Ezubere ọgwụ antidiabetic Humulin NPH iji mee ka glucose na ọbara na ọkwa nkịtị, nwere oge ogo ọrụ.
International Nonproprietary Aha
Humulin NPH, dị ka ọgwụ nwere usoro kemịkalụ na-enweghị mgbagha, enyerela aha International Nonproprietary - Insulin-Isophan (Injin Injinia).
Ọzọkwa, ọgwụ a kwekọrọ na aha ahịa Humulin® NPH yana aha Latin Insulinum isophanum (humanum biosyntheticum).
Ezubere Humulin NPH iji mee ka glucose ọbara dị na ọkwa nkịtị ma nwee oge ogo ọrụ.
ATX
Ọgwụ a kwekọrọ na koodu A10AC01, nke pụtara na ọ bụ nke otu insulins mmadụ.
Ha weputara udi ya na ihe mebere ya
Ngwakọta ọgwụ a dị ka ihe bụ isi na-agụnye insulin mmadụ na usoro onunu ogwu nke 100 IU / ml. Iji hụ na akụrụngwa dị mkpa, a na-emejupụta usoro onunu ogwu ya site na ihe inyeaka: metacresol, phenol, glycerol, protamine sulfate, sodium hydrogen phosphate heptahydrate, zinc oxide, hydrochloric acid solution, sodium hydroxide solution na mmiri iji gbaa ntụtụ.
Ngwakọta ọgwụ ahụ na vials (10 ml) na katridges (3 ml) nke iko na-anọpụ iche. Vials nke 1 pc. enyere n’ime igbe kaadiboodu, na katridges nke 5 pcs. edobere na blisters. Usoro mgbanwe dị iche iche enwere ike iji zite katrized tupu etinyere n’ime mkpịsịgba sirinji (na katọn 5 pcs.).
Nkwụsị
Maka nhazi dị n'okpuru ala. Mkpesa a na-acha ọcha nwere ike ịkọwapụta iji mepụta mkpachapụ ọcha na mmiri dị ọcha ma ọ bụ nke na-enweghị ụcha na elu mmiri. Tupu ijiri, jiri nwayọ maa jijiji ọgwụ ahụ ruo mgbe enwetara mmiri nwere njikọ.
A gwakọtara ọgwụ ahụ na karama (10 ml) na katridges (3 ml) nke iko na-anọpụ iche, ihe mejupụtara ahụ gụnyere insulin mmadụ na usoro nke 100 IU / ml.
Omume ọgwụ
Ọgwụ a bụ ọgwụ insulin nke mmadụ na - agbagha, ọ na - eji ya dịka onye na - achịkwa metabolism nke glucose. A na-ahụta ihe anabolic dị ka ndị ọzọ na Humulin NPH. Insulin na - akwalite njem intracellular ngwa ngwa nke glucose na amino acids na anụ ahụ (ewezuga ụbụrụ), yana ịme ka anabolism protein dị ngwa. N'ihi insulin, a na-agbanwe glucose n'ime imeju na glycogen. Ọgwụ a na-arụ ọrụ dị ka onye na - egbochi gluconeogenesis ma na - enyere aka ịgbanwe glucose ngafe ka abụba.
Mlọ ọgwụ
Ọgwụ na-amalite ime oge 50-60 mgbe nchịkwa gasịrị, kachasị dị mma na oge ahụ site na elekere nke abụọ mgbe nchịkwa, ngụkọta oge nke ikpughe bụ awa 18-20.
Mmetụta ọgwụ zuru oke na ojiji nke ọgwụ ahụ ka a na-emetụta saịtị ịgba ọgwụ, usoro onunu ogwu na ịta. Ejiri ya na nkesa ezighi ezi kpuchie anụ ahụ. Mmụta emere nwapụta na ọgaghị Humulin NPH n'ime mmiri ara ara na enweghị ike ịbanye na mgbochi placental. 30-80% kpụrụ akụrụ.
Ihe ngosi maka ojiji
Edere ọgwụ ahụ maka ụdị 1 na ụdị ọrịa shuga mellitus 2, yana n'oge afọ ime, nke a na-eme na ụdị ọrịa shuga 2 nke ọrịa mellitus.
Edere ọgwụ Humulin NPH maka ụdị 1 na ụdị shuga 2.
Ihe ngbanwe
A machiri ojiji nke Humulin NPH n'ihe banyere hypoglycemia yana mmụba nke insulin na ihe ọ bụla nke ndị mejupụtara ọgwụ ahụ.
Jiri nlezianya
N'oge ime na inye nwa ara, mkpa ịba insulin nwere ike gbanwee, yabụ ọ dị mkpa ịkpachara anya mgbe ị na-a takingụ ọgwụ, na-elele ọnọdụ ahụ ma na-edozi doses ma ọ bụrụ na ọ dị mkpa.
Etu ị ga-ewere Humulin NPH
Dabere na usoro ị theụ ọgwụ ahụ ka dọkịta si kee ya wee dabere na ọdịnaya glucose dị n'ọbara. Anabatakwa nchịkwa intramuscular nke ọgwụ ka agbanyeghị, ụzọ izizi bụ ịgba n ’n'okpuru anụahụ n’akụkụ, ubu, apata, ma ọ bụ afọ. Amachibidoro ịbanye n'ime intraven.
Tupu nchịkwa, a na-ebute okpomọkụ nke nkwusioru ahụ ka ọ nwee ọnọdụ ime ụlọ, a na-aghọrọ saịtị ndị ọzọ na-agbanyeghị na-ejighị otu ebe karịa otu oge kwa ọnwa. Site na nchịkwa subcutaneous, ọ dị mkpa iji hụ na arịa ọbara anaghị emetụta. Ebe a na-agba ọgwụ agba mgbe agba ntụtụ adịghị.
Na-arịa ọrịa shuga
Tupu nchịkwa, a ga-edozigharịkwa insulin, nke a na-akpọgharị karama ọtụtụ ugboro n'aka aka, na-adọkpụgharị katridges ugboro iri n'ọbụ aka ha, wee tụgharịa ugboro 10 ọzọ site na 180 Celsius. Ihe mejupụtara kwesịrị ịpụta ka ọ bụrụ mmiri mmiri na-enweghị ntụpọ. Cannweghị ike ịkwanye ngwaahịa a nke ọma ka ụfụfụ wee ghara ịpụta, nke na-egbochi ihe ịtọ ziri ezi. Tupu ntụtụ ahụ, onye ọrịa ahụ ga-amụ ntuziaka maka inye insulin site na mkpịsị sirinji.
Ntuziaka Syringe Pen
Ngwa ngwa Pen dị mfe ma dịkwa mma iji. Nmebata insulin bu otutu uzo.
- Mgbe ị sachara aka gị nke ọma, họrọ ebe nsị ma hichaa ya.
- Wepu okpu nke mkpụrụ sirinji site na ịdọrọ ya, mana ọ bụghị ịgbagharị. Ewepula akara a. Gbaa mbọ hụ na insulin rụzuru ihe niile achọrọ (ụdị, ụbọchị, ọdịdị). Kpoghachi usọbọ.
- Kwadebe agịga ọhụrụ site na iwepu akara mpempe akwụkwọ na okpu mpụta. Jiri mmanya na-ehichapụ diski rọba ahụ n'ọnụ ọnụ nke ihe dị n'ụgbọ ahụ, tinye ya na agịga, nke dị na okpu, kpom kwem na anyụike na penịire. Ghaa agịga ahụ ruo mgbe ọ gbasara.
- Wepu okpu nke dị na njedebe nke agịga ahụ, mana atụpụkwala, ma wepu okpu ime ma tufuo ya.
- Lelee oriri insulin na Ndenye Pen Pen.
- Fanye agịga n'okpuru anụ ahụ, na-agbaso usoro dibịa ga-agbado gị. Jiri nwayọ pịa bọtịnụ ọgwụ ọgwụ ike na mkpịsị aka gị. Enterbanye n ’ọgwụ ahụ kpam kpam, a na-ejide bọtịnụ ahụ ruo ogo 5.
- Mgbe i wepụsịrị agịga ahụ, jiri nwayọọ na-eji ajị anụ na-acha uhie uhie pịa ebe ntụtụ.
- Jiri nkpuchita nchebe ma tụfuo agịga.
Humulin NPH ka a gbara n’okpuru anụ ahụ, na-agbaso usoro dibia a na-ekwu okwu na-atụ aro ya, jiri mkpịsị aka ukwu pịa bọtịnụ injection.
Nsonaazụ Humulin NPH
Usoro endocrine
Mmetụta dị n'akụkụ nke nwere ike ịme n'ihi nsonaazụ bụ isi nke ọgwụ ahụ bụ hypoglycemia. N'ọnọdụ ndị dị oke njọ, ọnọdụ a nwere ike ibute hypoglycemic coma na ọnwụ nke mmụọ, na n'ọnọdụ pụrụ iche, ịnwụ.
Ahụhụ
Ngosipụta mmeghachi omume nfụkasị mpaghara, nke gosipụtara site na ịcha ọbara ọbara, ọzịza na itching na ebe a na-agba ya, ga-ekwe omume. N’okwu a, ịkwesịrị ijide n’aka na ọ bụ ọgwụ ahụ kpatara mmeghachi omume ya, ọ bụghị site nfụkasị onye na-asacha ma ọ bụ ihe ndị ọzọ.
N'okwu ndị ọzọ, enwere ike igosipụta mmeghachi omume nfụkasị ahụ dị njọ n'ụdị itching juputara, iku ume dị mkpụmkpụ, ume iku ume, mbelata ọbara, mmụba obi na ịsụsọ ọfụma ga-ekwe omume. Ọnọdụ ndị dị otú ahụ nwere ike igbu mmadụ ma chọọ ọgwụgwọ ozugbo. May nwere ike ịgbanwe ọgwụ ma ọ bụ mepụta nchegharị.
Ọ dịkarịghị ala (enwere ike nke 0.001-0.01%) lipodystrophy na-etolite.
Mmetụta ikike ịchịkwa usoro
Theakingụ ọgwụ ahụ anaghị emetụta njikwa nke ụgbọ njem na usoro ndị ọzọ. Agbanyeghị, mmetụta na-adịghị mma nwere mmetụta dị n'akụkụ - hypoglycemia, nke a na-eji nlebara anya dọpụ uche, ọbụlagodi enweghị mmasi.
Ntụziaka pụrụ iche
Imeghari doses na uzo nke mmụba nwere ike ịchọ mgbe ị na-agbanwe nri, na-abawanye ma ọ bụ belata mmega ahụ, nrụgide mmetụta uche. Imeghari usoro onodu ogwu a nwere ike ju gi aka nke aka a na akpo thyroid gland, pituitary gland na adrenal gland.
Jiri n'oge ime na lactation
Ọtụtụ mgbe, a na-ebelata mkpa insulin n'oge ọnwa nke mbụ ma na-abawanye n'oge oge nke abụọ na nke atọ, n'ihi ya, ọ dị mkpa iji nyochaa ndị na-egosi. Gwa dọkịta gị maka mgbanwe niile gbasara ọgwụgwọ. Ekwesịrị ka gị na onye ọkachamara kwurịkụta ịtụrụ ime na atụmatụ ya.
N'oge a na-enye nwa ara, o nwere ike ịdị mkpa ngbanwe usoro onunu ogwu.
Ngwa maka ọrụ ezughi oke ọrụ
Mkpa insulin nwere ike ibelata, a ga-achọ ndozi usoro ọgwụgwọ.
Jiri maka ọrụ imeju na-arụ ọrụ
Mkpa insulin nwere ike ibelata, a ga-achọ ndozi usoro ọgwụgwọ.
Nmefere nke Humulin NPH
Ọ bụrụ na ọkwa insulin n'ime ọbara adịghị atụnyere oriri a na anabata na ume ike, hypoglycemia nwere ike ịdapụta, nke a na-egosipụta site na ịba ụba, ọsụsọ mụbara, tachycardia, pallor nke anụ ahụ, isi ọwụwa, ịma jijiji, ọgbụgbọ na ọgbụgba. Ogo na usoro mgbaàmà nke hypoglycemia nwere ike ịdị iche na ọnọdụ.
Mmekọrịta na ọgwụ ndị ọzọ
Mmetụta hypoglycemic nke insulin na-eme ka ọ dịkwuo mma site na ọgwụ a na-akpọ hypoglycemic, MA inhibitors, ACE inhibitors, carbonic anhydrase inhibitors, ndị na-ahọrọ beta-adrenergic igbochi ọgwụ ethanol nwere ọgwụ.
Mmetụta hypoglycemic nke insulin na-ebelata site na mgbochi mgbochi ọnụ, glucocorticoids, homonụ thyroid, thiazide diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazole, clonidine, BKK, diazoxide, morphine, phenytoin na nicotine.
Reserpine na salicylates nwere ike ịda mba ma kwalite ọrụ Humulin NPH.
Mmanya ndakọrịta
Mmanya na-aba n'anya bụ ihe na-eme ka ịbawanye ụba ike hypoglycemia, ya mere, iji nlezianya na-eleba anya, ndụmọdụ ọkachamara na, ikekwe, mmezi nke usoro nchịkwa achọrọ.
N'ọnọdụ ụfọdụ, ị drinkingụ mmanya na-aba n'anya na ị canụ insulin nwere ike ibute lactic acidosis, ketoacidosis, na mmeghachi omume disclaimira dị mgbagwoju anya.
Alcohol Dụ mmanya na-aba n'anya na ọgwụ insulin nwere ike ime ka lactic acidosis na mmeghachi mmekpa ahụ dị ka ahụ.
Analogs
Enwere ike dochie ọgwụ ahụ naanị mgbe ịgachara ọkachamara. Dị ka analogues nwere ike a nyere ndị na-esonụ ngwaọrụ:
- Insuman Bazal GT;
- Biosulin N;
- Protafan HM;
- Protafan HM Penfill.
Ahịa ọgwụ na-ahapụ okwu
Enwere m ike ịzụta na ndenye ọgwụ
Ọgwụ site na Ndepụta B nke enweghị ike ịzụta na-enweghị ndenye dọkịta.
Ọnụ ego Humulin NPH
Ọnụ ego ahụ na-adabere n'ụdị ntọhapụ, ọnụ ọgụgụ nke karama ma ọ bụ katrized na ngwugwu. Ọnụ ego dị nso nke Humulin NPH 100 IU / ml:
- Cartridge 3 ml, pcs 5. na otu kaadiboodu (ya na QuickPen) - site na 1107 rubles .;
- karama nke 10 ml, 1 pc. na mkpọchi kaadiboodu - site na 555 rubles.
Ọnọdụ nchekwa maka ọgwụ
Iji chekwaa ngwaahịa a, ị chọrọ okpomoku nke + 2 ... + 8 Celsius C na ebe echekwara site na anwụ. Ekwesighi ngwaọrụ oku di nso. Amachibidoro iji ifriizi.
Ihe analog nwere ike ịbụ ọgwụ Insuman Bazal GT.
Mee ka ụmụaka ghara iru.
Bọchị mmebi
Nkwụsị ahụ n'ụdị emepere emepe na-ejigide ihe onwunwe ya ruo afọ 3. Mgbe ịmalitere ojiji - ụbọchị 28 (na + 15 ... + 25 Celsius C).
Emeputa
Onye jidere akwụkwọ ndebanye aha maka ọgwụ ahụ bụ ụlọ ọrụ Switzerland "Eli Lilly Vostok S.A."
A na-emepụta karama na USA (Indianopolis), Eli Lilly na Companylọ Ọrụ, yana ngwongwo syringe nwere mkpịsị mkpịsị - na France, Lilly France.
Nyocha banyere Humulin NPH
Ndi dibia
Anna, 45 afọ, Saratov
Anọwo m na-arụ ọrụ na endocrinology ruo ihe karịrị afọ 20. Echere m na Humulin dị mma n'ọtụtụ ọnọdụ, ọ na-enyekarị mmeghachi omume nfụkasị.
Andrey, 38, Kaliningrad
Ọgwụ nwere ike analogues siri ike. M na-ahọpụta ya ma ọ bụrụ na ha nwere nnagide onwe ha.
Ndị ọrịa
Alexandra, 32, Moscow
Nwatakiri si Humulin nwere mmerụ ahu na saịtị ịgba agba, ọ bụ ezie na m na-agbalị ịgbanye nwayọ. Otu niile, akàrà pụtara, nke ga - edozizi n'ime ụbọchị ole na ole. Anyị ga agba mbọ gbanwee ka analog, n’agbanyeghi mkpesa ndị ọzọ.
Mikhail, 42, Kazan
Agbalịrị m ịhapụ Humulin NPH maka Biosulin, mana achọpụtara m na ọ baghị uru, n'ihi na nsogbu usoro onodu ogwu bidoro ịpụta, ị na-eme ya nke ọma, ma ọkwa ọkwa enyeghị nsonaazụ achọrọ. Nke a emebeghị NPH.
Alexander, 52, Khanty-Mansiysk
Anọwo m na-arịa ọrịa shuga kemgbe afọ iri. Ejiri m Humulin NPH na mmalite ọrịa ahụ. Ọkwa shuga dị nkịtị, ana m ewere naanị ọnụ ọgụgụ kachasị elu nke ihe o mere dị ka ndọghachi azụ, achọtara m nhọrọ ndị ọzọ maka onwe m.
