Ọrịa mamịrị bụ ọgwụ na-arụ ọrụ nke ọma n'ọrịa shuga 2. Ngwaọrụ ya na-arụ ọrụ bụ gliclazide. Ejiri ọgwụ ewepụtara ngwa ngwa na ọnụahịa dị elu, ya mere, ọtụtụ ndị ọrịa na-achọ analogues Diabeton nke nwere ike ịba uru. Amachibidoro iji ọgwụ dochie onwe onye: a chọrọ ndụmọdụ ọkachamara.
Nkọwapụta Ngwaahịa
Ọrịa mamịrị bụ ihe nnọchianya hypoglycemic na usoro nke sulf-sulfonylurea, nke a na-ewere n'ọnụ. Ọdịiche ya na njikọta bụ ọnụnọ nke heterocyclic mgbanaka nwere N-ejikọtara ya na njikọ njikọ endocyclic. Ọgwụ ahụ na-akpali imepụta insulin site na mkpụrụ ndụ β-sel nke agwaetiti nke Langerhans ma na -ebelata ọdịnaya glucose na ọbara.
Mgbe afọ abụọ nke ọgwụgwọ gasịrị, mmụba nke ọnụọgụ C-peptide na insulin postprandial na-anọgide. Akụkụ nọ n'ọrụ na-egosipụta mmetụta haemovascular ma na-emetụta metabolism metabolism. N'ime ụdị shuga 2, ọ na-eme ka ịbawanye insulin nke abụọ wee weghachite ọnụ ọgụgụ nke ihe nzuzo ya na ịba glucose. A na-ahụ usoro ndị a karịsịa na ntinye ya na nzaghachi mkpali, bụ nke nri na-akpata.
Ọgwụ a na --ewepụta ihe ize ndụ nke thrombosis nke obere arịa ọbara na mmepe nke nsogbu ndị sitere na ọrịa shuga. Mgbe otu ụbọchị nke ọgwụ ahụ, ịta nke metabolites na-arụ ọrụ na pioglitazone n'ọbara ọbara na-anọgide n'ogo dị elu.
Ntụziaka maka ojiji
Nkọwa ahụ gosipụtara mmachi ị restrictionsụ ọgwụ. Ya isi contraindications bụ ọnọdụ ndị a:
akpịrị na-arịa ọrịa shuga na precoma;- oge ịctụ nwa na ịmụ nwa;
- nnukwu ịba ọcha n'anya na akụrụ;
- ọdịnaya dị elu nke ahụ ketone na glucose ọbara;
- anabataghi nke lactose, sulfanilamide, gliclazide.
akpịrị na-arịa ọrịa shuga na precoma;Ọ bụ naanị ndị okenye ka o bu ọgwụ nyere ọgwụ ahụ. A ga-ewere mbadamba ihe otu ugboro n’ụbọchị n’oge nri. Usoro kachasị elu kwa ụbọchị bụ 120 mg. Ọgwụ ahụ enweghị ike gwepịa ya ma rie ya, ọ ga-eji mmiri dị ọcha sachaa ya. Ọ bụrụ na ịmịchaa ị theụ ọgwụ, a naghị etinye usoro okpukpu abụọ.
Na usoro ọgwụgwọ mbụ, ọgwụ a bụ 30 mg. Ọ bụrụ na ọ dị mkpa, ọ na - abawanye site n'aka onye ọkachamara na-erughi ụbọchị 40 ka emesịrị nhọpụta nke gara aga. Ọrịa dị mkpa karịa ndị ọrịa karịrị afọ iri isii na ise. N'oge ọgwụgwọ, o kwesịrị ịtụle oge iwepu ọgwụ ndị gara aga. Mgbe ị na-a theụ ọgwụ ahụ, mmeghachi omume ojoo nwere ike ịmalite. Ndị a gụnyere:
ọnwụ nke nsụhọ;- ura nwere ura ma ọ bụ ura;
- obi anụ ahụ;
- enweghi mgbakasị ahu;
- ogwugwu na adighi ike;
- nhụjuanya ezughị ezu, nkụda mmụọ.
ọnwụ nke nsụhọ;Analogs na dochie ọgwụ ahụ
Ogwu ahu nwere ego di elu. A na-anọchi anya ọrịa mamịrị analogs na ndị nọchiri anya ọgwụ ndị a:
- Diabetalong;
- Gliclazide;
- Glidiab;
- Diabefarm MV;
- Predian;
- Glucostabil;
- Piroglar.
Diabetalong -Akọkọtara ọnụ nke Diabeton, okwu ana - eme ka insulin na - abawanye, ọ ga - eme ka akụrụngwa anụ ahụ na - ebelata oke glucose na ọbara. Ọ bụghị ihe riri ahụ ọbụna mgbe afọ 3 nke iji. Ọgwụ na -ebe hyperglycemia postprandial, na-eweghachi ọnụ ọgụgụ mbụ nke mmepụta insulin, na-ebelata oge etiti dị n'etiti iri nri na insulin. N’ime imeju, ọgwụ a na - ebelata oruru glucose ma rụkwaa ọrụ ya.
Ihe ahụ na - arụ ọrụ na - eme ka microcirculation na carbohydrate metabolism dịkwuo ala, belata ihe ize ndụ nke thrombosis ma weghachi ọrụ nke onye na - eme ka plasminogen anụ ahụ.
Gliclazide - Nke a bụ ụdị hypoglycemic ọgwụ nke edepụtara n'ime. O nwere mgbanaka heterocyclic nwere njikọ endocyclic. Ọgwụ na-akpali mmepụta nke insulin ma belata oke glucose. Mgbe ọgwụgwọ afọ atọ gasịrị, mmụba nke ịba ụba nke C-peptide na inspinaldial insulin na-anọgide. Ihe nọ n'ọrụ na-egosipụta ọrụ haemovascular ma na-emetụta metabolism nke carbohydrate nke ọma. Iji ọgwụ eme ihe na-ebelata ihe ize ndụ nke ọrịa shuga.
Glidiab bu usoro ogwu nke anakpo mmadu abuo na ogwu hypoglycemic. Ọ na - eme ka ọrụ glucose insulin na - arụ ọrụ, ịwa ahụ na - emegharị ahụ ma nwee uru bara uru na mmịnye insulin, na - akpali ọrụ nke enzymes intracellular muscle glycogen synthetase, ma belata ọnụ ọgụgụ kachasị elu nke hyperglycemia mgbe ị risịrị nri. Ekwesịrị ịmalite iji ọgwụ a ga-amalite megide nri dị kalori nwere obere carbohydrates.
A na-atụ aro ka ị na-elele glucose n'ọbara mgbe emesịrị nri na afọ efu. A na-ahazi usoro ọgwụgwọ maka nrụgide obi ma ọ bụ nke anụ ahụ.
Diabefarm MV - Nke a bụ analog nke Diabeton 60, nke bụ ọgwụ hypoglycemic ma nwee ọmụmụ ya na ọgbọ nke abụọ nke ihe atọmịkị nke sulfonylurea. Ọ na - eme ka mmepụta nke insulin site na sel nke pancreas na ihe nke enzymes intracellular. Ọgwụ ahụ dị oke mma na ụdị ọrịa shuga na-arịa insulin na-abụghị insulin na-arịa microangiopathy na-arịa ọrịa ụbụrụ yana dịka prophylactic nke ọrịa microcirculation.
Predian - ọgwụ ogwu sitere na sịntetik. Enwere ike ịzụta ya n'ụdị mbadamba nkume nwere usoro nke 0.08 g, juru n'ọnụ n'ime kaadiboodu. Ihe na-arụ ọrụ na-ebelata coagulation ọbara ma belata shuga. Ekwesiri iji ọkara ọgwụ ga-amalite iji ọgwụ ahụ. Agaghị ejikọta ọgwụ ahụ na acetylsalicylic acid, butadione, amidopyrine n'ihi iyi egwu hypoglycemia.
Glucostabil na-eme ka akwara vaskụla fibrinolytic, belata mmepe nke thrombus parietal, nchịkọta platelet na adhesion. Ọgwụ ahụ na-abawanye microcirculation, ọnụọgụ nke HDL-C, na-ebelata oke cholesterol, mmetụta nke arịa ọbara na adrenaline ma na-egbochi mmepe nke atherosclerosis na microthrombosis. A na-ahụ mbelata ogologo oge na proteinuria na-emegide usoro ojiji nke gliclazide ruo ogologo oge na nephropathy mamịrị.
Pioglar - ọgwụ hypoglycemic ọgwụ na ike agmaist gamma nke nhọrọ gamma. Akụkụ nọ n'ọrụ gosipụtara mgbanwe mkpụrụ ndụ ihe nketa na-etinye aka na nkwụsị nke lipid na nchịkwa glucose. N’ime imeju na akwara ndị dị n’ime ala, ọ na - ebelata insulin iguzogide. Na ụdị ọrịa shuga abụọ nke ọrịa mellitus na-eme ka haemoglobin glycated na insulin na plasma.
Inwere ike ichota onye oria di dochie anya dokita gi. A naghị atụ aro ka ị jiri ọgwụ ahụ n'onwe gị, n'ihi na nke a nwere ike ibute nsonaazụ ndị dị ize ndụ.
