Extentsef bụ ọgwụ mgbochi dị irè site na otu nke cephalosporins, nke a na-eji maka ọnụ ọgụgụ buru ibu nke ọrịa na-efe efe. Site na nchịkwa intramuscular kwesịrị ekwesị, ọ nweghị mmetụta yana ọ na-eso na mgbake ngwa ngwa.
International Nonproprietary Aha
Oge ememe.
ATX
Koodu dika ATX bu J01DE01. Ekepụtara ya dị ka IV ọgbọ cephalosporin.
Produdị mmepụta: uzuzu maka parenteral.
Ha weputara udi ya na ihe mebere ya
Produdị mmepụta: uzuzu maka parenteral. A na-etinye ya n'ime karama nwere 500 ma ọ bụ 1000 mg nke cefepime hydrochloride.
Omume ọgwụ
Ihe ahụ nwere mmetụta dị iche na ụmụ nje. O nwere ọrụ maka ụmụ anụmanụ dị otú a:
- Staphylococcus spp., Gụnyere ọtụtụ ụmụ nje na-etolite ma ọ bụ na-etolite penisiliniase;
- ọnụ ọgụgụ dị ukwuu nke streptococci, Corynebacterium diphtheriae;
- Mkpụrụ ndụ ihe na-adịghị mma Escherichia coli, Salmonella spp., Shigella spp., Proteus mirabilis, Klebsiella spp., Haemophilus influenzae, Enterobacter aerogenes, Neisseria gonorrhoeae.
Protedị protein na-apụtaghị ìhè (P morgani, P. vulgaris, P. rettgeri) anaghị emetụta ọgwụ nje. Cefazolin anaghị eme ihe na rickettsia, virus, fungi na protozoa. Ọ na-egbochi ike ịghasa mgbidi akụkụ nke nje.
Mlọ ọgwụ
Emere ọgwụ a naanị maka ịbanye n’akpụ anụ ahụ yana n’ime akwara. Enweghị ike iji ya kwuo okwu. Mgbe ịgba ọgwụ ahụ gasịrị, ọgwụ ahụ na-abanye ọbara nke ọma ma nwee ike itinye uche ya kachasị n'ime nkeji 60. A na-echekwa nsonaazụ ahụ n'ime awa 8-12. Ya mere, anaghị atụ aro injections ugboro ugboro: ọbụlagodi n'ọnọdụ dị oke njọ, a na-atụ aro ka ịnye ọgwụ ahụ kwa elekere asatọ.
A na - ezube Extentsef naanị maka itinye ya na akwara anụ ahụ yana akwara; a gaghị enwe ike iji ya ọnụ.
Cefazolin na-agafe ihe mgbochi site na oghere dị n'ime akpa nwa yana ọbara eriri nwa. A na - achọta ya n’ime mmiri ara ara n’iru nke ala.
Ọ na-abanye n'ụzọ zuru oke site na n'ọnụ ahụ gaa na nkwonkwo nke ọrịa nwere nkwonkwo.
Nlekọta ọgbụgba ọbara na-enye ngwa ngwa ngwa ngwa yana ọdịnaya dị elu nke ọgwụgwọ ahụ na ọbara. Mana na nke a, ngwaọrụ nwere ogologo ndụ ogologo - naanị awa 2-2.5.
Ihe ngosi maka ojiji
E gosipụtara ọgwụ ahụ maka ọgwụgwọ nke:
- ofufe ọrịa nke ala akụkụ okuku ume na - bronchitis na exacerbation nke bronchitis na-adịghị ala ala, oyi baa;
- ọrịa na - efe efe nke akụkụ ahụ - pyelonephritis, cystitis, urethritis;
- akpụkpọ anụ ahụ na anụ ahụ;
- prostatitis;
- ọrịa nke eriri afọ - peritonitis, ọnya nke ọnya biliary;
- ọrịa gynecological;
- ọrịa mkpụrụ akụ;
- ọrịa nje meningitis.
E gosipụtara ọgwụ ahụ maka ọgwụgwọ nke ọrịa nke obere akụkụ okuku ume na - bronchitis na njọ nke bronchitis na-adịghị ala ala, oyi baa.
A na-ejikwa ha maka ịgwọ ọrịa neutropenia.
Ihe ngbanwe
Amachibidoro ị antiụ ọgwụ nje bacteria na klas cephalosporin na ịba ha n'ahụ, ịtụrụ ime.
Jiri nlezianya
Kpachara anya dị mkpa iji nye ọgwụ maka ọrịa gbasara akụrụ, akụkọ akụrụngwa nke akwara afọ.
Uzo esi ewere Extentsef
A na-enye ọgwụ ahụ intramuscularly na intravenously (n'ime jet na dropper). Maka ntinye n'ime akwara anụ ahụ, a na-agwakọta ihe mejupụtara vial ahụ na milimita 2 ma ọ bụ 4 nke lidocaine. Mgbe ahụ, a na-agbanye ngwakọta a kwadebere abanye n’ime akwara.
Maka nchịkwa intraven, a na-eji ọgwụ isotonic, ọgwụ glucose 5% ma ọ bụ mmiri deionized merụọ ọgwụ ahụ. N’ụdị a, ọgwụ a na-eji nwayọ abanye n’akwara. Na nchịkwa ntapu, usoro ahụ dịkarịa ala ọkara elekere.
Amachibidoro ya ịgwakọta ọgwụ ahụ na ọgwụ ndị ọzọ na-agwọ ọrịa na sirinji.
Usoro onunu ogwu ogwu di iche dika ndi mmadu:
- na ọrịa nke urinary tract nke nwayọ nwayọ na nfe - 0.5-1 g n’ime akwara ma ọ bụ akwara anụ ahụ kwa awa 12;
- ya na mwakpo nje ndị ọzọ - 1 g n’ime akwara ma ọ bụ intramuscularly kwa awa iri na abụọ;
- na nnukwu oria - 2 g intravenly kwa awa iri na abuo;
- ọnọdụ egwu ndụ - 2 g intravenly kwa elekere asatọ ọ bụla.
Oge ngụkọta oge ọgwụgwọ bụ ụbọchị asaa ruo ụbọchị iri. Ogologo oge ị ofụ ọgwụ ahụ enweghị isi.
A na-eji ọgwụ ahụ eme nkwadebe maka ọrịa na mgbochi nke nsogbu ịmụ nwa. Measurekpụrụ a na-ebelata ohere mmadụ nwere ibute ọrịa mgbe cholecystectomy (mwepụ nke gallbladder) yana oghere hysterectomy. Iji ọgwụ cefazolin na ọgwụ nje ndị a na-ahụkarị na-adịkwa mma n'ọnọdụ ebe njikọta nke nje nje na-eyi ndụ egwu.
A ga-akwụsịkwa ọrụ nlekọta nke Exentsef kpọmkwem otu ụbọchị mgbe ọrụ ahụ gachara. Mgbe prosthetics vaskụla na imeghe obi, a na-enye ọgwụ ahụ maka ụbọchị 3-5.
Amachibidoro ya ịgwakọta ọgwụ ahụ na ọgwụ ndị ọzọ na-agwọ ọrịa na sirinji.
Na-arịa ọrịa shuga
Na ọgwụgwọ ndị ọrịa nwere ọrịa mellitus kwesịrị ilegide glucometer oge niile.
Na ọgwụgwọ ndị ọrịa nwere ọrịa mellitus kwesịrị ilegide glucometer oge niile.
Mmetụta ọghọm nke Extentsef
Enwere ike sonyere nsonaazụ ndị a.
- Site na ngwe nri, ọgbụgbọ, ọgbụgbọ, ọgbụgbọ na-agafeghị oke, ahụ erughị ala n’akpa nwa. Mgbe ụfọdụ ndị ọrịa na-enwe ọrịa colitis na dyspepsia.
- Ikekwe, mmebi nke arụ ọrụ gbasara akwara na akwara ozi, nke a na-egosipụta n'ihe mgbu, obi na-ebukwuwanye ibu.
- A na - egosipụta ọghọm nke akụkụ iku ume na oke iku ume yana mmetụta nke enweghị ikuku. Mgbe ụfọdụ ụkwara siri ike nwere ike inye onye ọrịa ahụ nsogbu.
- A na-egosipụta ngbanwe nke sistemụ akwara ozi na mgbu, isi, olu, ọgbụgba, nsogbu ụra abalị, nkwarụ. Patientsfọdụ ndị ọrịa nwere ike ịna-echegbu onwe ha.
- N'etiti azịza ahụ na-adịghị mma, ihe ndị kachasị ewu ewu bụ: itching, ihe ọkụ ọkụ, ahụ ọkụ, mmeghachi omume anaphylactic.
- Enwere ike imebi ọbara mejupụtara: leukopenia (mbelata ọnụ ọgụgụ sel ọbara ọcha n'ime ọbara), enweghị granulocytes n'ime ọbara, yana mbelata nke agịga platelet. Ikekwe mmepe nke ụdị anaemia dị iche iche, mbelata hematocrit, mmụba na oge prothrombin. Na thrombocytopenia - nsogbu nke ọbara ọgbụgba dị ukwuu.
- Cefazolin nwere ike ibute nsị akụrụ. Ọ na-egosipụta onwe ya na mmụba nke ọnụọgụ nitrogen na urea ọbara. N'okwu ndị na-adịghị ahụkebe, ndị ọrịa mepụtara neuropathy, necrosis nke papillae nke akụrụ, ọdịda akụrụ.
- N'ebe a na-agba ntụtụ, enwere mgbu na mmụba nke ogo anụ ahụ dị nro. Site na nchịkwa intraven, a hụrụ nsogbu nke phlebitis.
Ihe egwu ndi ozo:
- adịghị ike
- ikpu akpukpo aru;
- obi mmụba;
- ọbara ọgbụgba
- candidiasis nwanyị;
- itgenital itching;
- vaginitis.
Superinfection ga-ekwe omume naanị site n'iji ọgwụ nje cephalosporin ruo ogologo oge.
Mmetụta ikike ịchịkwa usoro
Ebe ọgwụ a nwere ike ibute ọgbụgbọ, ọ machibidoro ịnya ụgbọ ma rụọ ọrụ dị mgbagwoju anya n’oge ọgwụgwọ.
Ntụziaka pụrụ iche
Iji belata ohere mmepe nke microorganisms na-eguzogide ọgwụ, ekwesịrị ị antibioticsụ ọgwụ nje cephalosporin naanị ma ọ bụrụ na egosipụtara ihe kpatara ọrịa ahụ n'oge bacanalysis. Ọ bụrụ na enweghị ozi dị otú ahụ, mgbe ahụ, a na-ekpebi ajụjụ banyere ịgbanwe ọgwụ mgbochi na usoro ọgwụgwọ.
Mgbe afọ ọsịsa dakwasịrị, a ga-ezigara onye ọrịa ahụ maka nchọpụta maka wezuga colitis enwere ike. Mgbe ikwenye nchoputa, a na-emezi usoro ọgwụgwọ. Na enweghị usoro ọgwụgwọ, onye ọrịa anaghị ewepu mmepe nke megacolon, peritonitis, na ọbụna ujo.
Ilebọchị agadi abụghị ihe ngosipụta maka belata etu esi were ọgwụ ahụ, ọ dị mkpa iji nyochaa nha ọbara.
N'ọnọdụ ezughi oke ma ọ bụ pathology nke e guzobere vitamin K (Vikasol), a ga-enyocha ihe ngosi prothrombin mgbe niile.
Jiri na agadi
Ilebọchị agadi abụghị ihe ngosipụta maka belata etu esi eme ọgwụ. Ọ dị mkpa inyocha ọnụ ọgụgụ ọbara.
Inye umuaka
Enwere ike inye ọgwụ ọgwụ ụmụaka ka ọnwa abụọ gbagote. Nwatakịrị na-eru ogo 40 n'arọ, ọgwụ kachasị na-erute 50 mg kwa 1 n'arọ nke ịdị arọ. Site na ọrịa na-enweghị nsogbu, enwere ike belata ya.
Site na mmebi ụbụrụ meningococcal, nke ọrịa na-efe efe nke akụkụ okuku ume na -akpata, a na-atụ aro ka a na-enye ọgwụ ahụ kwa elekere asatọ.
Jiri n'oge ime na lactation
Amachibidoro ọgwụ a kpamkpam n'oge atụmanya na inye nri.
Ngwa maka ọrụ ezughi oke ọrụ
N'ọnọdụ nkwarụ akụrụ, a na-ebelata doses ka a wee hụ otu usoro ọgwụgwọ ahụ yana akụrụ anaghị emetụta ya. Site na nhazi nke creatinine n'okpuru 10 ml / min, a na-egosipụta njikwa nke 0.25 ruo 1 g nke Extentsef kwa awa 24 ọ bụla.
N'ịmebi arụmọrụ akụrụ, ọrụ nke nephrotoxicity nwere ike ime. E gosipụtara ha na mmụba dị ukwuu na nitrogen na mmamịrị na creatinine. Ọ bụrụ na enwere ihe mgbaàmà nke nephrotoxicity, ọ dị mkpa iji belata usoro onunu ogwu.
Jiri maka ọrụ imeju na-arụ ọrụ
Ibelata oke nke ọgwụ a ka ezighi ezi n'ihe banyere ọrụ imeju na-arịa oke, cirrhosis, ịba ọcha n'anya. Anaghị anabata oge itinye ego na mmepe nke jaundice.
Dodoụbiga ihe ókè n’ime
Site na njikwa m / m ma ọ bụ iv nke nnukwu doses, ọgwụ ahụ na-akpata syncope, ọnya na ọnụọgụ nke aka. N'ime ndị mmadụ nwere ọrịa akụrụ siri ike ma ọ bụ ọrịa ogologo oge, iji ogologo ọgwụ doses na-akpata mmụba nke cefazolin. Na nchịkọta, ihe mgbaàmà ndị a na-apụta:
- palpitations
- ogwe
- vomiting
Ọ dị mkpa ịkwụsị ị Extụ Extentsef site na ngosipụta nke mgbaàmà ndị akọwapụtara. N'ọnọdụ ndị dị ize ndụ, a na-eme ọgwụgwọ anticonvulsant na desensitization. Na oke nnyefere, akụkụ iku ume, akụrụ gbasara akịrịga kwesịrị ilegide anya mgbe niile.
A na-ewepụ ọgwụ ahụ site na iji ọgwụ. Idopu ezumike n’oge adịghị ka nke ọma.
Mmekọrịta na ọgwụ ndị ọzọ
A naghị akwado ya ịnye cefazolin ya na ndị na-eche echiche nke ọbara, diuretics. Ọ bụrụ na-eji loop diuretics n’otu oge, mgbe ahụ enwere mmebi nke iwepụ oge abalị n’oge.
Ojiji nke probenecid na-ebelata mwepu nke cefazolin n'ọbara ma mee ka mmetụta ọgwụgwọ dịkwuo elu.
Ejikọtara ya na aminoglycosides mgbe ụfọdụ iji welie synergism. Na nsogbu akụrụ, ngwakọta a ga-abụ ihe a na-achọghị. Ekwesighi ijikọ ya na metronidazole, vancomycin, na gentamicin.
Ojiji nke probenecid na-ebelata mwepu nke cefazolin n'ọbara ma mee ka mmetụta ọgwụgwọ dịkwuo elu.
Ogwu a ekwekorita na:
- Amikacin;
- sodium amobarbital;
- Bleomycin;
- calcium gluceptate ma ọ bụ gluconate;
- Cimetidine;
- Colistimetate;
- Pentobarbital;
- Polymyxin;
- Tetracycline.
Ogwu nwere ike ibelata ịba uru nke BCG, ọgwụ mgbochi ịba. Acgba ọgwụ mgbochi bụ naanị mgbe akwụsịrị ọgwụ nje.
Mmanya ndakọrịta
Cefazolin ekwekọghị na mmanya. Patientsfọdụ ndị ọrịa nwere ike ịmalite mmeghachi ahụ disulfiram. Mmetụta dị otú a nwere ike itinye aka na mmepe nke ọnọdụ ụjọ.
Ent Extụ ọgwụ extraentsef ekwekọghị na mmanya.
Analogs
Ihe analogues nke ogwu a bu:
- Efipim;
- Megapim;
- Zebopim;
- Europim;
- Kefpim;
- Kefsepim;
- Posineg;
- Ceficad
- Abaiim;
- Akpim;
- Dimipra.
Ahịa ọgwụ na-ahapụ okwu
N'aka ọgwụ ka erere ọgwụ ahụ.
Enwere m ike ịzụta na ndenye ọgwụ
N'ime ọtụtụ ụlọ ahịa ọgwụ, onye ọrịa nwere ike ịzụta ọgwụ na-enweghị ndenye ọgwụ. N'okwu a, ọ nwere ike ibute nsị ma ọ bụ kpasuo iwe nke usoro a na - aga.
Efipim nwere ike ime ihe dịka analog nke ọgwụ Exentsef.
Ọnụ ego maka Exentsef
Ọnụ ego nke karama ahụ bụ 450-550 rubles.
Ọnọdụ nchekwa maka ọgwụ
A na-edebe ọgwụ ahụ n'ebe anwụ na-enweghị ya na okpomọkụ ọ bụla dị elu karịa 25ºС.
Bọchị mmebi
A na-etinye ntụ ntụ maka ojiji maka ọnwa 36. Ejila mgbe ngafe nke oge a.
Emeputa
Emeputara ogwu ahu na Samrudh Pharmaceuticals Pvt. Ltd ma ọ bụ Astral steritech Private Limited, India.
Nyocha nke Exentsef
Irina, dị afọ 40, Syzran: "Mgbe ọ nọsịrị oyi ma nwee nsogbu" ọ nwetara "oke oyi na-efe efe. Dọkịta ahụ bịarutere n'ụlọ wee nyefee ya ụlọ ọgwụ .. Thelọ ọgwụ ahụ nyere iwu ka ọ bụrụ nke ọpịpị ugboro abụọ n'ụbọchị n'ụdị ya. Site na ụbọchị 3. Oke belata ụbọchị 5. ugbua. Na ngụkọta, a gwọchara ụbọchị iri. "
Svetlana, onye dị afọ 39, Moscow: “entlụrụ oke gwọọ ọrịa nje cystitis .. ọgwụ nje ndị ọzọ enyereghị aka ịnagide ọrịa a n'ụzọ dị irè. Ọ nabatara injelo ya nke ọma, enweghị mmetụta ọ bụla n'ihi ọgwụgwọ. Ọ nweghị ahụ mgbu ọ bụla, n'ihi na a na-agwakọta ntụ ntụ ahụ. na-eji ihe ngwọta nke lidocaine. "
Igor, onye gbara afọ iri atọ na ise, Ryazan: “Dọkịta nyere iwu ka ịgba ọgwụ ịgba ọgwụ mgbochi ọria. Mgbe mbụ m na-atụ egwu ịgba ntụtụ ndị a, n'ihi na amaara m na ha na-egbu mgbu ma na-akpata ọria. Ma ejiri m Lidocaine gbasaa ha, mgbe ahụ enweghị m mmetụta mgbe ọ gbasịrị m. A naghị enye ya ọgwụ ugboro abụọ n'ụbọchị. A na-agwọ ọrịa prostatitis kpamkpam n'ime otu izu. "
