Aterocardium bụ otu iji belata ike nchịkọta platelet.
International Nonproprietary Aha
Clopidogrel.
Aterocardium bụ otu iji belata ike nchịkọta platelet.
ATX
Koodu ATX bu B01AC04.
Weputara udi ya na ihe mebere ya
Ọgwụ ahụ dị n'ụdị mbadamba. Mbadamba ụrọ nke ọ bụla nwere 75 mg nke ihe na - arụ ọrụ - clopidogrel.
Mbadamba ndị ahụ bụ ihe eji ekpuchi fim. Ha nwere udi biconvex okirikiri na agba pink.
Omume ọgwụ
Ọrụ ọgwụ ọgwụ metụtara ọgwụ na-egbochi mmachi nke adenosine diphosphate na ndị na-anabata ya nke dị na platelet. Na-enweghị adenosine diphosphate, ọrụ nke membrane protein dị mgbagwoju anya nke na-eme ka nchịkọta nke arịa ọbara belata.
A na-egbochi nchịkọta Platelet ọ bụghị naanị site na igbochi mgbakwunye ADP, kamakwa site na ihe ndị ọzọ na-etinye aka na coagulation ọbara. Mgbanwe nke ndị na-anabata membrane nke platelet ọbara na-agbanwegharị. Iji weghachite ọkwa nke coagulability nke gara aga, platelet mejupụtara ọbara kwesịrị ka emelite ya.
Omume nke clopidogrel na-amalite na ụbọchị izizi. Enwere oge ịgbatị oge ọbara na-agbanwe na ike nchịkọta ọbara. Ọrụ nke ọgwụ ike dị na ọgwụ ahụ na-aga n'ihu na iji mbadamba nkume ugboro ugboro, na-eme ka ọ kwụsie ike ruo ụbọchị 3-7.
N'okpuru ikike nke Aterocardium, ikike nke platelet na-agbaso jiri ihe kariri 50% belata.
N'okpuru ikike nke Aterocardium, ikike nke platelet na-agbaso jiri ihe kariri 50% belata. Normalization nke ihe ngosi a putara na ubochi 4-6 mgbe ogwugwo oria. Ọnụego mgbake dabere na ọrụ hematopoietic nke ụmị ọkpụkpụ, nke na-ahụ maka ịmepụta ụdọ ọbara ọhụrụ.
Mlọ ọgwụ
Site na nchịkwa ọnụ nke ọgwụ ahụ na usoro ọgwụgwọ (75 mg), ọ na-etinye obi gị dum site na mucosa eriri afọ. A na-enweta nsonaazụ kachasị dị irè nke ihe na-arụ ọrụ n'ime ọbara n'ọbara na awa 0.5-1. Usoro ndu nke ogwu a di ihe di ka 50% nke onara. Mmechi nke ihe eji arụ ọrụ na peptides ebufe sitere na 95% ruo 99%. Ogo nke ikeji n’adighi ike dabere na onunu ogwu eji eme ya ma bulie elu elu.
Ntughari metabolic nke ogwu a n’okpuru nduzi nke enzymes imeju. Metabolism na - apụta ma n'ihi ichebezymes nke cytochrome Z450, yana n'ihi enzymes ndị ọzọ. Mgbanwe kemịkalụ nke clopidogrel na-apụta n'ọtụtụ nkebi, nsonaazụ nke ya bụ nguzobe nke metabolites nọ n'ọrụ na arụ ọrụ. Nke izizi ozugbo e guzobere n’ụzọ n’ejighi ụkwụ na - ejikọ aka na ngwa nnabata nke platelet, wee si na --ebelata coagulation ọbara.
Isi isoenzyme metụtara na ntụgharị nke ihe arụ ọrụ bụ CYP2C19. Mepụta metabolite na-arụ ọrụ na-adabere na njirimara genotypic nke isoenzyme a. Enwere 8 nke ụzọ mbata ya. Nke mbu weghachitere clopidogrel, na-enye aka na mgbochi kachasị nke usoro nchịkọta. Ndị nke ọzọ anaghị metabolize ihe akụrụngwa arụ ọrụ zuru oke. Kachasị n’ime ha bụ 2 na 3 alleles.
Akụkụ ọgwụ ọjọọ ahụ na-ewepụta ahụ site na eriri afọ.
Mkpochapu ihe na-arụ ọrụ na metabolites ya na-ewe ihe dị ka ụbọchị ise. Site n'ahụ ya, ọgwụ ahụ na-emegharịkwa akụrụ ya na eriri afọ ya. Ọkara ọkara nke ọgwụ ahụ bụ awa 6-8. Ọ dabereghị na oge ọgwụgwọ.
Gịnị na-enyere aka?
Ngwá ọrụ ka edepụtara n'okwu ndị a:
- atherothrombotic na-etinye na isi ma ọ bụ gburugburu akwara;
- nnukwu ọrịa obi na - arịa otu nnukwu akpa ọbara;
- ndị ọrịa nwere nkụchi obi ma ọ bụ nkụchi azụ;
- maka mgbochi nke ngọngọ nke mkpụrụ nke akwara ọbara n'oge akwara fibrillar nke atria.
Edere ya na ngwakọta na acetylsalicylic acid. Ewuputara ngwakọta yiri nke a maka ndị ọrịa na-arịa ọrịa angioplasty.
Ihe ngbanwe
Ihe ndi ozo na ntinye aka nke Clopidogrel bu:
- ịgwọ ọrịa mmadụ n'ọrụ ma ọ bụ ihe ndị ọzọ dị n'ọgwụ ahụ;
- oke ọnya ọria;
- ọbara ọgbụgba na nke dị n’ime;
- ụkọ lactase;
- ọnya ọnya akpụkpọ ahụ mucous nwere nsogbu nke ọbara ọgbụgba.
Na nnukwu ọrịa ịba ọcha n'anya, ị theụ ọgwụ a ka amachibidoro.
Etu esi ewere Aterocardium?
Standardkpụrụ ọgwụ nke ọgwụ maka ndị okenye bụ 75 mg otu ugboro kwa ụbọchị, n'agbanyeghị nri oriri.
Na nnukwu akwara ozi na-enweghị ụma akụkụ ST, a na-edenye otu iko 300 mg nke clopidogrel. Usoro ọgwụgwọ na-aga n'ihu na usoro onunu ogwu. Ọzọkwa, acetylsalicylic acid ka edepụtara, usoro nke ejiri kpebie n’otu n’otu. A naghị atụ aro ka ị were ihe karịrị 100 mg nke acetylsalicylic acid yana ngwakọta a. Nke a nwere ike ibute ọbara ọgbụgba. Obere oge ọgwụgwọ dị ụbọchị 90. A na-atụ aro ka ọ nọgide na-agwọ ọrịa ruo otu afọ.
Ọ bụrụ na onye ọrịa ahụ bilitere na ngalaba nke ST, a na-enye otu usoro onunu ogwu ahụ. Ndị gaferela afọ iri asaa na ise agaghị anata ọgwụ eji ebido mbido. Ndị ọrịa ruo afọ a na-amalite usoro ọgwụgwọ na 300 mg nke Aterocardium. Site na ọrịa a, ọgwụgwọ ahụ dị ọnwa 1, amụbeghị mkpa maka ọgwụgwọ na-aga n'ihu.
Maka ọgwụgwọ nke ihe mbufụt ọgbụgba na ụrọ, a na-atụkwa usoro kwa ụbọchị nke ọgwụ ahụ. Ọzọkwa, acetylsalicylic acid ka edepụtara.
Na-arịa ọrịa shuga
A na-enye ndị na-arịa ọrịa shuga otu ọgwụ ndị ahụ. Ọgwụ ahụ anaghị eji ọgwụ antidiedi ma ọ bụ insulin emekọrịta.
Nsonaazụ Aterocardium
Na akụkụ ahụ akụkụ nke ọhụụ
Ọbara site na arịa nke anya nwere ike ime.
Site na anụ ahụ na akwara
Ọgwụgwọ nwere ike gbagwojuru anya site n'ọbara ọgbụgba na akpa nkwonkwo, mgbu nkwonkwo, ogbu na nkwonkwo, ọnya olu.
Ọkpụkpụ afọ
Mmeghachi omume ọjọọ ndị a nwere ike ime:
- ihe mgbu epigastric;
- ọgbụgbọ
- vomiting
- ọbara arịa nke akpụkpọ mucous;
- ọria umeji;
- ọnụ;
- ọnya afọ-ụlo;
- gbanwee n’ụdị oche ahụ;
- stomatitis
- eriri afọ.
Ahụhụ Hematopoietic
Omume puru omume:
- thrombocytopenia;
- leukopenia;
- neutropenia;
- thrombocytopenic purpura;
- agranulocytosis;
- anaemia
- eosinophilia;
- pancytopenia.
Sistemụ akwara Central
Nwere ike ịzaghachi ọgwụgwọ site n'ọdịdị nke:
- Dizziness
- paresthesia;
- isi ọwụwa;
- ọgba aghara;
- ọrịa nke ntị;
- ọbara ọgbụgba n'ime intracranial;
- isi nzuzu;
- ọrịa hallucinatory.
Site na usoro urinary
Ohere omume:
- hematuria;
- glomerulonephritis.
Site na sistem iku ume
Nwere ike ime:
- ọbara arịa nke akpụkpọ mucous;
- mọzụlụ nke akwara ozi;
- oyi baa.
Na anụahụ
Omume puru omume:
- ọbara ọgbụgba n’okpuru anụ ahụ;
- ihe odide
- amu amu
- ọrịa akpịrị;
- ọzịza;
- lichen planus;
- purpura.
Site na usoro mkpụrụ ndụ ihe nketa
Ọgwụ anaghị emetụta ọmụmụ.
Site na usoro akwara obi
Nwere ike ime:
- ọbara ọgbụgba
- hypotension;
- mbufụt vasculitis ọbara.
A na-ahụta ọdịdị nke ịba ọcha n'anya dị ka akụkụ nke ọgwụ ...
Usoro endocrine
Ngwá ọrụ ahụ anaghị akpata mgbanwe n'ọkwa nke homonụ ma ọ bụ dysfunctions ndị ọzọ nke akụkụ endocrine.
N'akuku nke imeju na akụkụ biliary
Nwere ike iputa:
- ịba ọcha n'anya;
- Njide;
- mmụba nke enzymes imeju.
Site n'akụkụ nke metabolism
Nwere ike iwelie ego nke creatinine na n'ọbara.
Ahụhụ
Nwere ike ime:
- mmeghachi omume anaphylactic;
- ọrịa ọbara;
- ahụ ọkụ.
Mmetụta ikike ịchịkwa usoro
Ngwá ọrụ ahụ nwere ike imetụta nsonaazụ uche na ọnụego mmeghachi omume naanị mgbe ọdịdị nke nsonaazụ na-adịghị mma site na sistemụ ụjọ. N'ụdị ndị a, ịkwesịrị ịbelata oge iji akwọ ụgbọala yana iji usoro.
Aterocardium nwere ike ibute ahụ ọkụ.
Ntụziaka pụrụ iche
Jiri na agadi
Na enweghị ọgwụ contraindications maka ndị mmadụ gafere afọ 75, a na-eme ọgwụgwọ ha dika otu atụmatụ ahụike dị na ndị ọrịa siri ike karịa afọ a.
Cribdebere ụmụaka Aterocardium
Ezubere ọgwụ ahụ maka ọgwụgwọ nke ụdị ndị ọrịa a. A na-atụ aro ịhọrọ analogue dị mma.
Jiri n'oge ime na lactation
Emebeghi ihe omumu banyere Aterocardium na udi ndi oria a. Iji hụ na nchekwa nke nwatakịrị ahụ, a naghị atụ aro ịkọ ya ọgwụ ndị inyom dị ime.
Ọmụmụ anụmanụ na-egosi na ọ ga-ekwe omume banye n’ime mmiri dị ike n’ime mmiri ara. Ọ bụrụ na ọ dị mkpa ịde ọgwụ ahụ na ụmụ nwanyị na-enye nwa ara, a na-atụ aro ịnyefe nwata ahụ ka ọ na-enye nri afọ.
Ngwa maka ọrụ ezughi oke ọrụ
Ihe omuma banyere iji ọgwụ eme ihe maka ọgwụgwọ nke ndị ọrịa na-ezughi oke ọrụ nke akụkụ a nwere oke. Ekwesịrị ịkpachara anya mgbe ị na-ede ọgwụ ahụ na n'oge ọgwụgwọ. A na-atụ aro ka egosiputa ndị na-egosi ọrụ gbasara akụrụngwa bụrụ ihe ọjọọ dị na sistem urinary.
Ihe omuma banyere iji ogwu eme ihe maka ọgwụgwọ nke ndị ọrịa nwere ọrịa akụrụ.
Jiri maka ọrụ imeju na-arụ ọrụ
Enweghi ike nke ọrụ ịba ọcha n'anya bụ nkwekọrịta na oge nke Aterocardium. N'okwu ndị dị ala, a na-adụ ịdọ aka na ntị n'oge eji.
Aterocardial overdose
Anụbiga ọgwụ ọ overụ isụ ókè, a na-enwe ọbara ọgbụgba. Mwepu nke mgbaàmà nke ọnọdụ a ga - ekwe omume site na enyemaka nke mmịnye platelet. Nke a ga - enyere aka weghachite ọrụ ịmịnye ọbara tupu imelite ihe mejupụtara platelet ọbara.
Mmekọrịta na ọgwụ ndị ọzọ
Ngwakọta ndị a na-egbochi
Onweghị ọgwụ ọ bụla achọtara onye ojiji yana clopidogrel ga-ebute mmepe nke mmetụta ndị na-eyi ndụ egwu.
Ngwakọta agwaghị ya
Anticoagularal nke na-egbu egbu nwere ike ime ka ogologo oge ịwụ ọbara na njikọta ya na clopidogrel.
A naghị atụ aro ka ikpokọta ojiji nke ọgwụ a na iji ndị na-egbochi cytochrome P450 isoenzymes.
A naghị atụ aro ka ikpokọta ojiji nke ọgwụ a na iji ndị na-egbochi cytochrome P450 isoenzymes.
Mgwakọta chọrọ ịkpachara anya
Site na njikọta ọgwụ a na Omeprazole, Fluconazole, Carbamazepine, a na-ebelata ọrụ nke isoenzymes na mgbanwe metabolic nke clopidogrel. Njikọ ndị dị otú a nwere ike ibute mbelata nke ọma na Aterocardium na plasma ọbara.
Ekwesịrị ịkpachara anya mgbe ị na-eji Heparin, cyclooxygenase inhibitors, ọgwụ mgbochi mkpali na-abụghị steroidal.
Mmanya ndakọrịta
Enweghị data banyere mmetụta mmanya na-aba n'anya na ọgwụ ọgwụ nke ọgwụ. A naghị atụ aro ị drinkụ mmanya maka ọrịa obi, maka ọgwụgwọ nke clopidogrel ka edepụtara.
Analogs
Analogs nke ngwaọrụ a bụ:
- Avix;
- Agrel;
- Gridoklein;
- Deplatt;
- Sylt;
- Claudia
- Clopix;
- Clorelo;
- Lopigrol;
- Nkekpo;
- Plagril;
- Tessiron;
- Ihe nkwado
Ahịa ọgwụ na-ahapụ okwu
Enwere m ike ịzụta na ndenye ọgwụ?
Ọgwụ dị na ndenye ọgwụ.
Ọnụahịa Atherocard
Ọnụ ego nke Aterocardium na Ukraine bụ 25 UAH maka mbadamba 10, 120 UAH maka mbadamba 70.
Ọnọdụ nchekwa maka ọgwụ
Ekwesịrị idobe ya na oge okpomọkụ ruo + 25 Celsius.
Bọchị mmebi
Kwesịrị ekwesị maka iji n'ime afọ 3 site na ụbọchị ntọhapụ.
Emeputa
PJSC "Mkpụrụ osisi Vitamin Kiev".
Nyocha maka Atherocard
Stanislav Kaverin, dibia bekee, Kiev.
Ngwá ọrụ a na-enyere ndị ọrịa chọrọ belata ike nchịkọta ọbara. Edebere m ya ndị nwere nnukwu ọrịa myocardial infarction, atherothrombosis. Uru nke ọgwụ a bụ na enwere ike inye ya ndị agadi. Ekwesiri ileba anya n ’ebe onye ọrịa na-ata ahụhụ n’ọrụ ezughi oke.
Ọ dị mkpa n'oge ọgwụgwọ ịgbaso ntuziaka dọkịta. Ya mere, usoro ọgwụgwọ ahụ ga-agafe na-enweghị nsogbu ma ọ ga-adịkwa irè dịka o kwere mee.
Maria Spivak, dibia bekee, Zaporozhye.
Clopidogrel bụ ezigbo ọgwụgwọ na-enyere aka belata nchịkọta platelet ngwa ngwa. Ọ bụrụ na ị jiri ọgwụgwọ mee ihe n'ụzọ amamihe dị na ya, enwere ike iji ya gbochie ọtụtụ ọrịa. Agaghị m akwado ọgwụ ịchọrọ onwe gị, ebe nke a dị ize ndụ.
Ogwu nwere ike ime ka nsogbu obara di ukwuu. Nke a na - aputa mgbe ogwu a tụrụ aro a gafere. Enwere ike ịhụ mmetụta yiri nke ahụ mgbe ịwachara ahụ. Zụta ọgwụ site na ndenye ọgwụ wee were naanị ntuziaka ahụ.
Denis, 59 dị afọ 59, Donetsk.
Agbalịrị m iwere clopidogrel mgbe marcardial infarction. Dọkịta depụtara ya, ya mere, ọ chịkwara usoro ịsụ ọgwụ yana oge ọgwụgwọ ọ bụla.
Bọchị ole na ole ịlechara ọgwụ, ahụrụ m nsonaazụ. Ha bidoro gbawara imi. Agara m ụlọ ọgwụ. Emere ọbara nke gosipụtara na haemoglobin nwere ntakịrị. Na mbụ, ndị dọkịta dere ihe niile, mana ọgbụgba mechara sonye na akara ndị ahụ. Ọ nwere ọbara dị egwu n'ime ya. Ha mere eriri afọ nke na ha hụrụ ọnya afọ. Akwụsịrị m ịnara ego ndị ahụ.
Boris, dị afọ 62, Dnipro.
Anọwo m na-ata ahụhụ ogologo oge site na arrhythmia, nke na-aga n’ihu. N’oge na-adịbeghị anya, na nnọkọ na-esote nke a na-esochi dibịa na-esote, a chọpụtara m na ọrịa firamillation. Ebe ọ bụ na m na-emebu ultrasound nke arịa akwara ozi na-ahụ ebe epeepe nke atherosclerotic, dọkịta nyere m iwu clopidogrel iji gbochie nrapado platelet. O kwuru na ọ ga - ekwe omume igbochi ikewapụ oghere ndị nwere ike ịbanye n’akpa ume na akụkụ ndị ọzọ site na ịmachi arịa ebe ahụ ma bute nkụchi obi.
Anọ m na-a theụ ọgwụ ahụ maka ọnwa nke abụọ. Enweghị mkpesa ruo ugbu a. M na-a aụ ọgwụ ole na ole ọzọ iji chịkwaa obi m. Ahụghị m mmetụta ọ bụla.
Julia, onye gbara afọ 67, Kiev.
Ejiri m ọgwụ a mgbe obi nkụchi. N'oge ọgwụgwọ, enwere m mmeghachi omume na-adịghị mma, mana m nọgidere na-ewere ya.Usoro ọgwụgwọ ahụ were ihe karịrị otu ọnwa. E nwere afọ ntachi, mgbu afọ. Ma mgbaàmà ya adị oke njọ. Ahụike obi dị mkpa karịa.
Enwere m ekele maka ngwa a maka inye aka ịlaghachi na nkịtị. Ugbu a ana m abanye nwayọ gara aga na-aga, na-emegharị, na-eme mmega ahụ. Knowsnye maara otú ọ ga-esi kwụsị n'enweghị ọgwụgwọ ọ bụla.
