi nwere ike ịpụta. Ọkpụkpọ mucous na-abawanye ụba na-eduga n'ịba ụba na ọnụ ọgụgụ nke akụkụ iku ume, sinusitis, laryngitis.
Na anụahụ
N'ime ụfọdụ ndị ọrịa, akpụkpọ ahụ nwere ike ịza hyperhidrosis na mmepe nke eserese. Nwepu mmiri dị ukwuu na-eduga n'ọkpụkpụ epidermis.
N'ime ụfọdụ ndị ọrịa, akpụkpọ ahụ nwere ike ikwu na hyperhidrosis.
Site na usoro mkpụrụ ndụ ihe nketa
Urinchapu mmamiri na-aghọrọ mmeghachi omume ugboro ugboro. Mgbe ụfọdụ ị ga-ebili gaa mposi n’abalị. Ọrịa nke akụkụ akwara mkpụrụ ndụ na-esikarị esonye, ibelata libido na ibelata.
Site na usoro akwara obi
Ikekwe mmepe nke arrhythmias n'ihi enweghị echiche na isi ion. Vasculitis, hyporat orthostatic nwere ike ịpụta.
Ahụhụ
N'okwu nke mmadụ, ọnya akpụkpọ nke ụdị urticaria, itching skin na-apụta. Mmeghachi omume siri ike ma dị ụkọ bụ anaphylaxis, angioedema.
Mmetụta ikike ịchịkwa usoro
Mwepu, mbelata nke mmeghachi omume na nlebara anya nwere ike ịbụ nsonaazụ ebumpụta nke ị theụ ọgwụ. Ya mere, ikwesịrị ịjụ ịnya ụgbọ ala ma jiri ya rụọ ọrụ nke ọma.
Ọ bara uru ịkwụsị ịkwọ ụgbọ ala na ọrụ ọfụma.
Ntụziaka pụrụ iche
Ndị ọrịa nke agbụrụ Negroid na-anabata ọgwụ na-adịghị mma. O nwere arụ ọrụ dị ala na-arụ ọrụ na usoro mmepe nke ọbara mgbali elu, nke na-eme na mkpụmkpụ nke renin.
Jiri n'oge ime na lactation
Igosiputa n’ime usoro renin-angiotensin-aldosterone nwere ike bute oke arụ nke nwa ebu n’afọ nke abụọ na nke atọ wee kpatara ọnwụ intrauterine. Ya mere, mgbe ịtọsịrị eziokwu banyere ịtụrụ ime, a na-atụ aro ka iji dochie ọgwụ ahụ.
Thiazide diuretics nwere ike ịbanye n'ọbara nwa ebu n’afọ ma nwee ike ibute n’azụ jaarice ma ọ bụ mee ka ahụike hyperbilirubinemia nke amụba amụba. N'ime ụmụ nwanyị dị ime, ha nwere ike ibute thrombocytopenia, nke nwere ike ibute hypocoagulation na ọbara ọgbụgba. Mgbe ị na-enye nwa ara, a machibidoro ọgwụ a iwu.
Lozarel agba na gbakwunye ụmụaka
Achọpụtaghị ọgwụ n'ime ụmụaka n'ihi enweghị nyocha ụlọ ọgwụ yana ozi nchekwa na nwata.
Mgbe o mechara ntọala nke afọ ime, a na-atụ aro ka iji dochie ọgwụ ahụ.
Jiri na agadi
Maka ndị ọrịa karịrị afọ 60, ọgwụ adịghị contraindicated. Ọ dị mkpa iburu n'uche ọnụnọ nke ọrịa obi na ọrịa ndị ọzọ nke a ga-egbochi ọgwụgwọ. N'ọnọdụ na-eju afọ, usoro ọgwụgwọ ahụ anaghị agbanwe agbanwe.
Ngwa maka ọrụ ezughi oke ọrụ
Ọdịda akwara na-adịghị agafe agafe, ọchọghị ngbanwe nke dose, ọbụlagodi ma ọ bụrụ na onye ọrịa ahụ nọ n'ọrịa ahụ.
Jiri maka ọrụ imeju na-arụ ọrụ
Ejighi ya maka ezughi oke ike, n'ọnọdụ ndị ọzọ - na-elezi anya.
Ngwakọta riri ọnụ nke lasarel gbakwunyere
Ọ bụrụ na ị gafere ogo a tụrụ aro gị, ike ndọda akpọpụtara. Mmụba electrolytes na-abawanye nwere ike iduga mmepe nke arrhythmias, ọdịdị nke tachy- ma ọ bụ bradycardia.
Mmụba nke electrolytes nwere ike iduga mmepe nke arrhythmias.
Ọ nweghị ọgwụ mgbochi. A na-eme ọgwụgwọ dabere na mgbaàmà ahụ.
Mmekọrịta na ọgwụ ndị ọzọ
N'iji Aspirin na usoro ndị ọzọ n'otu oge a, a na-ebelata nsonaazụ na nrụgide na diuresis. Mmetụta nsí yana akụrụ na-agbatịkwu, ọ nwere ike mebie ọrụ ha.
Emebila mkpochasị nke akụrụngwa lithium, yabụ, ọgwụ ndị sitere na ya anaghị ejikọ otu oge.
Pointgba akwụkwọ na diuretic ndị ọzọ na-eduga na ịba ụba diuretic na mmetụta hypotensive. Ọgwụ antidepressants Tricyclic, antipsychotics, barbiturates, narcotic analgesics nwere ike belata nrụgide ruo ebe dị mkpa ma ọ bụ kpatara hyperension orthostatic.
Ọgwụ maka gout mgbe ị na-achọ mgbanwe mgbanwe, n'ihi A na-egbu oge na serum uric acid.
Ndị ọrịa na-eji glycosides cardiac nwere ike ịmalite tachycardia ventricular tachycardia n'ihi enweghị potassium.
Preparationsnwe nri n’odị dị iche iche nwere ike iwelite ihe ọghọm nke ọrịa imeju na-akpata, yabụ mmiri dị mkpa tupu ịmị ha.
Mmanya ndakọrịta
Ethanol nwere ike iwelie mmeghachi omume ojoo na-achọghị, mmetụta na-egbu egbu na imeju na akụrụ.
Analogs
N'ime ụlọ ahịa ọgwụ, a na-ewepụta ọgwụ analogues ndị a:
- Losartan-n;
- Gizaar Forte;
- Lorista ND;
- Lozap gbakwunyere.
Ahịa ọgwụ na-ahapụ okwu
Ọgwụ a na-ezo aka na ọgwụ ndenye ọgwụ.
Enwere m ike ịzụta na ndenye ọgwụ?
Onwe ya, n’enweghi ọgwụ n’aka dọkịta.
Ọnụ ego maka losarel gbakwunyere
Ọnụ ego ahụ sitere na 230 ruo 325 rubles maka mbadamba 30.
Ọnọdụ nchekwa maka ọgwụ
N'ụlọ, ọ dị mkpa idobe ụmụaka ghara iru ụmụaka nwere okpomọkụ ọ bụla dị elu karịa + 25 Celsius.
Bọchị mmebi
N'okpuru ọnọdụ nchekwa, ọ dabara adaba afọ abụọ. Ka oge a gasịrị, amachibido itinye ya n'ọrụ.
Emeputa
A na-emepụta ọgwụ ahụ site na ụlọ ọrụ Sandoz, Slovenia.
Nyocha na Lozarel gbakwunyere
Karina Grigoryevna, 65 afọ, Moscow.
Ọ dịla anya m na-arịa ọrịa ọbara mgbali. Dọkịta tiri ọgwụ a. Anọwo m na-eji ya maka izu abụọ, nrụgide ahụ kwụsiri ike ma ọ dịghị abawanye. Ahụghị m mmeghachi omume ọ bụla, mana mgbe ụfọdụ afọ m na-egbu mgbu.
Alexander Ivanovich, onye gbara afọ 59, St. Petersburg.
Ejiri m mbadamba nkume iche iche ogologo oge, mana agbanwere ya na ọgwụ ngwakọta. Nke a dabara adaba, ịkwesighi icheta ọgwụ m ji na nke m chefuru. Nrụgide ahụ akwụghị ọtọ, ọnweghị nkwanye ọkụ. Mana ụlọ mposi ahụ agaghị agba ọsọ mgbe niile.
Elena, 45 afọ, Bryansk.
Ha nyere nna ya ọgwụ ahụ, mana ọ ghaghị ịjụ ya. Papa m buru ibu, mgbe ụfọdụkwa, ọbara shuga na-ebili. Na imegide usoro ọgwụgwọ, glucose pụtara na mmamịrị. Ya mere, ha gbanyere ọgwụ ọzọ. Aghaghị m ịmalite nri na-enweghị carbohydrate.
