Liraglutide - ọgwụ maka ịgwọ ụdị ọrịa shuga 2: ntuziaka na nyocha

Gịnị bụ ọgwụ nri?

Liraglutide bụ analogue nke homonụ nke ya - glucagon-dị ka peptide-1 (GLP-1), nke a na-ewepụta na nri diges na nzaghachi maka nri oriri ma na-akpata njikọ nke insulin. Natural GLP-1 bibiri n’ime ahụ n’ime nkeji ole na ole, otu ihe na-eme ka ọ dị iche na ya bụ naanị ọnụọgụ abụọ nke amino acid na kemịkal. N'adịghị ka GLP-1 mmadụ (nwa amaala), liraglutide na-ejigide ndọpụ uche n'ehihie, nke na-enye ya ohere ịhazi ya naanị otu oge n'ime awa 24.

Enwere ya n'ụdị edozi doro anya, a na-eji ya maka injections subcutaneous na usoro nke 6 mg / ml (ngụkọta nke 18 mg nke ihe ahụ kpamkpam). Companylọ ọrụ mbụ mepụtara bụ ụlọ ọrụ Danish Novo Nordisk. A na-ebunye ọgwụ ahụ n'ụlọ ahịa ọgwụ n'ụdị katriiki, ejiri ya na mkpịsị mkpụrụ sirinji, nke a na-eji ọgwụ kwa ụbọchị. Ike ọ bụla nwere 3 ml nke ihe ngwọta, na ngwugwu nke 2 ma ọ bụ 5 iberibe.

Emere ọgwụ ọgwụ

N'okpuru ọrụ nke ihe na - arụ ọrụ - liraglutide, a na - eme ka ịmụgharị insulin nke onwe ya na - arụ ọrụ nke mkpụrụ ndụ sel. Na nke a, a na - emechi njikọta nke homonụ glucose na - glucose -.

Nke a pụtara na site n'ọtụtụ shuga dị n'ọbara, imepụta insulin na-abawanye ma na - egbochi ihe glucagon. N'ọnọdụ ọzọ, mgbe mgbanye glucose dị ala, mmiri nke insulin na-ebelata, mana njikọ glucagon na-anọgide n’otu ọkwa.

Mmetụta dị mma nke liraglutide bụ oke ibu na mbelata anụ ahụ adipose, bụ nke metụtara usoro nke na-eme ka agụụ kwụsịlata ma kwụsịlata ike.

Ihe omumu emere na anahu ahu egosiputala na ogwu nwere ike ime ezigbo ike n’anu-ihe, n’erughi onu ogugu.

Ihe ngosi maka ojiji

Liraglutide bụ maka naanị ndị gbara afọ 18 gbagotere ụdị ọrịa shuga 2. Ihe ga-eme bu ezi ihe oriri na aru gi.

Enwere ike iji ya dịka:

1. Naanị ọgwụ maka ịgwọ ụdị ọrịa shuga 2 (ọgwụgwọ mbụ).
2. Na mpempe mbadamba (metformin, wdg) n'ọnọdụ ebe mmadụ enweghị ike nweta njikwa glycemic chọrọ site n'enyemaka nke ọgwụ ndị ọzọ.
3. Na njikọta insulin, mgbe ngwakọta nke liraglutide na metformin enyeghị nsonaazụ achọrọ.

Ngwurugwu mgbochi na nsonaazụ ya

Ndepụta nke ọnọdụ mgbe amachibidoro ma ọ bụ amachibido iji liraglutide:

• mmadụ inwere onwe ya;
• akpụ akpụ-na-emetụta homonụ nke thyroid gland, ọbụlagodi na a hụrụ ya otu mgbe na nso ndị ikwu;
• neoplasms na-emetụta akụkụ abụọ nke sistem endocrine;
• Ọrịa shuga ;dị 1;
• ọbara mgbali elu na ahụ ketone;
• ogbo nke ikpeazụ nke ọdịda akụrụngwa;
• ọrịa obi na-adịghị ala ala;
• egbula oge ịkwafu afọ;
• ọrịa afọ ọsịsọ;
• oke imeju akwara;
• oge ime na inye nwa ara;
• afọ ruo afọ 18.

Ihe ojoo ojoo nwere ike iputa n'oge eji ogwu a:

1. Ọkpụkpụ afọ. Ọgbụgbọ, ọgbụgbọ, ọnya ọgbụgba, ihe mgbu nke afọ, bloating.
2. Akpụkpọ ahụ. Itching, ihe ngbu, urticaria. Mmeghachi omume nfụkasị ahụ na ntụtụ.
3. Metabolism. Enweghị agụụ, anorexia, hypoglycemia, akpịrị ịkpọ nkụ.
4. STS. Rateba ụba n’obi.
5. Usoro ụjọ. Isi ọwụwa na anya isi.

Ọ bụrụ na otu n'ime ihe ịrịba ama nke mmetụta ọjọọ nke liraglutide pụtara, ị kwesịrị ịgwa dọkịta gị ozugbo. Ma eleghị anya, nke a bụ mmeghachi omume nwa oge nke anụ ahụ, ma ọ bụ ikekwe nnukwu ihe egwu nye ahụike.

Ntụziaka maka ojiji

A na-edozi Liraglutide naanị n'okpuru anụahụ. Amachibidoro iji ya intramuscularly na ọkachasị intraven! A na-eji ihe ngwọta ahụ eme ihe n'otu oge otu ugboro n'ụbọchị, n'agbanyeghị nri. Ebe a họọrọ ahịrị dị mma bụ ubu, apata ụkwụ na afọ.

Obere nke malitere bụ 0.6 mg kwa ụbọchị, ekwesịrị ịnye ọnụ maka opekata mpe otu izu, emesia ọ ga - eme ka ịbawanye ọgwụ were ya ruo 1.2 mg. Iji nweta nsonaazụ kacha mma, enwere ike ịkọ ọgwụ a na ọgwụ nke 1.8 mg. Usoro ọgwụgwọ kachasị dị irè bụ 1.8 mg (n'ọnọdụ nke Victoza). Ọ bụrụ na-eji Saksenda, mgbe ahụ, usoro ọgwụgwọ kachasị bụ 3 mg kwa ụbọchị.

Ọ bụrụ n’agaghị ọgwụ ọzọ, ị ga-abanye ọgwụ ngwa ngwa o kwere omume n’ime awa iri na abụọ na-esote. Ọ bụrụ na ihe karịrị oge a agafeela, mgbe ahụ dose ahụ gafere ma ọ bụrụ n’ebido iwepụta ọgwụ na -echi ya echi. Mmeghe nke okpukpu abụọ anaghị enye nsonaazụ dị mma.

Ihe dị n'ọrụ dị na katriki pụrụ iche, nke a na-ewukwasị ya na sirinji sirinji. Tupu ojiji, gbaa mbọ hụ na edozi ya doro anya na enweghị agba. Maka nchịkwa ọgwụ, ọ ka mma iji agịga na-erughị 8 mm ogologo ma ruo 32G.

A machibidoro Liraglutide ịhapụ! Ekwesịrị ịchekwa ya na friji ma ọ bụrụ na mkpụrụ sirinji dị ọhụrụ. Mgbe ojiji nke mbụ, enwere ike idobe ya na okpomọkụ ruo 30 Celsius, ma ọ ga-ekwe omume ịhapụ ya na friji. Ekwesịrị iji katịlet ga-eji otu ọnwa mgbe emepechara.

Njikọ Ọgwụ

Ihe analog nke GLP-1 nwere ikike di ala nke iso ndi ozo na nmekorita, nke metabolism di iche iche kowara na akowa ya na ntinye aka na protein ndi chosara.

N'ihi eriri afọ nke na-egbu oge, a na-etinye ọgwụ ụfọdụ n'ụdị ọgwụ na-egbu oge, mana idozigharị dose na nke a achọghị.

Liraglutide na-ebelata oke ị ofụ ọgwụ ụfọdụ, mana idozi usoro ọgwụgwọ adịghịkwa mkpa.

Liraglutide n'oge ime

Enwebeghị ọmụmụ pụrụ iche na ìgwè ndị ọrịa a, ya mere amachibidoro ọgwụ a maka iji ya. Nlele na anụmanụ anụmanụ n’ụlọ nyocha egosila na ihe nwere nsị na-egbu egbu n’ebe nwa ebu n’afọ nọ. Mgbe ị na-eji ọgwụ ahụ, nwanyị kwesịrị iji ọgwụ mgbochi zuru oke, ma ọ bụrụ na a na-eme atụmatụ ime, ọ ga-agwa dọkịta na-aga ọmụmụ banyere mkpebi a ka o nyefee ya na ọgwụgwọ ahụ ka mma.

Ọmụmụ ihe gbasara ọgwụ

Ule nyocha ụlọ ọgwụ LEAD nyochachara ịdị irè nke ihe arụ ọrụ. 4000 ndị nwere ụdị ọrịa shuga 2 butere onyinye ha bara oke na ya. Nsonaazụ gosipụtara na ọgwụ ahụ dị mma ma dịkwa nchebe ma dịka ọgwụgwọ kachasị, yana yana yana mbadamba shuga ndị ọzọ.

Achoputara na ndi mmadu ndi na anata anakpo ahira mmanu ogologo oge belatara ahuhu ahu na obara obara. Ọnọdụ nke hypoglycemia belatara ugboro 6, ma e jiri ya tụnyere glimepiride (Amaril).

Nsonaazụ nke mmemme ahụ gosiri na gemoglobin glycated na ahụ ya belatara nke ọma na liraglutide karịa insulin glargine yana nchịkọta metformin na glimepiride. Edeela ya na ọnụ ọgụgụ ọbara ọbara na-agbada mgbe izu 1 nke iji ọgwụ ahụ, nke na-adabereghị n'ibu oke.

Nsonaazụ nyocha ikpeazụ:

• n'ịhụ na uru ebumnuche glycated glycated dị;
• wedata ọnụọgụ dị elu nke ọbara mgbali elu;
• ọnwụ nke mmezi paụnd.

Uru na ọghọm dị n'ime ya

Njirimara Dị Mma:

• Ọ nwere ike belata agụụ ma belata oke ahụ.
• Na-ebelata ihe egwu dị na nsogbu ndị siri ike metụtara CVS.
• Itinye 1 oge kwa ụbọchị.
• Ọ bụrụhaala o kwere omume, a na-ejigharị mkpụrụ ndụ nke sel.
• Na-akwalite njikọ nke insulin.

Nju:

• Ngwa subcutaneous.
• Ndị ntị chiri nwere ike ịnwe nsogbu ụfọdụ mgbe ha na-eji sirinji pen.
• Ndepụta nke contraindications buru ibu.
• Enweghi ike ime site na ime ime, ịsụ nwa na ụmụaka na-erubeghị afọ 18.
• Nnukwu ọgwụ ọjọọ.

Enwere analogues ọ bụla?

Ọgwụ na-enwe naanị liraglutide:

1. Victoza;
2. Saxenda.

Ngwakọta ọgwụ a jikọtara ọnụ, gụnyere ya na insulin degludec - Sultofay.

Kedu ihe nwere ike dochie liraglutide

Nyocha vidiyo nke ọgwụ maka ịta oke

Ọnụahịa

N'iburu n'uche ọgwụ ndị ahụ Viktoza na Saksenda n'ụzọ echiche akụ na ụba, anyị nwere ike ikwubi na ọgwụ mbụ ga-efu obere. Isi okwu ahụ abụghị na ọ bụ naanị ya na-efu obere, kama na usoro onunu ogwu nke kacha nta kwa ụbọchị bụ naanị 1.8 mg, ebe ọgwụ ọzọ nwere 3 mg. Nke a pụtara na 1 Victoza katrij zuru ezu maka ụbọchị 10, yana Saxends - maka 6, ma ọ bụrụ na ị were oke kachasị.

Nyocha banyere ọrịa mamịrị

Marina Enwere m ọrịa na-arịa ọrịa shuga 2 ihe dị ka afọ 10, m na-a metụ metformin na insulin insulin, shuga dị elu nke 9 mmol / l. Ibu m dị kilogram 105, dọkịta ahụ tụrụ aro ịnwale Viktoza na Lantus. Mgbe otu ọnwa gasịrị, kilogram 4 na shuga ya furu efu dị 7-8 mmol / L.

Alexander Ekwenyere m na ọ bụrụ na metformin enyere aka, ọ ka mma ị drinkụ ọgwụ. Mgbe ị gbanwere insulin, ị ga - anwale liraglutide.