Gensulin bụ ọgwụ ntụtụ maka ọrịa shuga mellitus. A na-egbochi ọgwụ ahụ maka ọdịmma dị elu na mmiri ahụ yana hypoglycemia.
Gensulin H bụ insulin nke oge mmadụ. A na-enweta ọgwụ ahụ site na iji usoro ọgbara ọhụrụ nke inyocha mkpụrụ ndụ ihe nketa. A na-eji Gensulin H mee ihe iji chịkwaa metabolism.
N'aka Gensulin N na-acha ọcha, mgbe izu ike ya edozi oke ọcha, n’elu ya bụ mmiri mmiri n’enweghị agba.
Ogwu na ihe mejuputara
Gensulin H bụ insulin mmadụ nke emepụtara site na iji teknụzụ DNA recombinant ọgbara ọhụrụ. Ngwọta a na-arụ ọrụ dị ka nkwadebe insulin na-enwe oge ọrụ.
Ọgwụ a na-emekọ ihe na ndị na - anabata mkpụrụ ndụ cytoplasmic nke mkpụrụ ndụ. E guzobere otu ihe na-akpali, yana njikọ nke ụfọdụ enzymes isi, ya bụ:
- pyruvate kinase,
- hexokinase
- glycogen synthetase.
Ihe omume insulin ahụ ga-anọ ogologo oge iji mee ka ọ dị mma ịnabata. Ngwa ọsọ a dabere n'ọnọdụ dịka:
- usoro onunu ogwu
- mpaghara na usoro nchịkwa.
Ihe omume nke ngwaahịa a gbanwere. Ọzọkwa, nke a metụtara ndị dị iche iche, yana ọnọdụ steeti otu onye ahụ.
Ogwu ahu nwere otutu ihe omuma banyere ya. Ya mere, akụrụngwa amalite ime ihe mgbe otu elekere na ọkara, a na-enweta nsonaazụ kachasị ya na oge 3-10 awa. Ogologo oge ọgwụ ahụ bụ awa 24.
Ihe mejupụtara ọgwụ ahụ nwere 100 IU nke insulin na-arụ ọrụ mmadụ kwa 1 ml. Ndị pụrụ iche bụ:
- metacresol
- glycerol
- sọlfọ protamine,
- zinc oxide
- phenol
- sodium hydrogen phosphate dodecahydrate,
- mmiri maka ịgba ntụtụ
- hydrochloric acid ka pH nke 7.0-7.6.
Ciplekpụrụ nke ịrụ ọrụ
Gensulin H na-anabata ndị na-anabata mkpụrụ ndụ. Ya mere, ogige nnabata insulin na-apụta.
Mgbe mmepụta nke AMP n’ime mkpụrụ ndụ akwara na-abawanye ma ọ bụ mgbe akwara dị iche iche batara n’ime sel ndị ahụ, insulin receptor complex na-amalite ime ka usoro intracellular dị n’ime.
Mbelata ogo guga bụ ihe kpatara:
- ịba ụba n'ime mkpụrụ ndụ,
- mmụba shuga site na anụ ahụ,
- njikọ protein
- ebighị nke lipogenesis,
- glycogenesis
- mbelata na ọnụego shuga nke imeju na-eme.
Ntuziaka maka iji ọgwụ ahụ
Ndị dọkịta kpebiri iji usoro ịsụ ọgwụ ahụ kpebie ihe ọ bụla. Site na ngosipụta nke ịka ọkwa ọbara ọbara, na-eburu n’uche omume mmadụ.
Ọkpụkpụ n'ime apata ụkwụ kachasị mma, a pụkwara itinye insulin n'ime ihe mgbochi, mgbidi dị n'ihu, yana uru akwara. Ọnọdụ okpomọkụ nke nkwusioru kwesịrị ịbụ okpomoku ụlọ.
A alcoholụ mmanya na-egbu ya tupu ya abanye ya. Jiri mkpịsị aka abụọ, kpoo anụ ahụ. Na-esote, ikwesiri itinye agịga na akụkụ ala nke ihe dịka ogo 45 n'ime ntọala nke ogige a wee tinye ọgwụ insulin n'okpuru ya.
Ikwesighi iwepu agịga ahụ ruo ihe dị ka sekọnd 6 mgbe ịgba nchara ahụ iji jide n'aka na a na-enye ọgwụ ahụ nke ọma. Ọ bụrụ na ọbara dị na mpaghara ịgbapụ, mgbe iwepụrụ agịga ahụ, jiri mkpịsị aka gị wepụta ntụpọ ahụ. Oge ọ bụla a gbanwere ebe ọgwụ ntụtụ.
A na-eji Gensulin N eme ihe dị ka ọgwụ monotherapy yana na usoro ọgwụgwọ nwere insulins adịghị mkpụmkpụ - Gensulin R.
N'ime katriiki enwere obere bọl nke iko, nke na-enyere aka ịkpali ngwọta. Kwesighi ịma jijiji katalọgụ ma ọ bụ karama ike, n'ihi na nke a nwere ike ime ka etolite ụfụfụ, nke na-egbochi nchịkọta ego ziri ezi.
Ọ dị mkpa iji nyochaa ọdịdị nke ngwaahịa ahụ na katridges na vials mgbe niile.
Amachibidoro iji ọgwụ ahụ ma ọ bụrụ na enwere flakes ma ọ bụ mpempe ọcha na-agbaso na mgbidi ma ọ bụ na ala nke akpa.
Ihe ngosi na contraindications
Enweghi ike iji insulin Gensulin mee ihe ma ọ bụrụ na enwere mmụba dị ukwuu, yana hypoglycemia.
A na-eji ọgwụ ahụ eme ihe n'ụzọ dị irè maka ụdị ọrịa mellitus 1 na nke 2.
Na mgbakwunye, enwere akara ndị a:
- ogbo nke iguzogide ọgwụ hypoglycemic,
- ele mmadụ anya n'ihu na-egbochi ọgwụ ọgwụ hypoglycemic,
- ogwu ogbugba,
- arụmọrụ
- ọrịa shuga n’ihi afọ ime.
Ihe ndị a ka ama ama mmetụta ndị a:
- mmeghachi omume nfụkasị ahụ: mkpụmkpụ ume, fever, urticaria,
- hypoglycemia: ndakpọ, palpitations, isi ọwụwa, egwu, ehighi ura, obi erughị ala, enweghi ike imeghari, ọhụhụ isi na ikwu okwu, hypoglycemic coma,
- acid na-arịa ọrịa shuga na hyperglycemia,
- nkwarụ anya nwa oge,
- itching, hyperemia na lipodystrophy,
- ihe egwu nke coma
- mmeghachi omume immunological na insulin nke mmadụ;
- mmụba na titant antibody na-abawanye na glycemia.
Na mmalite ọgwụgwọ, enwere ike ịnwe mmejọ na edema, nke na-adị nwa oge na okike.
Usoro injection mgbe eji insulin na vials
Iji gbanye insulin, a na-eji sirinji pụrụ iche dabere na ego nke agịrị. Odi nma ijiri sirinji otu emeputa na udiri. Ọ dị mkpa ịlele mmezi nke sirinji, na-eburu n'uche nchịkọta nke insulin.
Kwadebe maka ntụtụ dị ka ndị a:
- wepu okpu kpuchie aluminom na flagon,
- were mmanya na-egbu karama ahụ, ewepụkwala roba,
- gbanye ikuku n'ime sirinji nke kwekọrọ na insulin,
- fanye agịga ahụ na stopa rọba wee nweta ikuku,
- tụgharịa karama ahụ na agịga (njedebe nke agịga na-anọdụ ala),
- banye ego kwesịrị ekwesị n'ime sirinji,
- wepu afụ ikuku site na sirinji,
- soro izi ezi nke nnabata insulin ma wepụ irighiri ahụ na vial ahụ.
Ekwesịrị ịgwọ ọgwụ ahụ otu ụzọ a kapịrị ọnụ. Iji mee nke a, ịchọrọ:
- mee ka akpụkpọ ahụ mee ka mmanya na-egbu egbu na saịtị ahụ
- iji chịkọta akpụkpọ anụ n'aka gị,
- Tinye aka ntụtụ nke aka gi site n'aka nke ozo 90 digiri. Ikwesiri igba mbọ hu na agwara gị na ọ dị n’akụkụ miri emi,
- iji duzie insulin, kpoo piston ahụ gbadata, na-ewebata usoro ị nweta ihe na-erughị sekọnd ise,
- wepu agịga ahụ n’akpụkpọ ahụ site na ijide mmanya na-egbu egbu dị nso. Pịa swab na mpaghara ịgba ọgwụ maka sekọnd ole na ole. Etela ebe a na-agba ntụtụ,
- Iji zere mmebi anụ ahụ, ịkwesịrị iji ebe dị iche iche maka ntụtụ ọ bụla. Ọnọdụ ọhụrụ kwesịrị ịbụ ma ọ dịkarịa ala sentimita ole na ole site na nke gara aga.
Usoro eji eme ihe Cartridge
Cartridges nwere insulin Gensulin N dị mkpa iji jiri mkpịsị sirinji, dịka ọmụmaatụ, Gensupen ma ọ bụ Bioton Pen. Onye nwere ọrịa shuga kwesịrị iji nlezianya mụọ ntuziaka maka iji mkpịsị akwụkwọ dị otú ahụ wee soro ndụmọdụ ndị a.
Ngwa katriiki anaghị ekwe ka agwakọta na ihe ndị ọzọ dị n’ime katalọgụ. Agaghị emejupụta katrized efu.
Must ga-abanye n ’insulin chọrọ ya, nke dọkịta gị depụtara. Ekwesịrị ịgbanwe saịtị ntụtụ ahụ ka ọ ghara iji otu ebe karịa oge 1 kwa ọnwa.
Nwere ike gwakọta Gensulin P ogwu ntụtụ yana nkwụsịtụ nke Gensulin N. Mkpebi a ga-eme nke a. Mgbe ị na-akwadebe ngwakọta ahụ, insulin nwere obere oge iji mee ya, ya bụ, Gensulin P, kwesịrị ibu ụzọ họrọ n'ime sirinji ahụ.
Iwebata ngwakọta a kọwara dị ka akọwara n’elu.
Eleghị anya mmetụta
Ihe nrịba ama oriọna bu ịba ụba hypoglycemia. Enwere ike ị takenụ ọgwụ shuga ma ọ bụ carbohydrate maka ọgwụgwọ nke ọkwa dị nro Maka ndị na-arịa ọrịa shuga, ọ dị mkpa ka ị na-ebu swiiti, shuga, mmanya ọ sweetụ sweetụ, ma ọ bụ kuki na-aga n'ihu.
Enwere ike ịchọpụta mmetụta na carbohydrate, nke gosipụtara na ụfọdụ ahụ erughị ala. N'ọnọdụ ụfọdụ, ọ nwere ike ịbụ:
- nkwarụ hypoglycemic: isi ọwụwa, akpịrị nke anụ ahụ, ịsụsọ nke ukwuu, mkpịsị ahụ, ịma jijiji nke oke ahụ, mkpasu iwe na-enweghị isi, mmetụta nke agụụ dị ukwuu, paresthesia na oghere ọnụ,
- n'ihi ọrịa hypoglycemia, Coma nwere ike ịmalite,
- ihe ịrịba ama nke hypersensitivity: n'ọnọdụ ụfọdụ, ụkwara Quincke na ọnya akpụkpọ ya, yana ujo anafilactic,
- mmeghachi omume na mpaghara nchịkwa: hyperemia, itching, swelling, with use muddo - lipodystrophy in diabetes mellitus injection injection.
Site na mbelata nke ukwuu na mgbanye glucose, yana ọ bụrụ na mmadụ amataghị, ọ dị mkpa inye 40% glucose na ntinye uche. Mgbe eweghachiri mmụọ, ị ga-eri nri nwere carbohydrates.
Ekwesịrị ime nke a iji gbochie usoro hypoglycemia ugboro ugboro.
Ntụziaka pụrụ iche
Enwere ike belata ịba uru ọbara shuga mgbe enyere mmadụ site na insulin anụmanụ site na insulin nke mmadụ. Ntugharị a kwesịrị ka a zie ezi mgbe nile ma eme ya naanị n'okpuru nlekọta ahụike.
Ọchịchọ ịkpụpụta hypoglycemia nwere ike belata ikike mmadụ nwere ịkwọ ụgbọala, ọrụ ụfọdụ. Ọrịa shuga na-dụrụ ọdụ ka ha na-ebu okpukpu 20 shuga mgbe niile.
A na-edozi doses nke insulin mgbe:
- ọrịa na-efe efe
- ndakpọ nke thyroid gland,
- Ọrịa Addison
- hypopituitarism,
- CRF,
- ọrịa shuga n’ime ndị karịrị afọ 65.
Hypoglycemia nwere ike ịmalite n'ihi:
- ulindoụ ọgwụ insulin
- ọgwụ idochi
- nchekasị anụ ahụ
- vomiting na afọ ọsịsa
- ọrịa na-ebelata mkpa insulin,
- ọrịa nke imeju na akụrụ,
- ịractionụ ọgwụ ụfọdụ
- mgbanwe mgbanwe mpaghara.
N'oge ịmụ nwa na nwa oge mgbe amuchara nwa, enwere ike belata mkpa nke insulin. N’oge ị na-enye ara, ekwesịrị ka ị na-ahụ ya kwa ụbọchị ruo ọtụtụ ọnwa.
Mmetụta hypoglycemic nke ọgwụ na-abawanye site na sulfonamides, na-:
- Ndị na - egbochi MAO
- carbonic anhydrase inhibitors,
- Ndị na - egbochi ACE, NSAID,
- anabolic steroid
- bromocriptine
- tetracyclines
- clofibrate
- ketoconazole,
- mebendazole,
- theophylline
- cyclophosphamide, fenfluramine, nhazi Li +, pyridoxine, quinidine.
Analogs na ọnụahịa
Ọnụ ego ọgwụ a na-akwụ na-adabere na usoro onunu ogwu na onye nrụpụta. Na Internetntanetị, ha na-ere ọgwụ ahụ n'ọnụ ego dị ala karịa na ụlọ ahịa ọgwụ.
Ọnụahịa nke Gensulin N dịgasị iche site na 300 ruo 850 rubles.
Analogues nke ọgwụ bụ:
- Biosulin N,
- Ka anyị mee ka N,
- Mgbapụta insulin mberede
- Insuman Bazal GT,
- INPANET NPH,
- Rosinsulin C,
- Insulin Protafan NM,
- Protafan NM Penfill,
- Rinsulin NPH,
- Humodar B 100 Rec.
Ọgwụ nwere ọkacha mma nyocha sitere n’aka ndị nwere ọrịa shuga 1 na ụdị nke abụọ.
Ntuziaka maka iji insulin eme ihe dị na vidiyo dị n'isiokwu a.
