Dabere na ndekọ ọnụ ọgụgụ ị drugsụ ọgwụ ọjọọ gburugburu ụwa, akụkụ mbụ nwere oke ala bụ nke ejiri statins nọrọ ebe ọ bụ na ọ bụ patted.
Atorvastatin bụ ọgwụ izizi nke ihe a. A gwakọtara ọgwụ ahụ na August 1985 na Germany.
Statins bụ ọgwụ e mere iji lụ ọgụ hypercholesterolemia, yana atherosclerosis na - etolite n'ihi ya. Ihe ha mere bụ imezi ihe ngosipụta nke lipid, na-agwọ ntụpọ na mgbidi akwara ma belata ọnya ya.
Mmetụta nke statins na cholesterol biosynthesis
Statins belata cholesterol ọbara site na itinye ya na biosynthesis na imeju.
Iji nweta nghọta nke ọma, ọ bara uru iwere usoro niile gaa nkebi.
E nwere ihe karịrị iri abụọ mmiri etinye aka na usoro biosynthesis.
Maka n ’ọmụmụ ihe na nghọta dị mma, e nwere nanị ụzọ anọ dị mkpa:
- ọkwa mbu bu nnabata glucose zuru oke na hepatocytes iji bido imeghachi omume, emesia enzyme HMG-CoA reductase bidoro ịgụnye na usoro a, n'okpuru ike nke ihe ana - akpọ mevalonate mebere site na biotransformation;
- mevalonate ahụ gbasasịrị na usoro phosphorylation, ọ mejupụtara na nnyefe nke ìgwè phosphorus na ijide ha site na adenosine tri-phosphate, maka njikọ nke isi mmalite ike;
- ọkwa nke ọzọ - usoro nke oghere - ọ mejupụtara na iji nwayọ nwayọ nke mmiri na ntughari mevalonate n'ime squalene, wee banye lanosterol;
- na lanosterol, site na ịtọlite agbụ abụọ, a na-ejikọ carbon carbon - nke a bụ ọkwa ikpeazụ nke mmepụta cholesterol na-eme na akụkụ pụrụ iche nke hepatocytes - endoplasmic reticulum.
Statins na-emetụta ogbo mbu mgbanwe, na-egbochi enzyme HMG-CoA reductase na ọ fọrọ nke nta ịkwụsị ọrụ mevalonate. Usoro a bụụrụ ndị otu ahụ niile. Yabụ izizi ndị sayensị German mere ya na Pfizer na narị afọ gara aga.
Mgbe afọ iri nke ule ụlọ ọgwụ, statins pụtara n'ahịa ahịa ọgwụ. Nke mbụ n'ime ha bụ ọgwụ Atorvastatin mbụ, ndị ọzọ pụtara ọtụtụ oge mgbe e mesịrị ma bụrụ ndị nwe ya - ndị a bụ ihe ndị a na-akpọ generics.
Uzo ime ihe n’ahu
Tevastor bụ statin ọgbọ anọ nwere, dị ka ihe na-arụ ọrụ, rosuvastatin. Tevastor bụ otu n’ime usoro iwu Atorvastatin kachasị ewu ewu na mba CIS - nke bu ya ụzọ.
Pharmacodynamics na pharmacokinetics na-akọwa etu Tevastor si eme ihe mgbe ọ batachara ahụ mmadụ.
Site n’etu afọ mucous nke afọ, ihe na-arụ ọrụ bụ n’ọbara ọbara na-ebugharị n’ahụ niile wee na-agbakọ na imeju mgbe awa ise gachara. Ndụ ọkara ahụ bụ awa iri abụọ, nke pụtara na ọ ga-ewe awa iri anọ iji kpochapụ ya. A na-ewepụ ọgwụ ahụ site n'okporo ụzọ ndị sitere n'okike - eriri afọ na-ewepụ 90%, ihe fọdụrụnụ bụ akụrụ. Site na iji ọgwụ ahụ mgbe niile, a na-egosipụta mmetụta ọgwụgwọ kachasị na otu ọnwa mgbe mmalite ọgwụgwọ.
Ọ bụrụ na onye ọrịa ahụ nwere ọrịa na-adịghị ala ala, ọgwụ pharmokokinetic na-agbanwe:
- Na nnukwu ọdịda akụrụngwa, mgbe nhichapụ nke creatine na-ebelata ugboro 4 ma ọ bụ karịa, ntinye nke rosuvastatin na-abawanye site na oge 9. N'ime ndị ọrịa na hemodialysis, ihe ndị a na-abawanye ruo 45%;
- N’ime ọgbụgba akwara na-adị nwayọ na agafeghị oke, mgbe iwepu ihe karịrị 30 milliliters kwa nkeji, ịta ihe n’ime plasma ahụ na-anọgide n’ọkwa ọgwụgwọ;
- Site na ọrịa imeju mepụtara, iwepu ọkara ndụ na-abawanye, ya bụ, ihe ndị dị n'ọrụ na-aga n'ihu na-ekesasị ọbara. Nke a nwere ike ibute nsí na-adịghị ala ala, mmebi akụrụ, na nsị na-egbu egbu. Ya mere, n'oge ọgwụgwọ, ọ dị mkpa ịgbasochi anya idebe ọgwụ dọkịta ahụ, iji gbochie ịdoụbiga mmanya ókè na ka oge na-agafe ule ule;
Mgbe ị na-eji ọgwụ ahụ, ekwesịrị icheta na n’agbụrụ agbụrụ Eshia, a na-eji nwayọ nke rosuvastatin ngwa ngwa, yabụ na a ga-enyocha ya obere nke obere.
Ngwakọta na usoro onunu ogwu
Ọdịdị na ọdịnaya nke mbadamba nkume ndị ahụ dịgasị iche dabere na usoro ha.
Tevastor 5 milligrams - nwere ọdịdị gbara okirikiri, agba site na odo na-egbuke egbuke ruo oroma. Enwere mmetụta dị n'akụkụ abụọ nke mbadamba mbadamba: n'otu aka n'ụdị leta N, n'aka nke ọzọ, ọnụọgụ 5. Ọ bụrụ na ịkụtu mbadamba ahụ, ị ga-ahụ isi ọcha n'ime, nke nwere nnu rosuvastatin;
Tevastor 10 milligrams, milligrams 20, milligram 40 - pink pink na mbadamba biconvex. Mpempe akwụkwọ ahụ dị n'akụkụ akụkụ nke akwụkwọ ozi ahụ bụ otu, n'akụkụ ọnụọgụ abụọ ọ dabara na usoro ọnụọgụ egosipụtara na ọnya. N'oge mmebi ahụ, a na-ahụkwa etiti ọcha, kpuchie ya na shei.
Ihe mejupụtara nke Tevastor bụ otu maka usoro onunu ogwu niile, ihe dị iche bụ naanị na ọnụọgụ onyinye na ndị na - arụ ọrụ:
- calcium rosuvastatin - ihe na-arụ ọrụ na-egbochi enzyme nọ n'ọrụ na-eme ka glucose gbanwee mevalonate;
- microcrystalline cellulose - ntụ ntụ na-emegharị emegharị, ewepụtara iji mee ka friability na eriri afọ;
- A na-eji lactose eme ihe dị ka ihe nzacha iji mee ka ọ̀tụ̀tụ̀ ya na ịdị arọ ya bukwuo ibu, tinyere cellulose na-eme ka mbibi ahụ na-agbakwu;
- povidone na crospovidone - ihe mgbochi iji hụ na ilo ilo;
- sodium stearine fumarate - na-eme ka mmiri na-aga nke ọma, na-eme ka ọrụ na igwe na-arụ ọrụ pịa site na mbenata mgbakwunye na ngwa.
Na mgbakwunye na ihe ndị a, ọgwụ nwere pink na agba mmanụ iji nye mbadamba ọmarịcha agba.
Ntuziaka maka iji ọgwụ ahụ
Enwere ụfọdụ ndepụta nke ihe ngosi maka iji ọgwụ ahụ.
Egosipụtara ihe niile na ntuziaka maka ojiji.
Akwụkwọ ntuziaka a bụ ihe dị mkpa na nchịkọta nke ọgwụ rere site na netwọ ahịa ahịa ọgwụ.
Isi ihe eji egosi ogwu a bu:
- Ihe mbu (ya na obere lipoproteins dị ala na-ebuli elu) na agwakọta (nke ukwuu lipoproteins dị ala dịkwa elu) hypercholesterolemia. Mana naanị na ikpe mgbe mmụba nke mmega ahụ, ịhapụ omume ọjọọ na nri nri anaghị eweta nsonaazụ kwesịrị ekwesị;
- Hypertriglycerinemia, yana mmụba n'otu oge na lipoproteins dị ntakịrị, ma ọ bụrụ na nri siri ike emebelata kọlestrọl;
- Atherosclerosis - iji mee ka ọnụọgụ nke ndị na-anabata lipoprotein dị ukwuu na imeju belata mkpokọta cholesterol ọjọọ;
- Iji gbochie mmepe nke ọrịa obi nke atherosclerosis: infarction nnukwu myocardial, ọrịa ischemic, angina pectoris, ọkachasị na ọnụnọ nke ihe ndị dị ize ndụ - ị smokingụ sịga, ị alcoholụbiga mmanya ókè, oke ibu, karịa afọ 50.
Ntụziaka maka ojiji gosipụtara usoro ọgwụgwọ doro anya maka ị takingụ ọgwụ.
Were ọnụ, na-a plentyụ nnukwu mmiri, n'agbanyeghị nri, na-enweghị ịta ata ma ọ bụ mebie ya. A na-atụ aro ị drinkụ mmanya n'abalị, n'ihi na n'ụbọchị a na-eme ọgwụ nke ọgwụ ngwa ngwa, ọ na-ewepụkwa ọnụọgụ dị ukwuu n'ahụ ya.
Ọgwụ izizi bụ 5 mg 1 oge kwa ụbọchị. Kwa ọnwa, ọ dị mkpa ka a na-ahụ maka njikwa ike mmanya na oge ndị dọkịta na-achọ. Tupu ịmalite ọgwụgwọ, ọ dị mkpa ka akwara banyere ịtụ ụtụ ga-enye nduzi maka nnabata ma kọwaa ihe mmetụta ndị ọ ga-akwụsị ịkwụsị na ịchọ enyemaka site n'ụlọ ọgwụ.
Na mgbakwunye, n'oge usoro ọgwụgwọ ọ dị mkpa ịgbaso nri hypocholesterol, nke a pụtara igbochi oriri nke abụba, nri eghe, àkwá, ntụ ọka na nri ụtọ.
Ọrịa mmetụta na ahụ
A na-ekewapụta nsonaazụ dabere na etu oge ọgodi si dị ugboro ugboro, ọ na-adịkarị obere.
Ugboro ugboro - otu ikpe na otu narị mmadụ - ọgbụgba, ihe mgbu na ụlọ nsọ na olu, mmepe nke ụdị shuga 2, ọgbụgbọ, vomiting, stool iwe, olu mgbu, ọrịa asthenic;
Ọ dị obere - otu ikpe na mmadụ 1000 - mmeghachi omume nfụkasị akụkụ nke ọgwụ sitere na urticaria ruo edema nke Quincke, nnukwu pancreatitis (mbufụt nke pancreas), ọnya anụ ahụ, myopathy;
Ihe dịkarịsịrị njọ - 1/10000 ikpe - rhabdomyolysis pụtara, nke a bụ mbibi nke akwara anụ ahụ na mwepụta nke protein na-emebi emebi na mpaghara ọbara yana ihe ọdịda nke ọdịda akụrụ.
Ihe mgbochi maka ojiji ogwu a bu okwu ndi a:
- Ime ime - Rosuvastatin bụ ihe dị oke egwu nye nwa ebu n’afọ n’ihi na, site na igbochi njikọta cholesterol, ọ na - emebi ọgba nke sel. Nke a, n'aka nke ya, ga-eduga n'ịzụlite intrauterine, akwara nke na - ada akụkụ akwara, na nsogbu nke iku ume. Nwa ebu n’afọ nwere ike ịnwụ ma ọ bụ mụọ nwere ajọ ọrịa, ya mere, a na-atụ aro ya ka edee ọgwụ ndị ọzọ maka onye ọrịa dị ime.
- Aụrụ nwa - a nwaleghị ya na nyocha ụlọ ọgwụ, yabụ ihe ọghọm ndị ahụ enweghị atụ. N'oge a, a ga-ahapụ ọgwụ ahụ.
- Childrenmụaka na ndị nọ n'afọ iri na ụma n'ihi organogenesis na-ezughị okè nwere ike inweta arụmọrụ, yabụ, amachibido ịbanye afọ 18 ka amachibidoro.
- Nnukwu gbasara akụrụ.
- Ọrịa nke imeju, nnukwu ma ọ bụ nke na-adịghị ala ala.
- N'oge ịka nká, ọ dị mkpa iji nlezianya dezie ọgwụ ahụ. Mmalite nke 5 mg, nke kachasị karịa 20 mg kwa ụbọchị n'okpuru nlekọta ahụike siri ike.
- Mgbe ebugharị akụkụ ahụ n'ihi ịkpa ókè nke cyclosporine, nke na-egbochi mmeghachi omume jụrụ na rosuvastatin.
- Yana anticoagulants, ebe Tevastor na-eme ihe ha na-eme, na-abawanye oge prothrombin. Nke a nwere ike juputara na obara obara.
- Nweghị ike iji ya na statins ndị ọzọ na ọgwụ hypocholesterolemic n'ihi nchikota nke pharmacokinetics.
- Nlepụghị anya nke Lactose.
Na mgbakwunye, amachibidoro ị medicationụ ọgwụ ma ọ bụrụ na onye ọrịa enwee mmụọ ịpersụ mmanya mgbe ọ bụla mejupụtara ọgwụ ahụ.
Enyere ozi banyere akpụ na vidiyo na edemede a.
