Tegretol CR - ọgwụ ọgwụ antiepileptik na-emechi ọnụ ụzọ nke ịdị nkọ, wee si otú a gbochie mbuso agha.
International Nonproprietary Aha
Carbamazepine.
Tegretol CR - ọgwụ na - egbochi ọgwụ nke na - emechi ọnụ ụzọ nke ịdị njikere.
ATX
Koodu ATX bu N03AF01.
Ha weputara udi ya na ihe mebere ya
Ọgwụ dị n'ụdị mbadamba mkpuchi. Mbadamba ahụ nwere ọdịdị okike biconvex.
Ihe dị n’ime ihe eji arụ ọrụ n’ime tebụl nwere ike ịbụ 200 mg ma ọ bụ 400 mg. Ihe na-arụ ọrụ bụ carbamazepine.
Mbadamba 200 mg dị na ngwugwu katọn nke iberibe 50. N'ime mkpọ nke 5 blisters nke 10 iberibe.
Mbadamba 400 mg dị na ngwugwu nke iberibe 30. N'ime mkpọ ahụ 3 blisters nke 10 iberibe.
Omume ọgwụ
E gosipụtara Carbamazepine maka nnwere onwe nke ihe ọdịdọ ahụ. Ngwakọta bụ isi nke ọgwụ bụ ọgwụ dibenzoazepine. Ọ nwere mmetụta antiepileptik yana neurotropic yana psychotropic.
Emebeghị ka ihe omumu nke ogwu a mezue. Enwere ozi na akụrụngwa nọ n'ọrụ na-emetụta ụbụrụ sel nke neurons, na-eme ka ha kwụsie ike ma gbochie ịreụbiga mmanya ókè. Nke a na - emekwa n'ihi nkwụsị nke ngwa ngwa neuronal, n'ihi nke enwere hyperactivation nke akụkụ akwara.
Ojiji nke Tegretol na ndi oria oria juputara na nbudata nke oria n’enye nsogbu.
Akụkụ bụ isi nke ọrụ ọgwụ ahụ na-egbochi iweghachi mkpali nke neurons mgbe depolari. Nke a bụ n'ihi ebugharị ụgbọ nke ion na-eweta ụgbọ njem sodium.
Nnyocha e mere egosiwo na ojiji nke Tegretol na ndị ọrịa nwere nkwarụ na-esochi ya na njigide nke mgbaàmà arụmọrụ na-arụpụta: ọgba aghara obi ọjọọ, oke iwe na nchekasị.
Onweghi ihe akaebe doro anya banyere ma carbamazepine na-emetụta ọnụego nke mmeghachi omume psychomotor na ikike ọgụgụ isi nke ndị ọrịa. N'oge ọmụmụ ụfọdụ, enwetara data esemokwu, ndị ọzọ gosipụtara na ọgwụ ahụ na-eme ka ikike ọgụgụ isi kwụsị.
Mmetụta neurotropic nke Tegretol na-enye gị ohere iji ya maka ọgwụgwọ nke ọrịa akwara ozi. Edere ya ọgwụ maka ndị ọrịa nwere neuralgia n. trigeminus maka enyemaka nke ọgụ nke oge na-ebilite mgbu.
E nyere ndị ọrịa mmanya na-aba n'anya ịbelata ihe egwu ọdịdọ.
E nyere ndị ọrịa mmanya na-aba n'anya ịbelata ihe egwu ọdịdọ. Ọ na-ebelata ịdị njọ nke ngosipụta ọrịa nke ọrịa nkwarụ.
N'ime ndị na-arịa ọrịa shuga insipidus, ojiji nke ọgwụ a normalizes diuresis.
A na-eji mmetụta psychotropic nke tegretol agwọ ọrịa nsogbu iche echiche. Enwere ike iji ya mee ihe iche iche ma jikọtara ya na ọgwụ ndị ọzọ na-agwọ ọrịa, ọgwụ na-alụso ọrịa ọgụ. A na - akọwa mbelata ihe mgbaàmà manic site na mgbochi nke ọrụ dopamine na norepinephrine.
Mlọ ọgwụ
Mwepu nke ihe nọ n'ọrụ na-apụta site na mucosa eriri afọ. Nwepụta ya site na mbadamba nkume adịghị nwayọ, nke na-enye ohere ka ọ rụọ ọrụ ogologo oge. Oke ihe nke ihe dị n’ime ọbara ka abatachara n’ihe dịka awa iri abụọ na anọ. Ọ dị ala karịa itinye uche mgbe ị na-ewere ụdị usoro ọgwụ ahụ.
N'ihi nwayọ nwayọ nke ihe ahụ na-arụ ọrụ, mgbanwe na ntinye ya na plasma enweghị ihe ọ bụla. Bioavailability nke carbamazepine mgbe ị na-ewere mbadamba mbugharị mbubata belata belata 15%.
Mgbe ọ batara n'ọbara, akụrụngwa nọ n'ọrụ na-ebugharị ebugharị peptides site na 70-80%. Ọ na-agafe Plasenta na n’ime mmiri ara. Ntinye uche nke ogwu n’azu nke ikpe azu kariri 50% nke otu ihe gosiputara n’ime obara.
Bioavailability nke carbamazepine mgbe ị na-ewere mbadamba mbugharị mbubata belata belata 15%.
Metabolism nke ihe na-arụ ọrụ na-apụta n'okpuru nduzi nke enzymes imeju. N'ihi mgbanwe nke mmiri ọgwụ, etinyere metabolites na-arụ ọrụ nke carbamazepine na ya na glucuronic acid. Na mgbakwunye, etinyere obere metabolite na-adịghị arụ ọrụ.
E nwere ụzọ metabolic na-ejikọtaghị cytochrome P450. N'ihi ya, a na-eme ka mmiri ọgwụ kemikal monohydroxylated nke carbamazepine mejupụta.
Nkeji ọkara nke ndụ na-arụ ọrụ bụ awa 16-36. Dabere na oge ọgwụgwọ. Site na ngagharị nke enzymes imeju site na ọgwụ ndị ọzọ, enwere ike belata ọkara ndụ.
2/3 nke ọgwụ ahụ ka a na-apịpụta site na akụrụ, 1/3 - site na eriri afọ. Ọ fọrọ nke nta ka ọgwụ ahụ kwụsị kpamkpam n'ụdị metabolites.
Ihe ngosi maka ojiji
Ihe ngosiputa maka eji ihe eji eme ihe a bu:
- Akwụkwụ na-adọ (nke etinyere maka ọdịdọ ma dị mfe ma juputara na nke abụọ);
- ihe imeru ahu agha;
- nnukwu manic psychosis;
- trigeminal neuralgia;
- ọrịa mamịrị, na-eso mgbu;
- ọrịa shuga na -esi insipidus na ụba diuresis na polydipsia.
Ihe ngbanwe
Ihe Tegretol bu ihe ndi ozo:
- ịgwọ ọrịa mmadụ n'ọrụ ma ọ bụ ihe ndị ọzọ dị n'ọgwụ ahụ;
- mgbochi nke ọnụnọ;
- mmanya ịkwụsị ọrịa;
- imebi ọrụ hematopoietic nke ụmị ọkpụkpụ;
- nnukwu intermittent porphyria;
- ngwakọta nke ọgwụ ahụ na monoamine oxidase inhibitors.
Uzo esi ewere Tegretol CR
Nri anaghị emetụta ịdị irè nke ọgwụ. Were mbadamba ihe niile ma were mmiri ole achọrọ.
Monotherapy na Tegretol ga-ekwe omume, yana njikọta ya na ndị ọrụ ọzọ.
Standardkpụrụ maka ị theụ ọgwụ a metụtara nchịkwa oge abụọ. N'ihi nsonaazụ ọgwụ nke ọgwụ nwere mmetụta na-adịte aka, enwere ike ịrịọ mmụba nke usoro ọgwụ kwa ụbọchị.
Were mbadamba ihe niile ma were mmiri ole achọrọ.
A na - atụ aro ka ndị na - arịa ọrịa akwụkwụ na - arịa tegretol monotherapy. Nke mbu, a na-enye usoro onyonyo dị ala, nke na-eji nwayọ nwayọ gaa ọkwa. Usoro akwadoro ọgwụ ịchọrọ ị initialụ ọgwụ bụ 100 mg 1 ma ọ bụ ugboro abụọ kwa ụbọchị. Otu ezigbo usoro bụ 400 mg 2-3 ugboro n'ụbọchị. N'ọnọdụ ụfọdụ, ịnwere ike ịbawanye usoro ọgwụ kwa ụbọchị ruo 2000 mg.
Na neuralgia n. trigeminus nke usoro ị ga - ebido kwa ụbọchị ruru 400 mg. Mmụba na-abawanye na 600-800 mg. Ndị ọrịa merela agadi na-enweta ọgwụ mg (200 mg) nke ọgwụ kwa ụbọchị.
Edere ndị mmadụ ị withụ mmanya na-egbu site na 600 ruo 1200 mg / ụbọchị. Na nnukwu mgbaàmà mgbapụta, a na-ejikọ ọgwụ ahụ na ọgwụ mgbochi.
A na-enye ndị ọrịa nwere nnukwu mkpaghasị uche site na 400 ruo 1600 mg nke Tegretol kwa ụbọchị. Usoro ọgwụgwọ na-amalite site na usoro onunu ogwu dị ala, nke na-eji nwayọ nwayọ.
Na-arịa ọrịa shuga
E gosipụtara Carbamazepine maka ndị ọrịa nwere ọrịa neuropathy mamịrị. Ọgwụ na-akwụsị ihe mgbu nke na-ebute n'ihi mgbanwe mgbanwe metabolism n’arụ akwara. Usoro a na-atụ aro ka a na-atụ ya maka ịba ọcha n'anya nke neuropathy dị kwa ụbọchị bụ 400 ruo 800 mg.
E gosipụtara Carbamazepine maka ndị ọrịa nwere ọrịa neuropathy mamịrị.
Nsonaazụ Tegretol CR
Na akụkụ ahụ nke ọhụụ
Nwere ike ime:
- ọgba aghara n’uche ịdị ụtọ;
- ẹphe emekota iphe dụ ẹji;
- tinnitus;
- hypo-hyperacusia;
- igwe ojii.
Site na anụ ahụ na akwara
Mmeghachi omume ọjọọ ndị a nwere ike ime:
- olu mgbu
- nkwonkwo mgbu.
Ọkpụkpụ afọ
Ihe omume mmeghachi omume ndị dị otú ahụ adịghị ekwe omume:
- ọgbụgbọ
- vomiting
- mbufụt nke mucous nke ọnụ;
- gbanwee n’ụdị oche ahụ;
- ọria umeji;
- mgbanwe na ọkwa nke ọrụ nke enzymes imeju.
Ahụhụ Hematopoietic
Ha nwere ike ịzaghachi ọgwụgwọ n'ọdịdị nke:
- leukopenia;
- thrombocytopenia;
- agranulocytosis;
- anaemia
- belata ọkwa folic acid.
Akụkụ Hematopoietic nwere ike ịzaghachi ọgwụgwọ na thrombocytopenia.
Sistemụ akwara Central
Nwere ike ikwu ọgwụgwọ na ndị na-eso ajọ omume:
- Dizziness
- isi ọwụwa
- nsogbu neuropathy;
- paresis;
- nkwarụ okwu;
- ike adighi ike;
- iro ụra
- ọrịa hallucinatory;
- ụba iwe;
- nsogbu nke ịda mba;
- ọhụụ
- nsogbu ngaghari;
- ọghọm uche;
- ike ọgwụgwụ.
Sistemụ akwara nke dị n'etiti nwere ike ịzaghachi ọgwụgwọ na ọhụụ abụọ.
Site na usoro urinary
Nwere ike hụrụ:
- wakwaa;
- pollakiuria;
- njigide urinary.
Site na sistem iku ume
Ohere omume:
- mkpụkpu ume
- oyi baa.
Na anụahụ
Nwere ike hụrụ:
- nsị;
- ọrịa akpịrị;
- itching
- erythema;
- hirsutism;
- ẹhu-ụtso;
- rashes;
- hyperhidrosis.
Site na usoro mkpụrụ ndụ ihe nketa
Enweghị ike nwa oge nwere ike ime.
Site na sisitemu mmadụ, enweghi ike nwa oge.
Site na usoro akwara obi
Nwere ike ime:
- mgbochi nke ọnụnọ;
- arrhythmia;
- mbelata nke obi;
- obi mgbawa nke mgbaàmà nke akwara obi ọrịa.
Usoro endocrine
Omume puru omume:
- ọzịza;
- gynecomastia;
- hyperprolactinemia;
- hypothyroidism.
Site n'akụkụ nke metabolism
Nwere ike ime:
- hyponatremia;
- elu triglycerides;
- abawanye na cholesterol ịta.
Ahụhụ
Omume puru omume:
- mmeghachi omume hypersensitivity;
- lymphadenopathy;
- ahụ ọkụ
- angioedema;
- menyere ọrịa nwoke bidoro.
Site na iwere Tegretol CR ka ọ bụrụ nsonaazụ, onye ọrịa ahụ nwere ike ịhụ ahụ ọkụ.
Mmetụta ikike ịchịkwa usoro
A ga-ezere mmemme ihe egwu nwere ike itinye uche na ịbawanye ụba mgbe ị na-ewere carbamazepine. Nke a bụ n'ihi ohere nke nsonaazụ ndị sitere na sistem ụjọ.
Ntụziaka pụrụ iche
Jiri na agadi
N'ọnọdụ ụfọdụ, enwere ike ịchọ ndozigharị kwa ụbọchị.
Inye umuaka
Enwere ike inye ọgwụ ọgwụ maka ụmụaka. Usoro usoro ubochi sitere na 200-1000 mg, dabere na afọ na ịdị arọ nke onye ọrịa. Mgbe ị na-ede ọgwụ ahụ, a na-atụ aro ka ụmụaka na-erubeghị afọ atọ ka ịhọrọ ọgwụ n'ụdị sirop.
Jiri n'oge ime na lactation
Usoro ọgwụgwọ nke nwere carbamazepine n'oge afọ ime kwesịrị iji nlezianya buru ibu. Buru n'uche eziokwu ahụ bụ na tegretol nwere ike ịbawanye ụkọ nke vitamin B12 n'ime ụmụ nwanyị dị ime.
Mgbe ị na-agwọ carbamazepine nke nne na-enye nwa ara, ọ ga-ekwe omume ịnyefe nwatakịrị ahụ na nri anụ ahụ. Feedingga n'ihu na nri ga - ekwe omume ma a na-enyocha ya mgbe niile gbasara ụmụaka ahụ. Ọ bụrụ na nwatakịrị etolite na mmeghachi omume ọ bụla, nri ahụ ga-akwụsị.
Ngwa maka ọrụ ezughi oke ọrụ
Na-enye Tagretol ihe dị mkpa mgbe ị tụlechara ọrụ gbasara akụrụ. A naghị akwado ya ka ọ jiri ọgwụ ahụ mee ihe n’ebe ndị ọrịa nwere ajọ ọrịa gbasara akụrụ.
Na-enye Tagretol ihe dị mkpa mgbe ị tụlechara ọrụ gbasara akụrụ.
Jiri maka ọrụ imeju na-arụ ọrụ
Akụkọ banyere ọrịa imeju bụ ihe kpatara akpachara anya mgbe ị na-a theụ ọgwụ. Oge nlekọta nke ọrụ imeju dị mkpa iji zere mgbasa nke ọrịa nke hepatobiliary tract.
Nmefere nke Tegretol CR
N'ihi ịba ụba nke carbamazepine, ọrịa na-efe efe na-apụta na akụkụ nke sistem ụjọ, nkụda mmụọ na ọrụ obi. Vomiting, anuria, mgbochi ihe niile na-apụta.
Symptomsụbiga ihe ọ symptomsụseụ na-aba n’anya ókè bụ ịsacha afọ ya na iji mgbaasị. Ekwesịrị ịmalite ọgwụgwọ n'ụlọ ọgwụ. A na-egosi usoro ọgwụgwọ Symptomatic, nleba anya nke ọrụ gbasara obi.
Mmekọrịta na ọgwụ ndị ọzọ
Mgbe ejikọtara Tegretol na ndị ọrụ ndị ọzọ na-agbanwe ọkwa nke ọrụ CYP3A4 isoenzyme, ịta ahụhụ nke carbamazepine na ọbara. Nke a nwere ike ibute mbelata nke arụmọrụ ọgwụgwọ. Ngwakọta dị otú ahụ nke ọgwụ nwere ike ịchọ nhazi mmezi.
Belata itinye uche nke ihe na-arụ ọrụ na mgbakwunye na phenobarbital.
Macrolides, azoles, mgbochi ihe mgbochi histamine, ọgwụ maka ọgwụgwọ retroviral nwere ike ime ka ịba ụba nke arụ ọrụ dị n'ọbara.
Njikọ ya na phenobarbital, valproic acid, rifampicin, felbamate, clonazepam, theophylline, wdg, na-ebelata itinye uche nke ihe na-arụ ọrụ.
Oge otu oge nke ọgwụ ụfọdụ chọrọ imeghari ọgwụ ha: tricyclic antidepressants, corticosteroids, protease inhibitors, calcium channel blockers, estrogens, antiviral virus, antifungal ọgwụ.
Nchikota ya na ụfọdụ ihe diuretara n’eduba na mbelata plasma nke sodium. Carbamazepine nwere ike belata ịdị irè nke ọgwụgwọ na-enweghị ntụgharị akwara.
Iji ọgwụ mgbochi afọ na -emebi ọnụ nwere ike ibute ọbara ọgbụgba.
Mmanya ndakọrịta
A naghị atụ aro ka ị rie ụdị mmanya ọ bụla n'oge eji Tegretol.
Analogs
Analogs nke ngwaọrụ a bụ:
- Finlepsin Retard;
- Finlepsin;
- Carbamazepine.
Otu n'ime analogues nke ọgwụ bụ Finlepsin Retard.
Ọdịiche dị n'etiti Tegretol na Tegretol CR
Ọgwụ a dị iche na Tegretol ọkọlọtọ na oge mgbapụta nke carbamazepine. Mbadamba ụrọ nwere mmetụta dị ogologo.
Ahịa ọgwụ na-ahapụ okwu
Ọgwụ ndenye ọgwụ.
Enwere m ike ịzụta na ndenye ọgwụ
Ee e.
Ọnụahịa
Dabere na ebe ịzụta ihe.
Ọnọdụ nchekwa maka ọgwụ
Ekwesịrị ịchekwa n'ebe ọkpọ nkụ mgbe okpomọkụ agaghị erute + 25 Celsius.
Bọchị mmebi
N'okpuru ọnọdụ nchekwa, ndụ shelf bụ afọ atọ site na ụbọchị nke edepụtara.
Emeputa
Emere ọgwụ ahụ site n'aka Novartis Pharma.
Nyocha
Artem, gbara afọ 32, Kislovodsk
Tegretol bụ ezigbo ọgwụ na-enyere aka ịnagide ọdịdọ. Amalitere iji ọgwụ a, enwetara m ohere ibi ndụ dị mma. Mbadamba ụta ga-anagide ma ọdịdọ dị obere ma nnukwu. Achọghị m mmetụta ọ bụla dị na ya n'oge ngwa ahụ. Ana m agwa onye ọ bụla na-arịa ọrịa akwụkwụ.
Nina, dị afọ 45, Moscow
Ejiri ngwa a rụọ ọrụ otu afọ gara aga. Ọgwụ ochie antiepileptik riri ahụ, dọkịta depụtara Tegretol dị ka onye nnọchi. Aụrụ m mbadamba ihe dị ka izu abụọ. Mgbe ah u nsogbu putara. Nausea na vomiting pụtara. Ahụike m akala njọ, enwere m nchegbu banyere nkụda mmụọ. Ekwesịrị m ịgakwuru dọkịta ọzọ. O mere nyocha ahụ. Ọgwụ ahụ mere mmeghachi omume hematological: anaemia na thrombocytopenia mepụtara. Ekwesịrị m ịgbanwe ọgwụ ọjọọ ngwa ngwa.
Cyril, 28 afọ, Kursk
Dọkịta tiri ọgwụ a yana ndị ọzọ maka ịgwọ ọrịa trigeminal neuralgia. Amaghị m ma Tegretol ma ọ bụ ọgwụ ndị ọzọ nyeere aka, mana mgbaàmà ahụ anaghịzi adị. Mwakpo ihe mgbu malitere inye obere nsogbu. Alaghachikwara m ụra ma rie nri nkịtị. Enwere m ike ịkwado ọgwụ a na onye ọ bụla nweela ụdị nsogbu ahụ.
