Ndị ọrịa na-arịa ọrịa shuga maara nke ọma mkpa ọ dị ịchekwa glucose ọbara nkịtị. Nke a ga - egbochi nsonaazụ ọjọọ nke ọrịa ahụ. Ọtụtụ mgbe, endocrinologists na-ede ọgwụ maka nchịkwa ọnụ, gụnyere Diabinax.
International Nonproprietary Aha
Gliclazide
Ọgwụ nwere aha njirimara mba ụwa - Gliclazide.
ATX
A10VB09
Ha weputara udi ya na ihe mebere ya
Ọgwụ ahụ dị naanị n'ụdị mbadamba ihe siri ike: gburugburu, ewepụghị ya na bevel n'akụkụ ya na ọkaibe n'otu akụkụ, ọcha. Usoro ogwu ọ bụla nwere 0.02, 0.04 ma ọ bụ 0.08 g nke ihe na-arụ ọrụ. Agụnyere ihe ndị a dị ka ndị ọzọ dere maka mbadamba ihe:
- MCC;
- aerosil;
- stachi na sodium stachi glycolate;
- talc;
- povidone;
- sodium methylparaben;
- steeti magnesium;
- mmiri.
Mpempe kaadiboodu nwere 1, 2, 3, 4, 5, ma ọ bụ 6 nke nwere mbadamba 10 ma ọ bụ 20 na nke ọ bụla.
Omume ọgwụ
Ngwongwo na -eme ka okpukpo a gwusi okpukpo a dabere na ikike nke ihe aru oru puru iche na uzo ATP ndi mmadu nwere ike imeghari ahu n’ime nkpuru ogwu. N'ihi nke a, ụzọ kalịlị ga-emeghe ma nubata nke sọlfọ ion n’ime cytoplasm na-aba ụba, nke a na-eduga n’inweta insulin na akpụkpọ ahụ na nnubata nke homonụ n’ime ọbara.
Enwere ike ịkwado ọgwụ ahụ maka ndị ọrịa nwere oke ibu, n'ihi ọ naghị ebute oke ibu.
Ihe nọ n'ọrụ na-emetụta ntọhapụ nke insulin nke mbụ na nzaghachi hyperglycemia mgbe ị risịrị nri. Nke a na-egosi ọdịiche dị n'etiti ya na usoro ọzọ nke sulfonylurea 2 ọgbọ. N'akụkụ a, enwere ike ịkwado ọgwụ ahụ maka ndị ọrịa nwere oke ibu, n'ihi ọ naghị ebute oke ibu.
Na mgbakwunye na ịba ụba insulin n'ime plasma, ọgwụ ahụ nwere ike ịkwalite usoro glucose n'ihi ọrụ nke glycogen synthetase na-arụ ọrụ, yana nwee ike ime ka usoro ndị a pụta:
- uche nke ndị na - anabata vaskụla adrenergic ndị na - anabata ya;
- na-agbadata adaba na platelet na nchịkọta, nhazi nke usoro fibrin lysis;
- Mbelata cholesterol;
- mweghachi nke vaskụla permeability.
N'ihi akụrụngwa ndị a, ọgwụ ahụ nwere ike iweghachi microcirculation ọbara, yabụ, ọ nwere ike belata ọnwụ protein site na akụrụ ma gbochie mmebi nke arịa azụ na ọrịa mellitus.
Mlọ ọgwụ
Onye na-ahụ maka ọnya hypoglycemic na-etinye obi gị dum na eriri afọ, nke na-adịghị na nnabata nri. N'ime usoro ọbara, ihe karịrị 90% na-ejikọ na hemoproteins, na-eru ọdịnaya kachasị elu mgbe ihe dị ka awa anọ gachara nchịkwa.
Ndụ ọkara ahụ bụ ihe dị ka awa iri na abụọ, ya mere, ọgwụ ahụ na-adịgide otu ụbọchị. Otu oge n'ime sistemụ ịba ọcha n'anya, ọ na-eme mgbanwe. Otu n'ime ihe ndị emepụtara nwere mmetụta na sistem vaskụla. A na - achọta ihe dịka 70% nke ịnara n'ụdị metabolites na mmamịrị, ihe dịka 12% na feces.
A na-eji ọgwụ ahụ eme ka profaịlụ glycemic dị n'etiti ndị ọrịa nwere ọrịa shuga nke 2.
Ihe ngosi maka ojiji
A na-eji ọgwụ ahụ eme ka profaịlụ glycemic dị n'etiti ndị ọrịa nwere ọrịa shuga nke 2. Nke a na - enyere aka igbochi nsonaazụ na nsogbu ndị hyperglycemia kpatara.
Ihe ngbanwe
N'ime usoro ọgwụgwọ ụdị ọrịa shuga mellitus nke 1, iji ọgwụ eme ihe adịghị mma n'ihi mmebi mkpụrụ ndụ beta pancreatic. A naghị akwado ya maka iji ya mee ihe na ụmụaka, ụmụ nwanyị dị ime na ndị na-enye nwa ara, yana ọnọdụ ndị a:
- oria ọrịa a: ketoacidosis na-arịa ọrịa shuga, ma ọ bụ precoa nke mamịrị;
- nnukwu akwara ma ọ bụ ụkọ akwara;
- pathologies nke mkpa insulin na-abawanye n'ike: ọrịa, mmerụ ahụ, ọkụ, ịwa ahụ;
- nsị thyroid;
- nnabata gliclazide;
- Oge nchịkwa imerizole ihe irighiri (fluconazole, miconazole, wdg).
Uzo esi ewere Diabinax
A na-atụ aro ị beụ ọgwụ a ugboro abụọ n'ụbọchị maka 0,5-1 awa tupu nri ụtụtụ yana tupu nri abalị, jiri mmiri sachaa ya. A na-edobe usoro ọgwụ kwa ụbọchị dabere na profaịlụ glycemic, ọnụnọ nke ọrịa na-abaghị uru, ogo nke ngosipụta ụlọ ọgwụ.
Enwere ike ijikọ ya na ndị nnọchianya hypoglycemic sitere na otu ndị ọzọ (ọ bụghị na usoro nke sulfonylurea) yana yana insulin ọgwụgwọ.
Na-arịa ọrịa shuga
A na-atụ aro ka ịmalite site na nke obere ọgwụ dị ala - 20-40 mg kwa dose. Nkezi onwa kwa ubochi bu 160 mg na nkewa abuo. Mkpụrụ akwụkwọ kachasị anabata nke a na-anabata kwa ụbọchị bụ 320 mg.
Nsonaazụ Diabinax
Ọgwụ ọgwụ belata belata, nsị na-egbu egbu nwere ike:
- ngosipụta anụ ahụ: ihe ọkụ ọkụ, itching, urticaria;
- nsogbu mgbanwe nke usoro hematopoietic: thrombocytopenia, leukopenia, anaemia;
- isi ọwụwa, nkụda mmụọ;
- jaundice.
Ihe nọ n'ọrụ nwere ike ime ka mmadụ mara ihe ihe ọjọọ dị na ya. N'ime mkpesa ndị ọzọ, ngosipụta dyspeptik, dịka:
- ọgbụgbọ
- vomiting
- agụụ riri;
- afọ ọsịsa
- gastralgia.
Enwere ike inwe usoro nke ịdalata glukos ọbara nwere mgbaàmà ndị a:
- adịghị ike
- palpitations
- mmetụta nke agụụ;
- isi ọwụwa;
- ịma jijiji na anụ ahụ, wdg.
Mmetụta ikike ịchịkwa usoro
N'akụkụ mmetụta ndị ọ ga-ekwe omume, onye ọrịa ahụ kwesịrị ịkpachara anya mgbe ọ na-ejikwa ngwaọrụ ọrụ mgbagwoju anya.
Ntụziaka pụrụ iche
A na-eme ọgwụgwọ na ọgwụ ahụ na nnabata ya na nri nwere obere ọdịnaya shuga na carbohydrates ndị ọzọ dị na ngwaahịa ahụ. Ma a na-atụ aro ka nri na-edozi ahụ zuru oke na usoro nke nri mejupụtara na ọdịnaya nke vitamin nwere ihe metụtara ya. Ekwesịrị ịgwa onye ọrịa ahụ na mgbanwe mgbanwe nri, oke ibu, ọrịa na-efe efe, ọgwụgwọ ịwa ahụ, ndozi ma ọ bụ dochie ọgwụ nwere ike ịdị mkpa.
Jiri na agadi
N'ime ndị agadi, ojiji ọgwụ a nwere uru ọ dị ma e jiri ya tụnyere ọgwụ ndị na-eme ogologo oge nke otu a. Ọgwụ na-eme ka mwepụta homonụ nke mbu site na akwara, ya mere, belata nsogbu hypoglycemia n'oge a. Site na usoro ọgwụgwọ ogologo oge, ibelata ịdị irè nke ọgwụ na mkpa nke ịba ụba usoro onunu ogwu kwa ụbọchị ga-ekwe omume.
Inye umuaka
A machibidoro ọgwụ a n'afọ 18, n'ihi na Enweghị ozi na nchekwa nke iji.
Jiri n'oge ime na lactation
N'ime oge iko, eji eme ihe n'ọgwụ abụọ nke ihe eji eme ihe na ihe adịghị mma, dịka FDA si kọọ ha, ha na-ekenye klas C. Site na ọmụmụ ọmụmụ na-egosi na ọnụnọ teratogenic na nsị ọmụmụ ahụ na-emetụta nwatakịrị ahụ mgbe ị na-a thisụ ọgwụ a, ojiji a machibidoro ndị inyom dị ime.
Enweghị data na ntinye nke ihe arụ ọrụ n'ime mmiri ara. Ọ bụrụ na ọ dị mkpa, nhọpụta ya na ịdọ ụmụ nwanyị ara ga-ewepụ nwa ara.
Ngwa maka ọrụ ezughi oke ọrụ
Site na nkwarụ akwara siri ike, nke a na-egosipụta site na mbelata nke GFR n'okpuru 15 ml / min, a na-egbochi ọgwụ ahụ. A na-eji usoro nlezianya rụọ ọrụ na ịkpachapụ anya gbasara obere akwara, mana a na-eji otu usoro ahụ eme ihe dị ka akọpụtara na ntuziaka ahụ.
Jiri maka ọrụ imeju na-arụ ọrụ
Site na nsogbu nke usoro ịba ọcha n'anya, mmụba nke ị ofụ ọgwụ na ọbara ga-ekwe omume. Nke a na - ebulite ihe ize ndụ nke hypoglycemia. Ya mere, enweghi ike ịkọ ọgwụ a maka ndị ọrịa nwere oke imeju.
Mgbe ị na-a theụ ọgwụ ahụ na usoro onunu ogwu nke gabigara ihe dị mma maka mmadụ, akara nke mbelata nke glycemia na-apụta.
Do Overụbiga mmanya ókè nke Diabinax
Mgbe ị na-a theụ ọgwụ ahụ na usoro onunu ogwu nke gabigara ihe dị mma maka mmadụ, akara nke mbelata nke glycemia na-apụta. Ejiri ọnọdụ a na ọnọdụ ịdị mma nke ịdị iche iche: site na adịghị ike izugbe na ịda mbà nke nsụhọ. A aụbiga mmanya ókè nwere ike ịmalite.
Ọgwụgwọ: weghachi glucose ọbara. A na-enye ndị ọrịa nwere obere ahụike na ngwaahịa nwere shuga nwere n'ime, ma ọ bụrụ na mmụọ adịghịzi ike, a ga-achịkwa glucose ọbara mgbe ọ bụla.
Mmekọrịta na ọgwụ ndị ọzọ
Ogo nke mbelata nke glycemia na-abawanye na oge nke oge a na ọgwụ ndị a:
- tetracyclines;
- sulfonamides;
- salicylates (gụnyere acetylsalicylic acid);
- anticoagulants na-apụtaghị ìhè;
- steroid anabolic;
- ndị na - egbochi beta;
- fibrates;
- chloramphenicol;
- fenfluramine;
- fluoxetine;
- guanethidine;
- Ndị na - egbochi MAO;
- pentoxifylline;
- theophylline;
- kafiin
- phenylbutazone;
- cimetidine.
Mgbe ị na-eji acarbose dee Gliclazide, a na-ahụ nchịkọta nke mmetụta hypoglycemic.
Mgbe ejiri acarbose jikwaa, a hụrụ nchịkọta nke mmetụta hypoglycemic. Emeputara na nnwebe ma ọ bụ ibelata na mmetụta nke iji ọgwụ ahụ na nchịkwa nke imekotaotu aka ya na ihe ndị a:
- mgbochi;
- chlorpromazine;
- glucocorticosteroids;
- ihe nnabata;
- glucagon;
- nicotinic acid;
- estrogens;
- progestins;
- ọgwụ mgbochi ịmụ nwa;
- diureta;
- rifampicin;
- homonụ thyroid;
- nnu nke lithium.
Ọgwụ a na - eme ka ọnọdụ nke ventricular extarsystole na - eme ihe mgbe ọ na - emeso glycosides cardiac.
Mmanya ndakọrịta
N'ime ndị na-ejikwa oge ethanol na glycazide, ogo hypoglycemia mụbara, na-enwe mmetụta disulfiram. Iji nlezianya mee ihe, a na -eme ọgwụgwọ maka ndị ọrịa na-arịa ị alcoholụ mmanya.
Analogs
Maka ọgwụ ndị India na Russia, a na-enye analogs ndị a maka ihe dị n'ọrụ a:
- Glidiab;
- Ọrịa mamịrị;
- Gliclazide;
- Diabefarm MV;
- Gliclazide MV, wdg.
Ahịa ọgwụ na-ahapụ okwu
Ọ bụ dọkịta na-edenye ọgwụ ahụ kpamkpam.
Enwere m ike ịzụta na ndenye ọgwụ
Ekwesịrị ịhọrọ ọgwụ ndị dị mkpa maka njikwa glycemic kachasị mma maka nchebe maka onye ọrịa, yabụ ereghị ọgwụ a na-enweghị ndenye ọgwụ.
Diabinax ọnụahịa
Edere ọgwụ a na Vital na Mkpa Ọgwụ. A na-achịkwa ọnụ ahịa ya. Ọnụ ego nke mbadamba 1 na 20 mg na nkezi nkezi 1.4 rubles, 40 mg - site na 2.4 ruo 3.07 rubles, na 80 mg - 1.54 rubles.
Ọnọdụ nchekwa maka ọgwụ
A na-echekwa ngwungwu ọgwụ a na okpomọkụ n'okpuru +25 Celsius C n'ebe a na-echebe ya site na anwụ na anwụ. Ekwela ka ụmụaka ghara iru ya.
Bọchị mmebi
Afọ 3
Emeputa
A na-emepụta ọgwụ ahụ site na ụlọ ọrụ ndị India Shreya Life Science, nke nwere ụlọ ọrụ nnọchite anya na Russia kemgbe 2002.
Ọ bụ dọkịta na-edenye ọgwụ ahụ kpamkpam.
Nyocha banyere Diabinax
Elizabeth, gbara afọ 30, Nizhny Novgorod
A chọpụtara na nne ochie nwere ọrịa shuga afọ ise gara aga. Kemgbe ahụ ọ na-a regularlyụ ọgwụ ahụ kwa ụbọchị ugboro abụọ n'ụbọchị. Anyị na-enyocha ọkwa shuga dị n'ọbara ya kwa oge - ọ na-akwụsi ike ịnọ n'ọnọdụ nkịtị. Nne nne na-anabata ọgwụgwọ ahụ nke ọma. Ọgwụ endocrinologist tụụrụ ya aro mgbe niile.
Stanislav, 65 afọ, Chelyabinsk
Erere ọgwụ n'ụtụtụ tupu nri ụtụtụ. Ejirila m ọgwụ ahụ ọkara ọkara afọ ugbu a. Ahụ adị m mma: Enwere m ike ịrụ ọrụ ọzọ, ike gwụrụ m, akpịrị kpọrọ nkụ belata. O yikarịghị ka ọ takeụrụ ọgwụ maka nsogbu ọria ọbara.
Regina, 53 afọ, Voronezh
N'ihi ọrụ siri ike, nsogbu ahụike malitere: dị ka nyocha ndị ahụ si kwuo, ha chọpụtara na ha nwere ọbara mgbali elu. Mgbe nyocha ahụ gasịrị, etinyere mbadamba ọgwụ 0,5 nke ọgwụ tupu nri ụtụtụ na nri abalị. Ana m anabata oge niile, mana jide n'aka na ị ga-agbaso nri. Ngụkọta ọbara niile laghachiri na nkịtị.
